The article considers the most general prerequisites for creating a new model of the ecological picture of the world, which is characterized by the comprehensiveness and completeness of coverage of various aspects of the study of the relationships between man and nature. For its formation, it is proposed to use an ecological version of the worldview-methodological platform, called ‘postholism’ by the author, which is able to coordinate the one, whole, many and singular, unique in (among others) the environmental relations of man, society and nature. This allows us to eliminate the methodological shortcomings of the reduction to the individual (merism), to the whole (holism), to the one (onecentrism) of human worldview orientations in the nature of naturcentrism, anthropo(socio)centrism, technocentrism, theocentrism. Such categories of philosophy as ‘reality’, ‘being’, ‘otherness’, ‘non-existence’, ‘being’, ‘nature’, ‘matter’, ‘physical’, ‘metaphysical’, and ‘spiritual’ were important tools for constructing a picture of the world of ecocentrism. They were refined and correlated with the latest achievements in quantum physics, astrophysics, cosmology, as well as reflexed based on extra-scientific representations of ancient cultures and religions. Physical, as well as metaphysical features of nature and man are briefly discussed. Nature is represented at various levels of physical organization (micro-world, macro-world and mega-world) and outside of physical dimensions. These dimensions presumably contain the ‘metaphysical’ content of nature. In them, the objective ‘spiritual’ of the universe, deified by man, is allowed. This does not exclude the pantheistic presence of metaphysical transcendence, estimated as ‘nonexistence’, ‘nothing’ for the reality of man within nature. Man himself is positioned as one whole of physical and spiritual existence, serving as a semblance of a Single Whole of nature. In conclusion, a list of the main environmental invariants of the world picture is given in comparison with the proposed picture of the world of ecologized postholism − ecocentrism, the advantages of which are emphasized. The Universe and quantum-field reality, along with the Earth, become components of the All-unified Whole authentic home of the ‘ecos’ of man. Further conditions and prospects for the direct development of this model are discussed.