Metabolic Syndrome In Koreans Research Articles

Association between nut consumption and metabolic syndrome in Korean adults: results from the Korean Genome and Epidemiology Study–Health Examinees

BackgroundThe epidemiological evidence regarding nut consumption and metabolic diseases focuses on Western populations. Nut consumption among Koreans is relatively low, and the prevalence of metabolic syndrome is rapidly increasing, highlighting the need for more focused studies in this population. This cross-sectional study aimed to investigate the relationship between nut consumption and metabolic syndrome in Korean adults.MethodsA total of 112,501 adults (39,481 men and 73,020 women) aged 40–79 years were selected from baseline data of the Korean Genome and Epidemiology Study–Health Examinees. Nut consumption was assessed using a validated semi-quantitative food frequency questionnaire and categorized as non-consumers, <1 serving/week, ≥1 to <2 servings/week, or ≥2 servings/week (15 g per serving). Metabolic syndrome and its components were defined according to the Korean Society of CardioMetabolic Syndrome criteria. Associations between nut consumption and metabolic syndrome and its components were examined using multiple logistic regression with adjustments for potential confounders.ResultsIn the study population, the prevalence of metabolic syndrome was 21.4% (26.9% in men and 18.4% in women), and the mean nut intake was 0.8 serving/week (0.7 serving/week in men and 0.8 serving/week in women). After adjusting for confounders, higher nut consumption was associated with a lower odds ratio (OR) of metabolic syndrome in individuals consuming ≥2 servings/week compared with non-consumers [OR = 0.85, 95% confidence interval (CI) = 0.80–0.91, p for trend <0.001]. Specifically, in men, this level of consumption was associated with a 14% reduction in the OR of metabolic syndrome (OR = 0.86, 95% CI = 0.77–0.95, p for trend = 0.028). In women, a similar reduction of 14% was observed (OR = 0.86, 95% CI = 0.80–0.93, p for trend <0.001). Among the metabolic syndrome components, nut consumption was inversely associated with abdominal obesity, low high-density lipoprotein-cholesterol, and elevated triglycerides in men and women, whereas no associations were observed for elevated blood pressure or elevated fasting blood glucose.ConclusionOur findings suggest that higher nut consumption is inversely associated with metabolic syndrome and its components in Korean adults. Further studies are needed to examine the longitudinal association between nut consumption and metabolic diseases in this population.

Effect of Household Type on the Prevalence of Metabolic Syndrome in Korea: Using Propensity Score Matching.

This study analyzed the effect of the household type on the prevalence of metabolic syndrome in Koreans utilizing data from the sixth, seventh, and eighth Korea National Health and Nutrition Examination Surveys conducted by the Korea Disease Control and Prevention Agency from 2015 to 2019. The demographic characteristics, metabolic syndrome characteristics according to household type, and risk factors of 25,092 subjects were identified using the Rao–Scott χ2–test and weighted multiple logistic regression results. Furthermore, to understand the effect of the household type on prevalence of metabolic syndrome, the selection bias between the groups was eliminated using the propensity score matching method. The average treatment effect for those treated for metabolic syndrome prior to propensity score matching was higher for single-person households, with 0.353 and 0.268 for single- and multi-person households, respectively. The difference was statistically significant (p < 0.0001). However, after propensity score matching, it was observed to be higher for multi-person households, with 0.290 and 0.316 for single- and multi-person households, respectively. However, the difference was not statistically significant (p < 0.1822). Difference was observed regarding the prevalence of metabolic syndrome by individual characteristics, some of which were considered in previous studies. However, the household type alone did not explain the prevalence of metabolic syndrome.

Neck Circumference as a Predictor of Metabolic Syndrome in Koreans: A Cross-Sectional Study.

Metabolic syndrome (MetS) is a complex metabolic disorder and a high-risk condition for type 2 diabetes and cardiovascular disease. Rapid screening of at-risk individuals using accurate and time-saving tools is effective in disease management. Using the Korea National Health and Nutrition Examination Survey (KNHANES) data, we collected data from 2234 participants suitable for the study design, of which 974 (43.6%) were men and 1260 (56.4%) were women. We used receiver operating characteristic (ROC) curve analysis to estimate the optimal sex-specific neck circumference (NC) cut-off point to predict the MetS risk. To analyze the risk of MetS according to the estimated NC, logistic regression analysis was performed to identify the confounding factors. The result of the ROC analysis showed that the optimal neck cut-off points for predicting the risk of MetS were 38.25 cm (AUC: 0.759, 95% CI: 0.729–0.790) in men and 33.65 cm (AUC: 0.811, 95% CI: 0.782–0.840) in women. In the upper NC cut-off point compared to the lower NC cut-off point, NC was associated with an increased MetS risk by 2.014-fold (p = 0.010) in men and 3.650-fold (p < 0.001) in women, after adjustments. The current study supports NC as an effective anthropometric indicator for predicting the risk of MetS. It is suggested that more studies should be conducted to analyze the disease prediction effect of the combined application of anthropometric indicators currently in use and NC.

