Mesoporous Metal Research Articles

Spatiotemporal Encapsulation of Tandem Enzymes in Hierarchical Metal-Organic Frameworks for Cofactor-Dependent Photoenzymatic CO2 Conversion.

The photo-enzyme coupling system (PECS) holds immense potential in "green" biomanufacturing, encompassing the realms of pharmaceuticals, fuels, and carbon sequestration. Nevertheless, the intricate nature of enzymes' structures significantly impedes the seamless integration of multiple enzymes in a precise, tandem fashion, with exact control over their distribution, posing a formidable challenge. Herein, it has devised a mesoporous csq-type metal organic framework (Zr-MOF) from meso-tetrakis-(4-((phenyl)ethynyl)benzoate)porphyrin (Por-PTP) and Zr6(μ3-O)4(μ3-OH)4(OH)4(H2O)4) nodes (Zr6clusters), featuring intricate hierarchical hexagonal (5.8nm) and triangular (2.9nm) channels, enabling the simultaneous encapsulation of Formate dehydrogenase from Candida boidinii (CbFDH)and ferredoxin-NADP+ reductase (FNR) via a spatiotemporally controlled strategy for cofactor-dependent photoenzymatic carbon dioxide (CO2) conversion. Upon illumination, photoexcited electrons originating from the Zr-MOF frameworks migrate to the adjacent FNR for cofactor NADH regeneration, which is then harnessed by proximal CbFDH for CO2 fixation. Concurrently, the resulting holes are neutralized by AA for system recovery. The results demonstrated the confinement of tandem enzymes within MOF channels significantly enhanced the performance of multi-enzyme cascade pathways as well as augmenting the local NAD+/NADH, which leading to a further improvement in the efficiency of tandem biocatalytic formic acid generation (55mm) from CO2. Crucially, the photo-enzyme-coupled factories exhibited remarkable stability alongside exceptional recyclability, attributed to the preservation of MOF skeletons.

Solid-state synthesis of mesoporous metals via mechanochemical coordination self-assembly

Solid-state synthesis of mesoporous metals via mechanochemical coordination self-assembly

Depolymerization of Lignosulfonate Catalyzed by Different Solid Base Oxides to Prepare Phenolic Compounds

Lignin is the most abundant aromatic renewable polymer in nature. However, its very stable structure limits its widespread application. To achieve high-value utilization of lignin, this study used solid base oxides to depolymerize calcium lignosulfonate (CLS) for the synthesis of phenolic compounds. The catalyst precursors were prepared by hydrothermal synthesis, and the corresponding mesoporous metal oxides NiO, MgCoOx, and NiMgCoOx were obtained after calcination. MgCoOx and NiMgCoOx had similar but stronger basicity compared to NiO. While all oxides promoted the depolymerization of CLS, NiMgCoOx was identified as the best catalyst, achieving a maximum liquid product yield of 74.3 wt.% and a selectivity of phenolic compounds of 74.52% in the liquid product. In addition, NiMgCoOx showed satisfactory structural and catalytic stability. The experimental results indicated that solid base oxides can capture the active hydrogen in CLS, causing the hydrolysis reaction of ether bonds, and the resulting products continuously depolymerize or polymerize; Co present in the catalyst promotes the adsorption of hydrogen by Ni, while NiO in NiMgCoOx facilitates the adsorption of both reactants and hydrogen. The combination of Ni and Co improves hydrogenation performance.

Molten Salt Assisted Assembly (MASA) of novel mesoporous Ni0.5Mn0.5Co2O4 for high-performance asymmetric supercapacitors

