Delivery Medium Research Articles

Physical Therapist Perspectives on the Use of Telehealth with First Nations Peoples in Canada: A Qualitative Study.

This study aims to explore physical therapists' perspectives on providing physical therapy to First Nations peoples in Canada via telehealth, specifically to understand 1) their perspectives on the feasibility of telehealth as a medium for health care delivery and 2) their experiences building trusting therapeutic relationships via telehealth care. This study included 13 physical therapists who provided clinical care via telehealth for First Nations individuals in northern British Columbia in the past 3years, and 7 master of physical therapy students undergoing or who completed their Indigenous Health clinical placement in the past 3years and utilized telehealth. In-depth semi-structured interviews were conducted. Interview questions explored: telehealth usage and acceptance, experiences with telehealth, and overall recommendations for telehealth. Audio recordings were transcribed, and reflexive thematic analysis was conducted. Three overarching themes were identified: "Telehealth can make a huge difference, but it is widely underutilized;" "Telehealth is a little bit less personal and in-depth;" and "There is a time and place for telehealth." Telehealth shows promise in the delivery of physical therapist services to First Nations communities in Canada, enhancing accessibility, offering flexible scheduling options, and optimizing therapist time efficiency. However, successful implementation in these communities is contingent upon addressing several challenges, including building trusting therapeutic relationships. Technological glitches, the absence of physical interaction, and a history of trauma may hinder the development of the therapeutic relationship in telehealth encounters. To mitigate these challenges, cultural safety training, initial in-person appointments, community familiarity, and in-person support from a caregiver or other health care provider may play pivotal roles. This study not only sheds light on the underutilization of telehealth but also underscores its potential to significantly improve the accessibility and efficiency of physical therapist services to First Nations peoples in Canada. The findings emphasize the nuanced dynamics of therapeutic relationships in telehealth, offering critical insights for the integration of culturally sensitive practices. Addressing the challenges pinpointed can enhance the quality of telehealth care for First Nations individuals, promote more equitable healthcare delivery, and foster positive health outcomes.

Innovative applications of oligopeptides in drug delivery systems: Strategies, progress and challenges

Abstract. Targeted drug delivery systems play an important role in new drug development. Oligopeptides, as an excellent drug delivery medium, have great biocompatibility, targeting ability, and functionalized modifications. Therefore, oligopeptides have shown great potential for application in diverse pathological conditions such as cancer, inflammatory diseases, and cardiovascular diseases, and have begun to be used in clinical therapy. This review provides a comprehensive overview of the development and applications of oligopeptide drug delivery systems and analyzes the excellent properties of oligopeptides as well as the challenges. Further research is needed to optimize the biocompatibility of oligopeptides, improve their targeting and solubility, as well as explore other new application areas.

Assessing the Feasibility and Acceptability of Virtual Reality for Remote Group-Mediated Physical Activity in Older Adults: Pilot Randomized Controlled Trial.

