Mesoporous Silica Nanospheres Research Articles

Porous polyimide composite films containing mesoporous hollow silica nanospheres with ultralow dielectric constant and dissipation loss

Porous polyimide hybrid films with ultralow dielectric constant and dissipation loss were synthesized during chemical imidization and rapid evaporation of polymer solutions. Polyimide (PI) of bis(4-aminophenyl)-1,4-diisopropylbenzene (BISP) and 4,4′-(hexafluoroisopropylidene) diphthalic anhydride (6FDA) were synthesized in N-methylpyrrolidinone (NMP) to yield the corresponding poly(amic acid)s (PAA)s, which were then chemically imidized. To reduce the dielectric properties of the porous PI films, amine-functionalized, surface-modified hollow silica nanoparticles (AHNS) with various sizes from 100 nm to 1 μm, prepared via sol-gel process, were added with PAA at 3, 5, or 10 % weight content, followed by chemical imidization to produce the porous PI/AHNS films. To avoid the high-volume shrinkage of wet gels and maintain the high porosity of the PI with low polarizability, AHNS nanoparticles were added to the porous structure of the PI xerogels as a physical crosslinker. The polyimide hybrid film with 10 nm AHNS nanoparticles at 10 % weight content showed a dielectric constant of 1.151 and a dissipation rate of 0.001 at a frequency of 10 GHz.

Construction of dendritic mesoporous SiO2 supported Cu catalyst for hydrodeoxidation of lignin derivatives

Chemoselective hydrodeoxygenation (HDO) of lignin derivatives is of great importance in converting biomass into high value-added chemicals. Herein, we report a simple hydrothermal pathway to fabricate a highly active, chemically selective, and reusable catalyst (Cu/DMSN) by loading copper clusters on “dendritic” mesoporous silica nanospheres. Cu/DMSN exhibits exceptional catalytic activity (conversion > 99 %, selectivity > 99 %) in the HDO of vanillin toward 2-methoxy-4-methylphenol under mild conditions (140 °C, 0.5 MPa, 3 h), along with good scalability and a wide range of substrates. The excellent catalytic performance can be owed to the combination of suitable acid site and more exposed metal site. This study provides a new strategy for designing supported metal catalysts for hydrodeoxidation of biomass and its derivatives.

Efficient hydrogen production from formic acid dehydrogenation over ultrasmall PdIr nanoparticles on amine-functionalized yolk-shell mesoporous silica

Developing heterogeneous catalysts with exceptional catalytic activity over formic acid (HCOOH, FA) dehydrogenation is imperative to employ FA as an effective hydrogen (H2) carrier. In this work, ultrasmall (1.4 nm) and well-dispersed PdIr nanoparticles (NPs) immobilized on amine-functionalized yolk-shell mesoporous silica nanospheres (YSMSNs) with radially oriented mesoporous channels have been synthesized by a co-reduction strategy. The optimized catalyst Pd4Ir1/YSMSNs-NH2 (Pd/Ir molar ratio = 4:1) exhibited a remarkable turnover frequency (TOF) of 5818 h−1 and remarkable stability at 50 °C with the addition of sodium formate (SF), resulting in complete FA conversion and H2 selectivity, exceeding most of the solid heterogeneous catalysts in previous reports under similar circumstances. Kinetic isotope effect (KIE) exploration indicates the cleavage of the CH bond is regarded as the rate-determining step (RDS) during the FA dehydrogenation process. Such excellent catalytic properties arise from the ultrafine and well-dispersed PdIr NPs supported on the nanosphere support YSMSNs-NH2, the electronic synergistic effect of PdIr alloy NPs, and the strong metal-support interaction (MSI) effect between the introduced PdIr NPs and YSMSNs-NH2 support. This work offers a new paradigm for exploiting the highly effective silica-supported Pd-based heterogeneous catalysts over the dehydrogenation of FA.

Microgel Encapsulated Mesoporous Silica Nanoparticles for Releasing Wnt16 to Synergistically Treat Temporomandibular Joint Osteoarthritis.

