ABSTRACTOur research group has focused on the long‐term performance degradation of micro‐electro‐mechanical systems (MEMS) devices under mechanical, thermal, and electrical stresses. We previously used physics‐based models for performance prediction, but the diverse materials, structures, and environmental conditions of MEMS devices affect their long‐term stability. Traditional physics‐based models struggle to account for these factors, limiting practical application. To address this, we employ data‐driven methods to include more variables. This paper introduces a hybrid approach combining physical principles with data‐driven techniques, specifically physics‐informed neural networks (PINN), to model and analyze performance degradation in MEMS resonators. We compare this method with previous physics‐based and data‐driven approaches (support vector machine and random forest) under identical conditions. The hybrid method not only provides accurate predictions but also considers more operating conditions, enhancing practical application.