The focus of this research is to investigate magnetohydrodynamic flow, entropy generation, heat and mass transfer analysis for fourth grade nanofluid over a vertical plate in a porous medium subject to slip and convective boundary conditions. Lie group invariant similarity variable is used to transform the partial differential equations (PDEs) governing the problem to system of coupled nonlinear ordinary differential equations (ODEs). The resulting dimensionless ODEs are solved using Homotopy Perturbation Method (HPM). HPM results are validated with the numerical solutions via shooting method alongside the six order Runge-Kutta integration technique. The results revealed effects of new embedded governing flow parameters on velocity, temperature, entropy generation and concentration profiles.Furthermore, the impact of new embedded flow parameters on skin friction coefficient, Nusselt number and Sherwood number at the plate surface are investigated and the results are shown in tabular forms. The results indicate that suction on the plate can be used to control momentum, thermal and solutal boundary layer thickness. This research discovered that magnetic parameter, Eckert number, Biotsolutal number and Hartmann number can be respectively used to adjust fluid flow’s velocity, temperature, concentration and entropy generation. This research also detected that the force driving the fourth grade nanofluid flow called buoyancy driven force can be accelerated or decelerated by adjusting angle of magnetic field inclination. The present investigation has applications in industries and engineering, such as petroleum industries, chemical industries and metallurgy sciences