In this study, a novel hybrid solar-biomass residential micro – Combined Heat and Power system driven by the Partially Evaporating Organic Rankine Cycle is proposed and its operation is simulated, by applying an in-house numerical model. The simulation tool is applied for a test case in Athens, Greece, where the micro-CHP system operates to cover the annual energy demand of a multi-family building. The proposed cogeneration unit covers 97.10 % and 25.85 % of the modeled building’s annual Space Heating and electricity demand, respectively, by using renewable energy sources. The annual average total energy and exergy efficiencies are equal to 53.33 %, and 10.35 %, respectively, while the power cycle can achieve thermal efficiencies as high as 9.73 %. Competitive Levelized Cost of Electricity (0.072–0.133 €/kWhel), and Levelized Cost of Heat (0.036–0.067 €/kWhth) values are estimated, with a PayBack Period between 5.17 and 9.64 years. The environmental impact of the proposed hybrid micro-CHP is anticipated to be significant, rising to 46.25 kWh of Primary Energy Savings, and 31.22 kg CO2-eq. reduction in carbon emissions per m2 of residence annually.