Mental Status Scale Research Articles

Analysis of the current status and associated risk factors of cognitive function in Tibetan hypertensive patients at various altitudes

ABSTRACT Objective This study aims to explore the current cognitive status and identify risk factors associated with cognitive function in Tibetan hypertensive patients living at various altitudes. Methods The Simple Mental Status Scale (MMSE) was used to evaluate the cognitive function of 611 Tibetan hypertensive patients at various altitudes in Gannan Tibetan Autonomous Prefecture. Afterward, we conducted an analysis to identify the factors influencing their cognitive function. Results The study found that the prevalence of cognitive dysfunction was 22.3%, with a higher incidence at high altitude (group D 29.0%) compared to low altitude (group A 16.0%). The study conducted a binary logistic regression analysis to identify the risk factors for cognitive dysfunction. The analysis revealed that altitude, age, body mass index, marital status, education, income level, and blood pressure control level were all significant risk factors. After controlling for age, body mass index, marital status, educational level, income level, and blood pressure control level, the risk of developing cognitive dysfunction was 2.773 times higher (p < .05) for individuals in group C at high altitude and 2.381 times higher (p < .05) for individuals in group D at high altitude compared to those in group A at low altitude. Conclusions Altitude plays a role in the development of cognitive dysfunction in hypertensive patients. Tibetan hypertensive patients living at high altitudes may be at a higher risk of cognitive dysfunction compared to those living at lower altitudes. Therefore, interventions should be targeted to prevent or mitigate potential cognitive impairment.

Clinical efficacy of scalp electroacupuncture combined with rehabilitation training for aphasia after head injury and its effect on patients' language function and quality of life: An observational study.

To explore the clinical efficacy of scalp electroacupuncture combined with rehabilitation training for aphasia after head injury, and analyze its effect on patients' language function and quality of life. Our hospital randomly enrolled 100 aphasia patients caused by head injury treated from March 2020 to March 2022 as the experimental object and divided them into the control group and experimental group, with 50 cases in each group. The general rehabilitation training was performed to the control group and the scalp electroacupuncture combined with rehabilitation training was performed to the experimental group to compare their mini-mental state examination scores, communicative activities in daily living scores, aphasia battery of Chinese scores, quality of life scores, mental status scale in nonpsychiatric settings scores, National Institutes of Health Stroke Scale scores, effective rates, satisfaction of patients, and adverse reaction rates. In the between-group comparison, the patients in the experimental group had significantly higher mini-mental state examination scores, communicative activities in daily living scores, aphasia battery of Chinese scores, quality of life scores, effective rates, and satisfaction, and significantly lower mental status scale in nonpsychiatric settings scores, National Institutes of Health Stroke Scale scores and adverse reaction rates, which was statistically significant (P < .05 in all cases). The combination treatment of scalp electroacupuncture and rehabilitation training can effectively improve the language function and quality of life of patients with aphasia after head injury and remarkably enhance the treatment effect.

Analysis of the effect of comprehensive physical and mental nursing for patients with acute cerebral infarction in intravenous thrombolytic therapy.

To evaluate the efficacy of comprehensive physical and mental nursing for patients with acute cerebral infarction (ACI) undergoing intravenous thrombolytic therapy and its impact on patients' quality of life and psychological state. A total of 200 patients with ACI, admitted to our hospital between December 2018 and December 2019, were included in the study. They were randomly assigned to either the control group or the experimental group using a random number table. The control group received routine care (basic care such as monitoring vital signs, assisting with daily activities, administering medications, and providing comfort measures), while the experimental group received comprehensive physical and mental nursing (physical care, phsycological surpport, education and conceling). Various parameters including quality of life index (QLI) scores, mental status scale in non-psychiatric settings (MSSNS) scores, self-rating anxiety scale (SAS) scores, self-rating depression scale (SDS) scores, National Institute of Health Stroke Scale (NIHSS) scores, changes in hemodynamic indicators, and incidence of adverse events during intravenous thrombolysis were compared between the two groups. The experimental group had higher QLI scores and lower MSSNS, SAS, SDS, and NIHSS scores compared to the control group (p = 0.33, 0.22, 0.35, 0.26, 0.042). The experimental group also exhibited a lower incidence of adverse reactions during intravenous thrombolysis (p = 0.02). Comprehensive physical and mental nursing for patients with ACI undergoing intravenous thrombolysis improves nursing efficacy, nursing satisfaction, quality of life, and patients' psychological state. These findings highlight the importance of implementing holistic nursing interventions to optimize patient outcomes in ACI management.

