Mesoporous Glass Research Articles

Regional Chitosan and Melaleuca armillaris Essential Oil with Mesoporous Glass Particles for Enhancing Bioactive and Antibacterial Behaviour of Ti6Al4V Implants

Regional Chitosan and Melaleuca armillaris Essential Oil with Mesoporous Glass Particles for Enhancing Bioactive and Antibacterial Behaviour of Ti6Al4V Implants

Evaluation of the behaviour of hydrogels containing mesoporous glasses doped with cerium and loaded with polyphenols

Hydrogel dressings are emerging as a promising option for the treatment of chronic wounds due to their tailorable functional properties, which can accelerate the healing. These properties can be improved by the addition of fillers such as bioactive glasses (BGs), and among these, mesoporous glasses doped with cerium (Ce-MBGs) also loaded with polyphenols (Ce-MBGs-POLY) are of interest for their antioxidant properties and dissolution behavior. Here we report the synthesis and characterization of stable hydrogels with high water content and swelling ratio (80 %) containing Ce-MBGs or Ce-MBGs-POLY. These hydrogels show a fast and significant release of ions aimed at stimulating cellular functions and retain the excellent antioxidant properties of the fillers. The new composites are thus promising starting points for the development of injectable hydrogels for chronic wound healing.

Bifunctional mesoporous glasses for bone tissue engineering: Biological effects of doping with cerium and polyphenols in 2D and 3D in vitro models

This study evaluates the cytocompatibility of cerium-doped mesoporous bioactive glasses (Ce-MBGs) loaded with polyphenols (Ce-MBGs-Poly) for possible application in bone tissue engineering after tumour resection. We tested MBGs powders and pellets on 2D and 3D in vitro models using human bone marrow-derived mesenchymal stem cells (hMSCs), osteosarcoma cells (U2OS), and endothelial cells (EA.hy926). Promisingly, at a low concentration in culture medium, Poly-loaded MBGs powders containing 1.2 mol% of cerium inhibited U2OS metabolic activity, preserved hMSCs viability, and had no adverse effects on EA.hy926 migration. Moreover, the study discussed the possible interaction between cerium and Poly, influencing anti-cancer effects. In summary, this research provides insights into the complex interactions between Ce-MBGs, Poly, and various cell types in distinct 2D and 3D in vitro models, highlighting the potential of loaded Ce-MBGs for post-resection bone tissue engineering with a balance between pro-regenerative and anti-tumorigenic activities.

Osteogenic-angiogenic coupled response of cobalt-containing mesoporous bioactive glasses in vivo

The incorporation of cobalt ions into the composition of bioactive glasses has emerged as a strategy of interest for bone regeneration purposes. In the present work, we have designed a set of bioactive mesoporous glasses SiO2-CaO-P2O5-CoO (Co-MBGs) with different amounts of cobalt. The physicochemical changes introduced by the Co2+ ion, the in vitro effects of Co-MBGs on preosteoblasts and endothelial cells and their in vivo behaviour using them as bone grafts in a sheep model were studied. The results show that Co2+ ions neither destroy mesoporous ordering nor inhibit in vitro bioactive behaviour, exerting a dual role as network former and modifier for CoO concentrations above 3 % mol. On the other hand, the activity of Co-MBGs on MC3T3-E1 preosteoblasts and HUVEC vascular endothelial cells is dependent on the concentration of CoO present in the glass. For low Co-MBGs concentrations (1mg/ml) cell viability is not affected, while the expression of osteogenic (ALP, RUNX2 and OC) and angiogenic (VEGF) genes is stimulated. For Co-MBGs concentration of 5 mg/ml, cell viability decreases as a function of the CoO content. In vivo studies show that the incorporation of Co2+ ions to the MBGs improves the bone regeneration activity of these materials, despite the deleterious effect that this ion has on bone-forming cells for any of the Co-MBG compositions studied. This contradictory effect is explained by the marked increase in angiogenesis that takes place inside the bone defect, leading to an angiogenesis-osteogenesis coupling that compensates for the partial decrease in osteoblast cells. Statement of significanceThe development of new bone grafts implies to address the need for osteogenesis-angiogenesis coupling that allows bone regeneration with viable tissue in the long term. In this sense the incorporation of cobalt ions into the composition of bioactive glasses has emerged as a strategy of great interest in this field. Due to the potential cytotoxic effect of cobalt ions, there is an important controversy regarding the suitability of their incorporation in bone grafts. In this work, we address this controversy after the implantation of cobalt-doped mesoporous bioactive glasses in a sheep model. The incorporation of cobalt ions in bioactive glasses improves the bone regeneration ability of these bone grafts, due to enhancement of the angiogenesis-osteogenesis coupling.