Temporomandibular joint osteoarthritis (TMJOA) is a commonly encountered degenerative joint disease in oral and maxillofacial surgery. Recent studies have shown that the excessive unbalanced activation of Wnt/β-catenin signaling is connected with the pathogenesis of TMJOA and due to the inability to inhibit the over-activated Wnt pathway, while Wnt16-deficient mice has a more severe Knee OA. However, the efficacy of direct intra-TMJ injection of Wnt16 for the relief of TMJOA is still not directly confirmed. Moreover, small-molecule drugs such as Wnt16 usually exhibit short-lived efficacy and poor treatment adherence. Therefore, in order to obtain a stable release of Wnt16 both in the short and long term, this study fabricates a double-layer slow-release Wnt16 carrier based on mesoporous silica nanospheres (MSNs) encased within hyaluronic acid (HA) hydrogels. The biofunctional hydrogel HA/Wnt16@MSN is analyzed both in vitro and in vivo to evaluate the treatment of TMJOA. As a result, it shows superior pro-cartilage matrix restoration and inhibition of osteoclastogenesis ability, and effectively inhibits the over-activation of the Wnt/β-catenin pathway. Taken together, biofunctional hydrogel HA/Wnt16@MSN is a promising candidate for the treatment of TMJOA.

Anions‐Trappable Hollow Mesoporous Nanoparticle Coating Enables High‐Performance and Safe Lithium Metal Batteries

AbstractPolyolefin separators, such as polypropylene (PP) and polyethylene (PE) separators, are the commonly used separators for lithium batteries, which have good mechanical properties and chemical/electrochemical stability, but their high‐temperature dimensional stability is poor and Li+ transference number (t Li+) is low. Recently, much attention has been paid to developing separators with new substrates, but so far there is no separator to replace the polyolefin separator for large‐scale application. Therefore, the surface modification of the polyolefin separator to enhance its functionality is a simple and effective method. Among many modified layers, the porous modified layer can store the electrolyte and provide enough space for ion transport. In this work, a hollow mesoporous silica nanosphere (mSiO2) is prepared for the PP separator multifunctional coating to improve the electrochemical performance and high‐temperature safety of the PP separator. The experimental and theoretical results show that the mSiO2 coating can not only improve the electrolyte wettability and high‐temperature dimensional stability of the PP separator, but also promote the Li+ transport, so that the mSiO2/PP separator exhibits high ionic conductivity (2.35 mS cm−1) and high t Li+ (0.63). As a result, Li//LiFePO4 cells using mSiO2/PP separators exhibit excellent cycling performance, rate performance, and high‐temperature safety.

Enhancing lithium-storage properties through amino functionalization in two-dimensional lamellar carbon-supported mesoporous SiO2 nanospheres

Currently, common two-dimensional (2D) carbon materials composited with Si-based materials as anode for lithium-ion batteries exhibit excellent electrochemical properties. In this study, we describe the one-step synthesis of amino-functionalized mesoporous silica (SiO2) nanospheres through self-assembly. Morphology modulation and amino group grafting were performed simultaneously without secondary modification. Using tartaric acid and melamine as dual carbon sources, the 2D lamellar structure was constructed using the dehydration condensation reaction, with the mesoporous SiO2 nanospheres uniformly intercalated within the carbon sheets. The composites were securely bonded by chemical bonding, effectively addressing the issue of structural collapse often encountered in silica–carbon composites. Ultimately, the lamellar SiO2@NC composite exhibited stable capacity of 539.5 mAh g−1 after 500 cycles at 1 A g−1. This strategy is simple and effective, compared to the complex processes typically associated with 2D carbon materials synthesis, and can be potentially extended to applications in catalysis, adsorption, and separation within diverse fields.

DOPO chemically modified mesoporous silica composites: Preparation, flame retardancy, and thermodynamic properties

AbstractOrganic flame retardant 9,10‐dihydro‐9‐oxa‐10‐phosphaphenanthrene‐10‐oxide (DOPO) was used to decorate the pores of mesoporous silica (m‐SiO2) nanospheres to prepare a new composite flame retardant (DK‐SiO2). The content of DOPO in DK‐SiO2 is about 17 wt%. Due to the chemical bonding, DK‐SiO2 not only enhances the flame retardant performance, but also effectively avoids adverse effects of DOPO on the glass transition temperature and mechanical properties of epoxy resin (EP). At 9 wt% loading, the limiting oxygen index of the EP increased from 25.7 to 31.2, and successfully passed the UL‐94 V‐0 rating. Besides, DK‐SiO2 can significantly reduce the peak heat release rate, total heat release, and total smoke production of EP, with reductions of 26%, 32%, and 20.8%, respectively. Compared with the simple blended sample, DK‐SiO2 not only has better flame retardant performance but also shows significant advantages in thermodynamic properties. The glass transition temperature, impact, and tensile strength, as well as storage and flexural modulus have been improved. This excellent flame retardant performance is mainly attributed to the gas‐condensed synergistic flame retardant mechanism between DOPO and m‐SiO2. The good thermodynamic performance is due to the excellent dispersion of DK‐SiO2 nanospheres in the EP.

