A library of new thiazole linked tetrahydropyridines (6a‐q) synthesized and screened for their invitro anticancer activity against human breast adeno carcinoma cell viz. MCF‐7 and MDA‐MB‐231. The two compounds 6d containing ‐F and ‐Cl functions in para and meta position of phenyl ring (9.94 ± 1.02µM, 9.78 ± 1.08µM) and 6e with ‐Cl and ‐NH2 functions on pyridine ring (9.72 ± 0.91 µM,9.54 ± 0.95µM) demonstrated outstanding activity against both the cell lines when compared to Doxorubicin. The benzofuran analogue 6o presented good activity with an IC50 value of 12.19 ± 1.03µM (MCF‐7) and 12.22 ± 1.07µM (MDA‐MB‐231). The molecular docking study of potent molecule 6e against crystal structure of breast tumor kinase presented promising docking score and binding interactions. Predicted pharmacokinetics properties of compounds 6a‐q and presented boiled diagram of compounds 6d and 6e implied favourable drug‐likeness properties.