The Association between Pulmonary Function and Metabolic Syndrome in Koreans: A Cross-Sectional Study

The Association between Pulmonary Function and Metabolic Syndrome in Koreans: A Cross-Sectional Study

HDL Subclass Analysis in Predicting Metabolic Syndrome in Koreans With High HDL Cholesterol Levels.

BackgroundHigh-density lipoprotein cholesterol (HDL-C) is a complex mixture of subclasses with heterogeneous atheroprotective activities. We analyzed HDL-C subclass in relation to cardiovascular risk and metabolic syndrome (MetS) in a population with high HDL-C levels.MethodsA total of 300 Korean individuals with high HDL-C levels (≥2.331 mmol/L) were enrolled following a comprehensive general medical examination including body composition analysis. HDL3-C levels were measured using the HDL3-EX SEIKEN kit (Randox Ltd., Crumlin, UK) and non-HDL3-C levels were calculated by subtracting HDL3-C levels from total HDL-C levels.ResultsHDL3-C levels and HDL3-C proportion had a weak positive correlation with low-density lipoprotein cholesterol (LDL-C) and triglycerides (r=0.21, r=0.25; r=0.26, r=0.34, respectively, all P<0.001); in contrast, non-HDL3-C levels had a weak negative correlation with these parameters (r=−0.17 and r=−0.25, respectively, both P<0.005). HDL3-C levels and HDL3-C proportion were significantly higher in the MetS group (N=8) than in the non-MetS group (0.71 vs 0.63 mmol/L, P=0.001; 29.7 vs 25.8%, P=0.001, respectively); these were the only predictors of MetS among the lipid variables (areas under the curves [AUC]=0.84 and 0.83, respectively, both P=0.001).ConclusionsIn populations with high HDL-C levels, HDL-C subclass may provide a greater amount of information on cardiovascular risk and MetS than HDL-C levels alone.

Prevalence of metabolic syndrome in ethnic groups in China: a cross-sectional study

BackgroundMetabolic syndrome is common in China, which has a multiethnic population of 1·3 billion. We set out to establish the prevalence of metabolic syndrome and its components in different ethnic groups. MethodsWe did a nationwide cross-sectional survey of eight ethnicities from six provinces in China. Metabolic syndrome was defined with the modified National Cholesterol Education Program Adult Treatment Panel III criteria. We analysed results using SPSS version 22·0. We used logistic regression for deriving odds ratios (OR) and 95% confidence intervals of risk factors for the metabolic syndrome. FindingsBetween June 1, 2008, and Dec 31, 2011, 24 796 participants were involved in the survey. The crude prevalence of metabolic syndrome ranged from 3·60% to 21·70% depending on the age group. After age standardisation, the respective prevalence of metabolic syndrome in descending order was 34·53% (Korean), 22·81% (Hui), 19·80% (Han), 13·72% (Miao), 12·88% (Tujia), 12·04% (Li), 11·58% (Mongolian), and 6·18% (Tibetan). Korean ethnicity was associated with a higher prevalence in five components of metabolic syndrome, whereas Tibetan ethnicity was associated with lower prevalence in most of the components except decreased HDL cholesterol. Logistic regression analyses showed that age (OR for 60–86 years old 34·12; 95% CI 24·67–47·18), drinking status (1·35; 1·20–1·51), and not being Tibetan (Han 2·975; 2·194–4·034; Li 2·096; 1·487–2·954; Miao 1·961; 1·262–3·048; Mongolian 1·835; 1·272–2·648; Korean 5·989; 4·249–8·442; Hui 4·020; 2·859–5·653; and Tujia 1·753; 1·166–2·637) were all associated with a higher risk of metabolic syndrome. InterpretationThe prevalence of metabolic syndrome in Korean and Hui ethnicities was higher than for the other ethnic groups. Tibetan ethnicity was associated with a lower risk of metabolic syndrome. The ethnic differences in the prevalence of metabolic syndrome and its components mean that measures to tackle the metabolic syndrome should be tailored to the characteristics of that population. FundingThe Ministry of Science and Technology of P R China (2006FY110300).