Electrochemiluminescence Lateral Flow Immunoassay Using Ruthenium(II) Complex‐Loaded Dendritic Mesoporous Silica Nanospheres for Highly Sensitive and Quantitative Detection of SARS‐CoV‐2 Nucleocapsid Protein

AbstractLateral flow immunoassays (LFIA) are widely used for the cost‐effective and rapid detection of diverse analytes. However, traditional LFIA suffers from difficulties in providing quantitative results and has low sensitivity. Herein, LFIA is combined with electrochemiluminescence (ECL), a leading transduction technique with high sensitivity and wide dynamic range, to achieve highly sensitive and quantitative detection of severe acute respiratory syndrome coronavirus nucleocapsid protein (SARS‐CoV‐2 N protein). Ruthenium(II)‐based complexes are synthesized and loaded into dendritic mesoporous silica nanospheres (PEI‐Ru/dSiO2), which possessed central‐radial pore channels and served as tags for ECL‐LFIA. The electrodes are fabricated on a nitrocellulose (NC) membrane, which simplifies the structure of the ECL‐LFIA. PEI‐Ru/dSiO2 is captured on the electrode surface via a sandwich immunoreaction, which enhances the ECL signal by decreasing the distance between PEI‐Ru/dSiO2 and the electrode surface. Using 2,2‐bis(hydroxymethyl)‐2,2′,2′'‐nitrilotriethanol (BIS‐TRIS) as coreactant, the ECL‐LFIA is used for detecting SARS‐CoV‐2 N protein, with a linear range of 1–104 ng mL−1 and a limit of detection (LOD) of 0.52 ng mL−1. ECL‐LFIA can also be used to detect analytes in complex matrices. These results demonstrate that the prepared ECL‐LFIA has great potential as a point‐of‐care testing platform for the rapid and quantitative detection of disease biomarkers.

Facile fabrication of fluorescent composite sensor based on carbon dots/ mesoporous silica nanospheres for sensitive detection of Hg(II) in cells

Mercury ion (Hg(II)) is one of the most toxic heavy metals in the environment and has seriously damaged human health. Based on this, we designed a novel fluorescence-enhanced carbon dots/mesoporous silica fluorescent composite (CDs/MSNs) fluorescent composite sensor for rapid and sensitive detection of Hg(II) in environmental and biological systems. Carbon dots (CDs) are one of the most promising carbon-based nanomaterials of the new generation, and we chose them as template molecules, and CDs were embedded in mesoporous silica nanospheres (MSNs) by hydrothermal method to form CDs/MSNs fluorescent composite with aggregation-induced emission enhancement (AIEE). Notably, the CDs/MSNs fluorescent composite has a yellow luminescence with a photoluminescence intensity several times higher than the original one, and have high stability, excellent selectivity, and good biocompatibility, which can realize the selective and sensitive detection of Hg(II) in the environment, with a limit of detection as low as 0.89 μM. The material can also be used as an effective luminescent biological probe for the detection of Hg(II) in cells. and these properties provide long-term practical applications of CDs/MSNs fluorescent composite in the fields of biological detection.

Ternary electrochemiluminescence biosensor based on Ce2Sn2O7@MSN luminophore and Au@NiO-CeO2 as a co-reaction accelerator for the detection of prostate specific antigen

A ternary ECL system was constructed with Ce2Sn2O7@MSN composite as luminophore, potassium persulfate as co-reactant and Au@NiO-CeO2 as co-reaction accelerator to realize ultra-sensitive biosensing detection of prostate specific antigen (PSA). The abundant oxygen vacancies in Ce2Sn2O7 endow it with powerful electrochemical redox ability, accelerate energy transfer, and ensure Ce2Sn2O7 excellent electrochemical luminescence performance as a luminophore. Furthermore, to optimize the luminescence energy, enhance stability, and reduce the background signal to improve its signal-to-noise ratio, a highly selective Ce2Sn2O7@MSN biological probe was obtained by coating cerium stannate (Ce2Sn2O7) with mesoporous silica nanospheres (MSN). Au@NiO-CeO2 with a large specific surface area and high oxygen vacancy activity was synthesized as the co-reaction accelerator, which promoted the generation of SO4•− through the rapid reversible oxidation and reduction of Ce4+/Ce3+, thereby the ECL signal amplified effectively. Under optimal conditions, the linear detection range of PSA spans from 100fg mL−1 to 100 ng mL−1, with a remarkable lowest detection limit of 0.037pg mL−1, showcasing significant application potential. This study provides a valuable reference for pyrochlore to be used as luminophore in the detection of various biomarkers by ECL biosensing.

