Nearly 108-km lengths of Mersin shores are composed of natural beaches. The region is located between major tourist centers. In the future, this region is thought to be built with a great number of tourist facilities. Turkey’s largest seaport, Atas refinery (Mersin International Port) is located in Mersin. Recently, Mersin is becoming of great importance to Turkey as the latter plans to construct its second nuclear power plant in the region. Therefore, as nuclear power plants are built to withstand environmental hazards, it is very important to analyze the seismic risk of the areas where the nuclear power plant will be constructed. The region is located between the East Anatolian Fault Zone and Center Anatolian Fault Zone. Based on the Turkey Earthquake Regions Map, Mersin is divided into second-, third-, and fourth-degree earthquake regions. In this study, we sampled earthquakes of magnitude of 4.0 or greater between 01 Jan 1900 and 31 Dec 2010 in the area; seismic hazard of Mersin province was estimated with probabilistic and statistical methods. The study area was selected as the coordinates between 36.03° and 37.42° North and 32.57° and 35.16° East. On the study area, different scaled magnitude values in the last 110 years converted to a common scale (Mw) and earthquake catalog was re-compiled and also seismic sources that may affect the area was determined. In this study, the seismic hazards of the region were obtained using the methods of probability and statistics. This study used three different attenuation relationships. Using the attenuation relationships suggested by Boore et al. (Seismol Res Lett 68(1):128–153, 1997) and Kalkan and Gulkan (Earthquake Spectra 20:1111–1138, 2004), the largest ground acceleration which corresponds to a recurrence period of 475 years was found as 0.08–0.09 g and Akkar and Cagnan (Bull Seismol Soc Am 100 6:2978–2995, 2010), 0.04 g for bedrock at the central district. When computing for seismic hazard curves, Mut district appears to have a greater seismic hazard compared with other districts. Moreover, according to the attenuation relationships, seismic hazard curves corresponding to a recurrence period of 475 years were obtained for the Mersin Central, Mut, Erdemli, Camliyayla, and Tarsus districts.