Enhancing Osteoblastic Cell Cultures with Gelatin Methacryloyl, Bovine Lactoferrin, and Bioactive Mesoporous Glass Scaffolds Loaded with Distinct Parsley Extracts.

The increasing interest in innovative solutions for addressing bone defects has driven research into the use of Bioactive Mesoporous Glasses (MBGs). These materials, distinguished by their well-ordered mesoporous structure, possess the capability to accommodate plant extracts with well-established osteogenic properties, including bovine lactoferrin (bLF), as part of their 3D scaffold composition. This harmonizes seamlessly with the ongoing advancements in the field of biomedicine. In this study, we fabricated 3D scaffolds utilizing MBGs loaded with extracts from parsley leaves (PL) and embryogenic cultures (EC), rich in bioactive compounds such as apigenin and kaempferol, which hold potential benefits for bone metabolism. Gelatin Methacryloyl (GelMa) served as the polymer, and bLF was included in the formulation. Cytocompatibility, Runx2 gene expression, ALP enzyme activity, and biomineralization were assessed in preosteoblastic MC3T3-E1 cell cultures. MBGs effectively integrated PL and EC extracts with loadings between 22.6 ± 0.1 and 43.6 ± 0.3 µM for PL and 26.3 ± 0.3 and 46.8 ± 0.4 µM for EC, ensuring cell viability through a release percentage between 28.3% and 59.9%. The incorporation of bLF in the 3D scaffold formulation showed significant differences compared to the control in all assays, even at concentrations below 0.2 µM. Combinations, especially PL + bLF at 0.19 µM, demonstrated additive potential, with superior biomineralization compared to EC. In summary, this study highlights the effectiveness of MBGs in incorporating PL and EC extracts, along with bLF, into 3D scaffolds. The results underscore cytocompatibility, osteogenic activity, and biomineralization, offering exciting potential for future in vivo applications.

Nanodevices based on mesoporous glass nanoparticles enhanced with zinc and curcumin to fight infection and regenerate bone.

Nanotechnology-based approaches are emerging as promising strategies to treat different bone pathologies such as infection, osteoporosis or cancer. To this end, several types of nanoparticles are being investigated, including those based on mesoporous bioactive glasses (MGN) which exhibit exceptional structural and textural properties and whose biological behaviour can be improved by including therapeutic ions in their composition and loading them with biologically active substances. In this study, the bone regeneration capacity and antibacterial properties of MGNs in the SiO2-CaO-P2O5 system were evaluated before and after being supplemented with 2.5% or 4% ZnO and loaded with curcumin. in vitro studies with preosteoblastic cells and mesenchymal stem cells allowed determining the biocompatible MGNs concentrations range. Moreover, the bactericidal effect of MGNs with zinc and curcumin against S. aureus was demonstrated, as a significant reduction of bacterial growth was detected in both planktonic and sessile states and the degradation of a pre-formed bacterial biofilm in the presence of the nanoparticles also occurred. Finally, MC3T3-E1 preosteoblastic cells and S. aureus were co-cultured to investigate competitive colonisation between bacteria and cells in the presence of the MGNs. Preferential colonisation and survival of osteoblasts and effective inhibition of both bacterial adhesion and biofilm formation of S. aureus in the co-culture system were detected. Our study demonstrated the synergistic antibacterial effect of zinc ions combined with curcumin and the enhancement of the bone regeneration characteristics of MGNs containing zinc and curcumin to obtain systems capable of simultaneously promoting bone regeneration and controlling infection. STATEMENT OF SIGNIFICANCE: In search of a new approach to regenerate bone and fight infections, a nanodevice based on mesoporous SiO2-CaO-P2O5 glass nanoparticles enriched with Zn2+ ions and loaded with curcumin was designed. This study demonstrates the synergistic effect of the simultaneous presence of zinc ions and curcumin in the nanoparticles that significantly reduces the bacterial growth in planktonic state and is capable to degrade pre-formed S. aureus biofilms whereas the nanosystem exhibits a cytocompatible behaviour in the presence of preosteoblasts and mesenchymal stem cells. Based on these results, the designed nanocarrier represents a promising alternative for the treatment of acute and chronic infections in bone tissues, while avoiding the significant current problem of bacterial resistance to antibiotics.

Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes.

Bioactive mesoporous glass nanospheres (nanoMBGs) charged with antiosteoporotic drugs have great potential for the treatment of osteoporosis and fracture prevention. In this scenario, cells of the immune system are essential both in the development of disease and in their potential to stimulate therapeutic effects. In the present work, we hypothesize that nanoMBGs loaded with ipriflavone can exert a positive osteoimmune effect. With this objective, we assessed the effects of non-loaded and ipriflavone-loaded nanoparticles (nanoMBGs and nanoMBG-IPs, respectively) on CD4+ Th2 lymphocytes because this kind of cell is implicated in the inhibition of osseous loss by reducing the RANKL/OPG relationship through the secretion of cytokines. The results indicate that nanoMBGs enter efficiently in CD4+ Th2 lymphocytes, mainly through phagocytosis and clathrin-dependent mechanisms, without affecting the function of these T cells or inducing inflammatory mediators or oxidative stress, thus maintaining the reparative Th2 phenotype. Furthermore, the incorporation of the anti-osteoporotic drug ipriflavone reduces the potential unwanted inflammatory response by decreasing the presence of ROS and stimulating intracellular anti-inflammatory cytokine release like IL-4. These results evidenced that nanoMBG loaded with ipriflavone exerts a positive osteoimmune effect.

Dual loaded Ce-MBGs with bioactivity, antioxidant and antibacterial properties

The performance of Bioactive Mesoporous Glasses (MBGs) as tissue regeneration scaffolds can be enhanced by the addition of therapeutic inorganic ions (TIIs) or organic molecules. In order to maximise the benefits conferred by different TIIs and organic molecules on bioactive glasses, we investigated the behavior of a 1:1 mixture (wt.%) of MBGs doped with cerium and loaded separately with gentamicin (Gen) and polyphenols (POLY). The resulting admixed material preserves bioactivity of the unloaded cerium-doped MBGs, assessed by evaluating the formation of an apatitic layer. Furthermore, it shows both antioxidant properties, evaluated by the reduction of Reactive Oxygen Species (ROS) measured by enzymatic assays, conferred by cerium POLY loadings and antibacterial properties conferred by Gen, and estimated by a modification of the Kirby-Bauer agar diffusion method. Ce-MBGs can thus be applied as a useful dual drug delivery system (DDS) with hard tissue regeneration capabilities.

Translated article] Design and comparison of bone substitutes. Study of in vivo behaviour in a rabbit model

AimTo compare the in vivo bone formation capacity of of biomaterials designed as bone substitutes with respect to iliac crest autograft, one based on carbonate hydroxiapatite and the other one on bioactive mesoporous glass. Materials and methodsExperimental study consisting on 14 adult female New Zeland rabbits where a critical defect was made in the rabbit radius bone. The sample was divided into four groups: defect without material, with iliac crest autograft, with carbonatehydroxyapatite scaffold, and with bioactive mesoporous glass scaffold. Serial X-ray studies were carried out at 2, 4, 6 and 12 weeks and a microCT study at euthanasia at 6 and 12 weeks. ResultsIn the X-ray study, autograft group showed the highest bone formation scores. Both groups of biomaterials presented bone formation similar and greater than the defect without material, but always less than in the autograft group. The results of the microCT study showed the largest bone volume in the study area in the autograft group. The groups with bone substitutes presented greater bone volume than the group without material but always less than the autograft group. ConclusionBoth scaffolds seem to promote bone formation but are not capable of reproducing the characteristics of autograft. Due to their different macroscopic characteristics, each one could be suitable for a different type of defect.

Electrokinetic Properties of Mesoporous Vitreous Membranes Doped by Silver-Silver Halides

Silver/silver halide materials are considered as efficient and highly stable plasmonic photocatalysts for the organic pollutant degradation and hydrogen evolution from water splitting under solar irradiation, and they possess promising antibacterial activity. Ordered mesoporous silica materials including porous glasses are considered as the most promising template for silver-containing structures. In the present work, Ag/AgHal-doped (Hal = Cl, Br) vitreous membranes on a base of the mesoporous glasses were prepared via step-by-step single-stage impregnation procedure. The chemical and phase composition of the modified membranes were identified by the X-ray photoelectron spectroscopy, the X-ray diffraction and the energy-dispersive X-ray spectroscopy. The structure and morphology of inner membrane space were studied by the scanning electron microscopy. Electrokinetic properties of the silver-containing vitreous membranes were determined by the differential method and the streaming potential method. The inner membrane space is modified unevenly with appearance of the clearly defined regions with different silver content. The formation of the Ag/AgCl clusters along with the individual nanoparticles over thickness of the 1-mm membrane with mean pore radius of 23 nm was detected. The modification of the pore space by Ag-containing structures and the type of halogen ion almost do not affect the electrochemical behavior of the mesoporous vitreous membranes.