Cравнительная эффективность различных режимов терапии рифаксимином-α у пациентов с минимальной печеночной энцефалопатией и циррозом печени (анализ шестимесячного наблюдения)

Minimal hepatic encephalopathy (MHE) is the earliest and mildest form of hepatic encephalopathy (HE), however, its occurrence is associated with an unfavorable prognosis for cirrhosis in patients in this category. MHE increases the number of falls, injuries, patients getting into road traffic accidents, and accidents, which has serious consequences for the quality of life, and also affects the increase in the frequency of hospitalizations and mortality in patients in this category. Timely correction of cognitive impairment is the key to treating and reversing MHE, as well as improving the quality of life in patients with cirrhosis. Objectives. To study the optimal regimens for the use of rifaximin-α and study its effect on the main clinical and laboratory parameters and quality of life of patients with MHE against the background of cirrhosis during long-term treatment. Material and methods. Inclusion criteria: men and women from 18 to 75 years old; availability of CPU; presence of MHE; signed voluntary informed consent. Non-inclusion criteria: refusal to participate in the study; acute hepatitis; HIV co-infection; severe comorbid pathology; mental illness; Wilson – Konovalov disease. Research methods: clinical examination (analysis of patient complaints, assessment of objective status); laboratory tests (ammonia levels); assessment of the severity of liver disease according to the Child – Pugh scale; assessment of the degree of HE based on the results of psychometric tests (number connection test, animal naming test, brief mental status scale); quality of life questionnaire (SF-36). Results. In the absence of rifaximin-α therapy, there is a deterioration in the quality of life due to a decrease in indicators of the mental component of health, as well as an increase in time in performing the psychometric number connection test. Against the background of continuous and cyclic therapy with rifaximin-α in patients with cirrhosis and MHE during 6 months of observation, the level of capillary blood ammonia decreases. Conclusions. When comparing the effectiveness of continuous and course therapy with rifaximin-α, the results did not show significant differences, which indicates the equivalence of these treatment regimens after 6 months of observations.

Effect of adding individualized health education for patients with brain metastasis of lung cancer undergoing radiotherapy, as measured by MRI and cognitive testing.

To explore the clinical efficacy of individualized health education (IHE) and care mode based on magnetic resonance imaging (MRI) combined with Mini-Mental State Examination (MMSE) for lung cancer patients with brain metastases undergoing radiotherapy. This retrospective study involved 50 lung cancer patients with brain metastases. Patients were divided into a control group (n=25, conventional care) and an intervention group (n=25, individualized health education (IHE) care) according to their nursing model. Both groups underwent enhanced brain MRI scans. The patients were assessed using the Mini Mental State Scale (MMSE) before and at 1 month after radiotherapy. At the same time, Montreal Cognitive Assessment (MoCA) was used to assess the degree of cognitive impairment in both groups before and after the intervention. Finally, the European Organization for Research and Treatment of Cancer (EORTC QLQ-C30) questionnaire was used to evaluate the overall health status and quality of life (QOL) (including physical function, emotional function, and social function) of the two groups of patients after radiotherapy. The patients' self-care ability in daily life was assessed using Alzheimer's Disease Collaborative Study Activities of Daily Living (ADCS-ADL). Following intervention, there was no significant difference in MMSE total scores between the control and intervention groups (P > 0.05), or in physical function scores (P > 0.05). However, the intervention group had significantly higher overall QOL scores compared to the control group (P < 0.05), particularly in emotional and social function (P < 0.05). There was no significant difference in total MoCA scores between the two groups (P > 0.05), but the intervention group showed superior scores in visual-spatial, executive function, naming, and attention compared to the control group (all P < 0.05). Following intervention, the intervention group demonstrated better ADCS-ADL scores than the control group (P < 0.05). The IHE mode effectively improved emotional and social functions and enhanced QOL in lung cancer patients with brain metastases undergoing radiotherapy.