Preparation of salicylic acid nano-protectant with dual synergistic mechanism: High direct fungicidal activity and plant defence toward cotton Verticillium wilt

Nanomaterials exhibit a wide range of potential applications in agricultural field. Here we construct a series of nano-protectants based on one model plant elicitor salicylic acid (SA) and six types of nanomaterials, including mesoporous silica nanosphere (MSN), mesoporous Fe3O4 nanosphere (Fe3O4), carbon quantum dot (CQD), polylactic acid-glycolic acid copolymer (PLGA), star polycation (SPc) and hydrophilic and lipophilic diblock polymer (HLDP), and explore the best nanomaterial for plant disease control. Our results demonstrate that the HLDP-SA nano-protectant displays the best control effects on cotton Verticillium wilt caused by one of the most notorious soil-borne fungi (Verticillium dahliae). The HLDP self-assembles with SA via electrostatic interaction into HLDP-SA nano-protectant, which changes the morphology of SA from needle-like particles to spherical particles. The loading efficiency of HLDP toward SA is calculated to be 49.28%, and the plant uptake of HLDP-loaded SA significantly increases by 3–4 times. HLDP-SA nano-protectant can suppress the spore germination of V991 strain with the spore germination rate of merely 2%, and its colony diameter is significantly decreased by 64.9%. Our transcriptome data demonstrate that the HLDP-SA nano-protectant accelerates the delivery and translocation of exogenous substances into V. dahliae, which exhibits the highest direct fungicidal activity via inhibiting the metabolism and weakening the pathogenicity. Meanwhile, its enhanced plant uptake with better adhesion performance on leaves amplifies the plant defense induced by SA via accelerating the biosynthesis of plant secondary metabolites, such as SA, abscisic acid (ABA) and gossypol. This study provides a powerful nanomaterial with dual synergistic mechanism for designing nano-protectant with high fungicidal activity and amplified plant defense.

Pd/N-doped carbon dots@dendritic mesoporous silica nanospheres: A highly efficient catalyst for the hydrogenation of 4-nitrophenol

Pd/N-doped carbon dots@dendritic mesoporous silica nanospheres: A highly efficient catalyst for the hydrogenation of 4-nitrophenol

Sub-femtomolar vertical graphene field effect immunosensor for detection of lung tumor markers

Lung cancer is the main cancer that endangers human life worldwide, with the highest mortality rate. The detection of lung tumor markers is of great significance for the early diagnosis and subsequent treatment of lung cancer. In this study, a vertical graphene field effect transistor (VGFET) immunosensor based on graphene/C60 heterojunction was created to offer quantitative detections for the lung tumor markers carcinoembryonic antigen (CEA), cytokeratin 19 fragment (Cyfra21-1), and neuron-specific enolase (NSE). The experimental results showed that the sensitive range for standard antigen is between 1 pg/ml to 100 ng/ml, with a limit of detection (LOD) of 5.6 amol/ml for CEA, 33.3 amol/ml for Cyfra 21–1 and 12.8 amol/ml for NSE (1 pg/ml for all). The detection accuracy for these tumor markers was compared with the clinically used method for clinical patients on serum samples. Results are highly consistent with clinically used immunoassay in its efficient diagnosis concentration range. Subsequently, the mesoporous silica nanospheres (MSNs) with an average size of 90 nm were surface modified with glutaraldehyde, and a second antibody was assembled on MSNs, which fixes nanospheres on the antigen and amplified the field effect. The LODs for three markers are 100 fg/ml (0.56 amol/ml for CEA) under optimal circumstances of detection. This result indicates that specific binding to MSNs enhances local field effects and can achieve higher sensing efficiency for tumor marker detection at extremely low concentrations, providing effective assistance for the early diagnosis of lung cancer.