Mesoporous transition metal oxides (TMO) are immensely investigated as electrode materials in supercapacitors. The molten salt assisted self-assembly (MASA) process enables a facile route for the synthesis of the mesoporous TMO. In this study, mesoporous nickel manganese cobaltite (Ni0.5Mn0.5Co2O4) is synthesized for the first time using a MASA process and is evaluated as a novel electrode-active material for asymmetric supercapacitors. The objective of this work is to quantitatively measure the performance improvement in the Ni0.5Mn0.5Co2O4 electrode based on its composition and reveal the improvement mechanism through electrochemical methods. The electrochemical performance of the NiCo2O4 and MnCo2O4 prepared by MASA is also investigated, in order to understand the synergistic effect of Ni and Mn elements in the same cobaltite structure. In line with the data obtained from half cells, a full asymmetric cell is prepared by assembling the appropriate amount of Ni0.5Mn0.5Co2O4 and activated carbon through the charge balance theory. The test results show that the specific capacitance (Cs) values are 2.62F/cm2 (92.1F/g) for mesoporous NiCo2O4, 0.26F/cm2 (9.8F/g) for mesoporous MnCo2O4, and 9.53F/cm2 (338.5F/g) for mesoporous Ni0.5Mn0.5Co2O4 under the test conditions of 5 mA/cm2. The asymmetric supercapacitor assembled with Ni0.5Mn0.5Co2O4 and activated carbon demonstrates a superior energy density of 79.52 Wh.kg−1 at 1 mA/cm2. The findings of the study highlight the importance of substituting the electrode with Ni0.5Mn0.5Co2O4 to enhance the Cs by achieving proper surface properties and electrochemical activity.

New Suggestion of Highly Durable Electrode Design for Ordered Mesoporous Ni-Mn Binary Transition Metal Oxide Anode Material in Lithium-Ion Batteries.

Anode materials storing large-scale lithium ions gradually decrease electrochemical performance due to severe volume changes during cycling. Therefore, there is an urgent need to develop anode materials with high electrochemical capacity and durability, without deterioration arising due to the volume changes during the electrochemical processes. To date, mesoporous materials have received attention as anode materials due to their ability to mitigate volume expansion, offer a short pathway for Li+ transport, and exhibit anomalous high capacity. However, the nano-frameworks of transition metal oxide collapse during conversion reactions, demanding an improvement in nano-framework structure stability. In this study, ordered mesoporous nickel manganese oxide (m-NMO) is designed as an anode material with a highly durable nanostructure. Interestingly, m-NMO showed better cycle performance and higher electrochemical capacity than those of nickel oxide and manganese oxide. Operando small-angle X-ray scattering and ex situ transmission electron microscopic results confirmed that the binary m-NMO sustained a highly durable nanostructure upon cycling, unlike the single metal oxide electrodes where the mesostructures collapsed. Ex situ X-ray absorption spectroscopy proved that nickel and manganese showed different electrochemical reaction voltages, and thus undergoes sequential conversion reactions. As a result, both elements can act as complementary nano-propping buffers to maintain stable mesostructure.

Effect of iron oxidation state on the catalytic performance of Fe/C in liquid phase flow hydrogenation of 2-butyne-1,4-diol

Cis-2-butene-1,4-diol and 1,4-butanediol are crucial precursors in producing bioplastics and biodegradable plastics. Moreover, cis-2-butene-1,4-diol is used in the production of vitamins A and B6, fungicides and insecticides. On an industrial scale, they are produced by hydrogenation of 2-butyne-1,4-diol with Ni Raney as catalyst at > 160 °C and > 15 MPa. Herein, the effect of mesoporous carbon, iron loading (2, 6, 10 and 14 wt%), and metal oxidation state on the activity and selectivity of iron catalysts in the liquid phase continuous flow 2-butyne-1,4-diol hydrogenation at mild conditions (at temperature range 10–65 °C and pressure range 1–20 bar) was performed. Catalytic investigations supported by statistical modeling and physicochemical characterization (TPR, H2-TPD, physisorption, TEM, XPS, and Mössbauer spectroscopy), showed that the activity of the Fe/C can be determined by the presence of functional groups in mesoporous support which are responsible for high metal dispersion and strong metal-support interaction, which boosts the catalytic activity of iron catalysts. Additionally, the formation of metastable iron carbides which are active in hydrogenation cannot be excluded. All of the catalysts showed 100% selectivity toward cis-2-butene-1,4-diol at the lowest temperature. However, the best compromise between selectivity and activity (TOF=336 h−1) was achieved with 2 wt% Fe at 1 bar and 25 °C.

Immobilization of laccase on mesoporous metal organic frameworks for efficient cross-coupling of ethyl ferulate.