Physical inactivity represents a major health concern for older adults. Most social, at-home physical activity (PA) interventions use videoconference, email, or telephone communication for program delivery. However, evidence suggests that these platforms may hinder the social connection experienced by users. Recent advancements in virtual reality (VR) suggest that it may be a rich platform for social, at-home interventions because it offers legitimate options for intervention delivery and PA. This pilot study aims to determine the feasibility and acceptability of VR compared to videoconference as a medium for remote group-mediated behavioral intervention for older adults. The information generated from this investigation will inform the use of VR as a medium for intervention delivery. Nine low-active older adults (mean age 66.8, SD 4.8 y) were randomized to a 4-week home-based, group-mediated PA intervention delivered via VR or videoconference. Feasibility (ie, the total number of sessions attended and the number of VR accesses outside of scheduled meetings) and acceptability (ie, the number of participants reporting high levels of nausea, program evaluations using Likert-style prompts with responses ranging from -5=very difficult or disconnected to 5=very easy or connected, and participant feedback on immersion and social connection) are illustrated via descriptive statistics and quotes from open-ended responses. None of the participants experienced severe VR-related sickness before randomization, with a low average sickness rating of 1.6 (SD 1.6) out of 27 points. Attendance rates for group meetings were 98% (59/60) and 96% (46/48) for the VR and videoconference groups, respectively. Outside of scheduled meeting times, participants reported a median of 5.5 (IQR 5.3-5.8, range 0-27) VR accesses throughout the entire intervention. Program evaluations suggested that participants felt personally connected to their peers (VR group: median 3.0, IQR 2.5-3.5; videoconference group: median 3.0, IQR 2.7-3.3), found that goals were easy to accomplish (VR group: median 3.0, IQR 2.8-3.3; videoconference group: median 3.0, IQR 2.6-3.4), and had ease in finding PA options (VR group: median 4.0, IQR 3.5-4.3; videoconference group: median 2.0, IQR 1.6-2.4) and engaging in meaningful dialogue with peers (VR group: median 4.0, IQR 4.0-4.0; videoconference group: median 3.5, IQR 3.3-3.8). Open-ended responses regarding VR use indicated increased immersion experiences and intrinsic motivation for PA. These findings suggest that VR may be a useful medium for social PA programming in older adults, given it was found to be feasible and acceptable in this sample. Importantly, all participants indicated low levels of VR-related sickness before randomization, and both groups demonstrated very high attendance at meetings with their groups and behavioral coaches, which is promising for using VR and videoconference in future interventions. Modifications for future iterations of similar interventions are provided. Further work using larger samples and longer follow-up durations is needed. ClinicalTrials.gov NCT04756245; https://www.clinicaltrials.gov/study/NCT04756245.

Enhanced emulsification properties of microalgae protein through gellan gum conjugation: Mechanistic insights and applications in curcumin encapsulation and delivery

The emulsification properties of microalgae protein (MP) are poor, especially under acidic and neutral conditions, which may limit the broad applications of MP in food processing. This study aims to explore the effects of gellan gum (GG) on the emulsification properties of MP. Firstly, MP-GG complexes were prepared and their structures characterized. Subsequently, MP-GG complexes stabilized emulsions were prepared and their stability evaluated. Finally, these emulsions were employed for the encapsulation and delivery of curcumin to evaluate their potential as an efficient nutrient delivery medium. Results indicated that MP-GG complexes were formed under various pH conditions, with pH 6 identified as optimal for complexes stability (zeta-potential value was −31 mV). UV–vis and fluorescence spectroscopy demonstrated that GG did not significantly alter the MP's structure but induced slight conformational changes, leading to the burial of some amino acid residues. Zeta potential measurements confirmed that MP-GG complexes were stabilized by strong electrostatic repulsions. The increase of GG content was conducive to providing more negative charge and promoting the dissolution and dispersion of the MP-GG complexes (MP: GG = 1: 1). Emulsions stabilized by MP-GG complexes exhibited smaller droplet sizes and improved stability compared to those stabilized by MP alone, especially at oil phase volume fractions of 60 % and 70 %. Rheological analysis indicated that GG enhanced emulsion stability by increasing viscosity, and higher oil phase volume fractions facilitated better MP-GG complexes adsorption on oil droplets, strengthening network structures of emulsions. During in vitro simulated gastrointestinal digestion, emulsions with a 70 % oil phase exhibited higher curcumin retention rate (31.09 %) and lower curcumin bioaccessibility (13.23 %) compared to those with a 60 % oil phase. This suggests that emulsions with higher oil phase volume fractions may be more suitable for colon-targeted curcumin delivery, with potential applications in promoting colon health. These findings confirm that the complexation of MP and GG was an effective way to improve the emulsification properties of MP. Emulsions stabilized by MP-GG complexes can serve as stable nutritional delivery systems for fat-soluble bioactive compounds.

