In this work, an Electro-Thermal Ice Protection System (IPS) design was refined and optimized on the NREL 5 MW reference wind turbine. These improvements involved optimization of the distribution of heat flux in both the stream-wise and span-wise directions to minimize power consumption and avoid run-back ice formation. The design conditions focus on a 3-hour rime ice accretion event. The chosen optimization algorithm is a derivative-free method called Mesh Adaptive Direct Search. his optimization effort results in a 55% reduction in power consumption necessary to maintain a completely clean blade surface. The power and energy losses associated with this new optimized design are compared with those from various ice shapes and with the clean blade conditions established in the initial design phase from previous work. The new optimized design allows to keep the blade clean from ice with much larger energy saving. Indeed, only initially, during the first two hours of ice accretion, the energy losses due to this IPS design are higher than without IPS. Beyond this short initial period, substantial energy savings are achieved, especially considering that after the accretion event, the blade remains ice-free, and there are no more power losses.