Diseño y comparativa de biomateriales para el tratamiento de defectos óseos. Estudio de su comportamiento in vivo en modelo animal de conejo

AimCompare bone formation capacity in vivo of two types of biomaterials designed as bone substitutes with respect to iliac crest autograft, one based on carbonate hydroxyapatites and the other one on bioactive mesoporous glass. Materials and methodsExperimental study consisting on 14 adult female New Zeland rabbits where a critical defect was made in the rabbit radius bone. The sample was divided into four groups: defect without material, with iliac crest autograft, with carbonatehydroxyapatite support, and with bioactive mesoporous glass support. Serial X-ray studies were carried out at 2, 4, 6 and 12 weeks and a microCT study at euthanasia at 6 and 12 weeks. ResultsIn the X-ray study, autograft group showed the highest bone formation scores. Both groups of biomaterials presented bone formation similar and greater than the defect without material, but always less than in the autograft group. The results of the microCT study showed the largest bone volume in the study area in the autograft group. The groups with bone substitutes presented greater bone volume than the group without material but always less than in the autograft group. ConclusionBoth supports seem to promote bone formation but are not capable of reproducing the characteristics of autograft. Due to their different macroscopic characteristics, each one could be suitable for a different type of defect.

Alginate Beads Containing Cerium-Doped Mesoporous Glass and Curcumin: Delivery and Stabilization of Therapeutics

Cancer is a leading cause of death worldwide, its genesis and progression are caused by homeostatic errors, and reactive oxygen species play a major role in promoting aberrant cancer homeostasis. In this scenario, curcumin could be an interesting candidate due to its versatile antioxidant, anti-inflammatory, anti-tumor, anti-HIV, and anti-infection properties. Nonetheless, the major problem related to its use is its poor oral bioavailability, which can be overcome by encapsulating it into small particles, such as hydrogel beads containing mesoporous silica. In this work, various systems have been synthesized: starting from mesoporous silica glasses (MGs), cerium-containing MGs have been produced; then, these systems have been loaded with 4 to 6% of curcumin. Finally, various MGs at different compositions have been included in alginate beads. In vitro studies showed that these hybrid materials enable the stabilization and effective delivery of curcumin and that a synergic effect can be achieved if Ce3+/Ce4+ and curcumin are both part of the beads. From swelling tests, it is possible to confirm a controlled curcumin release compartmentalized into the gastrointestinal tract. For all beads obtained, a curcumin release sufficient to achieve the antioxidant threshold has been reached, and a synergic effect of cerium and curcumin is observed. Moreover, from catalase mimetic activity tests, we confirm the well-known catalytic activity of the couple Ce3+/Ce4+. In addition, an extremely good radical scavenging effect of curcumin has been demonstrated. In conclusion, these systems, able to promote an enzymatic-like activity, can be used as drug delivery systems for curcumin-targeted dosing.

Optimization of an Injectable, Resorbable, Bioactive Cement Able to Release the Anti-Osteoclastogenic Biomolecule ICOS-Fc for the Treatment of Osteoporotic Vertebral Compression Fractures.

Vertebral compression fractures are typical of osteoporosis and their treatment can require the injection of a cement through a minimally invasive procedure to restore vertebral body height. This study reports the development of an injectable calcium sulphate-based composite cement able to stimulate bone regeneration while inhibiting osteoclast bone resorption. To this aim, different types of strontium-containing mesoporous glass particles (Sr-MBG) were added to calcium sulphate powder to impart a pro-osteogenic effect, and the influence of their size and textural features on the cement properties was investigated. Anti-osteoclastogenic properties were conferred by incorporating into poly(lactic-co-glycolic)acid (PLGA) nanoparticles, a recombinant protein able to inhibit osteoclast activity (i.e., ICOS-Fc). Radiopaque zirconia nanoparticles (ZrO2) were also added to the formulation to visualize the cement injection under fluoroscopy. The measured cement setting times were suitable for the clinical practice, and static mechanical testing determined a compressive strength of ca. 8 MPa, comparable to that of human vertebral bodies. In vitro release experiments indicated a sustained release of ICOS-Fc and Sr2+ ions up to 28 days. Overall, the developed cement is promising for the treatment of vertebral compression fractures and has the potential to stimulate bone regeneration while releasing a biomolecule able to limit bone resorption.