A Comprehensive Review of Advances in Nanoparticle-Based Cancer Therapy

A promising method for treating different kinds of cancer is cancer therapy based on nanoparticles. The goal of this thorough analysis is to present a summary of the most current developments in cancer treatment using nanoparticles and discuss the different kinds of nanoparticles and how they might be used to enhance therapeutic efficacy and deliver anticancer medications. These include mesoporous dendritic silica nanospheres, gold nanoparticles, and chitosan nanoparticles. The review stresses the significance of stability and dynamic interfaces in attaining effective drug administration and addresses the difficulties related to medication release and degradation in nanoparticle-based therapy. Moreover, it investigates the immune reactions, such as dendritic cell maturation and immune response activation, that are brought on by nanoparticle-based therapy. Overall, this thorough analysis highlights the promise of these cutting-edge strategies for enhancing the effectiveness of cancer treatment and offers insightful information about the developments in nanoparticle-based cancer therapy. The information provided in this study contributes to the growing corpus of information in the field of nanomedicine and suggests future avenues for investigation and development of treatments utilizing nanoparticles to treat cancer

Exploring nitrogen doped mesoporous carbon spheres for superior microwave absorption

Mesoporous carbon materials hold significant promise for usage in microwave absorption due to their wide and unique advantages stemming from their mesoporous structure. This study synthesizes N-doped mesoporous carbon spheres (NMCs) by carbonizing mesoporous silica nanospheres (MSN). By controlling the annealing temperature, the resulting NMCs exhibit a significant increase in pore size. The exceptional microwave absorption capability of multifunctional carbon with a mesoporous structure result from its appropriate composition. The minimum reflection loss (RL) can reach −58.04 dB with a thickness of 3.3 mm, and the corresponding effective absorption bandwidth (EAB) reaches up to 8.19 GHz, outperforming the many previously documented microwave absorbing materials. The material's practical application potential was evaluated using computer simulation technology (CST), resulting in a simulated RCS value of 32.88 dBm2.The microwave absorption process of this material has been extensively studied and thoroughly described. Our study offers valuable guidance for developing and producing efficient microwave absorbers doped with nitrogen and possessing a unique mesoporous structure.

One‐Step Synthesis of Thiol‐Functional Mesoporous Silica Nanospheres and Selective Removal of Cationic Dyes

AbstractThe surface characteristics of nanoparticles have a huge impact on adsorption effects. In this paper, thiol‐functional mesoporous silica nanospheres (MSNs−SH) are successfully prepared through simple one‐step hydrolysis and co‐condensation of tetraethyl orthosilicate and (3‐mercaptopropyl) triethoxysilane with hexadecyltrimethylammonium bromide and sulfobetaine 12 as dual‐template. The obtained MSNs−SH have high surface area (1260 m2 g−1), accessible mesopores (2.2 nm), great pore volume (1.7 cm3 g−1), and uniform adjustable diameter (90 nm). Furthermore, the diameter and pore‐size of MSNs−SH can be controlled via adjusting the ethanol content in the synthesis system. MSNs−SH exhibit a fast adsorption kinetics, marked adsorption capacity of cationic rhodamine B (RB 534.2 mg g−1), and remarkable selective adsorption for cationic dyes. Theoretical analysis reveals the adsorption behavior of RB on MSNs−SH follows the Langmuir isotherm models and pseudo‐second‐order kinetic. Additionally, the thermodynamic results indicate that the adsorption process is a spontaneous process driven by temperature. The results demonstrate that MSNs−SH are greatly potential for effectively removing cationic dyes from wastewater, with the advantages of simple preparation, high adsorption performance and perfect selectivity.

Chemoenzymatic cascade conversion of methyl parathion to 4-aminophenol with immobilized organophosphate hydrolase onto Cu-MOF-loaded mesoporous silica

Organophosphates (OPs), essential pesticide ingredients, are highly toxic and environmentally problematic. OPs can be efficiently hydrolyzed by the enzyme organophosphorus hydrolase (OPH). However, the resulting p-nitrophenol (4-NP) is still toxic, and its chemical reduction to p-aminophenol (4-AP) can be environmentally friendly and increase economic value. We constructed a chemical-enzymatic cascade catalyst system for methyl parathion (MP) using OPH and a copper-based metal-organic framework (HKUST-1) with 4-NP reduction catalytic activity. The nano-HKUST-1 was first loaded into aminated mesoporous silica nanospheres (MSN-NH2) to construct HKUST-1@MSN-NH2, and then OPH was immobilized into the HKUST-1@MSN-NH2 pores by a covalent method to obtain OPH@HKUST-1@MSN-NH2. The resulting composite catalyst, OPH@HKUST-1@MSN-NH2, achieved chemoenzymatic cascade catalysis of MP hydrolysis to 4-NP and subsequent reduction to 4-AP. The composite nano-biocatalyst has good catalytic performance and reusability, which can rapidly convert entirely 50 μM MP to 4-AP in 8 min at a dosage of 30 mM NaBH4. Still, it has 77% activity after 10 cycles and a stable material structure. The present study provides a strategy for constructing a chemoenzymatic cascade catalytic system, and the obtained composite nano catalysts achieve the continuous degradation and resourceful conversion of organophosphorus pollutants, which has specific practical application value.

