Health-related Quality Of Life Mental Component Summary Research Articles

Combined aerobic and resistance exercise in maintenance hemodialysis patients: A meta-analysis.

Exercise brings many benefits to patients undergoing maintenance hemodialysis (MHD), but the effect of combined aerobic and resistance exercise remains unclear. English and Chinese databases (PubMed, Cochrane Library, Embase, Web of Science, CNKI, VIP, Wan Fang, and CBM) were searched from inception to January 2023 to retrieve qualified randomized controlled trials. The literature selection, data extraction, and risk of bias assessment of included studies were conducted independently by two reviewers. Meta-analysis was performed using RevMan 5.3 software. A total of 23 studies with 1214 participants were included, and 17 of the interventions were conducted during dialysis. Results showed that combined aerobic and resistance exercise (CARE) improved the peak oxygen uptake, six-minute walking test, 60 s sit-to-stand test (STS), 30 s STS, dialysis adequacy, five (out of eight) domains and physical component summary of health-related quality of life (HRQOL) measured by the Medical Outcomes Study Short Form-36, blood pressure, and hemoglobin for MHD patients compared with usual care. No significant changes were found in the mental component summary of HRQOL, C-reactive protein, creatinine, potassium, sodium, calcium, and phosphate. Subgroup analysis showed that intradialytic CARE ameliorated more outcomes, except for handgrip strength and hemoglobin, than non-intradialytic ones. CARE is an effective way to improve physical function, aerobic capacity, dialysis adequacy, and HRQOL for MHD patients. Strategies should be implemented by clinicians and policymakers to motivate patients to do more exercise. Well-designed clinical trials are warranted to explore the effectiveness of non-intradialytic CARE.

The Mediating and Moderating Effects of Physical Fitness of the Relationship between Adherence to the Mediterranean Diet and Health-Related Quality of Life in University Students.

The aim of this study was to estimate the relationship between the adherence to the Mediterranean diet (MD) and health-related quality of life (HRQoL) in university students and to assess whether this relationship is mediated or moderated by cardiorespiratory fitness (CRF) and handgrip strength. A cross-sectional study was performed involving 310 first-year Spanish university students. Adherence to the MD was evaluated with the 14-item Mediterranean Diet Adherence Screener (MEDAS), and the HRQoL was evaluated with the Short Form-12 (SF-12) questionnaire. CRF was assessed by the 20 m shuttle run test, and the handgrip strength was determined by dynamometry. ANCOVA models showed that participants with higher CRF and handgrip strength levels had significantly higher scores in the physical component summary (PCS) and mental component summary (MCS) of the SF-12 and in the MEDAS questionnaire than those with medium and low scores (p < 0.050). Additionally, the ANCOVA models showed that students with good adherence to the MD showed higher scores in the MCS of HRQoL than those with low adherence (p = 0.044, ES = 0.013), but these results did not appear for the PCS of HRQoL (p = 0.728, ES = 0.001). In the mediation analysis, it was found that CRF and handgrip strength acted as full mediators of the relationship between adherence to the MD and the MCS of HRQoL. In the moderation analysis, it was evidenced that CRF and handgrip strength did not act as moderators in the relationship between adherence to the MD and the MCS of HRQoL. In conclusion, adherence to the MD does not seem to have a direct effect on the MCS of HRQoL because this association seems to be fully mediated by CRF and handgrip strength.

Abstract 4631: Pre-diagnosis comorbidity class, health-related quality of life, and treatment selection among older women with breast cancer

