Prospects For Media Research Articles

КОМПЛЕКСНАЯ ОЦЕНКА СОРТОВ ЛИЛЕЙНИКА ГИБРИДНОГО В УСЛОВИЯХ ЛЕСОСТЕПНОЙ ЗОНЫ БАШКИРСКОГО ПРЕДУРАЛЬЯ

A comprehensive assessment and selection of the most valuable taxa suitable for use in landscaping under certain natural and climatic conditions is one of the most important tasks of introduction studies of ornamental plants. The article presents the results of a comprehensive variety assessment, a study of the seasonal rhythm of growth and development, and morphometric characteristics of 20 hybrid daylily varieties (Hemerocallis hybrida hort.) in the South-Ural Botanical Garden-Institute of UFRC RAS. An assessment of the decorative and economically valuable qualities of daylily varieties was given on a 100-point scale, including 11 traits: color, size and shape of a flower, plant habitus, height of the flower stalk, abundance of flowering, originality, reproductive ability, duration of flowering, sustainability in unfavorable conditions, resistance to diseases and pests. As a result of our variety assessment of Hemerocallis hybrida hort., the entire studied assortment was divided into 3 groups according to the prospects for use in decorative floriculture. 8 highly promising varieties (‘Bela Lugosi’, ‘Bestseller’, ‘El Desperado’, ‘Ledgewoods Jumstar’, ‘Moon Over Monteray’, ‘Pardon Me’, ‘Red Rum’, ‘Stella de Oro’) have been identified for cultivation under conditions of Bashkortostan Republic. They are distinguished by their bright color and original flower shape, abundant and long flowering, strong peduncle, and high reproductive capacity. Nine varieties are characterized by medium prospects (‘Artic Snow’, ‘Cherry Eyed Pumpkin’, ‘Final Touch’, ‘Frans Hals’, ‘Macbeth’, ‘Mini Stella’, ‘Pandoras Box’, ‘Sea of Cortez’, ‘Tooth’); 3 − are unpromising (‘Night Embers’, ‘Prince of Lemon’, ‘Strawberry Candy’). All studied varieties can be used in various types of flower decoration under the conditions of the Bashkir Cis-Urals.

PREPARING THE ASEAN ECONOMIC COMMUNITY (MEA) WITH THE DEVELOPMENT STRATEGY OF SMALL AND MEDIUM ENTERPRISES (UMKM) TO GET BUSINESS CREDIT IN KELURAHAN CIBADUYUT BANDUNG

From the results of interviews and preliminary observations that the development of Small and Medium Enterprises is essentially a shared responsibility between the government and society. In order to support the empowerment and development of Micro, Small and Medium Enterprises, especially in encouraging the distribution of credit to Micro, Small and Medium Enterprises in Cibaduyut Urban Village, for the development of Micro, Small and Medium Enterprises in Cibaduyut Village, Bandung, the strategies included in the first Bank Partner Financial Consultants in fostering and mentoring Micro Small Enterprises and Medium prospects who apply for business loans; second, socializing profit sharing or venture capital financing; third Increasing the participation of credit guarantee institutions for Micro, Small and Medium Enterprises and prospects who are faced with collateral requirements. It is expected that with the implementation of the above strategies, Micro, Small and Medium Enterprises will no longer experience difficulties in the submission of business capital loans from Credit Distribution Agencies. From each solution above, it is building and mentoring Micro and Small and Medium Enterprises, prospects who will apply for business loans. The results of the study showed that the community in the Cibaduyut Village with the optimization of the role of the Bank Partner Financial Consultant (KKMB), the requirements and procedures established by the credit channeling institutions, were no longer an obstacle for Micro and Small Businesses in obtaining business capital loans. The success of this approach will be seen from the increasing number of bankable Micro, Small and Medium Enterprises and obtaining business capital loans, and having a Bank Partner Financial Consultant (KKMB) operating on a business (mutually beneficial) basis so that it can finance itself.

Long-term survival in advanced melanoma patients using repeated therapies: successive immunomodulation improving the odds?