Jargonaphasia in logopenic variant primary progressive aphasia

BackgroundLogopenic variant primary progressive aphasia (lvPPA), which is most commonly an early onset variant of Alzheimer's disease (AD), is a progressive impairment in word retrieval and language expression. Clinicians often misdiagnose these patients when they present with severely unintelligible speech consistent with jargonaphasia. MethodsWe reviewed all patients presenting to a behavioral neurology program over a 23-year period who met criteria for lvPPA after completion of an evaluation extending to positron emission tomography (PET) of the brain. Among these lvPPA patients, we additionally identified and characterized those whose presentation involved incomprehensible yet fluent verbal output. ResultsOut of 95 patients with lvPPA, 9 (9.47%) had jargonaphasia on presentation. These patients differed from the remaining 86 patients in lacking awareness or concern for their impaired communication, having worse mental status scale scores, greater auditory comprehension difficulty, and more bilateral temporo-parietal hypometabolism. In addition, 44.4% of those with jargonaphasia, compared to 14% of those without, were bi/multilingual. ConclusionNearly 1 in 10 patients with lvPPA present with severely unintelligible speech. These patients have disease extending to bilateral temporoparietal areas affecting language comprehension and disease awareness. Jargonaphasia can be a confusing presentation of AD and must be differentiated from other progressive aphasias, Wernicke's aphasia, and the word salad of “schizoaphasia”.

Association between serum lysophosphatidylcholine level and elderly health index in older people from longevity areas of Guangxi Province

Objective: To investigate the relationship between serum lysophosphatidylcholine (LPC) level and the health index of the elderly. Methods: A total of 251 subjects were selected from the 2016 baseline survey of the Yongfu Longevity Cohort in Guangxi Province among whom 66, 63 and 122 were in the young and middle-aged group (≤59 years old), the young group (60-89 years old) and the longevity group (≥90 years old), respectively. Demographic data were collected and related indicators of height, weight, blood pressure and lipid metabolism were measured. The cognitive and physical functions of the elderly were assessed by the results of the simple mental state scale and the daily living activity scale to construct the health index of the elderly. The serum levels of LPC16∶0, LPC18∶0, LPC18∶1 and LPC18∶2 were determined by liquid chromatography-tandem mass spectrometry, and the differences among different ages and health status groups were compared. The logistic regression model was used to analyze the relationship between the serum LPC level and the health index of the elderly. Results: With the increase in age, the proportion of female subjects increased, and the rate of smoking and drinking decreased. BMI, TC, TG, LDL-C, diastolic blood pressure, and the four LPCs levels decreased with the increase of age, and systolic blood pressure levels increased with the increase of age (all P values<0.05). There was no significant difference in HDL-C levels among age groups (P>0.05). With the decline of health status in the elderly, serum levels of LPC16∶0, LPC18∶0, LPC18∶1 and LPC18∶2 showed a downward trend (all P values<0.001). After adjusting for age and gender, only LPC18∶0 was associated with the health status in old age [OR (95%CI): 0.48 (0.25-0.92)]. For every 1 standard deviation (16.87 nmol/L) increase in serum LPC18∶0 concentration, the risk of poor health status in old age decreased by 52%. Conclusion: Serum LPC18∶0 was associated with the health status in old age independent of age and sex.

High-Frequency Repetitive Magnetic Stimulation at the Sacrum Alleviates Chronic Constipation in Parkinson's Patients.

This study was to investigate the therapeutic effect of high-frequency repetitive magnetic stimulation (HF-rMS) at the sacrum for chronic constipation in Parkinson's patients (PD). Eventually 48 PD patients were enrolled from July 2019 to October 2020, and randomly divided into the HF-rMS group (the intervention group, n = 24) and the sham HF-rMS group (the control group, n = 24). The intervention group received HF-rMS at the sacrum, whereas the control group received ineffective magnetic stimulation. We performed clinical evaluation before and after HF-rMS treatment, including constipation score scale (KESS questionnaire), Unified Parkinson's Disease Rating Scale (UPDRS-III exercise examination), Hoehn-Yahr (H-Y) stage of motor function; simple mental status scale (MMSE), anxiety/depression table (HAD-A/HAD-D), the activity of daily living (ADL), and quality of life scale for patients with constipation (PAC-QOL) to evaluate symptoms and satisfaction of PD patients with chronic constipation. There was no significant difference in the clinical characteristics between the two groups. As compared to the control group, the HF-rMS group displayed a larger change (pre and posttreatment) in the KESS scores of PD patients with chronic constipation, suggesting a significant improvement. Moreover, HF-rMS significantly promoted the mood, activity of daily living, and quality of life of PD patients when comparing the alteration of HAD-A/HAD-D scores, ADL scores, and PAC-QOL scores between the two groups. Finally, there was no significant difference in the change of the UPDRS III score and the MMSE score between the two groups. HF-rMS at the sacrum can improve chronic constipation in PD patients.