Abstract Purpose of the study: The NCCN guidelines state that adjuvant radiotherapy (RT) can be omitted in older women with estrogen receptor (ER)-positive, node-negative early-stage (i.e., Tis and T1) breast cancer (ESBC). However, there is no specific algorithm to select a subgroup of women who can safely forgo RT. Older women commonly present with multiple comorbid conditions with different levels of functional limitations and health-related quality of life (HRQOL), which challenge the RT-decision process. This study aimed to understand pre-diagnosis comorbidity burdens in this patient group and to examine its relationship with HRQOL and treatment selection in a retrospective cohort study design. Methods: From the SEER-MHOS database, we included 985 older women who were diagnosed at age ≥ 70 years, with ER-positive, node-negative ESBC between 1998 and 2013. SEER provides primary treatments (surgery and radiation), and MHOS provides self-reported comorbidity, functionality, and HRQOL. We used latent class analysis (LCA) to identify clinically distinct comorbidity burden classes. The associations between the comorbidity burdens with HRQOL and treatment selection (lumpectomy only, lumpectomy + RT, mastectomy, mastectomy + RT) were examined using generalized linear models. Results: A mean age at diagnosis was 77 years, 81 % of patients were whites, and 43 % were married. A majority had stage I disease (80 %) with 20 % stage 0. About one fourth (26 %) had ≤ 1 comorbid condition, whereas 28 % had ≥ 4 comorbidities. LCA identified four distinct comorbidity burden classes; healthy (n=577, 58 %), low comorbidity with limited functionality (n=64, 7 %), moderate comorbidity with symptoms (n=247, n=25 %), and high comorbidity with highly limited functionality and symptoms (n=97, 10 %). Classes were distinguished by the presence or absence of comorbid conditions and functional limitations as well as symptoms. Comorbidity burdens were independently associated with HRQOL mental component summary (MCS-12) score (p &amp;lt; .0001) and physical component summary (PCS-12) score (p &amp;lt; .0001) but not with treatment selection (p = 0.096). In stage 0, age (p=0.025) and education level (p=0.024) were the independent predictors of treatment selection while age (p&amp;lt;.0001), education level (p=0.0013), income (p=0.044), and obesity (p=0.026) determined the treatment selection in stage I. Conclusions: Older women with ESBC can be described by four distinct comorbidity burdens that are independent predictors of HRQOL. However, it seems that the comorbidity burdens were not considered in the treatment selection process. Future studies need to address treatment outcomes (such as changes in HRQOL and survival) by comorbidity burdens to better guide treatment decisions. Citation Format: Eunkyung Lee, Jianbin Zhu, Robert Hines, Eunji Nam, Cassie Odahowski. Pre-diagnosis comorbidity class, health-related quality of life, and treatment selection among older women with breast cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4631.

Long-Term Effect of a Nonrandomized Psychosocial Mindfulness-Based Intervention in Hispanic/Latina Breast Cancer Survivors.

Background: There is a paucity of research on the long-term impact of stress-reduction in Hispanic/Latina breast cancer (BC) survivors, a growing minority. In this article, we assess the long-term efficacy of an 8-week training program in mindfulness-based stress reduction (MBSR) on quality of life (QoL) in Hispanic BC survivors. Methods: Hispanic BC survivors, within the first 5 years of diagnosis, stages I to III BC, were recruited. Participants were enrolled in bilingual, 8-week intensive group training in MBSR and were asked to practice a- home, daily. They were also provided with audio recordings and a book on mindfulness practices. Patient-reported outcomes for QoL and distress were evaluated at baseline, and every 3 months, for 24 months. Results: Thirty-three self-identified Hispanic women with BC completed the MBSR program and were followed at 24 months. Statistically significant reduction was noted for the Generalized Anxiety Disorder measure (mean change −2.39, P=0.04); and Patient Health Questionnaire (mean change −2.27, P=0.04), at 24 months, compared with baseline. Improvement was noted in the Short-Form 36 Health-related QoL Mental Component Summary with an increase of 4.07 (95% confidence interval = 0.48-7.66, P=0.03). However, there was no significant change in the Physical Component Summary. Conclusions: Hispanic BC survivors who participated in an 8-week MBSR–based survivorship program reported persistent benefits with reduced anxiety, depression, and improved mental health QoL over 24 months of follow-up. Stress reduction programs are beneficial and can be implemented as part of a comprehensive survivorship care in BC patients.

ORAL HEALTH, HEALTH-RELATED QUALITY OF LIFE, AND WORK ABILITY AMONG PATIENTS WITH CHRONIC LIVER DISEASE

Oral infections are common causes of morbidity and mortality among patients with chronic liver diseases (CLD). Objective: To evaluate health-related quality of life (HR-QoL), work ability, and oral health among patients with CLD. Study Design: Cross-sectional study with 25 patients on the transplantation waiting list (group 1) and 25 patients with CLD (group 2) attended in a university hospital in Salvador, Brazil. HR-QoL and work ability were evaluated using standardized questionnaires (36-Item Short-Form Health Survey [SF-36] and Wok Ability Index [WAI], respectively). Oral health (DMFT index and periodontal disease) was evaluated using World Health Organization protocol. Mean differences were compared using t tests for independent samples. Results: The mental component summary of HR-QoL was lower in group 1 than in group 2 when WAI was low/moderate (43.3 ± 9.1 vs 51.8 ± 7.5, respectively; P = .003) or when gingivitis occurred (42.7 ± 9.3 vs 50.4 ± 3.6; P = .001); the physical component summary of HR-QoL was lower when periodontitis occurred (35.7 ± 10.2 vs 48.8 ± 6.4; P = .003). The groups presented similar DMFT index (19.1 ± 8.3 vs 18.7 ± 7.9; P = .86). Conclusions: Compared with patients with CLD, patients with CLD on the transplant waiting list presented lower HR-QoL because of its mental component when low work ability and gingivitis occurred; periodontitis was associated with low HR-QoL because of its physical component.

