Comprehensive Quality Evaluation Method Research Articles

Multicomponent Analysis of Liuwei Dihuang Pills by a Single Marker Quantification Method and Chemometric Discrimination of Fingerprints.

An effective and comprehensive quality evaluation method for Liuwei Dihuang pills (LDP) was established by the simultaneous determination of 8 active components in LDP by the quantitative analysis of multicomponents by single marker (QAMS) method and high-performance liquid chromatography (HPLC) fingerprint combined with chemometrics. These 8 active components were determined by QAMS and the external standard method (ESM), and the quantitative results of the two methods were compared to validate the accuracy and feasibility of the QAMS method. 8 active components showed good linear relationships within their ranges, whose average recoveries were 99.7∼102.3%. No significant difference was found (P > 0.05) in the quantitative results determined by QAMS and ESM. Furthermore, the fingerprint of LDP was also established, with 11 common peaks identified, and the similarity of the fingerprints of 21 batches of LDP was greater than 0.95. The 21 batches of LDP were basically divided into 3 groups by hierarchical cluster analysis (HCA) and principal component analysis (PCA), and 3 differential markers were screened out by orthogonal partial least squares discriminant analysis (OPLS-DA). The established QAMS method is accurate, economical, fast, and convenient and can simultaneously determine the content of 8 active components in LDP. HPLC fingerprint combined with chemometric analysis more comprehensively evaluated the quality consistency of different batches of LDP and analyzed the markers that cause quality differences between batches. It can provide a scientific basis and reference of quality consistency evaluation for the manufacturers and drug regulatory departments of the preparation.

A comprehensive quality evaluation method of different medicinal parts of Physalis Calyx seu Fructus by fingerprints, chemometrics, antioxidant activity, network pharmacology and molecular docking.

Physalis Calyx seu Fructus (PCF) is a herb widely used in China for its function of clearing heat and detoxifying, benefitting the pharynx and reducing phlegm, both in health care and in tea drinking. However, the quality of its fruit and calyx is uneven and the storage period is short. Therefore, it is crucial to develop other parts of PCF with longer storage periods and obvious medicinal effects. Firstly, high-performance liquid chromatography was used to develop the fingerprint of different parts of PCF, and various chemometric analyses were conducted to screen out chemical markers. The calyxes of PCF were found to cluster together, distinct from the fruits, roots, stems and leaves. The active components of PCF were concentrated in the persistent calyxes, and flavonoids were mainly found in the persistent calyxes and leaves. Secondly, the extraction of persistent calyxes showed the strongest scavenging ability of DPPH and ABTS. Finally, the important chemical markers were verified by network pharmacological analysis and molecular docking. It provides a reference for the clinical application of PCF, and the obtained chemical markers offer a scientific basis for quality evaluation.

Modeling and application of sensory evaluation of blueberry wine based on principal component analysis

In this study, eight different levels of commercial blueberry wines were studied to establish the comprehensive quality evaluation method of blueberry wine. Eleven physicochemical indexes (total carbohydrates (TC), total acids (TA), total esters (TE), total phenols (TP), total anthocyanins (ANT), color density (CD), tint (T), alcohol by volume (ABV), total soluble solids (TSS), Ph value, total dry extracts (TDE)) were used to establish the quality evaluation model and conduct the principal component analysis (PCA). Based on the results from PCA, the first three principal components accounted for 85.73% of the total quality variability. The consistent ranking of blueberry wines between quality evaluation model and sensory evaluation test verified the reliability of this model. In addition, ultrasonic-treated blueberry wine showed a higher score than the untreated group, which reflected the sensory quality changes of blueberry wine during ultrasonic treatment with high sensitivity. This study provides a theoretical basis for the comprehensive quality evaluation of blueberry wines and reasonable instruction for consumers’ choices.

Effect Evaluation of Multilevel Fuzzy Comprehensive Evaluation Mechanism Combined with Multimedia Teaching on the Cultivation of Comprehensive Quality of Vocational Students

The core goal of higher vocational education is to cultivate students with good professional quality. The employability of college students depends on their professional quality to a large extent. From the perspective of school education, all kinds of higher vocational colleges have entered a new level in practice, but the evaluation of comprehensive quality is still relatively weak. Therefore, in order to enhance the comprehensive ability of higher vocational students and cultivate their excellent comprehensive quality, this paper adopts the fuzzy comprehensive evaluation method and puts forward the evaluation method of the comprehensive evaluation system of higher vocational students, so as to provide reference for solving the problem of comprehensive quality evaluation. The specific process is as follows: in this paper, a two-level fuzzy mathematical model is established by using fuzzy mathematics theory and multimedia technology. First of all, according to the educational characteristics such as learning interest, psychological quality when encountering difficulties, and the ability to solve problems cooperatively, a set of secondary indicator system reflecting vocational college students is established. With this indicator, quantitative indicators are fuzzified by introducing membership functions, and a single factor evaluation matrix is established. Then, the specific steps are illustrated with examples to realize the qualitative analysis and quantitative evaluation of students’ comprehensive quality. The results show that the new comprehensive quality evaluation method established in this paper has strong practicality and innovation.