Medical Students’ Satisfaction with References Services in Afe Babalola University, Ado Ekiti

The study was conducted on the medical students’ satisfaction with references services in Afe Babalola University, Ado Ekiti, Nigeria, while the data collected for the study were analyzed using frequency tables and percentage. Observation was used to determine the types of reference services and it was found that five (5) out of seven (7) reference services are provided in the library. these include CAS, user educator, Reprographic services, select dissemination of information, computerized reference sources and it was discovered that purpose of using reference section is that it enhancing the use of the resources and services of the library, it save precious time of the readers, supporting research and learning, leisure and recreation and it helps readers in locating the sources of information relevant to their needs, the study further discovered that referral services, Selective Dissemination of Information (SDI) Current awareness services, and Photocopying services that are used on a daily basis while it also discovered that inability of reference librarians to utilize new technologies to provide reference services, lack of policy implementation, lack of policy implementation, inadequate qualified staff and poor internet connectivity were the major problems affecting the provision of reference services. In conclusion the study made some recommendations which include that: management of the libraries should look toward the implementation of other medium of reference service delivery which has not been implemented in their libraries and there should be constant training and retraining of library personnel in the reference section to upskill and learn the new method of reference service delivery; and Library policies must be updated regularly.

Effective prediction of drug transport in a partially liquefied vitreous humor: Physics-informed neural network modeling for irregular liquefaction geometry

As the medium for intravitreal drug delivery, the vitreous body can significantly influence drug delivery because of various possible liquefaction geometries. This work innovatively proposes a varying-porosity approach that is capable of solving the pressure and velocity fields in the heterogeneous vitreous with randomly-shaped liquefaction geometry, validated with a finite difference model. Doing so enables patient-specific treatment for intravitreal drug delivery and can significantly improve treatment efficacy. A physics-informed neural network (PINN) model is also established for the simulation, and three cases are used for validation. Despite limited information, the PINN model, together with the varying-porosity approach, captured fluid and drug transport in the partially liquefied vitreous. This opens the possibility for optimizing intravitreal drug delivery based on ultrasonography in clinical practice.

Physical properties of isolated cellulose fiber from jute and banana fiber through kraft pulping: Potential applications in packaging and regenerated fibers

AbstractCellulose, a naturally abundant biopolymer, holds great potential as a sustainable alternative to synthetic fibers. However, the limited understanding and awareness surrounding cellulose utilization, particularly from agricultural origins, have impeded the complete harnessing of this highly biodegradable resource. This study aimed to extract and characterize cellulose from jute and banana fibers. The extracted cellulose exhibits a light yellow to white color, and microscopic analysis of the fibers showed micro‐fibrils. X‐ray diffraction (XRD) characterization indicated that the extracted cellulose from biomass primarily consists of cellulose II structures, except for the treated banana fiber (M:L = 1:8), which contains both cellulose I and II. Moreover, increasing the M:L ratio of alkali treatment enhanced the percentage of cellulose‐II, as observed from the XRD data. The findings of this study carry significant implications for the efficient production of cellulose fibers, with diverse applications spanning from high‐volume products like regenerated fibers, automotive parts, packaging, absorbent products (diapers), textiles, and precast concrete, drug delivery mediums, electronics, additive manufacturing, bone and tissue scaffolding, and so on. This research opens the door to harnessing the potential of cellulose derived from jute and banana fibers in various industries.Highlights Extraction cellulose using the kraft process. Isolated cellulose shows a micron‐sized structure. Optimal extraction achieved with M:L ratio of 1:4. Applications of isolated cellulose: regenerated fibers, packaging, absorbent products (diapers), textiles, and so on.

The Transformation of Senkatana

The research question in this article is to trace how the legend of Senkatana was transformed first into a drama and then into a tragedy. The methodology that is applied is to compare the salient features of the legend, the drama, and then the tragedy. An overarching finding is that the playwright developed a number of transformational processes in order to transform the essence of the plot, the number and line-up of characters as well as the drama’s structure. A second overarching finding concerns the medium of delivery where an originally orally narrated legend is transformed into a drama text written for performance on a stage before an audience. The third finding applies to the transformation of the character of Senkatana. This happens on a transcendental level when the legendary hero and king dies and becomes a deity after death—an instance of transformation that leads to transfiguration. A concluding finding is that several contemporary contextual readings of Mofokeng’s classic are possible.