Highly porous phosphate-based glasses for controlled delivery of antibacterial Cu ions prepared via sol-gel chemistry.

Mesoporous glasses are a promising class of bioresorbable biomaterials characterized by high surface area and extended porosity in the range of 2 to 50 nm. These peculiar properties make them ideal materials for the controlled release of therapeutic ions and molecules. Whilst mesoporous silicate-based glasses (MSG) have been widely investigated, much less work has been done on mesoporous phosphate-based glasses (MPG). In the present study, MPG in the P2O5-CaO-Na2O system, undoped and doped with 1, 3, and 5 mol% of Cu ions were synthesized via a combination of the sol-gel method and supramolecular templating. The non-ionic triblock copolymer Pluronic P123 was used as a templating agent. The porous structure was studied via a combination of Scanning Electron Microscopy (SEM), Small-Angle X-ray Scattering (SAXS), and N2 adsorption-desorption analysis at 77 K. The structure of the phosphate network was investigated via solid state 31P Magic Angle Spinning Nuclear Magnetic Resonance (31P MAS-NMR) and Fourier Transform Infrared (FTIR) spectroscopy. Degradation studies, performed in water via Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES), showed that phosphates, Ca2+, Na+ and Cu ions are released in a controlled manner over a 7 days period. The controlled release of Cu, proportional to the copper loading, imbues antibacterial properties to MPG. A significant statistical reduction of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacterial viability was observed over a 3 days period. E. coli appeared to be more resistant than S. aureus to the antibacterial effect of copper. This study shows that copper doped MPG have great potential as bioresorbable materials for controlled delivery of antibacterial ions.

Diffusionlike Drying of a Nanoporous Solid as Revealed by Magnetic Resonance Imaging

Drying plays a central role in various fabrication processes and applications of functional nanoporous materials, most prominently in relation to energy storage and conversion. During such processes, liquid coexists with air inside the sample, leading to transport as a result of concentration gradients of vapor and/or liquid. Experimentally, it is extremely challenging to unravel this transport phenomenology inside the hidden geometry of porous media. Here, we observe the drying of a model nanoporous material (monolithic mesoporous silica glass, Vycor) with magnetic resonance imaging. We show that, for various boundary conditions (air-flux intensities), no dry region develops, but the sample desaturates in depth. This desaturation is almost homogeneous throughout the sample for weak air flux, while saturation gradients can be observed for sufficiently strong air flux. We demonstrate that the transport of water is mainly ensured by liquid flow towards the free surface, resulting from a gradient of vapor pressure, associated with local saturation (via the desorption curve), leading to a gradient of liquid pressure (via the Kelvin law). Assuming otherwise standard hydrodynamic characteristics of the nanoconfined liquid, this results in a diffusionlike model, which appears to represent experimental data very well in terms of the spatial distribution of water over time inside the sample for various boundary conditions (air-flux intensities). Finally, we propose a predictive model of the detailed drying characteristics of a nanomaterial from knowledge of its pore size, permeability, and desorption curve. This provides an insight into the rational design of drying-based processes employing functional nanoporous materials and allows for a mechanistic understanding of drying phenomenologies in natural nanoporous media.

All-inorganic robust absorber for high-sun solar steam generation and solvent recovery

The mechanical and chemical stability of the light-absorber creates a limitation of the STS applications, especially in harsh operating conditions such as high temperature or aggressive solvents environment. The current study addresses the issue by proposing a highly stable and durable light absorber based on the gold nanoparticles (Au NPs) immobilized on the mesoporous silica-covered glass fiber (MSGF). Mesoporous silica coating improves the attachment of Au NPs to the fiber surface, while simultaneously increasing specific surface area. The synthesis parameters of the mesoporous silica layer and the Au NPs were adjusted to obtain favorable morphology, resulting in a 16.7% increase in the total solar weighted absorptance. The STS system based on two-dimensional Au-MSGF achieved the highest evaporation rate of 1.22 kg·m −2 ·h -1 under 1 sun illumination at 20 °C and relative humidity of 40%. Furthermore, the thermal stability and durability of glass fiber allowed the application of Au-MSGF for the STS at sunlight illumination intensities as high as 50-suns without any visible or performance degradation over extended periods. The inertness of the Au-MSGF plays an important role in the solvent recovery applications of the STS system. It was found that the hydrophobic coating of the light absorber improves the performance of the STS system for non-polar solvent recovery. The results indicate a significant (over 100% as compared to the evaporation in the darkroom) evaporation rate increase of octane and decane in the STS system operating under 1 and 2 suns, making them suitable for the STS solvent recovery. • A highly stable all-inorganic absorber is developed for STS generation. • SiO 2 coating increases the surface area of glass fiber. • High sun STS generation is possible up to 50 Sun. • Solar induced solvent recovery using STS is successfully demonstrated. • STS-solvent recovery is efficient for solvents with low p v .