Long term effects of severe acquired brain injury: A follow-up investigation on the role of cognitive reserve on cognitive outcomes

In a recent study we showed that Cognitive Reserve (CR) did not significantly predict the neuropsychological outcomes of patients with severe Acquired Brain Injury (sABI), after a rehabilitation program. The present study aims to extend the previous results by assessing the role of CR on long-term neuropsychological outcomes of a subgroup (N = 27) of that same population. Patients took part in a telephone interview, where Tele-Global Examination Mental State (Tele-GEMS) and Glasgow Outcome Scale Extended (GOS-E) were administered. A linear regression model was conducted considering Tele-GEMS and GOS-E as dependent variables, while the scores on Cognitive Reserve Index questionnaire (CRIq), Disability Rating Scale (DRS), and Level of Cognitive Functioning (LCF), administered at discharge, were considered as predictors. Results show that higher levels of CR and LCF, significantly predicted cognitive performance 4 years later. However, in the same follow-up, CR did not predict functional outcome, which was only predicted by lower disability scores at discharge. Thus, even if CR seems not showing an effect on cognitive efficiency when tested after the first rehabilitation intervention, current results show that CR has significant effects on long-term cognitive outcomes.

Correlation Between Sleep Electroencephalogram, Brain-Derived Neurotrophic Factor, AVPR1B Gene Polymorphism, and Suicidal Behavior in Patients with Depression.

The purpose of this article was to investigate the level of serum brain-derived neurotrophic factor and its relationship with suicidal symptoms and severity in mentally ill suicide attempt patients, and to explore the possible role of serum brain-derived neurotrophic factor (BDNF) in the occurrence of psychotic suicidal behavior. A retrospective analysis was performed on patients with depression in the neurology department of a hospital. General physical examination, neurological specialist examination, and cranial magnetic resonance imaging (MRI) examination were performed on any selected group. We applied the 24-item Hamilton Depression Scale, Hamilton Anxiety Scale, and Mini-Intelligence Mental State Scale, and performed polysomnography and electroencephalography (EEG) monitoring to conduct statistical analysis on sleep indicators. The amplitude of low-frequency fluctuation (ALFF) values of the right frontal gyrus, left posterior cerebellar lobe, right anterior cerebellar lobe, and right occipital lingual gyrus of the patient group were significantly lower than those of the control group. The ReHo values of the right superior parietal lobule, the left precuneus, and the right occipital lingual gyrus were significantly higher than those of the control group. The genotype and allele frequency distribution of FKBP5, AVPR1B, and CRHR2 gene SNPs had no significant difference between the case group and the control group (P > 0.05). The ReHo value of the precuneus is significantly correlated with the proportion of N3 sleep, and the dysfunction of the precuneus or default network may be related to the altered sleep structure in patients with depression. The GT and TT genotypes at rs9324924 of the NR3C1 gene are associated with suicide attempts.