Laccases act as green catalysts for oxidative cross-coupling of phenolic antioxidnt compounds, but low stability and non-recyclability limit its application. To address that, metal-organic frameworks Cu-BTC and Cr-MOF were synthesized as supports to immobilize the efficient laccase from Cerrena sp. HYB07. The Brunauer-Emmett-Teller surface area of Cu-BTC and Cr-MOF were 1213.2 and 907.1m2/g, respectively. The two carriers respectively presented pore diameters of 1.2-10nm and 1.4-12nm as octahedron, indicating nano-scale mesoporosity. These Cu-BTC and Cr-MOF carriers could adsorb laccase with enzyme loading of 1933.2 and 1564.4U/g carrier, respectively. The stability and organic solvent tolerance of Cu-BTC-laccase and Cr-MOF-laccase were both obviously improved compared to free laccase. Thermal inactivation kinetics showed that both the two immobilized laccases displayed lower thermal inactivation rate constants. Importantly, the Cu-BTC-laccase and Cr-MOF-laccase both showed much higher activity for cross-coupling of ethyl ferulate than free laccase, which had 2.5-fold higher cross-coupling efficiency than that by free laccase. The ethyl ferulate coupling product was also analyzed by mass spectroscopy and the synthesis pathway of ethyl ferulate dimer was proposed. The cross coupling of ethyl ferulate required the formation of radical intermediates of ethyl ferulate generated by laccase mediated oxidation. This work paved the way for MOFs immobilized laccase for cross coupling of antioxidant phenols.

Surface Loading Dictates Triplet Production via Singlet Fission in Anthradithiophene Sensitized TiO2 Films.

Singlet fission, the process of transforming a singlet excited state into two lower energy triplet excited states, is a promising strategy for improving the efficiency of dye-sensitized solar cells. The difficulty in utilizing singlet fission molecules in this architecture is understanding and controlling the orientation of dyes on mesoporous metal oxide surfaces to maximize triplet production and minimize detrimental deactivation pathways, such as electron injection from the singlet or excimer formation. Here, we varied the concentration of loading solutions of two anthradithiophene dyes derivatized with either one or two carboxylic acid groups for binding to a metal oxide surface and studied their photophysics using ultrafast transient absorption spectroscopy. For the single carboxylic acid case, an increase in dye surface coverage led to an increase in apparent triplet excited-state growth via singlet fission, while the same increase in coverage with two carboxylic acids did not. This study represents a step toward controlling the interactions between molecules at mesoporous interfaces.

High Throughput Manufacturing of Highly Ordered Mesoporous Thin Film Oxides for Hybrid-Polymer Nanocomposite Dielectrics

Highly ordered mesoporous metal oxide thin films have potential to become integrated into widely impactful dielectric materials due to the tunable properties of the oxide and its polymer filling; however, current manufacturing techniques to form the mesoporous oxide greatly limit scalable fabrication. Sol-gel mesoporous metal oxides generated via traditional processes require multi-day aging and high temperature, prolonged curing processes to yield controlled porosity at the expense of manufacturability. Moreover, high cost and unstable alkoxide precursors require precision over the solution precursor pH and subsequent thin film aging humidity after deposition.Solution combustion synthesis (SCS) is a next-generation method of generating metal oxides at reduced process temperatures (often <300 ºC) and using green precursors compared to the sol-gel approach. The metal oxide is typically produced from a metal nitrate, which provides both the metal cation and oxidant and an organic chelator fuel. The fuel acts to stabilize the cation against hydrolysis and to participate in the exothermic redox reaction that results in the metal oxide.Here, we present porogen integrated rapid oxidation (PIRO) which utilizes the principles of SCS to fabricate large-area mesoporous thin films of AlOx in less than 1 hour and at a temperature of 230 ºC. The PIRO method uses low-cost precursors to generate micelles with a controllable open-cell porosity ranging from ~30 – 60% and with varying degrees of closed-packed cubic ordering at a nearly 95% reduction in overall processing time. We show the precursor chemistry can be deposited via ultrasonic spray or blade coating at up to 6 m/min to manufacture large area mesoporous oxides and demonstrate filling of the porous AlOx with TOPAS® polymer to generate a hybrid nanocomposite with a dielectric constant of 6.26.

The synthesis of Ni-Co@NOMC and the regulation of its active sites for the selective conversion of furfural to cyclopentanone

Catalysts play a critical role in the selective conversion of furfural (FAL) in the aqueous-phase hydrogenation-rearrangement tandem reaction (AP-HRT). Herein, the N-doped bimetallic Ni-Co@NOMC was synthesized by solvent volatilization self-assembly method. The morphology and structure of the APF precursors were effectively controlled through adjustments in the synthesis and the presence of numerous pore channels and the substantial specific surface areas contributed to enhancing catalytic efficiency. Furthermore, this study also examined the synergistic interaction between the acid-base sites of the novel mesoporous N-doped carbon (NOMC) carrier and metal active sites to advance the succession of the furan ring hydrogenation and rearrangement processes. Specifically, the 99.9 % conversion of 8 wt% FAL solution was successfully accomplished with the 90.5 % selectivity of cyclopentanone catalyzed by 1.2-Ni-Co@NOMC catalysts. Therefore, this research holds significant importance for advancing the sustainable utilization of biomass resources in the future.