Study of the synthesis, adsorption property, and photocatalytic activity of TiO2/coal gasification fine slag mesoporous silica glass microsphere composite.

In this study, TiO2/MSGM composite material with adsorption-photocatalytic properties was prepared by extracting mesoporous silica glass microsphere (MSGM) from coal gasification fine slag (CGFS) as a novel TiO2 carrier. The results of characterization and properties of the composite showed that MSGM could improve the adsorption capacity and photocatalytic activity of the composite by improving the pore structure of the composite, hindering the growth of TiO2 particles, increasing the phase transition temperature of TiO2, enhancing the dispersion of TiO2 particles. The sample 1:3-TiO2/MSGM-2-500 prepared under the optimized conditions possesses satisfactory morphology characteristics, high adsorption capacity, and photocatalytic activity to rhodamine B (RhB). The synergistic effects of adsorption and photocatalytic significantly increase the total removal rate of RhB. This study not only provides a new direction for high-value-added resource utilization of CGFS but also gives a new kind of low-cost carrier material with adsorption property for TiO2 loading to remove organic dye pollutants.

Exact stoichiometry high surface area mesoporous AlPO4 glass for efficient catalysis

Exact stoichiometry high surface area mesoporous AlPO4 glass for efficient catalysis

Mesoporous copper-based metal glass as current collector for Li metal anode

As functional materials, metal glass (MG) has yet been applied in rechargeable batteries. In this work, we expand their application fields into lithium (Li) metal battery by using them as the current collector for Li anode. To impede the Li dendrites growth during the repeated plating and stripping, we fabricated the CuZr MG ribbon into a genuine mesoporous surface covered with lithiophilic CuOx by a simple dealloying process, which was then used to plate Li metal. The dealloyed CuZr MG current collector with a deposited lithium capacity of 1.0 mAh cm−2 shows a high coulombic efficiency >98 % over 300 cycles at 1.0 mA cm−2. Under a high plating/stripping current density of 2.0 mA cm−2, this Li metal anode shows an ultra-low overpotential of 10 mV after >600 h cycling. Moreover, the full cell coupled with LiFePO4 cathode also displays superior cycling and rate performances. Since the CuZr MG ribbon is industrially produced, this work demonstrates the great potential of MGs for practical application in lithium batteries.

Characterization of Drug Release from Mesoporous SiO2-Based Membranes with Variable Pore Structure and Geometry.

Transdermal drug delivery systems (TDDSs) play important roles in therapy due to distinct advantages over other forms and types of drug application. While common TDDS patches mainly consist of polymeric matrices so far, inorganic carriers show numerous advantages such as high mechanical stability, possible re-use and re-loading of drugs, and a broad chemical compatibility with therapeutically relevant compounds and chemical enhancers. Mesoporous glasses can be prepared in different monolithic shapes, and offer a particularly wide range of possible pore volumes, pore diameters, and specific surface areas. Further, they show high loading capacities and favorable physical, technical, and biological properties. Here, we explored for the first time monolithic SiO2-based carriers as sustained release systems of therapeutic drugs. In an ideally stirred vessel as model system, we systematically analyzed the influence of pore diameter, pore volume, and the dimensions of glass monoliths on the loading and sustained release of different drugs, including anastrozole, xylazine, imiquimod, levetiracetam, and flunixin. Through multilinear regression, we calculated the influence of different parameters on drug loading and diffusion coefficients. The systematic variation of the mesoporous glass properties revealed pore volumes and drug loading concentrations, but not pore diameter or pore surface area as important parameters of drug loading and release kinetics. Other relevant effectors include the occurrence of lateral diffusion within the carrier and drug-specific properties such as adsorption. The structure–property relationships derived from our data will allow further fine-tuning of the systems according to their desired properties as TDDS, thus guiding towards optimal systems for their use in transdermal drug applications.