POSSIBILITIES FOR CORRECTING COGNITIVE DEFICITS IN STROKE IN PEOPLE WHO HAVE HAD COVID-19

Relevance. Mnestic functions in patients after stroke and coronavirus infection are not restored completely. Nowadays, the search for ways to overcome in such patients is actual.&#x0D; Objective: to find out the possibility of cognitive deficiency’ overcoming in persons after stroke who have suffered from COVID-19 by Phenibut pharmacocorrection and magnetic therapy.&#x0D; Materials and methods. 46 patients aged 40-60 years who had COVID-19 in anamnesis and ischemic stroke in the post-covid period were divided into 3 groups at the stage of comprehensive rehabilitation. In the 1st group (n=15) - the control group - no nootropic drugs and physiotherapeutic procedures were not asdministered; in group 2 (n=15), magnet stimulation procedures were performed for 20 days (frequency of basic impulses 180-195 Hz, frequency of a group of impulses 12,5-29 Hz, average induction of magnetic fields within 100 μT); group 3 (n=16) took Phenibut (β-Phenyl-GABA) one tablet (250 mg) 3 times a day for three months.&#x0D; The study of cognitive functions was carried out with the help of a short mental state scale - MMSE, a set of tests for the study of frontal dysfunction - FAB, a test for memorizing of 10 words according to the A.R. Luria’s method and clock drawing testing All groups were tested twice: at the beginning of the study and after three months.&#x0D; The obtained data were processed statistically; an ordinal logistic regression model was applied, in particular logistic regression with a cumulative relationship.&#x0D; The results. In group 2 the result of the subtest "Voluntary attention" improved (3,8±0,3 points vs. 3,1±0,2 in the control) and the FAB test (15, 2±1,2 points vs. 11,3±0,4 in control).&#x0D; In group 3, the cognitive functions in the MMSE (26,1±0,8 points vs. 21,2±0,6 in the control) and FAB (16,3±0,6 points vs. 11,3±0,4) tests probably improved. The results of the subtests "Discretionary attention" (3,8±0,1 points vs. 3,1±0,1) and "Memory" (2,6±0,2 points vs. 2,0±0,1) improved. In the test for 10 words memorizing, the difference in indicators, compared to the control, was in each subsequent presentation: 1,0±0,05; 1,1±0,09; 1,7±0,10 words, in delayed presentation 1,75±0,05 (in all cases p&lt;0.05).&#x0D; Conclusions. The use of Phenibut and magnetic therapy in patients who have suffered a stroke after COVID-19 leads to regression of cognitive deficiency and depressive symptoms. The effect of Phenibut turned out to be better - the odds ratio, compared to the control, was 13,1.

A Cross Sectional Study on Assessment of Cognitive Impairment and Behavioural Risk Factors Among Senior Citizens Living in Old Age Homes in Chengalpattu District, Tamilnadu

Background: Ageing is an irreversible, unavoidable, universal phenomenon accompanied by gradual reduction in functional capacity of the elderly. The number of elderly populations in India is expected to triple reaching 2 billion. This study aims to estimate the prevalence of cognitive impairment and evaluate the association between various socio demographic and behavioural risk factors. Methodology: This descriptive cross-sectional study was carried among 330 senior citizens living in old age homes by using a two-stage multistage sampling method. A standardized pretested structured questionnaire containing Brief Interview for Mental Status (BIMS) scale was used. Data was analysed using SPSS (Version 22). Results: Among 330 study respondents, around 44% had mild -to- moderate cognitive impairment and 36% had severe cognitive impairment. Nearly 74.8% have their habit of regular physical activity. Among the study subjects approximately 4% of them were current smokers, 5.2% had the habit of regular alcohol consumption previously. Conclusion: Integration of NPHCE and NMHP can be beneficial in early diagnosis of mild cognitive impairment during weekly outpatient visits at PHC. Level of attention given towards Alzheimer’s disease is more when compared to screening for cognitive impairment which is an early precursor for Alzheimer’s Disease.

Efficiency of Perioperative Comfort Care and Its Impact on Postoperative Recovery of Breast Cancer Patients

Objective: Breast cancer is a common malignancy with high mortality, and proper care after breast cancer surgery contributes to better prognosis and recovery of patients. This study was designed to explore the efficiency of perioperative application of comfort care and its impact on the postoperative recovery of breast cancer patients. Methods: A total of 46 breast cancer patients treated in our hospital between April 2020 and June 2021 were recruited and assigned to a control group and an experimental group. The control group adopted conventional nursing, while the experimental group received comfort care. The nursing efficiency, nursing satisfaction, mental status scale in non-psychiatric settings (MSSNS) scores, self-rating anxiety scale (SAS) scores, self-rating depression scale (SDS) scores, quality of life index scores, incidence of adverse reactions, and postoperative recurrence were compared between the two groups. Results: Comfort care resulted in higher nursing efficiency and nursing satisfaction versus conventional nursing (P&lt;0.05). Patients receiving comfort care were associated with lower MSSNS scores, SAS scores, SDS scores, incidence of adverse reactions, and postoperative recurrence rates versus those given conventional care (P&lt;0.05). Patients in the experimental group had higher quality of life scores than those in the control group (P&lt;0.05). Conclusion: Comfort care substantially promotes the recovery of breast cancer patients and lowers the risk of relapse, with a manageable safety profile.

Effective Analysis of Multichannel Functional Electrical Stimulation plus Early Rehabilitation Training for Hemiplegic Patients after Stroke.