Components of Metabolic Syndrome in Korean Adults: A Hospital-Based Cohort at Seoul National University Bundang Hospital.

BackgroundThe prevalence of metabolic syndrome is increasing in Korea, particularly among young adults. This trend will increase the incidence of cardiovascular and metabolic diseases in the future. Therefore, it is imperative to detect and prevent metabolic abnormalities early in life. Here, we established a hospital-based biobank cohort to identify the most prevalent dysmetabolic phenotype. The aim of this report was to inform other researchers of our protocol and to share our data for future collaboration.MethodsThe baseline examination comprised health-related questionnaires, anthropometric and handgrip strength measurements, bioelectrical impedance analysis of body composition, and nutritional assessment. Relevant biochemical parameters were measured, and oral glucose tolerance tests were performed. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria with Asian waist circumference criteria.ResultsFrom a total of about 3,000 employees aged 20 to 59 years working at Seoul National University Bundang Hospital, 1,017 were enrolled from 2015 to 2016. The mean age was 34.5±8.4 years for men (n=311, 30.6%) and 30.9±8.5 years for women (n=706, 69.4%). The overall prevalence of metabolic syndrome was 7.6% (17.7% in men and 3.1% in women). Among the five components of metabolic syndrome, high blood pressure was the most prevalent in both men (51.4%) and women (13.8%).ConclusionAlthough further follow-up data are needed, we expect that more adverse cardiovascular events may occur in men than in women. This hospital-based cohort will serve as the foundation for a comprehensive evaluation of metabolic syndrome and future cardiometabolic disease risk in middle-aged Koreans.

Association of Knee Osteoarthritis with Metabolic Syndrome in Koreans Aged 50-Years or Older

Association of Knee Osteoarthritis with Metabolic Syndrome in Koreans Aged 50-Years or Older

A study on the Development of a Korean Metabolic Syndrome Questionnaire

Segmentation of grayscale medical images is challenging because of the similarity of pixel intensities and poor gradient strength between adjacent regions. The existing image segmentation approaches based on either intensity or gradient information alone often fail to produce accurate segmentation results. Previous approaches in the literature have approached the problem by embedded or sequential integration of different information types to improve the performance of the image segmentation on specific tasks. However, an effective combination or integration of such information is difficult to implement and not sufficiently generic for closely related tasks. Integration of the two information sources in a single graph structure is a potentially more effective way to solve the problem. In this paper we introduce a novel technique for grayscale medical image segmentation called pyramid graph cut, which combines intensity and gradient sources of information in a pyramid-shaped graph structure using a single source node and multiple sink nodes. The source node, which is the top of the pyramid graph, embeds intensity information into its linked edges. The sink nodes, which are the base of the pyramid graph, embed gradient information into their linked edges. The min-cut uses intensity information and gradient information, depending on which one is more useful or has a higher influence in each cutting location of each iteration. The experimental results demonstrate the effectiveness of the proposed method over intensity-based segmentation alone (i.e. Gaussian mixture model) and gradient-based segmentation alone (i.e. distance regularized level set evolution) on grayscale medical image datasets, including the public 3DIRCADb-01 dataset. The proposed method archives excellent segmentation results on the sample CT of abdominal aortic aneurysm, MRI of liver tumor and US of liver tumor, with dice scores of 90.49±5.23%, 88.86±11.77%, 90.68±2.45%, respectively.

Consumption of black food decreases the risk of abdominal obesity in Korean women.

The association between black-colored foods (black foods) such as black beans, known for their high antioxidant capacity, and the prevention of metabolic diseases has been explored, but not in a large population. Therefore, this study examined relationships between the consumption of black foods and metabolic syndrome in Korean adults. Data from 9,499 40-65-year old subjects (3,675 men and 5,824 women) from the 2010-2015 Korea National Health and Nutrition Examination Survey were used in the analysis. Black food consumption was estimated using 24-h dietary recall data, and analyses were performed according to black food consumer and non-consumer groups. The average total consumption of black foods was higher in women than men. The total black food consumer group in women had a 24% reduced risk of abdominal obesity than the non-consumer group (p=0.007). Furthermore, waist circumference decreased significantly with an increase in total black food consumption in women. High consumption of total black foods and black beans reduced the risk of abdominal obesity by 26% (p for trend=0.012) and 29% (p for trend=0.003) compared with no consumption. No risk factors for metabolic syndrome were associated with black food consumption in men. In conclusion, black foods, including black beans, may have beneficial effects on metabolic syndrome components, especially abdominal obesity.

Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study.

Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population. Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria. After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09-1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65years old. H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65years old.

Association between Serum Uric Acid and Metabolic Syndrome in Koreans.

BackgroundAlthough previous studies have highlighted the importance of serum uric acid as a risk factor of metabolic syndrome, no study has previously used a national Korean survey to examine the association between serum uric acid level and metabolic syndrome. This study aimed to investigate this association among Korean adults, to determine whether it varies by age and gender, and to identify optimal serum uric acid level cutoffs for predicting the presence of metabolic syndrome by gender and age.MethodsWe included 5,758 Korean adults (aged ≥ 19 years) who participated in the seventh Korea National Health and Nutrition Examination Survey (KNHANES VII-1), 2016. Logistic regression analyses were performed to examine the association between serum uric acid and the presence of metabolic syndrome. Receiver operating characteristic analyses were used to assess optimal uric acid cutoff values for predicting the presence of metabolic syndrome.ResultsHigh serum uric acid levels were found to be associated with risk of metabolic syndrome. Area under the receiver operating characteristic curve (AUC) analyses of uric acid levels for the detection of metabolic syndrome produced good performances. Women subjects had significantly higher AUC values than men subjects, but this gender difference may also have been influenced by age. Among men, AUC values of those in their 20s, 30s, or 40s were significantly higher than those in their 70s (P < 0.05). The optimal uric acid cutoff was 6.05 mg/dL for men and 4.45 mg/dL for women, and men had higher cutoffs than women in all age groups.ConclusionAmong Korean adults, serum uric acid levels were found to be strongly associated with the presence of metabolic syndrome. More importantly, our findings suggest that derived optimal cutoff values of uric acid might offer a useful means of diagnosing metabolic syndrome in clinical settings.

Association between Exercise and Metabolic Syndrome in Koreans (J Obes Metab Syndr 2018;27:117-24).

Association between Exercise and Metabolic Syndrome in Koreans (J Obes Metab Syndr 2018;27:117-24).

Association between Exercise and Metabolic Syndrome in Koreans (J Obes Metab Syndr 2018;27:117-24).

Association between Exercise and Metabolic Syndrome in Koreans (J Obes Metab Syndr 2018;27:117-24).

The Association between Thyroid Stimulating Hormone and Metabolic Syndrome in Korean: The 6th Korean National Health and Nutrition Examination Survey (2015)

The Association between Thyroid Stimulating Hormone and Metabolic Syndrome in Korean: The 6th Korean National Health and Nutrition Examination Survey (2015)

Moderate coffee consumption is inversely associated with the metabolic syndrome in the Korean adult population.

Results from studies investigating the association between coffee consumption and the metabolic syndrome in Koreans have been inconsistent and remain controversial. We examined coffee intake in relation to the metabolic syndrome using data from the Korea National Health and Nutrition Examination Survey 2012-2015, with 8387 adults aged 19-64 years. Furthermore, we conducted a stratified analysis by obesity status (BMI <25 v. ≥25 kg/m2) to examine whether the association varied by obesity status. A 112-item FFQ was used to assess diet. Multivariable logistic regression models were used to determine the association of coffee consumption (<1, 1-2, 3-4 and ≥5 times/d) and the metabolic syndrome. Compared to people who consumed <1 time/d of coffee, the OR for the metabolic syndrome in those who consumed 3-4 times/d of coffee was 0·75 (95 % CI 0·58, 0·97). However, ≥5 times/d of coffee consumption was not significantly associated with the metabolic syndrome. By obesity status, in non-obese people, those consuming more coffee had lower odds of the metabolic syndrome, showing a significant linear trend (P-trend=0·0248). In obese people, the OR for the metabolic syndrome in people with 3-4 times/d of coffee consumption v. <1 time/d was 0·68 (95 % CI 0·50, 0·93), but ≥5 times/d of coffee consumption showed a non-significant positive association. Our findings suggest that moderate coffee consumption of 3-4 times/d is inversely associated with the metabolic syndrome in Korean adults. The association between heavy coffee consumption of ≥5 times/d and the metabolic syndrome varied by obesity status.

Diet quality, physical activity, and their association with metabolic syndrome in Korean adults.

