Methanol Poisoning Research Articles

TOXIC ALCOHOL POISONING: A CASE REPORT

During the COVID-19 pandemic, toxic alcohol poisoning, notably from methanol, has emerged as a significant concern due to increased consumption of illicit liquor amidst lockdown restrictions. We present a case of a middle-aged man who developed altered consciousness, metabolic acidosis, and shock two days after ingesting hospital spirit. Although initial qualitative tests only detected ethanol, subsequent MRI findings showed classical signs of methanol poisoning, including basal ganglia abnormalities. Prompt management with dialysis, ventilatory support, and adjunctive therapy successfully addressed the acute phase despite the patient remaining delirious for seven days. This case underscores the importance of considering methanol toxicity even in the absence of direct evidence, necessitating comprehensive diagnostic approaches. Awareness and incorporating point-of-care assessments such as arterial blood gas analysis and osmolar gap evaluation in suspected cases are crucial, especially in resource-limited settings. Recognizing unexplained high anion gap metabolic acidosis with a high osmolar gap and characteristic MRI findings can aid in the early diagnosis and management of toxic alcohol poisoning

Pyrolysis-Free Synthesis of Synergistic Single-Atom/Nanocluster Electrocatalysts for Hydrogen Evolution.

Constructing catalysts that simultaneously containing single atom/metal nanocluster active sites is a promising strategy to enhance the original catalytic behavior and accelerate the catalysis involving multi-electron reactions or multi-intermediates. Herein, the pyrolysis-free synthetic method is developed to integrate single atoms and nanoclusters towards highly satisfactory catalytic performances for both acidic and alkaline hydrogen electrocatalysis. The controllable pyrolysis-free strategy allows the precise modulation of the active centers, realizing the optimization of the adsorption energy and the regulation of the synergistic active components. Specially, the as-prepared catalysts with hybrid single-atom/nanocluster sites exhibited superior catalytic activities for hydrogen evolution in both acidic and alkaline media with low over-potentials at -10 mA cm-2 of 25 mV and 8.6 mV, respectively, combining with outstanding durability towards high current density and methanol poisoning. This work developed a universal synthetic strategy for the single atom/nanocluster synergy systems and further demonstrated the superiority of heterogeneous components.

Outcome assessment of acute methanol poisoning: A risk-prediction nomogram approach for in-hospital mortality

Outcome assessment of acute methanol poisoning: A risk-prediction nomogram approach for in-hospital mortality

Coordination Compound Derived Co9S8 Supported on Nitrogen and Sulfur Co‐Doped Porous Carbon for Oxygen Reduction Reaction

AbstractCobalt sulfide, a class of metal chalcogenide with tunable electronic structure and component distribution, has attracted considerable interest in renewable energy conversion and utilization. In this work, we report a facile, efficient and scalable method to synthesize Co9S8 supported on nitrogen and sulfur co doped porous carbon (Co9S8/N,S‐PC) hybrid from the annealing treatment of a coordination compound assembled by 2‐mercaptobenzimidazole, 4,4‐bipyridine and cobalt salt. The heteroatom of organic ligand could efficiently tune the electronic properties of Co9S8 nanoparticles and well‐designed carbon. Meanwhile the interaction of organic ligands provides a platform for the high dispersion of Co9S8. Owing to the synergetic effect, the Co9S8/N,S‐PC catalyst shows an admirable oxygen reduction reaction (ORR) activity with the E1/2 of 0.804 V vs. RHE, together with good durability, and tolerance to methanol poisoning in alkaline media.

Differentiation of Suspected Methanol Poisoning From Ethanol Poisoning: A Review Study and Consensus Statement