Purpose The research paper aims to investigate the value of multichannel functional electrical stimulation (FES) plus early rehabilitation training for hemiplegic patients after stroke attacks and assesses the impact of the combined therapy on walking capacity and daily life activities of patients. Methods Totally, 100 hemiplegic patients after stroke treated in No. 215 Hospital of Shaanxi Nuclear Industry from March 2019 to July 2020 were recruited and randomized into the control group and study group, with 50 cases in each group. The control group received early rehabilitation training, and the study group received multiple channel FES plus early rehabilitation. The rehabilitation effective rate, the Fugl–Meyer Assessment (FMA), the Berg Balance Scale (BBS), National Institutes of Health Stroke Scale (NIHSS), Barthel index (BI), the Quality of Life index (QLI), Mental Status Scale in Nonpsychiatric Settings (MSSNS), Self-rating Anxiety Scale (SAS), Self-rating depression scale (SDS), and the incidence of adverse response were evaluated. Results The study group patients had higher scores in FMA, BBS, BI, and QLI than the control group. Multiple channel FES plus early rehabilitation adopted in the study group resulted in a higher rehabilitation efficacy and a longer walking duration at 1, 2, and 4 weeks after the treatment. NIHSS score, MSSNS score, SAS score, SDS score, and incidence rate of adverse response in the study group were significantly lower compared to those of the control group. Conclusions Multichannel FES plus early rehabilitation training effectively enhances the rehabilitation of patients after stroke attacks.

Dynamic interaction nursing intervention on functional rehabilitation and self-care ability of patients after aneurysm surgery.

BACKGROUNDNursing practices based on the dynamic interaction model have been shown to be superior to generic nursing practices. However, whether this model is effective in patients recovering from intracranial aneurysm surgery is not well studied.AIMTo investigate the effect of nursing based on a dynamic interaction model on functional rehabilitation of patients after aneurysm surgery. METHODSA total of 86 cases in our hospital with intracranial aneurysm from April 2019 to April 2021, were selected and divided into the study group and the control group, with 43 patients in each group. The control group received routine nursing, and the research group received nursing intervention based on a dynamic interaction model. The daily living ability (activities of daily living, ADL), cognitive function (Simple Intelligent Mental State Scale, MMSE), quality of life (Generic Quality of Life Inventory-74, GQOL-74), self-care ability (Exercise of Self-Care Agency scale), incidence of complications, and nursing satisfaction were recorded before and after intervention.RESULTSBefore intervention, ADL (52.09 ± 6.44), MMSE (18.03 ± 4.11), and GQOL-74 (53.68 ± 4.34) scores in the study group were not significantly different from those in the control group (ADL: 50.97 ± 7.32, MMSE: 17.59 ± 3.82, GQOL-74: 55.06 ± 3.98) (P > 0.05). After intervention, ADL (86.12 ± 5.07), MMSE (26.64 ± 2.66), and GQOL-74 (83.13 ± 5.67) scores in the study group were higher than those in the control group (ADL: 79.81 ± 6.35, MMSE: 24.51 ± 3.00, and GQOL-74: 77.96 ± 6.27) (P < 0.05). Before intervention, self-concept (17.46 ± 4.44), self-care skills (25.22 ± 4.20), self-care knowledge (22.35 ± 4.74), and self-care responsibility (15.06 ± 3.29) scores in the study group was similar to those in the control group (self-concept: 16.89 ± 5.53, self-care skills: 24.59 ± 4.46, self-care knowledge: 21.80 ± 3.61, and self-care responsibility: 14.83 ± 3.11) (P > 0.05). After the intervention, self-concept (26.01 ± 3.18), self-care skills (37.68 ± 6.05), self-care knowledge (45.56 ± 5.83), and self-care responsibility (22.01 ± 3.77) scores in the study group were higher than those in the control group (self-concept: 22.97 ± 3.46, self-care skills: 33.02 ± 5.65, self-care skills knowledge: 36.81 ± 5.54, and self-care responsibility: 17.97 ± 3.56 points) (P < 0.05). The incidence of complications in the study group (4.65%) was lower than that in the control group (18.60%) (P < 0.05). Nursing satisfaction in the study group (95.35%) was higher than that in the control group (81.40%) (P < 0.05).CONCLUSIONNursing intervention based on a dynamic interaction model can improve postoperative cognitive function, daily living ability, self-care ability, quality of life, and patient satisfaction, while reducing the risk of complications.

Association of Ubiquitin C-Terminal Hydrolase-L1 (Uch-L1) serum levels with cognition and brain energy metabolism.