The aim of ths study was to investigate the combined association of overall diet quality and physical activity (PA) on the risk for metabolic syndrome (MetS) in Korean adults. This cross-sectional study extracted the data on 1008 adults (384 men and 624 women) 20 to 64 y of age. Dietary quality was assessed using a recommended food score (RFS) modified for a Korean diet. The total PA was summed to obtain a metabolic equivalent task score. Participants were classified according to the recommended levels of PA and RFS. Multiple logistic regression analysis was applied to determine the associations of RFS and PA with the prevalence of MetS after adjustment for potential confounders. About 21% of men and 19% of women were reported to have MetS. Nearly 5% of both sexes reached the recommended level of diet quality and PA. In men, a significantly reduced odds ratio (OR) for MetS (OR, 0.16; 95% confidence interval [CI], 0.09-0.93) and hypertriglyceridemia (OR, 0.25; 95% CI, 0.04-0.99) was found in those with better diet quality, within the strata of high PA. In women, compared with inactive individuals with poor diet quality, the OR for abdominal obesity in those with a better diet quality and who were active was 0.21 (95% CI, 0.05-0.86). Both diet quality and PA are associated with a lower risk for hypertriglyceridemia in men and abdominal obesity in women. These findings suggest that a sex-specific pattern of association between MetS and lifestyle factors (diet and PA) should be considered in clinical practice.

Association between Exercise and Metabolic Syndrome in Koreans.

BackgroundThe favorable role of exercise on metabolic syndrome is well established; however, there is a lack of consistent epidemiological data. Thus, we analyzed the association between exercise intensity and metabolic syndrome using data from the Fourth Korea National Health and Nutrition Examination Survey (2007–2009).MethodsA total of 10,533 Korean individuals were screened. Exercise amount and intensity were assessed from questionnaire responses. Subjects were divided into three groups according to exercise intensity: no activity (n=607), walking only without intense exercise (n=2,336), and moderate to vigorous activity with or without walking (n=3,855). Logistic regression analyses were used to evaluate the associations between exercise intensity and metabolic syndrome.ResultsThe overall prevalence of metabolic syndrome was 22.3% (total n=6,798). The prevalence of metabolic syndrome was 20.4% for the intense exercise group, 24.0% for the walking only group, and 29.9% for the no activity group (P<0.001). The intense exercise group had a significantly lower odds ratio for the prevalence of metabolic syndrome and its components, especially abdominal obesity and hypertriglyceridemia, but not for blood pressure. Interestingly, there were no negative associations identified within the walking only group, other than prevalence of metabolic syndrome itself. The risk of hyperglycemia was slightly lower in the walking group compared to the no activity group but disappeared after multiple adjustments.ConclusionA strong inverse relationship between metabolic syndrome and moderate to vigorous intensity exercise was identified, which may reflect a protective effect of intense exercise, but not walking, on metabolic syndrome. Further prospective studies are needed to consolidate our findings.

Exercise and cancer mortality in Korean men and women: a prospective cohort study

BackgroundLittle is known about longitudinal associations of exercise with different types of cancer, particularly in Asian populations. The purpose of this research was to estimate the association between the duration of exercise and all-cause and cancer-specific mortality.MethodData were obtained from the Korean Metabolic Syndrome Mortality Study (KMSMS), a prospective cohort study of 303,428 Korean adults aged 20 years or older at baseline between 1994 and 2004 after exclusion of individuals with missing variables on smoking and exercise. Death certificate-linked data until 31 December 2015 were provided by the Korean National Statistical Office. Cox regression models were constructed to evaluate the associations of exercise with cancer mortality after adjusting for potential confounders such as age, alcohol consumption and smoking status.ResultsDuring the follow-up period of 15.3 years (4,638,863 person-years), a total of 16,884 participants died. Both men and women who exercised showed approximately 30% decreased hazards of mortality, compared to those who did no exercise (hazard ratio (HR) 0.70, 95% confidence interval (CI)=0.68-0.73 for men, HR=0.71, CI : 0.67-0.75). A notable observation of this study is the curvilinear associations between the total duration of exercise per week and cancer mortality, with the lowest risk being observed at the low-to-medium levels of exercise; this trend of associations was found for esophagus, liver, lung, and colorectal cancer mortality in men, and all-cause, all-cancer and lung cancer mortality in women.ConclusionsIndividuals who exercised showed considerably lower all-cause and cancer mortality risks compared with those who did no exercise. Policies and clinical trials aimed at promoting minimal or moderate participation in exercise may minimize cancer mortality risk.

Role of allostatic load and health behaviours in explaining socioeconomic disparities in mortality: a structural equation modelling approach

BackgroundThe relationship between socioeconomic status and mortality has been well established; however, the extent to which biological factors mediate this relationship is less clear, and empirical evidence from non-Western settings...