Perspectives of people with spinal cord injury on a pain education resource.

Spinal cord injury (SCI) often leads to neuropathic pain that negatively affects quality of life. Several qualitative research studies in individuals with SCI who experience neuropathic pain indicate the lack of adequate information about pain. We previously developed an educational resource, the SeePain, based on scientific literature and a series of qualitative interviews of people with SCI, their significant others/family members, and SCI healthcare providers. However, to quantitatively evaluate the utility of this educational resource in a larger sample, we examined the agreement and usefulness ratings of statements regarding clarity/comprehensibility, content, and format of the SeePain, derived from the thematic analysis of our previous qualitative interviews. Participants completed a survey that provided a digital version of the SeePain and then rated their agreement/usefulness with the statements using numerical rating scales. There were overall high perceived agreement and usefulness ratings regarding the SeePain's clarity, content, and format. A factor analysis reduced the agreement and usefulness ratings into 4 components (content, clarity, format, and delivery medium). Group comparisons showed that individuals with higher education were more likely to endorse electronic and website formats, and the usefulness of a shorter version of the SeePain; females and younger individuals showed greater endorsement for clarity. Finally, higher pain intensity ratings were associated with greater agreement and usefulness of the content of the SeePain. Overall, these results support the utility of the SeePain as a source of information regarding pain that may facilitate communication about pain and its management following SCI.

What makes energy consumption behavior visible? Conceptualization, scale development and validation of customized information feedback

Customized information feedback (CIF) can significantly mitigate carbon emissions by stimulating changes in energy consumption behaviors among businesses and residents. However, the lack of conceptual clarity and standardized has hindered research into its mechanisms and impact on energy consumption. This study aims to bridge this crucial research gap by developing and validating a CIF scale and dimensional structure. In study 1, grounded theory methodology is utilized to define and identify the five dimensions of CIF: content presentation, time granularity setting, delivery medium selection, translation internalization, and environment creation. Study 2 then develops a dependable and validated 20-item CIF scale, subsequently affirmed for applicability and the nomological network in Study 3. Overall, our findings establish a fundamental measurement scale for quantitative studies of CIF, while also developing a theoretical framework for designing field experiments and interventions. Furthermore, this study contributes to the advancement of the existing literature on environmental behavior.

Precision Atomistic Structures of Actinium-/Radium-/Barium-Doped Lanthanide Nanoconstructs for Radiotherapeutic Applications.

Lanthanide vanadate (LnVO4) nanoconstructs have generated considerable interest in radiotherapeutic applications as a medium for nanoscale-targeted drug delivery. For cancer treatment, LnVO4 nanoconstructs have shown promise in encapsulating and retaining radionuclides that emit alpha-particles. In this work, we examined the structure formation of LnVO4 nanoconstructs doped with actinium (Ac) and radium (Ra), both experimentally and using large-scale atomistic molecular dynamics simulations. LnVO4 nanoconstructs were synthesized via a precipitation method in aqueous media. The reaction conditions and elemental compositions were varied to control the structure, fluorescence properties, and size distribution of the LnVO4 nanoconstructs. LnVO4 nanoconstructs were characterized by X-ray diffraction, Raman spectroscopy, and fluorescence spectroscopy. Molecular dynamics simulations were performed to obtain a fundamental understanding of the structure-property relationship between radionuclides and LnVO4 nanoconstructs at the atomic length scale. Molecular dynamics simulations with well-established force field (FF) parameters show that Ra atoms tend to distribute across the nanoconstructs' surface in a broader coordination shell, while the Ac atoms are arranged inside a smaller coordination shell within the nanocluster. The Ba atoms prefer to self-assemble around the surface. These theoretical/simulation predictions of the atomistic structures and an understanding of the relationship between radionuclides and LnVO4 nanoconstructs at the atomic scale are important because they provide design principles for the future development of nanoconstructs for targeted radionuclide delivery.

