2-methoxyethanol Research Articles

Effect of Bis (methyl glycol) phthalate on endoplasmic reticulum stress in endothelial cells

Phthalate-based polymeric plasticizers are widely used for their durability, transparency, and odorless nature, resulting in human exposure through inhalation, ingestion, or contaminated water. Epidemiological studies have identified bis-phthalate as a potential cardiovascular disease risk factor, though its mechanisms remain unclear. This study investigates the effects of bis-phthalate on endothelial dysfunction (ED), an early event in cardiovascular complications, with a focus on Endoplasmic Reticulum (ER) stress pathways. We observed dose- and time-dependent cytotoxicity in endothelial cells exposed to bis-phthalate, accompanied by elevated expression of ER stress markers (GRP78, IRE-1α, CHOP) and oxidative stress markers (TXNIP, P22phox), as measured by qPCR. Reactive oxygen species (ROS) levels also increased dose-dependently, as determined by H2DCFDA using flow cytometry. These findings suggest that bis-phthalate exposure induces both oxidative and ER stress, leading to the development of ED, providing insights into its potential role in cardiovascular disease progression.

Investigation into the Potential of Paullinia pinnata (Linn.) Methanol Leaf Extract against Toxicity by Ethylene Glycol Monomethyl Ether in Wistar Rats

Investigation into the Potential of Paullinia pinnata (Linn.) Methanol Leaf Extract against Toxicity by Ethylene Glycol Monomethyl Ether in Wistar Rats

Synthesis and properties of a visual fluorescence-enhanced HClO/ClO- probe

Hypochlorite ion (ClO-/HClO) is a reactive oxygen species that plays a vital role in biological systems and daily life. The accurate detection of ClO- is critical for disease prevention and environmental monitoring. Therefore, it is necessary to develop highly sensitive probes. In this study, we report a visual fluorescence-enhanced HClO/ClO- probe CN-TPE-PEG1900, which was obtained by grafting poly (ethylene glycol) monomethyl ether 1900 with tetraphenylethylene (TPE) as the fluorescent parent. The fluorescence intensity of a solution containing CH3OH/H2O (30 μM, v/v, 1/4, PBS, pH = 7.4) and the probe CN-TPE-PEG1900 was increased by 9 times at 525 nm due to the presence of ClO-. The color of the probe CN-TPE-PEG1900 solution changed from yellow to colorless after reaction with ClO-. The limit of detection (LOD) of the probe CN-TPE-PEG1900 was 5.48 × 10–8 mol/L. In addition, it had a high fluorescence quantum yield of 51.27 %, a large Stokes shift of 165 nm, good water solubility, and high water sample recovery rates. The calculated data, 1H NMR, mass spectrometry, DLS, and SEM results were combined to deduce the recognition mechanism of the probe CN-TPE-PEG1900 for ClO-. Thus, the presence of ClO- facilitated the cleavage of the double bond in CN-TPE-PEG1900, thereby separating the water-soluble poly (ethylene glycol) chain from TPE through oxidative cleavage. Moreover, this led to the formation of TPE-CHO, which was less water-soluble and more prone to aggregation, resulting in fluorescence enhancement at 525 nm. Meanwhile, the process also caused a blue shift in the emission wavelength and a change in the color of the probe solution.

Optimization of Interfacial Properties Improved the Stability and Activity of the Catalase Enzyme Immobilized on Plastic Nanobeads.

The immobilization of catalase (CAT), a crucial oxidoreductase enzyme involved in quenching reactive oxygen species, on colloids and nanoparticles presents a promising strategy to improve dispersion and storage stability while maintaining its activity. Here, the immobilization of CAT onto polymeric nanoparticles (positively (AL) or negatively (SL) charged) was implemented directly (AL) or via surface functionalization (SL) with water-soluble chitosan derivatives (glycol chitosan (GC) and methyl glycol chitosan (MGC)). The interfacial properties were optimized to obtain highly stable AL-CAT, SL-GC-CAT, and SL-MGC-CAT dispersions, and confocal microscopy confirmed the presence of CAT in the composites. Assessment of hydrogen peroxide decomposition ability revealed that applying chitosan derivatives in the immobilization process not only enhanced colloidal stability but also augmented the activity and reusability of CAT. In particular, the use of MGC has led to significant advances, indicating its potential for industrial and biomedical applications. Overall, the findings highlight the advantages of using chitosan derivatives in CAT immobilization processes to maintain the stability and activity of the enzyme as well as provide important data for the development of processable enzyme-based nanoparticle systems to combat reactive oxygen species.

