Perceived cultural distance (PCD) has been established as a significant factor influencing academic performance; however, limited knowledge exists regarding the intricate mediating and moderating mechanisms that underlie this relationship. The present study seeks to contribute to the existing literature by exploring the potential mediating role of cross-cultural adaptation and the moderating influence of cultural intelligence (CQ) in the relationships between PCD and academic performance among international students in China. The theoretical model was tested using survey data that measured international students' PCD, CQ, and cross-cultural adaptation in academic, psychological, and sociocultural domains, along with their academic performance. The findings revealed that (1) PCD exhibits a direct and negative influence on academic performance; (2) Three dimensions of cross-cultural adaptation, namely academic, psychological, and sociocultural adaptation, operate as mediators in the link between PCD and academic performance; (3) CQ, functioning as a moderator, weakens the negative association between PCD and academic performance. These results underscore the pivotal role of PCD in the realm of cross-cultural learning for international students, particularly those engaged in educational pursuits within the Chinese higher education landscape. The study also highlights the protective effects of all four aspects of CQ (metacognitive, cognitive, motivational, and behavioral CQ) on the adaptation processes and academic performance of these sojourning students in the face of cultural differences.