Meyerson Phenomenon Research Articles

Congenital Melanocytic Nevi With Meyerson Phenomenon: Two Case Reports and Review of the Literature.

Congenital Melanocytic Nevi With Meyerson Phenomenon: Two Case Reports and Review of the Literature.

Meyerson Phenomenon in Lobular Capillary Hemangioma.

Meyerson Phenomenon in Lobular Capillary Hemangioma.

Meyerson Nevus Mimicking Malignant Melanoma

Meyerson nevus represents an uncommon clinical and histological variation of melanocytic lesions that is characterized by an eczematous halo surrounding a melanocytic nevus.1It was first reported by Meyerson and it typically clears spontaneously or resolves with topical corticotherapy.2We report the case of an atypical Meyerson nevus in which, despite intense pruritus, both an eczematous eruption and dermoscopic patterns imputable to a melanocytic lesion were lacking.
 1. Balato A, Lembo S, Cirillo T, Megna M, Napolitano M, Balat N. Meyerson phenomenon around naevi: resolution after sun exposure? Acta Dermato-Venereol. 2011;91:352-3. doi: 10.2340/00015555-1059.2. Gabbi TV, Omar ED, Criado PR, Valente NY, Martins JE. Clinical, dermoscopic and histopathological evaluation of the Meyerson nevus: case report. An Bras Dermatol. 2010;85:681-3.

Meyerson Phenomenon Simulating a Halo Nevus

Meyerson phenomenon (MP) is an uncommon clinical condition that is characterized by an eczematous halo surrounding a preexisting melanocytic nevus (MN) and numerous other lesions. The etiology is unknown and the main concern is malignant transformation. We report an original case of a MP simulating a halo nevus.

Sudden eruption of multiple Meyerson naevi

<p>We present a case of a young patient presenting with a six-month history of multiple squamous pink and light brown papules surrounded by symmetrical eczema on the trunk. Dermoscopy revealed light brown structureless and avascular lesions with an erythematous scaly halo. The patient denied the presence of naevi on the sites of the newly emerging changes. Histopathology revealed acanthotic epidermis and linear clusters of morphologically normal naevi cells in the upper dermis, infiltration of lymphocytes, plasma cells, eosinophils and mild spongiosis in the dermis. Topical betamethasone/gentamicin ointment twice daily for 10 days was prescribed. The erythematous scaly area around lesions completely disappeared on the follow-up visit after six months. This is a unique case of a sudden appearance of newly formed multiple benign dermal naevi with Meyerson phenomenon—the sudden eruption of multiple Meyerson naevi.</p>

Solitary angiokeratoma with Meyerson phenomenon

Solitary angiokeratoma with Meyerson phenomenon

Eczema within a Capillary Malformation: A Case of Meyerson Phenomenon.

Eczema within a Capillary Malformation: A Case of Meyerson Phenomenon.

Blue areas on dermoscopy of a congenital nevus with Meyerson phenomenon

Blue areas on dermoscopy of a congenital nevus with Meyerson phenomenon

Melanocytic lesions with eczematous reaction (Meyerson's phenomenon) – a histopathologic analysis of 64 cases

Eczematous (spongiotic) reaction in melanocytic lesions (Meyerson's phenomenon) has not been systematically analyzed and has not been convincingly documented in melanoma. We analyzed 64 consecutive melanocytic lesions with spongiotic reaction, occurring in 57 patients (age range 14-81 years; mean, 39 years; 30 females, 27 males) including 16 common acquired nevi, 3 nevi with congenital features, 2 Spitz nevi, 29 dysplastic nevi, 6 in situ and 8 invasive melanomas. The intensity of the spongiotic reaction was graded as mild in 24 (38%), moderate in 22 (34%) and marked in 18 (28%) lesions. It was moderate/marked in 6 of 14 (43%) in situ or invasive melanomas. Upward migration of melanocytes in the epidermis was noted in 7 (33%) non-dysplastic and 10 (34%) dysplastic nevi but was generally limited to the lower half of the epidermis. Moderate/severe cytologic atypia was found in 14 (48%) dysplastic nevi and all melanomas but not in non-dysplastic nevi. Prominent spongiotic reaction with eosinophils in the inflammatory infiltrate can affect all types of melanocytic lesions. Upward migration involving the uppermost layers of the epidermis, especially when extensive and present in areas with a less pronounced spongiotic reaction, and moderate/severe cytologic atypia indicate a melanoma.