Unveiling the Failure Mechanism of Zn Anodes in Zinc Trifluorosulfonate Electrolyte: The Role of Micelle-like Structures.

Zinc trifluorosulfonate [Zn(OTf)2] is considered as the most suitable zinc salt for aqueous Zn-ion batteries (AZIBs) but cannot support the long-term cycling of the Zn anode. Here, we reveal the micelle-like structure of the Zn(OTf)2 electrolyte and reunderstand the failing mechanism of the Zn anode. Since the solvated Zn2+ possesses a positive charge, it can spontaneously attract OTf- with the hydrophilic group of -SO3 and the hydrophobic group of -CF3 via electrostatic interaction and form a "micelle-like" structure, which is responsible for the poor desolvation kinetics and dendrite growth. To address these issues, an antimicelle-like structure is designed by using ethylene glycol monomethyl ether (EGME) as a cosolvent for highly reversible AZIBs. The modified electrolyte shows lower dissociation ability to Zn(OTf)2 and higher coordination tendency with Zn2+ compared to the Zn(OTf)2 electrolyte, resulting in the unique solvation structure of Zn2+(H2O)1.2(OTf-)2(EGME)2.8, which significantly reduces the charge of micelle, damages the micelle-like structure, and boosts the desolvation kinetics. Moreover, the reduction of EGME and OTf- can form a robust dual-layered SEI with high Zn2+ ion conductivity. Consequently, the Zn/Cu asymmetric coin cell using ZT-EGME can work at a high rate and a capacity of 50 mA cm-2 and 5 mA h cm-2 for more than 120 cycles, while its counterparts using ZT can barely work. Moreover, a 505.1 mA h pouch cell with practical parameters including a lean electrolyte supply of 15 mL A h-1 and an N/P ratio of ∼3.5 can work for 50 cycles.

Molecular interactions and thermodynamic modelling of N,N-dimethyl benzyl amine-alkoxy ethanol mixtures: an FT-IR spectroscopy and Jouyban–Acree model approach

ABSTRACT This study examines intermolecular interactions in binary mixtures of N,N-dimethyl benzyl amine (DMBA) with short-chain alkoxy ethanols (2-methoxy ethanol (ME), 2-ethoxy ethanol (EE) and 2-butoxy ethanol (BE)). Densities (ρ), speeds of sound (u) and viscosities (η) were measured from 303.15 K to 313.15 K at atmospheric pressure for all compositions. These data were used to determine excess thermodynamic and transport properties: excess molar volume (V E ), excess isentropic compressibility (κs E ), viscosity deviation (Δη) and excess Gibbs free energy of activation (ΔG *E ). Partial and infinite dilution molar partial properties were also calculated. Results focus on complex formation driven by chemical forces. The Jouyban–Acree model predicted these properties, with accuracy assessed using mean relative deviations (MRDs) and individual relative deviations (IRDs). FTIR spectroscopy provided additional insights into intermolecular interactions.

Equilibrium solubility and mathematical modelling of glibenclamide in cosolvent mixtures of glycols and alcohols

ABSTRACT Glibenclamide (GBN) is a commonly used oral medication for treating type-II diabetes that acts by reducing high blood sugar levels. The effectiveness of GBN depends on the quality of the product. The quality is influenced by the solubility properties of a drug. This study aimed to measure the solubility of GBN in various solvent mixtures including some glycols and alcohols. The solubility was determined using a shake-flask method at 298.2 K under atmospheric pressure. The results showed that GBN had the highest solubility in ethylene glycol monomethyl ether and alcohol mixtures compared to the other tested glycols.

Copper-Free Synthesis of Cationic Glycidyl Triazolyl Polymers.

