Methylene Chloride Solubles Research Articles

New anti-inflammatory steroids from the Formosan soft coral Clavularia viridis

Four new steroids, stoloniferones R–T ( 1– 3), and (25 S)-24-methylenecholestane-3β,5α,6β-triol-26-acetate ( 4) were isolated from the methylene chloride solubles of the soft coral Clavularia viridis. The structures of the metabolites were elucidated by extensive spectral analysis and their anti-inflammatory activity was measured in vitro.

Prenylbicyclogermacrane Diterpenoids from the Formosan Soft Coral Nephthea elongata

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Nardosinane Sesquiterpenoids from the Formosan Soft Coral Nephthea elongata.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

New cytotoxic steroids from the soft coral Clavularia viridis

Ten new cytotoxic steroids, stoloniferones H–Q ( 1– 10) were isolated from the methylene chloride solubles of the soft coral Clavularia viridis. The structures of the metabolites were elucidated on the basis of spectroscopic (IR, MS, and 1D and 2D NMR) analysis and their cytotoxicity against selected cancer cells was measured in vitro.

Nardosinane Sesquiterpenoids from the Formosan Soft Coral Nephthea elongata

Seven new nardosinane sesquiterpenoids, elongatols A-G (1-7) were isolated from the methylene chloride solubles of the Formosan soft coral Nephthea elongata. Their structures were elucidated by extensive spectroscopic analysis and their cytotoxicity against selected cancer cells was measured in vitro.

Prenylbicyclogermacrane Diterpenoids from the Formosan Soft Coral Nephthea elongata

Seven new prenylbicyclogermacrane diterpenoids, pacificins K--Q (1--7), were isolated from the methylene chloride solubles of the Formosan soft coral Nephthea elongata. Their structures were elucidated by extensive spectroscopic analysis and their cytotoxicity against selected cancer cells was measured in vitro.

Cytotoxic Constituents from the Formosan Soft Coral Clavularia inflata var. luzoniana

Three new cytotoxic dolabellane diterpenes, 1-3, three new aromandendrane sesquiterpenoids, 4-6, a new sesquiterpene, 7 (having a new carbon skeleton), and a new cytotoxic xenicane diterpene, 8, were isolated from the methylene chloride solubles of the Formosan soft coral Clavularia inflata var. luzoniana. The structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Diterpenoids, Norditerpenoids, and Secosteroids from the Formosan Soft Coral Cespitularia hypotentaculata

Four new cespitularane diterpenes, cesputularins I-L (1-4), two new norverticillane norditerpenes, cespitularins M and N (5 and 6), two new verticillane diterpenes, cespitularins O and P (7 and 8), a new norditerpene, cespitularin Q (9) (having a novel carbon skeleton), a new xenicane diterpene, cespitolide (10), and two new secosteroids, 3beta,11-dihydroxy-5beta,6beta-epoxy-9,11-secocholestan-9-one (11) and 3beta,11-dihydroxy-5beta,6beta-epoxy-9,11-secogorgostan-9-one (12), were isolated from the methylene chloride solubles of the Formosan soft coral Cespitularia hypotentaculata Roxas. The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Cytotoxic Pregnane Steroids from the Formosan Soft Coral Stereonephthya crystalliana

Nine new steroids, stereonsteroids A-I (1-9), were isolated from the methylene chloride solubles of the Formosan soft coral Stereonephthya crystalliana Kükenthal. The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Sesquiterpenoids and Norsesquiterpenoids from the Formosan Soft Coral Lemnalia laevis

Eight new nornardosinane sequiterpenoids, laevinols A-H (1-8), a new neolemnane sesquiterpenoid, laevinone A (9), and the previously known 6beta-acetyl-4beta,5beta-dimethyl-1(10)alpha-epoxy-2beta-hydroxy-7-oxodecalin (10) and 11,12-dihydroxy-6,10-eremophiladiene (11) were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia laevis. Their structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Xenia Diterpenoids from the Formosan Soft Coral Xenia blumi