2D PtRhPb Mesoporous Nanosheets with Surface-Clean Active Sites for Complete Ethanol Oxidation Electrocatalysis.

The development of active and selective metal electrocatalysts for complete ethanol oxidation reaction (EOR) into desired C1 products is extremely promising for practical application of direct ethanol fuel cells. Despite some encouraging achievements, their activity and selectivity remain unsatisfactory. In this work, it is reported that 2D PtRhPb mesoporous nanosheets (MNSs) with anisotropic structure and surface-clean metal siteperform perfectly for complete EOR electrocatalysis in both three-electrode and two-electrode systems. Different to the traditional routes, a selective etching strategy is developed to produce surface-clean mesopores while retaining parent anisotropy quasi-single-crystalline structure without the mesopore-forming surfactants. This method also allows the general synthesis of surface-clean mesoporous metals with other compositions and structures. When being performed for alkaline EOR electrocatalysis, the best PtRhPb MNSs deliver remarkably high activity (7.8 A mg-1) and superior C1 product selectivity (70% of Faradaic efficiency), both of which are much better than reported electrocatalysts. High performance is assigned to multiple structural and compositional synergies that not only stabilized key OHads intermediate by surface-clean mesopores but also separated the chemisorption of two carbons in ethanol by adjacent Pt and Rh sites, which facilitate the oxidation cleavage of stable C─C bond for complete EOR electrocatalysis.

Self-Assembled Carbon Metal-Organic Framework Oxides Derived from Two Calcination Temperatures as Anode Material for Lithium-Ion Batteries.

Owing to their structural diversity and mesoporous construction, metal-organic frameworks (MOFs) have been used as templates to prepare mesoporous metal oxides, which show excellent performance as anode materials for lithium-ion batteries (LIBs). Co-ZnO/C and Co-Co3O4/C nanohybrids were successfully synthesized based on a precursor of Co-doped MOF-5 by accurately controlling the annealing temperature and atmosphere. Experimental data proved that their electrochemical performance was closely associated with the material phase, especially for Co-ZnO/C, indicating that carbon skeleton materials can maintain a good restoration rate of over 99% after undergoing high-current density cycling. Meanwhile, Co-Co3O4/C nanohybrids showed an exceedingly high reversible capacity of 898 mAh∙g-1 at a current density of 0.1 C after 100 cycles. Their improved coulombic efficiency and superior rate capability contribute to a mesoporous structure, which provides pathways allowing for rapid Li+ diffusion and regulates volume change during charge and discharge processes.

Mesoporous Metal Sponges Produced by Explosive Decomposition.

The formation of mesoporous gold sponges by explosive decomposition of 'knallgold' (also known as 'fulminating' gold) is studied. Proof-of-principle experiments are conducted and then the phenomena are further investigated using 'toy physics' molecular dynamics simulations. The simulations invoked various ratios of a volatile Lennard-Jones element G and a noble metal element N. In both experiment and simulation the morphology of the resulting sponge is found to depend on the stoichiometry of the starting material. As the mole fraction of G (χG) is increased from 0.5 to close to 1.0 in the simulations, the morphology of the sponges changes from closed to open, with a corresponding increase in the average mean curvature from 0 to +0.12 inverse Lennard-Jones length (L) units. The average Gaussian curvature of the simulated sponges is always negative, with the minimum value of 0.05 L-2 being found for χG≈0.65. In broad agreement with experiment, sponge formation in the simulations is bounded by stoichiometry; no sponges form if χG is <0.52, for χG between 0.52 and 0.70 the sponge is characterized by vermicular cavities whereas classic bicontinuous fibrous sponges form for 0.70<χG<0.85 and, finally, discrete particles result if χG>0.85.