Copper-free synthesis of cationic glycidyl triazolyl polymers (GTPs) is achieved through a thermal azide-alkyne cycloaddition reaction between glycidyl azide polymer and propiolic acid, followed by decarboxylation and quaternization of the triazole unit. For synthesizing nonfunctionalized GTP (GTP-H), a microwave-assisted method enhances the decarboxylation reaction of carboxy-functionalized GTP (GTP-COOH). Three variants of cationic GTPs with different N-substituents [N-ethyl, N-butyl, and N-tri(ethylene glycol) monomethyl ether (EG3)] are synthesized. The molecular weight of GTP-H is determined via size exclusion chromatography. Thermal properties of all GTPs are characterized using differential scanning calorimetry and thermogravimetric analysis. The ionic conductivities of these cationic GTPs are assessed by impedance measurements. The conducting ion concentration and mobility are calculated based on the electrode polarization model. Among three cationic GTPs, the GTP with the N-EG3 substituent exhibits the highest ionic conductivity, reaching 6.8 × 10-6 S cm-1 at 25°C under dry conditions. When compared to previously reported reference polymers, the reduction of steric crowding around the triazolium unit is considered to be a key factor in enhancing ionic conductivity.

La:ZnO nanoparticles: an investigation on structural, optical, and microwave properties

This paper presents the utilization of ethylene glycol monomethyl ether (EGME) during the synthesis of ZnO and La:ZnO with two tasks as a solvent and a fuel source within the gel combustion technique. The use of EGME for this purpose provides one-step production of the nanoparticles (NPs) and saves a considerable amount of time. The detailed characterization of the nanoparticles was carried out by X-ray diffractometer (XRD), scanning electron microscope (SEM), particle size analyzer, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL), and Vector Network Analyzer (VNA) measurements, respectively. The NPs exhibited a hexagonal wurtzite structure with good crystallinity and a porous spongy morphology. The photoluminescence emission maxima of the synthesized NPs appeared at 500, 560, and 676 nm, upon excitation by the 372 nm of excitation. La:ZnO NPs showed significantly better photoluminescent characteristics than La-free ZnO forms. When excited at the same wavelength, La-free ZnO, 3%, and 7% La:ZnO exhibited 92, 45, and 35 μs average decay times, respectively. Finally, the microwave properties of the relative complex permittivity and permeability characteristics were also investigated and discussed in detail, which were derived from the scattering parameters of S11 and S21 in the X band regime.

Solubility and thermodynamics properties of salicylic acid in binary mixtures 1-propanol and propylene glycol/ethylene glycol monomethyl ether at different temperatures

The research aimed to investigate the solubility and thermodynamics of salicylic acid in two binary solvent mixtures of (1-propanol+propylene glycol) and (ethylene glycol monomethyl ether+1-propanol). The study was conducted in the temperature range of 293.2 to 313.2K. To analyze the experimental solubility data, several linear and nonlinear cosolvency models, such as the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models were employed. The models' effectiveness was evaluated by comparing the mean relative deviations of the back-calculated solubility data to the experimental values. In addition, the apparent thermodynamic parameters, including Gibbs energy, enthalpy, and entropy, were calculated using the van't Hoff and Gibbs equations. Furthermore, the study measured the density values for salicylic acid-saturated mixtures and represented them mathematically through the Jouyban-Acree model.

Determination of the individual block lengths of the block copolymers of Poly(trimethylene carbonate) by liquid chromatography at critical conditions

Amphiphilic block copolymers based on poly(trimethylene carbonate) (PTMC) have gained significant attention for biomedical applications owing to their unique degradation characteristics. Ring-opening polymerization (ROP) is the most widely employed method for polymerization of cyclic carbonates, especially for trimethylene carbonate (TMC). Herein, di- and tri-block copolymers of PTMC are synthesized by ROP of TMC using poly(ethylene glycol) monomethyl ether (MeO-PEG) or poly(ethylene glycol) (PEG) as a macro-initiator, respectively. The synthesized products are characterized by size-exclusion chromatography (SEC) and nuclear magnetic resonance spectroscopy (1H NMR) for their molar mass and chemical composition, respectively. However, these techniques are inconclusive about several pertinent aspects of the block copolymers, such as individual block length and unwanted homopolymer content. To address these limitations, liquid chromatography at critical conditions of both PEG and PTMC are employed. Chromatographic critical conditions for PTMC are reported for the first time in the current study. The analysis protocol successfully reveals the individual block lengths of both blocks of the block copolymers, along with the quantification of the unwanted homopolymers in the samples. The individual block lengths and the presence of homopolymers significantly affect the self-assembly capability and drug-loading capacity of amphiphilic block copolymers. Thus, the study divulges important information crucial for the development of structure-property correlations, which is essential for optimizing the performance of these block copolymers in biomedical applications.