Establishment and Development of a Quality Evaluation Method for Sangbaipi Decoction.

Sangbaipi decoction (SD), a traditional Chinese "Ancient Classical Prescription" consisting of eight medicinal materials, is usually used to treat asthma due to excess lung Qi and phlegm fire. To establish a comprehensive quality evaluation method for SD. HPLC fingerprint analysis, hierarchical cluster analysis (HCA), and principal component analysis (PCA) were applied for the quality control of SD prepared from different batches of medicinal materials. A total of 10 batches of SD samples were prepared and analyzed. A total of 24 common peaks and six active components (gardenoside, rutin, berberine, palmatine, baicalein, and wogonin) were identified in the HPLC fingerprint of SD. The ten batches of SD samples were divided into four groups via HCA and PCA. The HPLC fingerprint similarities of the 10 batch samples were 0.934 or higher. The precision, stability, repeatability, and other methodological indexes suggested that the developed method met the requirements for qualitative fingerprint research. The results indicated that HPLC fingerprints combined with PCA and multicomponent determination can be successfully applied to SD quality control. This study also provides a basis for a more comprehensive quality evaluation method for SD. The fingerprint of SD, a TCM famous classical formula, was established by HPLC in this paper. Moreover, contents of six pharmacodynamic related components in SD were determined simultaneously in order to establish a comprehensive quality evaluation method of SD. This study can also provide a basis for raw material selection, quality evaluation, extraction process, preparation development and pharmacodynamic material basis research of SD.

Simultaneous quantitative analysis of ten bioactive flavonoids in Citri Reticulatae Pericarpium Viride (Qing Pi) by ultrahigh-performance liquid chromatography and high-resolution mass spectrometry combined with chemometric methods.

Citri Reticulatae Pericarpium Viride (Qing Pi in Chinese) is a clinically effective Chinese herb, which contains biologically valuable flavonoids. Qing Pi is divided into two commodity specifications, Si Hua Qing Pi (SHQP) and Ge Qing Pi (GQP), based on the harvesting time. The flavonoid contents in Qing Pi from different origins and commodity specifications may vary significantly, which will affect their therapeutic functions. Thus, it is crucial to set up a reliable and comprehensive quality evaluation method for flavonoid analysis in Qing Pi. We aimed to establish a rapid and sensitive ultrahigh-performance liquid chromatography method coupled with diode-array detection and high-resolution mass spectrometry (UPLC-DAD-HRMS) for identification and quantification of ten flavonoids in Qing Pi. Chemometric methods were further applied to distinguish Qing Pi of different origins and specifications. An UPLC-DAD-HRMS method was developed for the simultaneous separation and quantification of ten flavonoids in 46 batches of Qing Pi samples from different sources in China. Chemometric approaches were applied to discriminate Qing Pi from different origins and commodity specifications. The chemometric procedures (i.e., hierarchical clustering analysis and principal component analysis) were employed to identify the differences of Qing Pi samples with different origins and commodity specifications. The results showed that the contents of ten flavonoids in Qing Pi samples of different origins were significantly different, and the same results were found out between SHQP and GQP. This study provides a chemical basis for quality control of Qing Pi.

Comprehensive quality evaluation method of smart meters based on AHP-Critic

The quality of smart meters directly affects the stability, security and economy of information gather system and power grid. This paper proposes a comprehensive quality evaluation method of smart meters based on AHP-Critic theory. In this method, firstly, the hierarchy of AHP is established to determine the contents of target layer, rule layer and scheme layer; secondly, the judgment matrix is constructed to calculate the hierarchical single ranking value and carry out consistency test; thirdly, the objective weight of rule layer is calculated by using Critic theory; finally, the comprehensive weight of rule layer is obtained by combining AHP and Critic, and the hierarchical total ranking of target layer to scheme layer is calculated. The experimental analysis takes three types of smart meters as evaluation objects, and the results effectively evaluate the quality of each meter.