Background: Ethanol and methanol poisoning pose significant clinical challenges due to their overlapping clinical presentations. This literature review and consensus statement aim to provide evidence-based guidelines for differentiating these two poisonings.Methods: We conducted a comprehensive literature review of relevant literature, including individual patient data (IPD) meta-analysis, to assess clinical, laboratory, and diagnostic findings in cases with ethanol and methanol poisoning. A literature review was also performed to gather case series of electrocardiograms of ethanol and methanol poisoning. We synthesized the evidence and convened an expert panel to develop consensus-based recommendations.Results: Based on the literature review and IPD analysis, cases of methanol poisoning often present later than 24 hours after alcohol consumption, emphasizing the importance of assessing patients with delayed referrals. Methanol-poisoned patients are frequently awake and responsive after 12 hours of ingestion, but symptoms alone do not reliably differentiate between the two poisonings. Declines in visual acuity and symptoms are strongly associated with methanol poisoning and should prompt immediate hospitalization and ophthalmic examination. Oliguria and anuria are more common in cases of methanol poisoning, warranting detailed urinary symptom assessment and close monitoring of urinary output. Electrocardiograms are essential for all alcohol poisoning patients, with non-sinus rhythm suggesting methanol poisoning. Arterial blood gas analysis, with low pH values, favors methanol poisoning. However, blood sugar levels alone cannot definitively determine the type of poisoning. Laboratory point-of-care tests to diagnose methanol in serum are urgently needed.Conclusion: This literature review and consensus statement offer guidance for healthcare providers facing cases of alcohol poisoning where point-of-care testing methods of blood alcohol concentrations are unavailable. A comprehensive assessment, considering clinical history, physical examination, laboratory data, and specialized evaluations such as ophthalmic examination and electrocardiograms, is essential for accurately differentiating ethanol and methanol poisoning.

Predictive Factors of Mortality in Methanol Poisoning Outbreaks: A Cross-sectional Study During the COVID-19 Pandemic

Background: Methanol poisoning has increased in some countries after the recent coronavirus pandemic. This study aimed to investigate the clinical and paraclinical findings of patients with methanol poisoning during the COVID-19 pandemic.Methods: This cross-sectional study was conducted on patients diagnosed with methanol poisoning in Imam Reza and Hasheminezhad hospitals who were hospitalized from the beginning of March 2019 to the end of April 2020. Clinical and paraclinical data were extracted from patients’ files and subsequently categorized into three groups: deceased patients, living patients without complications, and living patients with complications. Results: Out of 107 patients included in the study, 20(18.69%) died, 50(46.7%) were discharged without complications, and 37(34.6%) with complications. The most frequent clinical symptoms in the patients were blurred vision (62.6%), lethargy (62.6%), nausea (43%), vomiting (41.1%), abdominal pain (15.9%), dizziness (11.2%), and dyspnea (6.5%). According to the multivariate logistic regression analysis, reduced pH (OR=0.007, P=0.009) and blurred vision symptoms (OR=5.096, P=0.007) significantly predicted complications. Based on univariate logistic regression, hypoxemia (OR=35.90, P=0.002), coma (OR=22.34, P<0.001), high creatinine (OR=62.39, P<0.001), and low pH (OR=0.001, P<0.001) had the greatest impact in predicting mortality. Conclusion: This study shows the clinical and paraclinical characteristics of methanol poisoning during the COVID-19 pandemic, identifying critical predictors of complications and mortality, including low pH, blurred vision, hypoxemia, coma, and high creatinine levels.

A simple and low-cost method for determination of methanol in alcoholic solutions

Methanol poisoning can occur through consumption of methanol-containing alcohols, especially in areas where production, distribution, sale and consumption of alcohol is lawfully prohibited. Due to its toxic potency, determination of methanol in alcoholic solutions is important. The aim of the present study was to develop a rapid, simple and inexpensive method for quantification of methanol in alcoholic solutions that uses minimal equipment available in most laboratories. The method developed is based microdistillation and chromotropic acid, which can be conducted without sophisticated instruments or personal. The system consists of a micro-tube suspended in a falcon tube to function as a collector. Methanol is separated from wine by microdistillation at 90°C in water bath and converted to formaldehyde in the collector. The collector contains an acidic permanganate solution that converts methanol to formaldehyde. Formaldehyde was then quantified by use of chromotropic acid in concentrated sulfuric acid. Experimental variables were optimized by using central composite design (CCD). Method detection and quantification limits were 183mgL−1 and 584mgL−1, respectively. The percent relative standard deviation (RSD%) were between 6.4 and 7.9. Accuracies were between 89.6% and 92.4%. Concentrations of methanol in five alcoholic solutions were between 2.9×104 and 3.0×104, mg/L, v/v (ppm). Due to its simplicity and cost effectiveness, this method can be used for routine, real-time determination of methanol in alcoholic solutions.