Direct benzylation of carboxylic acids using Pd@Cu2(BDC)2DABCO via C‐H (sp3) bond activation

In this study, Pd nanoparticles encapsulated in the copper‐based mesoporous metal–organic framework (Cu2(BDC)2DABCO) and used as a reusable heterogeneous catalyst to establish a method for the direct benzylation of carboxylic acids through C‐H (sp3) bond activation. The catalyst structure was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), X‐ray diffraction (XRD), Brunauer–Emmett–Teller (BET), and inductively coupled plasma (ICP). This catalyst showed high catalytic activity, selectivity, and good functional group tolerance for the direct benzylation of carboxylic acids.

A Straightforward Solvent-Pair-Enabled Multicomponent Coassembly Approach toward Noble-Metal-Nanoparticle-Decorated Mesoporous Tungsten Oxide for Trace Ammonia Sensing.

The straightforward synthesis of noble-metal-nanoparticle-decorated ordered mesoporous transition metal oxides remains a great challenge due to the difficulty of balancing the interactions between precursors and templates. Herein, a solvent-pair-enabled multicomponent coassembly (SPEMC) strategy is developed for straightforward synthesis of noble-metal-nanoparticle-decorated nitrogen-doped ordered mesoporous tungsten oxide (abbreviated as NM/N-mWO3, NM=Pt, Rh, Pd). The amphiphilic poly(ethylene oxide)-block-polystyrene (PEO-b-PS) copolymers coassemble with ammonium metatungstate (AMT) clusters and different kinds of hydrophilic noble metal precursors without phase separation. SPEMC synthesis requires no direct interaction between PEO-b-PS and AMT, thus the assembly equilibriums between noble metal precursors and PEO-b-PS can be readily controlled. The obtained NM/N-mWO3 nanocomposites possess ordered mesopores, abundant oxygen vacancies, and metal-metal oxide interfaces. As a result, the Pt/N-mWO3 sensors exhibit superior ammonia sensing performances with high sensitivity, an ultralow limit of detection (51.2 ppb), good selectivity, and long-term stability. Spectroscopic analysis reveals that ammonia is oxidized stepwise to NO, NO2 -, and NO3 - during the sensing process. Moreover, a portable wireless module based on Pt/N-mWO3 sensor can recognize ppm-level concentration of ammonia, which lays a solid foundation for its application in various fields.

Synthesis of Mesoporous Tetragonal ZrO2, TiO2 and Solid Solutions and Effect of Colloidal Silica on Porosity.

Metal oxides possessing a large surface area, pore volume and desirable pore size provide more varieties and active industrial potentials. Nevertheless, it is very challenging to produce crystal metal oxides while keeping satisfactory porosity features, especially for ternary compositions. High temperature is usually needed to produce crystal metal oxides, which readily leads to the collapse of the pore structure. Herein, by employing a 'soft' dispersant agent and a hard silica template, ZrO2, TiO2 and Zr-Ti solid solutions having a tetragonal crystal structure are produced and the silica-leached materials are characterized from macroscopic to atomistic scales. The micron-sized particulate powders are composed of nanoscale 'building blocks', with crystallite sizes between ~8 and 21 nm. These polycrystalline ceramic powders exhibit a high specific surface area (up to ~200 m2·g-1) and pore volume (up to 0.5 cm3·g-1), with a pore size range of ~5-20 nm. Importantly, the Zr/Ti-O-Si-OH chemical bonds exist on the particle surface, with about two-thirds of the surface covered by silica. The hydroxyl groups can further post-graft organic ligands or directly associate with species. Synthesized mesoporous metal oxides are highly homogenous and could potentially be used in various applications because of their tetragonal structure and porosity features.

Low-Temperature Decomposition and Oxidation of the Nerve Agent Simulant on Mesoporous Nickel Oxide and Cu-Doped Nickel Oxide.