Eczema Confined to Becker's Nevus on the Face: The Behavior of Melanocytes during Inflammation

Dear Editor: Becker's nevus is a unilateral, hyperpigmented hairy cutaneous hamartoma. Becker's nevi are commonly associated with several structural anomalies and cutaneous diseases1-5. They may be related to the presence of increased androgen receptors and/or mosaicism or be associated with the isotopic response phenomenon. Eczematous dermatitis associated with Becker's nevus is quite rare and described in only one case report. Herein, we describe a second case of eczema confined to Becker's nevus on the face. In addition, the melanocytes in Becker's nevus had the morphologic appearance of activated cells, a phenomenon which may have been due to inflammation. A 47-year-old man visited our clinic due to a pruritic, lichenified plaque overlying a hyperpigmented, hypertrichotic area on his left cheek. The hyperpigmented, hypertrichotic lesion had been present since around puberty and remained asymptomatic until 1 year prior to his arrival; at that time the pruritic lesion appeared. Physical examination revealed a lichenified plaque confined to the hyperpigmented, hypertrichotic patch on the left side of the patient's face (Fig. 1). A 3-mm punch biopsy was performed, and the histological findings were consistent with chronic eczema (Fig. 2A) coexisting with Becker's nevus (Fig. 2B). Interestingly, NKI/beteb staining showed hyperactivated dendritic melanocytes in the epidermis (Fig. 2C), which is not common in an ordinary Becker's nevus. The Becker's nevus is currently being treated with 5 sessions of fractional CO2 via laser therapy and is improving. Fig. 1 Eczematous lesion coexisting with Becker's nevus. Fig. 2 (A) H&E staining showed epidermal acanthosis with parakeratosis and superficial perivascular lymphohistiocytic infiltration in the upper dermis, consistent with chronic eczema (Original magnification ×50). (B) Hyperpigmentation of the ... Becker's nevi have been associated with several skin and structural anomalies. Cases of acneiform eruption, breast hypoplasia, smooth muscle hyperplasia, and hypertrophy of the sebaceous glands are reported to have been localized in Becker's nevi; this phenomenon is thought to be related to an increased level of androgen receptors in Becker's nevi1,2. Genetic mutation or mosaicism may contribute to the development of skin disorders, such as hypohidrosis colocalized with Becker's nevus3. Skin diseases, such as lichen planus and prurigo nodularis, have also been reported to be associated with Becker's nevi4,5. These occurrences may explain Wolf's isotopic response, which is the appearance of a new skin disorder at the exact site of another, unrelated skin disease that has long since healed. Our case, lichen simplex chronicus associated with Becker's nevus, may represent this isotopic response. The mechanism behind isotopic response is poorly understood6. Occurrence of a localized halo eczematous eruption surrounding acquired melanocytic nevi was first described by Meyerson in 1971 and was termed the Meyerson phenomenon or Meyerson's nevi7. This phenomenon is characterized by hypopigmentation around the involved nevi which clears after a few months. Our patient showed an eczematous eruption localized on Becker's nevus, but no surrounding halo like that seen in Meyerson's nevi was present. Therefore, our case is not considered to be Meyerson's nevi but an isotopic response. Melanocytes may respond to cutaneous inflammation. Inflammation-related factors, such as prostaglandins, histamine, and alpha-MSH may be responsible for the activation of melanocytes8. Our case clearly showed in vivo evidence of melanocytic activation during inflammation. The cells were large and dendritic, suggesting that the eczematous skin inflammation activated epidermal melanocytes. In conclusion, eczematous dermatitis localized in Becker's nevus represents an isotopic response, and cutaneous inflammation may activate melanocytes.

Phénomène de Meyerson périnævique disséminé révélateur d’un mélanome

Meyerson phenomenon (MP) consists of an eczematous reaction occurring around a pre-existing dermatologic lesion that is usually melanocytic and generally benign, and which is known as a Meyerson naevus. We report a case of multiple Meyerson naevi revealing melanoma, which itself was surrounded by a halo of eczema. A 55-year-old man of phototype III with atopic eczema presented for pruritic eczema present for a fortnight, found solely on and around the naevi on his trunk and at roots of his limbs. One of the melanocytic lesions affected by these Meyerson phenomena was clinically atypical and had been active for several years. Excision confirmed the diagnosis of level II extensive superficial melanoma measuring 0.75 mm in thickness and associated with lesional and perilesional eczematous remodelling. After surgery involving a 1-cm excision margin and local corticosteroid therapy of the eczema, the Meyerson phenomenon subsided with complete remission of the melanoma at 1 year. Meyerson phenomenon can affect one or more naevi at the same time; it is generally transient, may recur on occasion, and has a favourable outcome either spontaneously or with corticosteroid treatment. When not removed for histological verification, the melanocytic lesion regains its initial appearance following resolution of the phenomenon. MP differs from Sutton phenomenon (SP), which is a perinaevic vitiligo reaction leading to complete or partial regression of the melanocytic lesion, which may be either benign or malignant. This case of Meyerson phenomenon revealing melanoma shows that the melanocytic lesions targeted by MP are not necessarily benign.

Acquired Smooth Muscle Hamartoma of the Patchy Follicular Variant With Meyerson Phenomenon

Acquired Smooth Muscle Hamartoma of the Patchy Follicular Variant With Meyerson Phenomenon

Dermatofibroma and halo dermatitis

The occurrence of a halo of dermatitis surrounding acquired naevi was initially reported by Meyerson in 1971 with histological features of focal spongiosis, parakeratosis, irregular acanthosis and a lymphocytic infiltrate in the upper dermis. When the same inflammatory reaction occurs around other lesions it is referred to as the Meyerson phenomenon or halo dermatitis. We report a rare case of the Meyerson phenomenon occurring around a dermatofibroma in a 69-year-old woman. This case highlights that the phenomenon may occur in a broad range of clinical scenarios and is not limited to acquired naevi in young adults.