Progresses and perspectives on natural polysaccharide based hydrogels for repair of infarcted myocardium

Myocardial infarction (MI) is serious health threat and impairs the quality of life. It is a major causative factor of morbidity and mortality. MI leads to the necrosis of cardio-myocytes, cardiac remodelling and dysfunction, eventually leading to heart failure. The limitations of conventional therapeutic and surgical interventions and lack of heart donors have necessitated the evolution of alternate treatment approaches for MI. Polysaccharide hydrogel based repair of infarcted myocardium have surfaced as viable option for MI treatment. Polysaccharide hydrogels may be injectable hydrogels or cardiac patches. Injectable hydrogels can in situ deliver cells and bio-actives, facilitating in situ cardiac regeneration and repair. Polysaccharide hydrogel cardiac patches reduce cardiac wall stress, and inhibit ventricular expansion and promote angiogenesis. Herein, we discuss about MI pathophysiology and myocardial microenvironment and how polysaccharide hydrogels are designed to mimic and support the microenvironment for cardiac repair. We also put forward the versatility of the different polysaccharide hydrogels in mimicking diverse cardiac properties, and acting as a medium for delivery of cells, and therapeutics for promoting angiogenesis and cardiac repair. The objectives of this review is to summarize the factors leading to MI and to put forward how polysaccharide based hydrogels promote cardiac repair. This review is written to enable researchers understand the factors promoting MI so that they can undertake and design novel hydrogels for cardiac regeneration.

Development of pectin-based gel electrolyte for wireless electrochemical determination of cadmium and lead using smartphone

A portable device offering effortlessness, mobility, and affordability for real-time and on-site monitoring of heavy metals is currently in great demand to maintain environmental sustainability. Herein, a platform utilizing a biopolymeric gel-based electrolyte for the on-field simultaneous determination of Cd(II) and Pb(II) is described. Pectin, a natural polymer, was exploited as a chemical delivery medium on account of its biodegradability, environmental friendliness, and rapid dissolving characteristics. The gel electrolyte was prepared by having pectin dissolved in KCl mixed with Sb(III)–Bi(III) bimetallic alloy solution, and casted onto a paper substrate. An in situ bimetallic alloy and pre-mixed bismuth nanoparticles modified screen-printed graphene electrode (Sb–Bi/BiNP/SPGE) were employed to enhance the electrochemical signals of Cd(II) and Pb(II) for the differential pulse anodic stripping voltammetry (DPASV). It was demonstrated that the platform was capable of generating sharp and well-defined current signals, achieving the low detection limits of 50.98 ng mL−1 for Cd(II) and 40.80 ng mL−1 for Pb(II). The reproducibility, as indicated by the relative standard deviation, was found to be less than 10.4 % (n = 10) for the developed gel-based device when coupled with a wireless near field communication (NFC) potentiostat. Lastly, the obtained sensor was applied for quantification of Cd and Pb in potentially contaminated groundwater samples. The recoveries obtained were satisfactorily within the acceptable range. The newly designed platform exhibited several advantages, including small sample volume (μL), low-cost, no sample preparation requirements, and being environmentally friendly. The convenience of a portable device utilizing the proposed biopolymeric gel-based electrolyte for on-field analysis makes it highly appealing for various applications.