In an effort to develop the next frontier filtration material for chemical warfare agent (CWA) decomposition, we synthesized mesoporous NiO and CuxNi1-xO (x = 0.10 and 0.20) and studied the decomposition of CWA simulant diisopropyl fluorophosphate (DIFP) on their surfaces. Mesoporous NiO and CuxNi1-xO were fully characterized and found to be a solid solution with no phase separation up to 20% copper dopant. The synthesized materials were successfully templated producing ordered mesoporous metal oxides with high surface areas (67.89- 94.38 m2/g). Through Raman spectroscopy, we showed that pure NiO contained a high concentration of Ni2+ vacancies, while Cu2+ reduced these defects. Through in situ infrared spectroscopy, we determined the surface species formed, potential pathways, and driving factors for decomposition. Upon exposure of DIFP, all materials produced similar decomposition products CO, CO2, carbonyls, and carbonates. However, decomposition reactions were sustained longer on mesoporous NiO, facilitated by the higher Ni2+ vacancy concentration. NiO was further studied with DIFP, first at low dosing temperatures (-50 °C), which still resulted in the production of CO and carbonates, and then, second, with a higher pretreatment temperature, which showed the importance of terminal hydroxyls/water to fully oxidize decomposition products to CO2. Mesoporous NiO demonstrated high decomposition and oxidation capabilities at temperatures below room temperature, all without any external excitation or noble metals, making it a promising frontier filtration material for CWA decomposition.

Highly efficient aerobic epoxidation of styrene using mesoporous Co-Ni catalysts

This work reports the synthesis and characterization of mesoporous cobalt-nickel mixed metal oxide catalysts with varying Co:Ni ratios using an inverse micelle template self-assembly method. Their structural and morphological properties and catalytic performance in styrene epoxidation were evaluated. Among them, the 73CoNi-250 catalyst (Co: Ni70:30 mol/mol%, calcined 250°C) exhibited a unique flower-like morphology and the highest surface area, which XPS analysis linked to a higher concentration of oxygen vacancies. Notably,73CoNi-250 demonstrated exceptional catalytic activity for styrene epoxidation, achieving near-complete styrene conversion (>99 %) and high selectivity (94 %) for styrene epoxide under mild reaction conditions without the need for oxidants such as peroxides. Furthermore, the catalyst exhibited excellent reusability (≥ 4 cycles) without significant activity loss or changes in mesoporosity. Kinetic studies revealed a first-order reaction profile and a significantly enhanced rate constant compared to the best-reported values (fivefold) in the literature, further underlining the catalyst's efficiency, and emphasizing the environmentally friendly approaches in chemical synthesis.

Mesoporous amorphous non-noble metals as versatile substrates for high loading and uniform dispersion of Pt-group single atoms.

Atomically dispersed Pt-group metals are promising as nanocatalysts because of their unique geometric structures and ultrahigh atomic utilization. However, loading isolated Pt-group metals in single-atom alloys (SAAs) with distinctive bimetallic sites is challenging. In this study, we present amorphous mesoporous Ni boride (Ni-B) as an ideal substrate to uniformly disperse Pt atoms with tunable loadings (1.7 to 12.2 wt %). The effect of the morphology, composition, and crystal phase of the Ni-B host on the growth and dispersion of Pt atoms is discussed. The resulting amorphous Pt-Ni-B mesoporous nanospheres exhibit superior electrocatalytic H2 evolution performance in acidic media. This strategy holds the potential to synthesize a diverse library of mesoporous amorphous Pt-group SAAs, by leveraging functional amorphous nanostructured 3d transition-metal borides as substrates, thereby proposing a comprehensive strategy to control atomically dispersed Pt-group metals.

Review of Prodrug and Nanodelivery Strategies to Improve the Treatment of Colorectal Cancer with Fluoropyrimidine Drugs.

Fluoropyrimidine (FP) drugs are central components of combination chemotherapy regimens for the treatment of colorectal cancer (CRC). FP-based chemotherapy has improved survival outcomes over the last several decades with much of the therapeutic benefit derived from the optimization of dose and delivery. To provide further advances in therapeutic efficacy, next-generation prodrugs and nanodelivery systems for FPs are being developed. This review focuses on recent innovative nanodelivery approaches for FP drugs that display therapeutic promise. We summarize established, clinically useful FP prodrug strategies, including capecitabine, which exploit tumor-specific enzyme expression for optimal anticancer activity. We then describe the use of FP DNA-based polymers (e.g., CF10) for the delivery of activated FP nucleotides as a nanodelivery approach with proven activity in pre-clinical models and with clinical potential. Multiple nanodelivery systems for FP delivery show promise in CRC pre-clinical models and we review advances in albumin-mediated FP delivery, the development of mesoporous silica nanoparticles, emulsion-based nanoparticles, metal nanoparticles, hydrogel-based delivery, and liposomes and lipid nanoparticles that display particular promise for therapeutic development. Nanodelivery of FPs is anticipated to impact CRC treatment in the coming years and to improve survival for cancer patients.