Avaliação clínica, dermatoscópica e histopatológica do nevo de Meyerson: relato de caso

Meyerson nevi occur whenever a rare focal and transitory eczematous eruption arises around melanocytic lesions. The same phenomenon has also been observed in non-melanocytic lesions as well. Herein we report the case of a 25 year old, male patient, who had noticed, two months before, the arising of a pruriginous and erithematous halo around two nevi localized on his abdomen. The lesions were found to be atypical on dermoscopic examination and he was submitted to surgical excision of both nevi. Histopathological examination revealed displastic compound melanocytic nevi, surrounded by intraepidermical vesicles and spongiosis. Present report suggests that Meyerson phenomenon does not seem to alter dermoscopic features of nevi.

Early melanoma with halo eczema (Meyerson's phenomenon)

We present a case of a 49-year-old man who presented with a solitary atypical pigmented lesion with a surrounding halo of dermatitis. Dermoscopy showed a pigment network at the periphery with areas of scar-like depigmentation, negative pigment network and erythema. The lesion was treated preoperatively with a potent topical corticosteroid resulting in a reduction of inflammation. Histology showed an early Clark level 1 melanoma arising within a severely dysplastic compound melanocytic naevus. There was an adjacent perivascular chronic inflammatory cell infiltrate with occasional eosinophils. Minimal, though definite spongiosis with parakeratosis was also present. The scar was subsequently re-excised achieving appropriate excision margins for melanoma in situ. Six months later, there was recurrence of dermatitis at the scar with no evidence of recurrent melanoma. To our knowledge, melanoma with Meyerson phenomenon has not been reported in the literature. This case highlights that all lesions should be evaluated on clinical and dermoscopic grounds regardless of the presence or absence of eczema. Our case adds yet another entity that may display Meyerson phenomenon and consequently a halo of eczema cannot be considered a reassuring sign when evaluating melanocytic lesions.

Meyerson‐Phenomenon hides a nevus flammeus

Facial eczema is a common disease in daily dermatological practice. The cause of facial eczema is often atopic dermatitis or allergic contact dermatitis. Usually, the eczema resolves with correct topical treatment and by avoiding allergic trigger factors. A 49-year-old woman presented with persistent eczema on her forehead which recurred over decades despite correct topical therapy. A skin biopsy revealed the astonishing diagnosis of a nevus flammeus with an overlying eczema known as the Meyerson phenomenon. The Meyerson phenomenon is often described in children with nevi flammei suffering from atopic dermatitis - in adults the phenomenon is rarely recognized as a reason for eczema. We show the interesting case of an adult woman with the Meyerson phenomenon on a nevus flammeus and discuss the possible pathomechanisms.

Meyerson Phenomenon

Meyerson phenomenon is an uncommon clinical condition that is characterized by an eczematous halo surrounding a preexisting melanocytic nevus and numerous other lesions. The etiology of this condition is unknown. We suggest that the mechanism is due to the interaction between CD4 T lymphocytes and increased expression of intercellular cell adhesion molecule 1 (ICAM-1). This article provides a concise overview of Meyerson phenomenon. We present the case of a 37-year-old female with an inflamed nevus located on her thigh from no evident cause. Her condition resolved with surgical excision of the nevus. Histopathology of the specimen demonstrated spongiosis and lymphocytic infiltrate with eosinophils, which confirmed the diagnosis of Meyerson phenomenon. Meyerson phenomenon can resolve spontaneously or with treatment of either topical steroids or surgical excision. The main concern with benign lesions presenting with inflammation is malignant transformation; thus, clinicians need to be more aware of Meyerson phenomenon.

Meyerson Phenomenon in Children: Observation in Five Cases of Congenital Melanocytic Nevi

To describe the characteristics of five pediatric patients with the Meyerson phenomenon associated with congenital melanocytic nevi, five cases were reviewed to retrieve information relating to clinical presentation, treatment and evolution of the eczematous phenomenon and of the nevi. Three of five patients were male. Mean age at presentation of the Meyerson phenomenon was 23 months (range: 4 mos-4 yrs). Three patients presented with only one halo eczematous lesion, while two patients presented with more then one halo eczematous lesions. The halo eczematous lesions were located on the leg, arm, and trunk in four, two, and two patients, respectively. All were associated with congenital melanocytic nevi with overlying hypertrichosis. Four were treated with topical corticosteroids, and five developed some degree of hypopigmentation within the nevic lesion. In children with Meyerson phenomenon associated with congenital hairy melanocytic nevi, neither trigger to the eczematous eruption nor preferential gender or anatomical site location was identified. The Meyerson phenomenon evolved towards hypopigmentation of the congenital melanocytic nevic lesions in all patients but no other cutaneous changes were observed on follow-up.

The Meyerson phenomenon in a teenager

The Meyerson phenomenon in a teenager

Meyerson phenomenon associated with dysplastic compound nevi

Meyerson phenomenon associated with dysplastic compound nevi