إشعارات الهاتف المحمول كوسيط للمعلومات: دراسة إثنوجرافية للسلوك الإنساني للتفاعل مع المعلومات عبر الهاتف المحمول لدى طلاب التعليم العالي المصريين والألمان

This study explores the impact of mobile notifications on the information behavior and interaction attitudes of higher education students in Egypt and Germany. Using an ethnographic approach, the research investigates how mobile notifications serve as a crucial medium for information delivery, transforming user interaction with information. The study identifies significant challenges posed by the influx of notifications, such as information overload, distraction, and stress. It also examines the skills and strategies students employ to manage and prioritize notifications, emphasizing the need for improved mobile information literacy (MoIL). Interviews and observations reveal varied user engagement with notifications, highlighting the dual role of notifications as both end-point information containers and triggers for deeper information-seeking behavior. The findings suggest that while notifications enhance efficiency and immediacy in accessing information, they also necessitate new coping mechanisms to mitigate negative impacts. This research contributes to the field of information behavior by offering insights into the effective use of mobile notifications and proposing better notification system designs to foster enhanced information literacy in an increasingly connected world.

In vitro evaluation of intersubject variability in pediatric intranasal drug delivery using nasal spray suspension products

Evaluation of the regional intranasal delivery of locally acting drugs in children is challenging. Anatomical nasal airway replicas potentially can provide a robust pre-clinical tool to test the performance of devices and formulations. However, there is often a challenge in identifying the nasal geometries that can reasonably be indicative of in vivo regional mass distribution of administered drug. This in vitro study was designed to investigate the regional intranasal drug delivery in 20 children, 2–11 years old (50% 2–6 years old and 50% female), using two commercially available suspension nasal spray products with different nozzle designs, plume characteristics, and active pharmaceutical ingredients. High-resolution computed tomography scans of the sinonasal region of pediatric human subjects with healthy nasal airways, reviewed and scored by a head and neck surgeon, were used to develop 20 three-dimensional (3D) replicas of the nasal airways. The 3D replicas were segmented into the two regions: anterior and posterior to the internal nasal valve (INV). They were then rapid prototyped in high clarity rigid plastic (Accura ClearVue). Each side of the septum of the 20 subjects was examined separately, resulting in 40 singular nasal cavities. A nozzle-specific spray tip holder was designed for each case to ensure consistent administration (insertion length, sagittal angle, and coronal angle) in all replicates. The wide range of posterior drug delivery observed in the forty geometries indicated significant intersubject variability in pediatric intranasal drug delivery. Three nasal geometries representing low, medium, and high levels of drug delivery to the target region, posterior to the INV, were chosen from the 40 nasal cavities. Our vision is that these three nasal geometries can potentially be beneficial in determining whether performance differences between test and reference nasal spray products are present that may affect their bioequivalence in children. They also may be useful when applied in parallel with similar adult nasal geometries, previously developed following a similar procedure, to provide additional insights into pediatric nasal drug delivery with innovator products in children in lieu of extending clinical studies to include pediatric subjects.

Mobile notifications as an information medium: an ethnographic study of mobile human-information interaction attitudes of Egyptian and German higher education students

This study explores the impact of mobile notifications on the information behavior and interaction attitudes of higher education students in Egypt and Germany. Using an ethnographic approach, the research investigates how mobile notifications serve as a crucial medium for information delivery, transforming user interaction with information. The study identifies significant challenges posed by the influx of notifications, such as information overload, distraction, and stress. It also examines the skills and strategies students employ to manage and prioritize notifications, emphasizing the need for improved mobile information literacy (MoIL). Interviews and observations reveal varied user engagement with notifications, highlighting the dual role of notifications as both end-point information containers and triggers for deeper information-seeking behavior. The findings suggest that while notifications enhance efficiency and immediacy in accessing information, they also necessitate new coping mechanisms to mitigate negative impacts. This research contributes to the field of information behavior by offering insights into the effective use of mobile notifications and proposing better notification system designs to foster enhanced information literacy in an increasingly connected world.

Successes and lessons learned from a mobile health behavior intervention to reduce pain and improve health in older adults with obesity and chronic pain: a qualitative study.

