Meningioma is a prevalent intracranial malignancy known for its aggressive growth.Circular RNAs (circRNAs) play a crucial role in the development of various cancers. However, theirinvolvement in meningioma remains understudied. This study aimed to investigate the function andunderlying mechanism of hsa_circ_0004872 in meningioma.The molecular expression of hsa_circ_0004872, PD-L1 and EIF4A3 was identified by RT-qPCRand/or western blot assays. Cell viability, migration, and invasion were assessed throughCCK-8 and Transwell assays, respectively. Cytotoxicity was determined using an LDH assay, and cellapoptosis was monitored by flow cytometry. The RNA and protein interactions were assessed throughRNA-protein immunoprecipitation (RIP) and RNA pull down analyses.Our findings revealed that hsa_circ_0004872 expression was significantly downregulated inboth meningioma tissue samples and cells. Overexpression of hsa_circ_0004872 inhibited theproliferation, metastasis, and immune escape of meningioma cells, as well as enhanced the cytotoxicityof CD8+ T cells by suppressing PD-L1. Furthermore, hsa_circ_0004872 directly interacted withEIF4A3, leading to the degradation of PD-L1 mRNA. Finally, inhibiting EIF4A3 improved theproliferation, metastasis, and immune escape of meningioma cells, as well as the cytotoxicity of CD8+T cells.Our study demonstrated that hsa_circ_0004872 mitigated the proliferation, metastasis,and immune escape of meningioma cells by targeting the EIF4A3/PD-L1 axis. These findingssuggested that hsa_circ_0004872 and EIF4A3 might serve as promising biological markers andtherapeutic targets for meningioma treatment.