Bamboo-like nitrogen-doped carbon nanotubes directly grown from commercial carbon black for encapsulating FeCo nanoparticles as efficient oxygen reduction electrocatalysts

Efficient methods for preparing carbon nanotube (CNT)-confined metal catalysts are of great significance for electrocatalysis. Hence, in this study, Fe and Co promoters were added to the precursors of commercial carbon black and melamine to form N-doped CNTs confined bimetallic catalysts (FeCo@N-CNTs) via in situ pyrolysis. The FeCo@N-CNT catalysts exhibited a bamboo-like morphology with FeCo alloy nanoparticles encapsulated in the CNTs and high activity toward the oxygen reduction reaction, with a half-wave potential of 0.864 mV, higher than that of commercial Pt/C (0.827 mV) in alkaline solutions. The catalytic performance is attributable to the synergistic effects between the FeCo alloy and N-doped CNT structure. Moreover, the confinement of the FeCo nanoparticles inside the CNTs imparted the prepared catalysts with resistance to methanol poisoning and long-term stability. This versatile method of synthesizing CNTs directly from carbon black provides a new strategy for preparing high-performance non-precious-metal-based N-doped CNT catalysts for practical fuel cell applications.

Effect of structure of metal-free nitrogen-doped coal-based carbon on catalytic oxygen reduction

In carbon-based oxygen reduction reaction (ORR) catalysts, metal-free nitrogen-doped carbon-based materials generally have higher catalytic stability compared to metal catalysts with reduced catalytic activity due to the occurrence of metal agglomeration during the catalytic reaction. In this paper, a metal-free nitrogen-doped carbon-based ORR catalyst NCOH5-900 with a half-wave potential of 0.846 V and onset potential of 0.94 V was prepared using coal as the carbon source, dicyandiamide as the nitrogen source and KOH as the activator. The material has good ORR catalytic performance with half-wave potential and onset potential comparable to Pt/C catalyst with the same mass loading, with better resistance to methanol toxicity and catalytic stability. The physical and chemical properties of the prepared catalyst were controlled by adjusting the amount of nitrogen doping and activation temperature to establish the relationship between the material structure and the ORR performance. The results suggest that for the metal-free nitrogen-doped carbon-based material, the good ORR catalytic performance is attributed to the abundant edge defects, high graphitization, good mixed structure of micro/mesopores, large nitrogen content, and high ratio of pyridine to graphitic nitrogen. Finally, the catalytic mechanism of NCOH5-900 for ORR is investigated using in-situ attenuated total reflection Fourier infrared (ATR-FTIR) and in-situ Raman, confirming the four-electron reduction process of O2 via a continuous dual step of two-electron transfer process.

Retrospective Investigation of Alcohol Intoxications Followed in Intensive Care Unit

Aim: The majority of alcohol-related deaths are due to acute alcohol consumption. There are many factors affecting the prognosis of alcohol toxicity. It has been reported that by determining these factors, mortality rates can be reduced by early diagnosis and early initiation of treatment. In this study, we aimed to determine the prognosis by evaluating the clinical status and laboratory factors of patients followed up in intensive care unit (ICU) due to acute alcohol intoxication. Materials and Methods: The study included 21 patients with acute alcohol intoxication who were followed up in the ICU of our hospital between 2013-2021.Laboratory parameters, demographic characteristics and clinical status of the patients were recorded. Patients were divided into both exitus and survivors and according to the type of alcohol consumed (ethanol and methanol). Results: All patients were male with a mean age of 40.10 ± 15.9 years. 52.4% of the admissions were ethanol poisoning and 47.6% were methanol poisoning. Mortality rate was 33.3%. It was observed that symptoms appeared later in methanol intoxication compared to ethanol intoxication (p

Candida boidinii isolates from olive curation water: a promising platform for methanol-based biomanufacturing

Methanol is a promising feedstock for biomanufacturing, but the efficiency of methanol-based bioprocesses is limited by the low rate of methanol utilization pathways and methanol toxicity. Yeast diversity is an attractive biological resource to develop efficient bioprocesses since any effort with strain improvement is more deserving if applied to innate robust strains with relevant catabolic and biosynthetic potential. The present study is in line with such rational and describes the isolation and molecular identification of seven isolates of the methylotrophic species Candida boidinii from waters derived from the traditional curation of olives, in different years, and from contaminated superficial soil near fuel stations. The yeast microbiota from those habitats was also characterized. The four C. boidinii isolates obtained from the curation of olives’ water exhibited significantly higher maximum specific growth rates (range 0.15–0.19 h−1), compared with the three isolates obtained from the fuel contaminated soils (range 0.05–0.06 h−1) when grown on methanol as the sole C-source (1% (v/v), in shake flasks, at 30°C). The isolates exhibit significant robustness towards methanol toxicity that increases as the cultivation temperature decreases from 30°C to 25°C. The better methanol-based growth performance exhibited by C. boidinii isolates from olives´ soaking waters could not be essentially attributed to higher methanol tolerance. These methanol-efficient catabolizing isolates are proposed as a promising platform to develop methanol-based bioprocesses.

