Science organizes the recognizable targets of objects and phenomena in the testable form, and it functions to understand, define, quantify, visualize or simulate properties of the target in the syllogistic-hierarchy of framing, modeling, and explanation with sound inferences of language. Human Self maintaining the homeostasis is defined in the thinking-frame. The physical Self is the substantial model-system defined in the physical frame, and the mental Self is the recognition-behavioral model-system defined in the psychological frame. The recognition-behavioral model-system that was analyzed via the scientific procedure, was considered to perform language-metabolism with the thinking-codes of homology-/simplification, clustering, operation and modeling, which are mounted in the Modeling-layer of Neuronal Network of the brain, with economic and stubborn manner coming from the biological characteristics. Systems theory is the transdisciplinary study of systems complex-networked interrelated and interdependent components. Human Self is the meta-model-system complex-networked the functional single-model-systems. The mental Self that was re-defined corresponding to the physical/psychological model-system coming from Chinese philosophy and Chinese traditional medicine, developed to the neuro-psychological Self under the idea of Systems theory. Neuro-psycho-pharmacological effect of the anti-epileptic agents Carbamazepine, Lamotrigine and Valproate on Exceed Stimulation-amplify of patients suffering from Bipolar-disease, which was not clear until recently, was compatibly explained via the neuro-psychological Self. Finally, the emergent neuro-psycho-pharmacological explanation was considered to be induced by symbolically-figuring the neuro-psychological Self in the neuro-psychological frame.