H-bonding interaction study for binary mixtures of methyl cellosolve and ethanol: a dielectric, FTIR spectroscopic and volumetric approach

The dielectric measurement of neat ethylene glycol monomethyl ether (EGMME), neat ethanol and their binary mixtures have been carried out using time domain technique in frequency range of 10 MHz to 50 GHz at the temperature range from 10 °C to 25 °C with a difference of 5 °C. The frequency domain technique within the frequency range of 20 Hz to 2 MHz is used to obtain complex dielectric permittivity ε*(ω), electrical modulus M*(ω), complex electrical conductivity σ*(ω) and loss tangent (tan δ) at 25 °C. The dielectric spectra obtained using TDR technique are fitted in Cole-Davidson model to extract the dielectric parameters such as static dielectric permittivity (ε s), relaxation time (τ) and asymmetric distribution parameter (β). These relaxation parameter values are used to predict intermolecular hydrogen bonding between EGMME and ethanol molecules. Furthermore, the inter-molecular interactions through H-bonding between EGMME and ethanol molecules have been confirmed and discussed using Kirkwood correlation factor, excess permittivity, thermodynamic parameter, Bruggeman factor, excess molar volume, excess dielectric permittivity at high frequency and Fourier transform infrared (FTIR) spectra.

Self-Healing Ionogel-Enabled Self-Healing and Wide-Temperature Flexible Zinc-Air Batteries with Ultra-Long Cycling Lives.

Hydrogel-based zinc-air batteries (ZABs) are promising flexible rechargeable batteries. However, the practical application of hydrogel-based ZABs is limited by their short service life, narrow operating temperature range, and repair difficulty. Herein, a self-healing ionogel is synthesized by the photopolymerization of acrylamide and poly(ethylene glycol) monomethyl ether acrylate in 1-ethyl-3-methylimidazolium dicyanamide with zinc acetate dihydrate and first used as an electrolyte to fabricate self-healing ZABs. The obtained self-healing ionogel has a wide operating temperature range, good environmental and electrochemical stability, high ionic conductivity, satisfactory mechanical strength, repeatable and efficient self-healing properties enabled by the reversibility of hydrogen bonding, and the ability to inhibit the production of dendrites and by-products. Notably, the self-healing ionogel has the highest ionic conductivity and toughness compared to other reported self-healing ionogels. The prepared self-healing ionogel is used to assemble self-healing flexible ZABs with a wide operating temperature range. These ZABs have ultra-long cycling lives and excellent stability under harsh conditions. After being damaged, the ZABs can repeatedly self-heal to recover their battery performance, providing a long-lasting and reliable power supply for wearable devices. This work opens new opportunities for the development of electrolytes for ZABs.

A self-cascade terpolymer platform for amplified chemo-chemodynamic therapy with synergistic immunogenic cell death enhancement

Chemodynamic therapy, which relies on the generation of cytotoxic radicals, can be amplified by a nanoplatform that produces hydroxyl radicals while also compromising natural radical scavenging mechanisms. For this purpose, a well-defined amphiphilic terpolymer, poly(oligo(ethylene glycol) monomethyl ether methacrylate)-block-poly(N,N-dimethyl aminoethyl methacrylate-statistical-monomer bearing ferrocene graft via azobenzene linker) (POEGMA-b-P(DMAEMA-st-(M-Azo-Fc), denoted as PAzo-Fc) is prepared by a consecutive reversible addition-fragmentation chain transfer (RAFT) polymerization technique, and is further used for doxorubicin (DOX) encapsulation to afford DOX-loaded stabilized nanomicelles, DOX@PAzo-Fc with an average hydrodynamic diameter of 86.0 nm. DOX@PAzo-Fc shows a self-cascade property for amplified CDT. That is, Azo cleavage-induced glutathione (GSH) depletion alleviates reactive oxygen species (ROS) scavenging. Together with the DOX-enhanced hydrogen peroxide generation, the Fc-mediated Fenton reaction is boosted for enhanced CDT. More importantly, the resulting amplified cascade chemo-chemodynamic therapy exerts a synergistic immunogenic cell death (ICD) enhancement effect for effective cancer immunotherapy, which further resulted in a high tumor inhibition rate of 87.8 % in murine tumor models. The uniqueness of this study is the construction of a minimalist nanoplatform based on M-Azo-Fc units for amplified CDT via simultaneously producing hydroxyl radicals and compromising natural radical scavenging mechanisms. Overall, this self-cascade terpolymer platform fabricated herein offers a facile yet robust approach for advanced combinatory cancer therapy with great potential for clinical translations.