Uniformity and comprehensive quality evaluation of steel product via process capability index and TOPSIS

ABSTRACT The overall quality of the steel wire is composed of the mechanical properties, the key process parameters, the geometrical parameters, surface quality, etc. A uniformity and comprehensive quality evaluation method of steel product based on the improved process capability index and TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) is proposed. First, the uniformity of the process parameters is described by the volume ratio between the process data area and the specification area which is calculated via kernel density estimation. The relative closeness of the newly added batches is obtained by TOPSIS, which is used as a comprehensive quality evaluation index. A time dimension is added to the radar chart to visualize high-dimensional data, which is intuitive to compare the differences between batches. The results show that the evaluation method can accurately obtain the uniformity and comprehensive quality of steel products.

Study on quality standard of fried Vaccariae Semen standard decoction

According to the preparation principle of standard decoction of Chinese herbal medicines, fourteen batches of fried Vaccariae Semen decoction were prepared in this study and the quality research was carried out to establish a quality evaluation method for the standard decoction of fried Vaccariae Semen. The contents of vaccarin were determined, and its transfer rate from decoction piece to standard decoction was calculated. The extract rate and pH value were measured, and HPLC fingerprint method was established for analysis. The results of the 14 batches of samples revealed that the transfer rates of vaccarin were between 58.98%-93.94%; the extract rates were between 8.67%-17.83%, and the pH values were between 5.55-6.44. Moreover, 9 common chromatographic peaks were identified in fingerprints analysis. The similarities of the 14 batches of samples were analyzed and compared, and the results showed that the similarities were all higher than 0.96. In this study, the preparation process for fried Vaccariae Semen standard decoction was standard, with high similarities in fingerprint. A convenient and reliable method of comprehensive quality evaluation was established in this study, with a high precision, stability and repeatability, which can provide a reference for the quality control of fried Vaccariae Semen standard decoction, dispensing granule and related Chinese classical formulas(decoction).

Research on the Quality Evaluation Strategy of Multi-source Heterogeneous Aggregation Data

In the era of big data, the application of multi-source heterogeneous aggregation data is more and more extensive. If the quality of aggregation data is uneven, it will bring a lot of troubles to the subsequent data mining, and then lead to inaccurate decision-making. A comprehensive quality evaluation method for aggregation data is proposed in this paper, based on factor analysis and multivariate variance analysis which is from the perspective of multivariate statistical inference. The case study shows that the method proposed in this paper is feasible and adaptive for the long-term evaluation of the quality of multi-source heterogeneous aggregation data.

Comprehensive Investigation of the Differences of the Roots of Wild and Cultivated Mirabilis himalaica (Edgew) Heim Based on Macroscopic and Microscopic Identification Using HPLC Fingerprint.

Mirabilishimalaica (Edgew) Heim (MH) is an important Tibetan medicine with demonstrated medicinal efficacy and promising developmental value. A previous study of MH was limited to vague morphological and microscopic descriptions, restricting its clinical application and further development as a medicine. The goal of this study was to comprehensively characterize wild and cultivated products of MH using macroscopic and microscopic identification using HPLC fingerprint. The results revealed that the cultivated and wild MH exhibited differences in macroscopic and microscopic characteristics and chemical components. This analysis can facilitate the establishment of a more comprehensive quality evaluation method for MH. These results provide the basis for clinical applications and the improvement of quality standards of MH as a step towards modernization of Tibetan medicine.

A comprehensive data quality evaluation method for the currents of marine controlled-source electromagnetic transmitters based on the analytic hierarchy process

Abstract. We present a quality control methodology for the currents of marine controlled-source electromagnetic transmitters . The quality level of the transmitting current directly affects the signal-to-noise ratio (SNR) of the electromagnetic-field data, as received by a multicomponent electromagnetic receiver from the seabed. Although the transmitting-current stability is sufficient under normal circumstances, the SNR of the received signal can change owing to factors such as outside noise. In some emergency cases such as instrument failure or a sudden increase in electromagnetic interference that we are not aware of, the frequency and properties of the transmitting current, such as its size and waveform, may change. The traditional current monitoring and data playback tools fail to detect and evaluate the anomalies well and in a timely manner, which introduces considerable errors in the later data-processing procedure. Pertaining to these issues, this paper proposes a comprehensive quality evaluation method for the transmitting current. The proposed algorithm, based on the analytic hierarchy process, is first used to analyze five current stability parameters – current frequency, positive amplitudes, negative amplitudes, discrepancy of ideal waveform, and waveform repetition – and then to define the harmonic energy and calculate the quality of transmitting current (QTC) index of the final data to assess the quality of the transmitting current comprehensively. The results of a marine experiment performed in 2016 show that the algorithm can identify abnormal current data and quantitatively evaluate the current conditions. Under normal circumstances, the QTC index is less than 2 %. The key findings are that the QTC index changes to more than 4 % and some curvilinear features are observed if the transmitting-current quality is poor. These results will provide a positive, significant guide for the evaluation and monitoring of transmitting-current data in marine experiments.