Relationships between body image, sexual dysfunction, and health-related quality of life among middle-aged women: A cross-sectional study

ObjectivesTo examine whether body image, sexual function, and relationship with a partner influence health-related quality of life (HRQoL) among middle-aged women, as well as to identify the association with menopausal symptoms. Main outcome measuresPhysical component summary and mental component summary of HRQoL. MethodsThis was an analysis of 1026 women (2013–2014); data regarding demographic characteristics, sexual function, body image, relationship with partner, menopausal symptoms and HRQoL during middle age were collected. HRQoL, sexual function, body image, relationship with partner, and menopausal symptoms were measured using the Medical Outcomes Study SF-12, Female Sexual Function Index (FSFI), Multidimensional Body-Self Relations Questionnaire-Appearance Scale, the Relationship Assessment Scale, and the Greene Climacteric Scale, respectively. A multivariate regression was used to examine factors influencing HRQoL. ResultsAfter adjusting for covariates, significant factors predicting the physical component summary (PCS) of HRQoL among middle-aged women included the orgasm domain of the FSFI (β = 0.69; p = 0.023), appearance evaluation (β = 0.93; p = 0.037), and menopausal symptoms (β = −0.25; p < 0.001). The factors predicting the mental component summary (MCS) of HRQoL included the satisfaction domain of the FSFI (β = 0.70; p = 0.014), appearance evaluation (β = 2.09; p < 0.001), self-classified weight (β = 1.21; p < 0.001), relationship with partner (β = 0.16; p = 0.034), and menopausal symptoms (β = −0.36; p < 0.001). ConclusionThe results indicated that negative appearance evaluation and menopausal symptoms predicted poor HRQoL among middle-aged women. Higher frequency of orgasm predicted better PCS; sexual satisfaction and satisfaction with relationship with a partner predicted better MCS of HRQoL.

Relationship between functional capacity and health-related quality of life of patients with type—2 diabetes

AimsPhysical function is a determinant of survival in chronic diseases, however, little is known about functional capacity (FC) and self-reported health status of patients with type-2 diabetes (T2D). This study investigated the relationship between FC and health related quality of life (HRQoL) of patients with T2D. Materials and methodsThis cross-sectional survey recruited 150 patients with T2D from a Nigerian university teaching hospital using purposive sampling technique. Socio-demographic and physical characteristics were assessed. FC and HRQoL including physical and mental health component summary (PCS and MCS) were assessed using the six minute walk test (6MWT) and Short-Form (SF-12) questionnaire respectively. Maximum oxygen consumption (VO2 max) was estimated, pre and post 6MWT cardiovascular parameters and fasting blood glucose (FBG) were assessed. Data were analyzed using descriptive and inferential statistics. Alpha level was set at p<0.05. ResultsThere were 83(55.3%) women, means of age and FBG of participants were 64.2±8.7years and 7.4±2.4mmol/L respectively. The means of 6-min walk distance (6-MWD) and estimated VO2 max were 341.55±41.82m and 9.2±0.7mL/kg/min respectively. Significant differences were found between pre and post HR (t=−44.71; p=0.001), SBP (t=−38.38; p=0.001) and DBP (t=−38.58; p=0.001) following 6MWT. The means of PCS and MCS of HRQoL were 48.67±5.51 and 58.39±2.86 respectively. There were significant correlations between FC and each of PCS (r=0.678; p=0.001) and MCS (r=0.211; p=0.009). ConclusionPatients with T2D demonstrated low functional capacity and reduced HRQoL. Significant relationship exists between FC and physical and mental component summary of HRQoL. Exercise intervention to improve FC and HRQoL were recommended.

Social participation and health-related quality of life in people with multiple sclerosis

BackgroundSocial participation is an integral part of everyday life in society; however, evidence about its association with health-related quality of life (HRQoL) in people with multiple sclerosis (MS) is lacking. ObjectiveThe aim of this study is to explore whether social participation is associated with the Physical Component Summary of HRQoL (PCS) and Mental Component Summary of HRQoL (MCS) in people with MS, controlled for age, gender, disease severity and disease duration. MethodsThe sample consisted of 116 consecutive people with MS (response rate: 75.8%; 72.4% women; mean age 40.3 ± 9.8). People with MS completed the Short-Form Health Survey (SF-36) for measuring PCS and MCS and the Participation Scale, which measures the level of social participation. Disability was assessed using the Expanded Disability Status Scale (EDSS). The associations between social participation, PCS and MCS, were analyzed using linear regression that controlled for sociodemographic and clinical variables. ResultsPCS was significantly associated with age, disease duration, EDSS and social participation. MCS did not show significant association with the studied variables. Overall, a multiple regression model explained 48% of the PCS variance, while the proportion of MCS variance explained was not significant. ConclusionsSocial participation was significantly associated with PCS, suggesting a possibility for intervention in this domain.