Barium concentration controlled phase evolution in molecular solution processing of Cu2BaSnS4 thin films for solar cells with improved optical and electrical properties

Recently, Cu2BaSnS4 (CBTS) has emerged as a leading candidate to improve cationic ordering, which limits performance of solar cells, in Cu2ZnSnS4 (CZTS) absorber layers. While non-toxic solution based approaches appear very attractive for the deposition of the CBTS layers, the formation of secondary phases stemming from poor control of composition must be suppressed. While preparing CBTS thin films from 2-methoxy ethanol based molecular solutions, we find critical dependence of phase evolution on the Ba concentration in the solution. From the systematic variation in molar concentration of cations and sulfurization parameters we have established the favourable reaction pathway leading to the formation of the single phase CBTS via intermediate solid-state binary and tertiary compounds. The resultant films exhibited significantly reduced effects of cation antisite disorder compared to CZTS as reflected from a symmetric room temperature photoluminescence peak. The films had a band gap of ∼2.0 eV and showed considerable white light sensitivity. Detailed electrical and electro-impedance measurements were carried out that revealed p-type conductivity with a carrier concentration of 1.7×1014 cm−3.

Enhancement of Cu2ZnSn(S, Se)4 device performance using an IPA/MOE hybrid solvent system in ambient air.

In this work, a mixed precursor solvent system comprising isopropyl alcohol (IPA) and 2-methoxy ethanol (MOE) is introduced for the fabrication of Cu2ZnSn(S, Se)4 (CZTSSe) thin films under ambient conditions. The effects of different IPA/(MOE + IPA) ratios on the characteristics of CZTSSe films and the corresponding devices were investigated. Our research results indicate that the addition of IPA enhances the wettability of Cu-Zn-Sn-S precursor solution on the substrate, reduces Sn loss in the film during high-temperature annealing, and diminishes band tail states. Additionally, adding IPA leads to effective enlargement of grain size, improved crystallinity, and enhanced light absorption. However, excessive content of IPA negatively impacts CZTSSe film properties and the device's performance. Notably, when substituting 20% of MOE with IPA, the short-circuit current density (JSC) increased from 30.84 mA cm-2 to 35.55 mA cm-2 in the resulting CZTSSe device, and the efficiency improved from 9.19% to 10.63%. This work provides a new method of a solvent system for preparing efficient kesterite-based solar cells.

Amphiphilic Polyurethane with Cluster-Induced Emission for Multichannel Bioimaging in Living Cell Systems.

The development of single-component materials with low cytotoxicity and multichannel fluorescence imaging capability is a research hotspot. In the present work, highly electron-deficient pyrazine monomers were covalently connected into a polyurethane backbone using addition polymerization with terminal poly(ethylene glycol) monomethyl ether units containing a high density of electron pairs. Thereby, an amphiphilic polyurethane-pyrazine (PUP) derivative has been synthesized. The polymer displays cluster-induced emission through compact inter- and/or intramolecular noncovalent interactions and extensive through-space electron coupling and delocalization. Molecular rigidity facilitates red-shifted emission. Based on hydrophilic/hydrophobic interactions and excitation dependence emission at low concentrations, PUP has been self-assembled into fluorescent nanoparticles (PUP NPs) without additional surfactant. PUP NPs have been used for cellular multicolor imaging to provide a variety of switchable colors on demand. This work provides a simple molecular design for environmentally sustainable, luminescent materials with excellent photophysical properties, biocompatibility, low cytotoxicity, and color modulation.

Structured polymer dispersant for efficient phthalocyanine blue dispersion and color paste preparation

AbstractTo overcome challenges in pigment dispersion, especially for difficult‐to‐disperse pigments like phthalocyanine blue, the structure of dispersants has been studied in recent years. Herein, we present the development and performance evaluation of a structured polymer dispersant for efficient dispersion of phthalocyanine blue and color paste preparation. The dispersant was synthesized using a two‐step free radical polymerization process, allowing precise control over its structure. The study investigates the impact of key factors on dispersion, including the molecular weight of the hydrophilic long‐chain poly(ethylene glycol) monomethyl ether (MPEG), the ratio of anchoring groups styrene (St) and dimethylaminoethyl methacrylate (DMAEMA), and the dispersant dosage. Optimal stability was achieved with MPEG‐400 as the hydrophilic long chain and a St:DMAEMA ratio of 1:1, along with a MPEG‐400AA:AA ratio of 0.5:1 at 2000 r min−1. At a dispersant dosage of 25%, the particle size of the color paste measured 340 nm, with viscosity reaching 600 mPa·s. The structured dispersant effectively synergized spatial potential resistance and electrostatic effects to achieve stable pigment dispersion. These findings offer promising prospects for advancing dispersant technologies, with implications for improving color‐based applications across various industries, such as paints, coatings, and inks.