Prevalence of alcoholic beverage consumption among a population with a history of methanol poisoning in the southeast of Iran

ABSTRACT Background The use of alcoholic substances in adults is often associated with a wide variety of negative consequences. The aim of this study was to assess the prevalence of alcoholic beverage consumption in a population with a history of methanol poisoning in the southeast of Iran. Methods A total of 876 individuals were interviewed using a cross-sectional survey between 2020 and 2021. We used two methods of asking direct questions (ADQ) and network scale-up (NSU) for estimating the prevalence of alcoholic beverage consumption. Results The mean age of the participants was 41.07 ± 14.52; 46% were female. Based on the method of ADQ, the prevalence of alcoholic beverage consumption was 22.2% (95% confidence interval (CI): 18.45–25.95%) and 4.4% (95% CI: 2.24–6.16%) among men and women, respectively. While these values for the NSU method were 26.53% (95% CI: 19.93–35.88%) and 8.31% (95% CI: 6.32–10.58%) among men and women, respectively. Conclusions Our results show that asking direct questions about illegal behavior can provide a lower estimate than indirect questioning approaches. Due to the high prevalence of alcoholic beverage consumption in men, this issue may increase the risk of unintentional poisoning by methanol in this area.

Real-world safety and effectiveness of intravenous fomepizole in patients with ethylene glycol and methanol poisoning in Japan: results of a 7-year post-marketing surveillance study

ABSTRACT Background Fomepizole is a competitive alcohol dehydrogenase inhibitor used for the treatment of ethylene glycol and methanol poisoning. We evaluated the safety and effectiveness of fomepizole in patients with ethylene glycol or methanol poisoning in Japan. Research design and methods This retrospective post-marketing surveillance study conducted in Japan registered patients who received fomepizole intravenous infusion per the package insert (January 2015−June 2022). Endpoints included adverse drug reactions/infections (ADRs), arterial blood pH, and treatment outcomes. Results Of 147 patients registered (91 institutions), 131 and 126 were included in the safety and effectiveness analysis sets, respectively. Mean age was 43.6 years, and 66.4% were male. Mean time from poison ingestion to treatment was 15.1 hours; 66.4% received concomitant hemodialysis. No serious ADRs were reported. ADRs were reported in seven patients; the most-reported ADR was vomiting (2.3%). Seven patients died, 105 survived without sequelae, and 19 survived with sequelae. Most common sequelae were renal failure or renal dysfunction. Mean arterial blood pH increased to 7.4 by 4 hours of treatment, remaining stable for 24 hours post-treatment. Conclusions Fomepizole is well tolerated and helps improve clinical outcomes in patients with ethylene glycol or methanol poisoning in Japan. Trial registration Japanese Pharmaceutical Information Center (JapicCTI-152817).

Explainable artificial intelligence (XAI) for predicting the need for intubation in methanol-poisoned patients: a study comparing deep and machine learning models

