ABSTRACT As a direct product of lithospheric extension, the mafic dyke group have become an ideal object for studying the formation, evolution and dynamics of both the crust and continental orogenic belts. Given the scientific significance of mafic dykes and their utility in addressing outstanding questions concerning the origin and development mafic dyke swarms Mesozoic age with-in the South China Plate, in this study, 54 representative mafic dykes within the Guangxi Zhuang Autonomous Region, South China, were examined. Research methods include laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) U-Pb age-dating, whole rock geochemistry, and the Sr-Nd-Pb isotope geochemistry of the studied mafic dykes. The results indicate that these rocks formed between 139 Ma and 113 Ma and have typical doleritic and lamellar textures. They fall into the alkaline and shoshonitic series, are characterized by enrichment of light rare earth elements, some large ion lithophile elements (Rb, Ba, and Sr), Th, U, and Pb, and have depleted Nb, Ta, Hf, and Ti. Moreover, the mafic dykes studied have high initial87Sr/86Sr ratios (0.7055–0.7057), negative εNd(t) values (from −15.2 to −11.4), and relatively constant initial Pb isotopic ratios (that are Enriched Mantle-1 (EM I)-like; 206Pb/204Pb = 16.765–16.816, 207Pb/204Pb = 15.429–15.476, and208Pb/204Pb = 36.882–37.144). The above results indicate that the group of dolerites and lamprophyres studied herein were likely derived from magma generated via low-degree partial melting (1.0%–10%) of an EM1-like garnet-lherzolite mantle source. The parental magmas to these fractionated olivine-, clinopyroxene-, plagioclase, and Ti-bearing phases, with negligible crustal contamination during ascent and dyke emplacement. On the basis of existing research and evidence from this study, we propose a reasonable model for the origin of the mafic dykes: the ancient Pacific Plate subducting below the South China plate led to extension of the lithosphere, an upsurge of the asthenosphere, which triggered partial melting of the lower mantle lithosphere in the Early Cretaceous, and the formation of the parent magma to the Mesozoic mafic dykes in the Guangxi Zhuang Autonomous Region study area. The involvement of slab-derived fluids from the subduction of the ancient Pacific Plate was responsible for metasomatism of the mantle source to these mafic magmas.