Ignition and combustion characteristics of ultrasonically levitated single droplets of nano‑boron/oxygenated fuel slurries

Addition of boron nanoparticles to liquid oxygenated fuel lead to the formation of nano‑boron slurries with high energy density. This study focuses on ignition and combustion characteristics of single droplets of nano‑boron slurries during ultrasonic levitation and effects of different oxygenated fuels on ignition and combustion characteristics of single droplets. In this study, nano‑boron slurries of boron/ethanol, boron/1-hexanol, boron/dimethyl carbonate, boron/triacetate, boron/propylene glycol monomethyl ether and boron/tripropylene glycol monomethyl ether with 10 wt% solid loading were prepared. Moreover, an ultrasonic levitation system was designed and established, which was used for igniting single droplets in ultrasonic levitation state. The results indicate that ignition and combustion process of levitated single droplets of nano‑boron slurries can be divided into three stages: a stable endothermic stage, an oscillation and micro-explosion stage and an aerosol combustion stage. Smoke was observed before aerosol combustion stage of boron/triacetate and boron/tripropylene glycol monomethyl ether, whereas flame jets were observed during combustion of other fuels. Furthermore, emission spectra of BO2 with high intensity could be observed during aerosol combustion stage. A shorter main chain length of oxygenated fuel facilitates ignition of nano-B slurries. Boron/propylene glycol monomethyl ether exhibited shortest ignition delay, which was approximately 13.8% shorter than that of boron/tripropylene glycol monomethyl ether with the longest ignition delay. Furthermore, a longer main chain length of oxygenated fuel facilitates combustion of nano-B slurries. Nano‑boron slurries with longer main chains (boron/1-hexanol, boron/triacetate and boron/tripropylene glycol monomethyl ether) exhibited brighter and larger flames, regardless of whether they were alcohols, esters or ethers, and quenched zones with bright and clearly delineated edges were observed. Intensity integral and maximum intensity of emission of these three fuels were also higher than those of other fuels. Boron/triacetate demonstrated the best combustion performance, with maximum intensity and intensity integral at 547.8 nm being 3.88 times and 1.9 times those of boron/ethanol, respectively, which has the worst combustion performance. This study provides a theoretical basis and experimental reference for the application of oxygenated-fuel-based nano‑boron slurries and their base liquid fuel selection.

Synthesis internal-plasticized PVC copolymer resin from industrial application view: Copolymerization of vinyl chloride with poly(ethylene glycol) monomethyl ether methacrylate via suspension polymerization

Developing internal-plasticized poly(vinyl chloride) (PVC) resin has been recognized as an effective way to deal with the issues of conventional PVC products such as toxicity and deterioration in properties caused by the migration of plasticizer. Herein, the copolymerization of vinyl chloride with commercial available poly(ethylene glycol) monomethyl ether methacrylate (PEGMA) is firstly conducted via suspension polymerization and internally plasticized random copolymers (PVEGA) are synthesized successfully. These PVEGA copolymers were intensively characterized by FTIR, 1H NMR, GPC, DSC, DMTA, and SEM to determine the composition, number-average molecular weight (Mn), dispersity, glass transition temperature (Tg), and the micromorphology. As a result, the high transparency and the fracture images demonstrated the good compatability between PVC chains with long-chain polyether. The Tg of PVEGA decreased gradually from 80 to 0 °C with the fraction of PEGMA in the copolymer increased from 7 to 37 %. Furthermore, the PVEGA copolymer exhibits outstanding processibility and mechanical performance. Under optimal composition, the tensile strength and the elongation at break can reach to 8 MPa and 525 %, respectively. Meanwhile, the PVEGA copolymers exhibit much lower migration either in water or in orgnic solvent and excellent performance in hemolysis and cytotoxicity, showing great application potential in medical devices.