The need for intubation in methanol-poisoned patients, if not predicted in time, can lead to irreparable complications and even death. Artificial intelligence (AI) techniques like machine learning (ML) and deep learning (DL) greatly aid in accurately predicting intubation needs for methanol-poisoned patients. So, our study aims to assess Explainable Artificial Intelligence (XAI) for predicting intubation necessity in methanol-poisoned patients, comparing deep learning and machine learning models. This study analyzed a dataset of 897 patient records from Loghman Hakim Hospital in Tehran, Iran, encompassing cases of methanol poisoning, including those requiring intubation (202 cases) and those not requiring it (695 cases). Eight established ML (SVM, XGB, DT, RF) and DL (DNN, FNN, LSTM, CNN) models were used. Techniques such as tenfold cross-validation and hyperparameter tuning were applied to prevent overfitting. The study also focused on interpretability through SHAP and LIME methods. Model performance was evaluated based on accuracy, specificity, sensitivity, F1-score, and ROC curve metrics. Among DL models, LSTM showed superior performance in accuracy (94.0%), sensitivity (99.0%), specificity (94.0%), and F1-score (97.0%). CNN led in ROC with 78.0%. For ML models, RF excelled in accuracy (97.0%) and specificity (100%), followed by XGB with sensitivity (99.37%), F1-score (98.27%), and ROC (96.08%). Overall, RF and XGB outperformed other models, with accuracy (97.0%) and specificity (100%) for RF, and sensitivity (99.37%), F1-score (98.27%), and ROC (96.08%) for XGB. ML models surpassed DL models across all metrics, with accuracies from 93.0% to 97.0% for DL and 93.0% to 99.0% for ML. Sensitivities ranged from 98.0% to 99.37% for DL and 93.0% to 99.0% for ML. DL models achieved specificities from 78.0% to 94.0%, while ML models ranged from 93.0% to 100%. F1-scores for DL were between 93.0% and 97.0%, and for ML between 96.0% and 98.27%. DL models scored ROC between 68.0% and 78.0%, while ML models ranged from 84.0% to 96.08%. Key features for predicting intubation necessity include GCS at admission, ICU admission, age, longer folic acid therapy duration, elevated BUN and AST levels, VBG_HCO3 at initial record, and hemodialysis presence. This study as the showcases XAI's effectiveness in predicting intubation necessity in methanol-poisoned patients. ML models, particularly RF and XGB, outperform DL counterparts, underscoring their potential for clinical decision-making.

Biomass N/P co‐doped porous carbon plates for electrocatalytic oxygen reduction

AbstractNitrogen and phosphorus co‐doped porous carbon plate (NPCP) was prepared by simple pyrolysis carbonization and alkali activation of biomass duckweed NPCP displays the largest specific surface area (SSA) of 2023 m2 g−1, and is rich in pyridine N and P doping, which makes the metal‐free carbon have excellent electrocatalytic oxygen reduction performance. The best NPCP2 shows a half‐wave potential of 0.19 V vs. Ag/AgCl in alkaline electrolyte, and its activity is equivalent to that of commercial platinum carbon (Pt/C). In addition, it shows excellent methanol toxicity resistance and continuous catalytic stability. The experimental results show that the heteroatom doping method obtained by biomass hydroponics has great advantages and great application value in the catalytic field of porous carbon materials.

A potential prognostic indicator in methanol intoxication: Body temperature

Objective: Methanol intoxication is a type of poisoning with high mortality and morbidity. The current study aims to examine patients diagnosed with methanol intoxication and treated with standardized treatment to collect data that may be used to predict patient outcomes and mortality. Materials and Methods: The current study was a retrospective study and included patients over 18 years of age diagnosed with methanol intoxication between 1st March, 2011 and 1st March, 2021. All patients were treated with the treatment protocol determined by the clinic in accordance with the guidelines. Sociocultural characteristics, vital and laboratory findings, and clinical outcomes of the patients were analyzed. Results: Of the 28 patients included in the study, 80% were male, and the median age was 49. Patients were divided into two groups: survived and deceased. The median time since last alcohol intake was higher in surviving group (7 hours (Q1-Q3:6-12) vs 4 hours (Q1-Q3:2-17), p=0.005) and the amount of alcohol per kilogram of weight was lower in surviving group (3.13 ml/kg (Q1-Q3: 1.34-4.46) vs 8.81 ml/kg (Q1-Q3:5.22-9.49), p=0.002). The body temperature was lower in deceased group (35.40 °C (Q1-Q3:34.95-35.50) vs 36.40 °C (Q1-Q3:36.10-36.55), p=0.001). The current study showed that the other diagnostic factors of mortality in methanol intoxication are serum pH, lactate levels, bicarbonate levels, base deficit, anion deficit, the level of consciousness of the patient at admission, the time since the last alcohol consumption, and the amount of methanol ingested. Conclusion: In this study, it was concluded that moderate hypothermia may be an indicator of mortality in addition to classical findings. Thus, it has been shown that hypothermia will be effective in methanol intoxication in addition to other early markers for early diagnosis and rapid initiation of treatment.