In recent years, many researchers have taken serum ubiquitin c-terminal hydrolase (Uch-L1) as an indicator of post-traumatic brain injury and associated it with cognitive impairment. Alzheimer's disease is characterized by cognitive impairment and energy metabolism disorders. The purpose of this study was to detect whether serum Uch-L1 is related to cognition and brain energy metabolism in healthy people, and to explore whether it can be used as an early blood marker of Alzheimer's disease. In this prospective cohort study, adult outpatients from a Grade 3A hospital were recruited. They completed the 18F-FDG-PET/CT examination in the nuclear medicine department and were screened by the Mini Mental State scale (MMSE) and the Montreal Cognitive Assessment scale (MoCA). Blood samples were collected from all outpatients to detect the concentration of serum Uch-L1, and the mean standard uptake value (SUVmean) of energy metabolism in the hippocampus during PET/CT examination was collected. A total of 37 participants, 14 participants with cognitive impairment (MMSE score < 27) and 23 controls (MMSE score 27-30) were included. There was a significant difference in the SUVmean of the hippocampus between the cognitive impairment group and the normal control group (p < 0.05). There was a significant correlation between the SUVmean of the hippocampus and the total score of MMSE in all participants [r = 0.439, 95% CI: (0.139-0.668), p = 0.007]. There were also significant correlations between serum Uch-L1 and MMSE. Based on the significant differences of demographic variables between groups, we conducted a multivariate linear regression analysis of MMSE cognitive scores based on age (X1), length of education (X2) and SUVmean of hippocampus (X3). The regression equation is as follows: Y = 25.709-0.072 X1 + 0.422 X2 + 0.232 X3. Brain cognitive ability is closely related to energy metabolism and serum Uch-L1 concentration, so serum Uch-L1 may become a blood marker for extensive screening of dementia in the future. We look forward to the introduction of a more accurate and low-cost method for detecting serum Uch-L1 concentration.

Role of Nutritional Support under Clinical Nursing Path on the Efficacy, Quality of Life, and Nutritional Status of Elderly Patients with Alzheimer's Disease.

Objective To study the effect of nutritional support under the clinical nursing path on the nursing effect, quality of life, and nutritional status of elderly patients with Alzheimer's disease. Methods 110 elderly patients with Alzheimer's disease admitted to our hospital from February 2018 to October 2019 were randomly selected and assigned at a ratio of 1 : 1 via random draw to receive either routine nursing (control group) or nutritional support under the clinical nursing path (experimental group). Outcome measures included nursing efficiency, quality of life index (QLI) score, Pittsburgh sleep quality index (PSQI) score, Mental Status Scale in Non-psychiatric Settings (MSSNS) score, social disability screening schedule (SDSS) cognitive function score, and Mini Nutritional Assessment (MNA). Results Nutritional support under the clinical nursing path was associated with significantly higher nursing efficiency and quality of life scores versus routine nursing (P < 0.05). Nutritional support under the clinical nursing path resulted in significantly lower PSQI, MSSNS, and SDSS scores, and fewer malnourished cases versus routine nursing (P < 0.05). Conclusion Nutritional support under the clinical nursing pathway can significantly improve the quality of life, cognitive function, psychological status, and nutritional status of elderly patients with Alzheimer's disease, and has high application value.

A Readmission Risk Prediction Model for Elderly Patients with Coronary Heart Disease

Objective: To analyze the independent risk factors and establish a risk prediction model by investigating the readmission of elderly patients with coronary heart disease (CHD) within 1 year after discharge. Methods: A total of 480 CHD patients, who were hospitalized in the Affiliated Hospital of Hebei University from October 2019 to December 2020, were included in this study. A general data scale, mental health status scale, the Clinical Frailty Scale, Pittsburgh Sleep Quality Index, as well as the Family Adaptability and Cohesion Evaluation Scale were used to collect data. According to the number of readmissions due to CHD within 1 year after discharge, the patients were divided into two groups: the readmission group (n = 212) and the no readmission group (n = 268). General data, laboratory examination indicators, frailty, mental health status, sleep status, as well as family intimacy and adaptability were compared between the two groups. Logistic regression was used to analyze the independent risk factors for the readmission of these patients, and R software was used to construct a line diagram model for predicting readmission of elderly patients with CHD. Results: Five factors including body mass index (OR = 1.045), low density lipoprotein (OR = 1.123), frailty (OR = 1.946), mental health (OR = 1.099), as well as family intimacy and adaptability (OR = 0.928) were included to construct the risk prediction model for the readmission of elderly patients with CHD within 1 year after discharge. The ROC curve showed that the area under the curve for predicting readmission of elderly patients with CHD was 0.816; Hosmer-Lemeshow goodness of fit test showed X2 = 1.456 and P = 0.989; the maximum Youden index corresponding to the predicted value of risk was 0.526. The results showed that the model could accurately predict the risk of readmission in elderly patients with CHD within 1 year after discharge. Conclusion: This study constructed a line diagram model based on five independent risk factors of the readmission of elderly patients with CHD: body mass index, low density lipoprotein, frailty, mental health status, as well as family intimacy and adaptability. This model has good discrimination, accuracy, and predictive efficiency, providing reference for the early prevention and intervention of readmission in elderly patients with CHD recurrence.