Eight new xenia diterpenoids, blumiolide-A (1) (novel carbon skeleton), blumiolide-B (2), 9-deoxy-isoxeniolide-A (3), 9-deoxy-7,8-epoxy-isoxeniolide-A (4), 9-deacetoxy-7,8-epoxy-13-epi-xenicin (5), 9-deoxy-7,8-epoxy-xeniolide-A (6), blumiolide-C (7), and blumicin-A (8), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia blumi. Their structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Prenylbicyclogermacrane Diterpenoids from the Formosan Soft Coral Nephthea pacifica

Ten new prenylbicyclogermacrane diterpenoids, pacificins A-J (1-10), were isolated from the methylene chloride solubles of the Formosan soft coral Nephthea pacifica. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Steroids and Sesquiterpenoids from the Soft Corals Dendronephthya gigantea and Lemnalia cervicorni

One new cytotoxic steroid, dendronesterone A (1), two new steroids, dendronesterones B and C (2 and 3), and a known steroid (4) were isolated from the methylene chloride solubles of the Formosan soft coral Dendronephthya gigantea. Two cytotoxic ylangene-type sesquiterpenoids, lemnalol (5) and the new compound cervicol (6), as well as two ylangene-type sesquiterpenoids, isolemnalol (7) (a new compound) and 4-oxo-alpha-ylangene (8), were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia cervicorni. Their structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

New cytotoxic xenia diterpenoids from the Formosan soft coral Xenia umbellata.

Seven new cytotoxic xenicane-type diterpenoids, 9-deoxyxeniloide-E (1), 9-deoxy-7,8-epoxyxeniloide-E (2), xeniolide-G (3), 9-deoxyxenialactol-C (4), xenibecin (5), xeniolide-H (6), and xenitacin (7), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia umbellata. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

New cadinene sesquiterpenoids from the Formosan soft coral Xenia puerto-galerae.

Six new cadinene sesquiterpenoids, xenitorins A-F (1-6), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia puerto-galerae. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

New cytotoxic constituents from the Formosan soft corals Clavularia viridis and Clavularia violacea.

Three new cytotoxic prostanoids, claviridenone E-G (1-3), and three new cytotoxic steroids, stoloniferone E-G (4-6), were isolated from the methylene chloride solubles of the Formosan soft coral Clavulariaviridis. A cytotoxic cembranoid, claviolide (7), was isolated from the methylene chloride solubles of the Formosan soft coral Clavularia violacea. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

Novel terpenoids from the formosan soft coral Cespitularia hypotentaculata.

Four new cytotoxic diterpenes, cespitularins A-D (1-4), having the verticillane skeleton, a new cytotoxic norditerpene, cesputularin E (5), that possesses a novel norverticillane skeleton, and three new diterpenes, cespitularins F-H (6-8), possessing a novel carbon skeleton named cespitularane, were isolated from the methylene chloride solubles of the Formosan soft coral Cespitularia hypotentaculata. The structures of cespitularins A-H (1-8) were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

A comparison of mesophase formation under sparging and vacuum

A petroleum pitch was heat treated using nitrogen sparging or vacuum, and the constitution of samples was investigated as a function of heat-treatment time with microscopy, solid state 13C NMR, and ESR spectroscopy. The samples were extracted with methylene chloride, and the soluble fractions were characterized by number-average molecular weight, 1H and 13C NMR, and fluorescence spectroscopy. The free radical concentration and aromaticity of the two final (ca 80% mesophase) pitch samples were similar. Microscopic examination of samples showed extensive mechanical deformation of the isotropic phase whenever the anisotropic phase was continuous. Nucleation of anisotropic spheres continued throughout mesophase formation. The major difference between the two runs appeared to be the higher amount of methylene chloride-soluble components in the vacuum run. After vacuum heat treatment, the average MW of the methylene chloride solubles was considerably higher than for the starting pitch while, for samples which had been sparged, the MW of these solubles was slightly lower. Fluorescence and NMR spectroscopy indicated that considerable changes in the distribution of aromatic ring systems and alkyl substituents occurred in the methylene chloride-soluble fraction during heat treatment.