Chemical Profile and Multicomponent Quantitative Analysis for the Quality Evaluation of Toad Venom from Different Origins.

Toad venom (Chansu), a traditional Chinese medicine (TCM), has been widely used for treating various cancer. However, it is considerably difficult to evaluate the quality of Chansu due to its complex chemical compositions. Hence, finding the characteristic ingredients and developing a scientific and comprehensive quality evaluation method are essential for guaranteeing the safety and efficacy of Chansu. In this paper, the chemical composition database of Chansu was successfully established and HPLC-ESI-Q-TOF-MS/MS was applied for chemical profiling of the ingredients in Chansu. In total, 157 compounds were identified, including 22 amino acids, 8 alkaloids, 54 bufogenins, 63 bufotoxins, and 10 other compounds. Furthermore, HPLC fingerprints and quantitative analysis of its multicomponent were successfully developed to evaluate the quality consistency of Chansu from different origins. The results suggested that the HPLC fingerprint of Chansu could be divided into an amino acid and alkaloid region, as well as a bufogenins and bufotoxins region. The fingerprint profile of Chansu from different geographical origins were different, indicating that its quality was affected by the geographical factors. In addition, seven characteristic peaks were selected as the quantitative markers to evaluate the quality of the Chansu. The Kruskal–Wallis test illustrated that the contents of seven bufogenins in Chansu were significantly (p < 0.01) different among different origins. The total contents of the seven compounds ranged from 100.40 to 169.22 mg/g in 20 batches of Chansu samples. This study demonstrated that integrating HPLC-ESI-Q-TOF-MS/MS, HPLC fingerprints, and multicomponent quantitative analysis coupled with chemometrics was a comprehensive and reliable strategy for evaluation of Chansu in both qualitative and quantitative aspects. In addition, our study represented the most comprehensive characterization on the chemical compositions of Chansu, which could provide important reference information for the discovery of potential bioactive compounds.

Analysis of standard decoction of salt-processed Psoraleae Fructus

The traditional Chinese medicine standard decoction is prepared on the basis of the theory of traditional Chinese medicine and clinical application. With reference to the modern extraction method,the single decoction of traditional Chinese medicine is prepared by the standardized process,and the establishment of its quality standards is conducive to standardizing clinical medication. This research is to set an evaluation standard for the quality of salt-processed Psoraleae Fructus standard decoction. Twelve batches of salt-processed Psoraleae Fructus standard decoctions were prepared. The contents of psoralen and isopsoralen were determined,the transfer and extract rates were calculated,and the pH value was measured; HPLC fingerprint method was established for analysis. The results of the 12 batches of samples revealed that the transfer rates of psoralen and isopsoralen were 17. 10%-26. 40%,14. 70%-22. 70%,respectively; the extract rate was between 14. 7%-27. 0%,and the pH value was between 5. 4-6. 9. Moreover,7 common chromatographic peaks were determined based on fingerprint by using similarity evaluation system for chromatographic fingerprint of traditional Chinese medicine( 2012 A).The similarities of the 12 batches of samples were analyzed and compared,and the results showed that the similarities were all higher than0. 9. In this study,the preparation method for salt-processed Psoraleae Fructus decoction was standard,with high similarities in fingerprint. This study build a convenient and reliable method of comprehensive quality evaluation,with a high precision,stability and repeatability,which can provide a reference for the quality control of salt-processed Psoraleae Fructus dispensing granules.