Effects of a combination of moxapride and fluoxetine on gastrointestinal function in patients with functional dyspepsia-associated anxiety

&#x0D; &#x0D; &#x0D; &#x0D; Purpose: To study the effects of a combination of mosapride and fluoxetine in patients with functional dyspepsia-associated anxiety, and its impact on gastrointestinal function.&#x0D; Methods: One hundred (100) cases of patients with anxiety linked to functional dyspepsia, who were admitted to the Department of Gastroenterology of Shengjing Hospital, China Medical University from January 2019 to May 2020, were retrospectively selected and randomly divided into control and study groups (n = 50). The control group patients received moxapride monotherapy, while those in the study group were given moxapride in combination with fluoxetine. The two groups of patients were compared daily for 4 days with respect to treatment effectiveness, Mental Status Scale in Non-psychiatric Settings (MSSNS), Barthel Index (BI), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), time intervals for flatulence and defecation, as well as bowel sounds, and levels of gastric juice and cholecystokinin.&#x0D; Results: Treatment effectiveness, BI index, number of intestinal rumblings, and level of gastrin in the study group were significantly higher than those in control group after 1, 2, 3 and 4 days of treatment (p &lt; 0.05). Moreover, scores for SAS, SDS and MSSNS, as well as time intervals for flatulence and defecation, and level cholecystokinin in the study group were significantly lower than those in control group (p &lt; 0.05).&#x0D; Conclusion: The combination of mosapride and fluoxetine has high application benefit for patients with anxiety associated with functional dyspepsia when compared with the control.&#x0D; &#x0D; &#x0D; &#x0D;

Clinical Effect of Laparoscopic Radical Surgery Combined with Neoadjuvant Chemotherapy in Treating Cervical Cancer and Its Influence on Postoperative Complications and Adverse Reaction Rates.

Background Cervical cancer, the only gynecological malignancy for which a clear pathogeny has been established, has an incidence rate only second to breast cancer. Objective In our study, we aim to investigate the clinical effect of laparoscopic radical surgery combined with neoadjuvant chemotherapy in treating cervical cancer and its influence on postoperative complications and adverse reaction rates. Methods Cervical cancer patients admitted to our hospital from August 2018 to May 2020 were retrospectively analyzed as the research object and divided into the control group and the experimental group by the draw method, with 50 cases in each group. The laparoscopic radical surgery was performed on the control group, and the laparoscopic radical surgery combined with neoadjuvant chemotherapy was performed on the experimental group to compare their effective rates, adverse reaction rates, postoperative complication rates, expression levels of serum tumor necrosis factor-α (TNF-α) and soluble interleukin-2 receptor (SIL-2R) inside the body before surgery and at one week after surgery, quality of life (QLI) scores, and Mental Status Scale in Nonpsychiatric Settings (MSSNS) scores. Results Compared with the control group, the experimental group obtained significantly higher effective rate and QLI scores (P < 0.05) and significantly lower adverse reaction rates, postoperative complication rates, expression levels of serum TNF-α and SIL-2R inside the body at one week after surgery, and MSSNS scores (P < 0.05), with statistical differences; before surgery, the TNF-α and SIL-2R expression levels of the two groups were not significantly different (P > 0.05), but the levels at one week after surgery were significantly lower than those before, indicating statistical significance (P < 0.05). Conclusion The clinical effect of laparoscopic radical surgery combined with neoadjuvant chemotherapy can obviously improve the effective rate of cervical cancer patients and lower the incidence rates of postoperative complications and adverse reactions.