This study investigates the impact of creating a central square opening on reinforced concrete slabs and assesses the strengthening process using ferrocement layers. The investigated key parameters were the opening sizes, type, number, and extension length (outside the opening sides) of steel mesh layers used to strengthen the tested slabs. The experimental program included the preparation and testing of twelve two-way reinforced concrete slabs with identical dimensions, thickness, and reinforcement, but were different with respect to opening sizes and strengthening schemes. Four slabs acted as control specimens without strengthening; one was solid; the other three had different opening sizes; and the other eight slabs were strengthened using a ferrocement layer of 2 cm thickness applied on the bottom of the slab around the openings with various reinforcement schemes which included the number, type, and extension length (outside the opening) of steel mesh. All slabs were supported along the four sides with a clear span of 1 m in both directions and tested under four-point loading. The test results demonstrate that creating an opening in the slab decreases the ultimate load by 21.5 %, 31.9 %, and 40.7 % for opening dimensions (15, 25, and 35 cm), respectively. Using the ferrocement strengthening method helps to increase slabs’ flexural load-carrying capacities and reduce crack propagation from opening corners. The study found that strengthening specimens with opening sizes of 15, 25, and 35 cm increased their flexural load-carrying capacities by 26 %, 33 %, and 34 %, respectively. The expanded steel mesh type also resulted in a higher ultimate load by 6–7 % than the welded mesh type. When the length of the strengthening ferrocement layers was doubled, the ultimate load went up by 6–7 %. Increasing steel mesh layer numbers from 1 to 4 increased the ultimate load by 25 % to 40 % compared to the corresponding un-strengthened slab with an opening. The maximum load of a slab with an opening was achieved by applying a 2 cm thickness of ferrocement layer reinforced with expanded metal mesh, with extension lengths equal to the opening's length. The study utilizes commercial software ABAQUS for finite element analysis (FEA) to validate the experimental results, resulting in a great agreement between the analysis and the experimental findings.