A comprehensive quality evaluation method by FT-NIR spectroscopy and chemometric: Fine classification and untargeted authentication against multiple frauds for Chinese Ganoderma lucidum

The origins and authenticity against frauds are two essential aspects of food quality. In this work, a comprehensive quality evaluation method by FT-NIR spectroscopy and chemometrics were suggested to address the geographical origins and authentication of Chinese Ganoderma lucidum (GL). Classification for 25 groups of GL samples (7 common species from 15 producing areas) was performed using near-infrared spectroscopy and interval-combination One-Versus-One least squares support vector machine (IC-OVO-LS-SVM). Untargeted analysis of 4 adulterants of cheaper mushrooms was performed by one-class partial least squares (OCPLS) modeling for each of the 7 GL species. After outlier diagnosis and comparing the influences of different preprocessing methods and spectral intervals on classification, IC-OVO-LS-SVM with standard normal variate (SNV) spectra obtained a total classification accuracy of 0.9317, an average sensitivity and specificity of 0.9306 and 0.9971, respectively. With SNV or second-order derivative (D2) spectra, OCPLS could detect at least 2% or more doping levels of adulterants for 5 of the 7 GL species and 5% or more doping levels for the other 2 GL species. This study demonstrates the feasibility of using new chemometrics and NIR spectroscopy for fine classification of GL geographical origins and species as well as for untargeted analysis of multiple adulterants.

Green Architecture Model: The Modern Methods of Quality Assessment in City Prototype

As the trend of social and economic development of the modern world is moving forward the theory and practice of Green architecture and architects important role become more important. In this paper, green architecture and the main points Green architecture theory based on comprehensive analysis and historical rear, including its historical and modern theory and modern system of sustainable development practices is reviewed. In the world, in order to evaluate different areas newly refurbished buildings and the city's comprehensive environmental, social, economic, and groundbreaking features of the development of comprehensive quality evaluation method is to determine the most effective and advanced tools and methods of analysis. The importance of sustainable development is a comparative analysis of the basic characteristics of the construction quality assessment methods represent originated in different countries and regions, because it reveals the structure and weights of different evaluation methods of heavy impact. The article also describe through urban design, landscape architecture and architectural design volume Analysis Case Studies resolve outstanding Green architecture practices in architectural theory and methods of impact assessment. DOI: 10.5901/mjss.2016.v7n4S1p74

Fingerprint profiling of Astragalus polysaccharides based on partial acid hydrolysis-hydrophilic interaction chromatography analysis and comprehensive quality evaluation of Astragalus membranaceus combined with reversed-phase liquid chromatography fingerprint analysis

Astragalus polysaccharides (APS) are important components in Astragalus membranaceus ( A. membranaceus ). However, for the huge relative molecular mass, strong polarity, and difficulty in chromatographic separation, there's a lack of quality control finely reflecting the composition of APS up to now. To solve the problems, the key lies in degradation of polysaccharides and analysis of the hydrolyzates. A partial acid hydrolysis-hydrophilic interaction liquid chromatography (HILIC) fingerprint for APS and a comprehensive quality evaluation method for A. membranaceus combining with the traditional RPLC fingerprint were developed. Orthogonal experiments were designed to investigate the influencing factors of partial hydrolysis and the conditions were optimized based on HILIC analysis. The hydrolyzates were successfully separated using HILIC-evaporative light scattering detection (ELSD) method and the optimal conditions of hydrolysis were selected as 80℃, 1.5 mol/L trifluoroacetic acid and 4 h, which proved to be stable and repeatable after the validation. This method was applied for the fingerprint analysis of 20 batches of A. membranaceus . Cosine method was used for similarity calculation using the average of samples Nos. 1-10 as reference. Moreover, RPLC fingerprint analysis was processed on other components and the data were compared for comprehensive evaluation. The similarities of ten samples with the reference ranged from 0.258 to 0.949, which were consistent with the chromatograms reflecting the apparent disparity in APS, and could be as a supplement of the RPLC fingerprint. The new method, with the advantages of intuition, convenience, and quantifiable in similarity, could reflect the differences of the composition of polysaccharides after degradation and was successfully applied in profiling of APS, contributing to the quality control together with the RPLC fingerprint.

The Research of Comprehensive Quality Evaluation for Distant Education

The study on the quality evaluation and the related technology on distant education can provide evidence for the quality teaching and learning, and ensure the high quality and efficiency for distant education. It is highly significant to construct the teaching resources and learning supporting system by establishing an appropriate system that fits the level of education and guarantees the teaching quality. On the basis of the research results of programs, standards and technology for the quality evaluation of the distant education, this essay puts forward a method of comprehensive quality evaluation by applying the theory of comprehensive evaluation into this area, which is a quantitative research about how to set and calculate the weight indices for the evaluation. This method can process the quality indices by quantity efficiently, give a direct view of the quality by the comparative analysis, and provide the evidence for improving the quality.