Discontinuum analysis is a powerful tool for the detailed seismic assessment of unreinforced masonry (URM) structures, whose widespread use is however still mostly limited to small-scale assemblies or isolated components. Despite their unique capabilities, including the explicit simulation of separation phenomena, collapses and out-of-plane (OOP) failures that are hardly replicable using traditional continuum solutions, the high computational cost entailed by micro-to-meso-scale discontinuum modelling strategies, which are the standard approaches in applied research, presently prevent their employment for building-scale problems. The few available macro-scale discontinuum models specifically conceived for URM, on the other hand, rely on complex geometrical discretization processes that require costly manual work, as well as on less efficient deformable block formulations. In this paper, a new simplified discontinuum macro-model is presented and validated against full-scale laboratory test outcomes on walls, pier-spandrel systems and building specimens, in addition to various meso-scale numerical results, under either in-plane (IP) or OOP actions, and considering quasi-static (monotonic, cyclic) or dynamic loadings. The proposed simulation technique, implemented in a robust Distinct Element Method (DEM) framework, leverages a semi-automated Equivalent Frame discretization algorithm that idealizes masonry piers, spandrels and nodes as an assembly of interlocked rigid macro-blocks connected by a network of zero-thickness interface springs. The latter are herein demonstrated to effectively replicate URM damage at the component-level through fracture energy contact laws, providing macro-scale yet representative failure patterns, as well as adequate predictions of overall strength and deformation capacities. Results obtained show a good agreement between macro- and more sophisticated meso-scale predictions, as well as with experimental outcomes, albeit dissimilarities among measured and computed force-displacement responses – similarly to other simplified strategies – were detected as vertical overburden increases. Notably, for analogous levels of accuracy, the analysis time required by our new macro-models is up to 150 times lower than its meso-counterparts. The use of the proposed simplified strategy also enabled the satisfactory simulation of the quasi-static cyclic and seismic responses of full-scale building-scale specimens, prohibitive tasks using traditional detailed DEM models, while also being up to 10 times faster than previous deformable macro-models.