Presently described is a sliding-kernel computation-in-memory (SKCIM) architecture conceptually involving two overlapping layers of functional arrays, one containing memory elements and artificial synapses for neuromorphic computation, the other is used for storing and sliding convolutional kernel matrices. A low-temperature metal-oxide thin-film transistor (TFT) technology capable of monolithically integrating single-gate TFTs, dual-gate TFTs, and memory capacitors is deployed for the construction of a physical SKCIM system. Exhibiting an 88% reduction in memory access operations compared to state-of-the-art systems, a 32 × 32 SKCIM system is applied to execute common convolution tasks. A more involved demonstration is the application of a 5-layer, SKCIM-based convolutional neural network to the classification of the modified national institute of standards and technology (MNIST) dataset of handwritten numerals, achieving an accuracy rate of over 95%.