BackgroundPatients with advanced metastatic melanoma are often confronted with little prospect of medium- to longer-term survival by any currently available therapeutic means. However, most clinicians are aware of exceptional cases where survival defies the notion of futility. Prolonged survival from immunotherapies, including interleukin-2, vaccines and antibodies to cytotoxic lymphocyte antigen-4, and programmed death-1 receptor inhibitory monoclonal antibody, implies a role for immune system modulation. We aimed to identify cases where exceptional survival from advanced melanoma occurred prior to recent novel therapies to facilitate better understanding of this phenomenon.MethodsCases of long-term survival of ≥3 years’ duration (from diagnosis of metastatic disease) were identified from the database of one clinician; these cases were treated before the availability of newer immunotherapies, and they were documented and examined. A literature search for reported outcome measures from published studies using older and recent therapies for advanced melanoma was conducted to enable the comparison of data.ResultsEighteen cases were identified that identified survival of ≥3 years’ duration from metastatic disease (12 American Joint Committee on Cancer [AJCC] Stage IV cases; six AJCC III cases) diagnosis. These were assessed and reported to detail the clinical course. Standard clinical prognostication methods predicted high risk of early mortality in those patients. No identifiable differences could be detected between these and other patients with similar patterns of disease. At evaluation, 17 patients (94%) had survived ≥5 years, and eleven patients (61%) had survived ≥10 years (range: 3–15 years). The median survival duration with metastatic disease was 11 years; 15 remained alive and three had died. Published studies of melanoma therapies were tabled for comparison.ConclusionThe fact that 18 cases of exceptional survival in advanced melanoma were identified is remarkable in itself. Even with recent therapies, the factors for improved survival remain enigmatic; however, one apparent common denominator in most cases was the persistent use of repeated therapies to reduce tumor bulk, induce tumor necrosis, and/or cause immunostimulation. These cases are instructive, suggesting manipulation of an established, endogenous, existing immune response. These observations provide practical evidence that the course for any patient with advanced melanoma at the outset should be considered unpredictable, open to immunomanipulation, and thus not uniformly fatal. The findings were compared and interpreted with reported newer immunotherapeutic approaches.

Leveson and the prospects for media reform

Leveson and the prospects for media reform

Progress in hybrid-silicon photonic integrated circuit technology

Progress in hybrid-silicon photonic integrated circuit technology Martijn J. R. Heck, Michael L. Davenport, and John E. Bowers Adding III-V materials to the silicon-on-insulator platform enables increasingly complex devices, making it well-positioned to address energy-efficient, compact, and low-cost photonic applications. Photonic integration is the technology that allows the combi- nation of different optical components, such as lasers, modula- tors, and photodetectors, on a single photonic chip. Such devices are known as photonic integrated circuits (PICs). The prospect of medium- and large-scale integration, with tens to hundreds of components on a single chip, is a major driver for research on silicon photonics in the silicon-on-insulator (SOI) platform. The SOI fabrication infrastructure is compatible with the mature and high-quality CMOS technology, which is robust and repro- ducible and has high yield. It is possible to make PICs in the SOI platform on large 200mm-diameter wafers, and this allows for low cost and high volumes. Since these PICs can operate at wavelengths of 1.3 and 1.55 m, prime application candidates are telecommunication and interconnects. 1 The SOI platform offers an almost complete suite of pho- tonic components, including filters, (de)multiplexers, splitters, modulators, and photodetectors. However, electrically pumped efficient sources on silicon remain a challenge due to this substance’s indirect bandgap. The integration of III-V materials, such as indium phosphide (InP), gives the SOI platform access to the complete suite of high-speed and efficient III-V-based photonic components. The hybrid-silicon complex heterogeneously incorporates III-V func- tionality on the SOI platform by means of molecular wafer bonding. 2 Hybrid-silicon III-V waveguides have the proper- ties of the III-V material, such as gain, high-speed modulation, and photodetection, but are still located on an SOI circuit (see Figure 1). We can use tapered-mode converters to change a hy- brid mode into a mode that resides fully in the silicon wave- guide. We can also fabricate the active III-V components with Figure 1. Diagram showing a hybrid-silicon III-V optical amplifier in- tegrated with a silicon waveguide (bottom) and the hybrid waveguide cross section (top). Tapered-mode converters form the interface between the silicon and hybrid waveguide. The optical mode (white) overlaps with both the silicon waveguide and the III-V quantum wells (red). The top p-contact and the lateral n-contacts (yellow) provide electrical current. The device achieves current confinement by ion implanting the p-mesa (dashed). SOI: Silicon on insulator. lithographic precision and alignment accuracy, thereby enabling large-scale integration. This is done in a back-end process af- ter the SOI fabrication, which means we avoid contamination of a CMOS foundry and that the III-V manufacturing is in prin- ciple fully compatible with the SOI-CMOS fabrication proce- dure. The hybrid-silicon platform combines the maturity and scale of CMOS processing and SOI photonics with essential III-V functionality and, as such, is unique and well-positioned for medium-scale photonic integration. The timeline of Figure 2 shows the success of the hybrid- silicon technology, which we developed in collaboration with Continued on next page