The research was carried out in 2020–2023. at the Federal State Budgetary Institution FANTS of the North-East. The purpose of the research is to study the biological effectiveness of new agrochemicals with phytoregulatory, adaptive and immunomodulatory properties when cultivating spring barley under conditions of instability of climatic factors during the plant growing season. The FANC North-East selection varieties Novichok, Pamyati Rodinoy, Rodnik Prikamye were treated during the tillering phase of the plants with the organomineral fertilizer Amino Start (1 l/ha) and the urea-ammonium fertilizer KAS-28, (1 l/ha) at heading - with the growth regulator Alfastim ( 0.05 l/ha). Net and dark brown spotting and root rot were recorded using well-known meth ods. The experimental data were compared with the control (without treatment). The variety Pamyati Rodinoy is the most responsive to chemicalization; the least responsive is Rodnik Prikamye. The growth regulator Alfastim is quite effective in protecting against net spot in these varieties (disease development on average 11.8±3.61 % and 16.6±2.35 %; on control – 13.8±5.34 % and 20. 3±3.91 %), in the Novichok variety – Amino Start (6.8±2.68 %; on the control – 8.8±2.39 %). The drug Alfastim also has a more prolonged protective effect against all helminthosporium diseases, as evidenced by the lower PCRP value than in the control: by 5-96 for the Pamyati Rodinoy variety, by 30-120 for Rodnik Prikamye, by 32-118 for the variety Pamyati Rodinoy. Newbie. It is possible to highlight the inhibitory effect of the drugs CAS 28 and Amino Start in the Novichok variety (disease development 11.8±3.85 % and 11.5±2.16 %; on the control - 15.7±3.79 %) and CAS-28 in the Rodnik Prikamya variety (disease development 12.7±1.65 %; on control – 14.5±2.89 %). It was found that the greatest contribution to the development of leaf spots (40.0 and 48.5 %) is made by the combined effect of the “variety-year-preparation” factors; root rot – variety-drug interaction (23.7 %). The contribution of the genotype to the development of helminthosporium diseases of barley ranged from 19.0 to 22.0 %.
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