In inverse synthetic aperture radar (ISAR) imaging, range alignment (RA) is crucial for translational compensation. To address the need for rapidity and accuracy in the RA process, a fast and robust range alignment method is proposed based on a deep learning network and minimum entropy (ME) method. The proposed method consists primarily of two components: the CNN-RNN attention mechanism network (CRAN) architecture and the regional multi-scale minimum entropy (RMSME) method. The main distinction of this method from existing approaches lies in its utilization of a deep learning network for rapid coarse alignment, followed by the search for minimum entropy within local regions at multiple scales. The integration strategy effectively addresses the current challenges of poor generalization in deep learning networks and low efficiency in the traditional ME method. The experimental results of simulation data indicate that the proposed method achieves the best range alignment performance compared to RNN, CRAN, and the traditional ME method. The experimental results of the measured data further validate the practicality of the proposed method. This research provides reference significance for the joint application of deep learning and traditional methods in the RA process.