Sol-gel synthesis, physicochemical characteristics and in vitro pH-responsive metformin drug release of uniformly polydopamine coated mesoporous silica nanospheres

A recent attention has been paid to the repurposing potential of metformin drug for cancer chemotherapy. Herein, pH-responsive metformin drug delivery nanocarriers were achieved using sol-gel synthesized mesoporous silica nanospheres (MSN) uniformly coated with polydopamine (PDA) shell. The PDA coating shell around the MSN surface was in situ formed through oxidative self-polymerization of dopamine monomers in an alkaline solution at room temperature. The microstructure, structural and textural characteristics of PDA@MSN were examined and compared to uncoated MSN. Furthermore, PDA coated metformin (MET) drug-loaded MSN were used to study the pH-responsive MET drug release behaviour under neutral and acidic conditions. The in vitro release test showed that the PDA coating shell not only protects MET drug leakage under normal physiological conditions (pH 7.4) but also allows for its controlled/sustained release in acidic conditions (pH 4.5 and pH 5.5) which closely mimic the intracellular acidity (pH 4.5–5.5) of endosomes/lysosomes formed around drug-loaded nanocarriers after their endocytosis by cancer cells.

Mesoporous collapsing encapsulated carbon dots: Direct evidence for the effect of multiple-confined interactions of silica on efficient long-lived phosphorescence

Coupling with a matrix is the common strategy to improve the phosphorescence performance of carbon dots (CDs). However, there is a lack of clear and direct evidence about the formation mechanism of the inner relationship between CDs and matrix, and the specific effect of matrix on the phosphorescence performance. Mesoporous silica nanospheres (MSNs) were used as the research model to provide the direct evidence of the dense structure formation process and to construct a quantum chemical theoretical computational model of the effect of dense matrix on phosphorescence performance. Due to the multiple domain-limiting effects of rigid Si-C covalent bonds and SiO2 dense structure, the calcined-carbonized polymer dots-mesoporous silica nanospheres (C-CPDs-MSNs) can exhibit thermally activated delayed fluorescence (TADF) by tuning the HOMO-LUMO gap and enriching the electrons in the surface region. With a long lifetime of 3.07 s, the composite can also maintain stable phosphorescence performance under harsh conditions and has been successfully applied in multilevel information encryption, fingerprint identification, and cellular imaging. This work provides the direct evidence for the process of dense SiO2 structure enhancing the phosphorescence performance of CDs and offers a general strategy and method for the design and preparation of efficient and practical CDs-based phosphorescent materials.

Imidazolium based Ionic liquid Anchored over Dendritic Mesoporous Silica Nanospheres possessing a Magnetic Core as an Efficient and Recyclable Base Catalyst

AbstractIn this study, Magnetic core‐shell dendritic mesoporous silica nanospheres immobilized with imidazolium‐based di‐cationic ionic liquid (Fe3O4@SiO2@DSiO2‐Im‐IL) possessing a large surface area and numerous active site for adsorption of various molecules to carry out organic transformations have been successfully developed. The synthesized nanocatalyst was found to be easily recyclable by applying external magnetic force. The structure, morphology, thermal stability, and magnetic behavior of the synthesized magnetic nanocatalyst were confirmed by different physiochemical techniques like FT‐IR, P‐XRD, FE‐SEM, TGA, VSM, BET, and TEM analysis. The efficiency of the developed heterogeneous nanocatalyst has been investigated for the green synthesis of numerous benzopyran derivatives by employing different aldehydes and active methylene compounds. The catalyst exhibits marvellous activity and efficiency in terms of high product yield, less catalyst use, and wide substrate scope even at room temperature. Finally, after the successful formation of the product, the catalyst was regenerated by utilizing an external magnetic field. The catalyst has been reused multiple times without any noteworthy loss in its activity which confirms the stability of the developed catalyst. The preparation of the catalyst is cost‐effective, and shows atom economy with the utilization of green solvent and without any waste production, which authenticates that it could be a greener pathway for the synthesis of the benzopyran derivatives.