Fabrication of N and S co-doped lignin-based porous carbon aerogels loaded with FeCo alloys and their application to oxygen evolution and reduction reactions in Zn-air batteries

Zn-air batteries are a highly promising clean energy sustainable conversion technology, and the design of dual-function electrocatalysts with excellent activity and stability is crucial for their development. In this work, FeCo alloy loaded biomass-based N and S co-doped carbon aerogels (FeCo@NS-LCA) were fabricated from chitosan and lignosulfonate-metal chelates via liquid nitrogen pre-frozen synergistic high-temperature carbonization with application in electrocatalytic reactions. The abundant oxygen-containing functional groups on lignosulfonates have a chelating effect on metal ions, which can avoid the aggregation of metal nanoparticles during carbonation and catalysis, facilitating the construction of a nanoconfinement catalytic system with biomass carbon as the domain-limiting body and FeCo nanoparticles as the active sites. FeCo@NS-LCA exhibited catalytic activity (E1/2 = 0.87 V, JL = 5.7 mA cm−2) comparable to the commercial Pt/C in the oxygen reduction reaction (ORR), excellent resistance to methanol toxicity and stability. Meanwhile, the overpotential of oxygen evolution reaction (OER) was 324 mV, close to that of commercial RuO2 catalysts (351 mV). This study utilizes the coordination action of lignosulfonate to provide a novel and environmentally friendly method for the preparation of confined nano-catalysts and provides a new perspective for the high-value utilization of biomass resources.

Methanol Poisoning and Its Clinical Complications During the COVID-19 Pandemic in Iran: A Systematic Review

Background: During the COVID-19 pandemic, there was a surge in the consumption of beverages containing methanol, as individuals have erroneously surmised that the ingestion of alcohol could potentially serve as a protective measure against the virus. Objectives: The aim of this systematic study was to investigate methanol toxicity and its clinical complications during the COVID-19 pandemic. Methods: A comprehensive search for sources was conducted across multiple databases, including PubMed, Embase, Web of Science, and Scopus, as well as Iranian databases such as Magiran, Iran Doc, and SID. The search spanned from December 2019 to November 2022. The inclusion criteria for this review specified cross-sectional studies that examined the prevalence of methanol toxicity and its complications during the COVID-19 pandemic in Iran. Methodological quality was assessed for each study included in the review. Results: During the COVID-19 pandemic, the consumption of alcohol, including ethanol and methanol, increased. Men were more likely to consume alcohol compared to women, and a higher number of deaths were reported among young individuals. Visual impairment emerged as one of the most common complications of methanol poisoning, with an increase in its incidence during the disease outbreak. Conclusions: Given the growing concerns about methanol poisoning, enhancing public awareness could significantly reduce both the prevalence of clinical complications and mortality rates. Therefore, it is recommended that greater emphasis be placed on improving education and raising awareness about methanol poisoning within Iran.

Epidemiological Study of the Causes of Alcohol Drinks in Cases of Alcohol Poisoning among Patients who Referred to Amir Al-Momenin Hospital in Zabol in 2016-2019

Background: Abuse of substances such as alcohol as a social issue affects the health of human life. In this study, we decided to address the prevalence of alcohol poisoning and its effective factors among patients referred to Amir Al-Momenin Hospital in Zabol. Methods: In this cross-sectional study, 110 patients with alcohol poisoning who had referred to Amir Al-Momenin Hospital in Zabol in 2016-2019 participated. Necessary information was collected through a questionnaire. Finally, the obtained data were statistically analyzed by T-test, Chi-square and Fisher's exact tests. Results: In the present study, 110 patients with alcohol poisoning were included in the study, of which 91 (82.72%) had ethanol poisoning and 19 (17.27%) had methanol poisoning. The mean age of patients was 27.08 ± 3.2 years and 95.45% of them were male. Unemployment and lack of entertainment, mental disorders, alcoholic friends, psychological dependence were the most common causes of alcohol consumption in patients. In this study, decreased level of consciousness (57.27%) and gastrointestinal complications (43.63%) were the most common symptoms of alcohol poisoning in the studied patients. Conclusion: In the present study, male gender was significantly associated with alcohol poisoning (P). While the variables of age, sex and marital status were not significantly associated with the type of ethanol or methanol poisoning. The results of the study showed that male gender, social status and low education of parents, psychological problems and alcohol friends were risk factors and influential factors in alcohol poisoning.

Delayed bilateral blindness after methanol poisoning

Delayed bilateral blindness after methanol poisoning