Chronic pain is a prevalent issue among older adults in the United States that impairs quality of life. Physical activity has emerged as a cost-effective and non-pharmacological treatment for chronic pain, offering benefits such as improved physical functioning, weight loss, and enhanced mood. However, promoting physical activity in older individuals with chronic pain is challenging, given the cyclical relationship between pain and sedentary behavior. The Mobile Intervention to Reduce Pain and Improve Health (MORPH) trial was designed as an innovative, mobile health (mHealth) supported intervention to address this issue by targeting daylong movement, weight loss, and mindfulness to manage pain in older adults with chronic multisite pain. The objective of this paper is to provide the result of a qualitative analysis conducted on post-intervention interviews with MORPH participants. At the conclusion of the MORPH study, 14 participants were interviewed regarding their experience with the program. All interviews were conducted by phone before being transcribed and verified. A codebook of significant takeaways was created based on these accounts. Summaries were further synthesized into themes using the principles of thematic analysis. Three key themes of the MORPH intervention emerged from the qualitative interviews: MORPH technology (smart scales, Fitbit, MORPH Companion App) facilitated program adherence and accountability; MORPH intervention components (food tracking and mindfulness activities) facilitated program adherence and awareness, respectively; and, group meetings provided motivational support and accountability. Mobile health technologies, including a dedicated MORPH app, facilitated self-monitoring strategies, helped to break the cycle of old habits, and provided participants with immediate feedback on successes; however, technical issues required timely support to maintain engagement. Food tracking contributed to adherence and accountability for weight loss. Mindfulness activities increased participants' awareness of anxiety provoking thoughts and pain triggers. Finally, social support via group meetings and connection, played a crucial role in behavior change, but participants noted consistency in the delivery medium was essential to fostering genuine connections. Overall, the study results highlight the key considerations related to program technology, intervention components, and the value of social support that can help to guide the development of future interventions similar to MORPH.

Addressing rural and non-rural substance use disorder stigma: Evidence from a national randomized controlled trial

BackgroundIndividuals with substance use disorder (SUD) and recovery support services often face significant social stigma, especially in rural areas. One method of addressing stigma is through education and personal recovery stories. It is unclear if such messages will work similarly across rural and non-rural areas. MethodsWe conduct an exploratory analysis of data from a national randomized controlled trial (N = 2,721) to determine if there are differences in the effectiveness of messages at reducing stigma across rurality. Specifically, we test four interventions to reduce stigma: education about the effectiveness of recovery housing and three versions of a personal recovery story that varied social distance and delivery medium (identified written story, anonymous written story, and video). ResultsWe find that messages may not have the same effect across rurality, with non-rural participants in the identified and anonymous written recovery story groups having lower stigma scores and only rural participants exposed to the anonymous written story having lower stigma scores compared to their counterparts in the control group. Further, non-rural participants exposed to both written story treatments had higher positive feelings towards those in recovery compared to the control group, but only rural participants in the anonymous written story group had higher positive feelings compared to the control group. ConclusionOur results suggest that messages may have different effects on stigma across rurality and that rural participants’ beliefs may be particularly hard to change. Future research should examine what types of stigma reduction interventions are most effective in rural areas.

Ultra-stable nano-micro bubbles in a biocompatible medium for safe delivery of anti-cancer drugs

We conducted a series of experimental investigations to generate laser-stimulated millimeter bubbles (MBs) around silver nanoparticles (AgNPs) and thoroughly examined the mechanism of bubble formation within this nanocomposite system. One crucial aspect we explored was the lifetime and kinetics of these bubbles, given that bubbles generated by plasmonic nanoparticles are known to be transient with short durations. Surprisingly, our findings revealed that the achieved lifetime of these MBs extended beyond seven days. This impressive longevity far surpasses what has been reported in the existing literature. Further analysis of the experimental data uncovered a significant correlation between bubble volume and its lifetime. Smaller bubbles demonstrated longer lifetimes compared to larger ones, which provided valuable insights for future applications. The experimental results not only confirmed the validity of our model and simulations but also highlighted essential characteristics, including extended lifetime, matching absorption coefficients, adherence to physical boundary conditions, and agreement with simulated system parameters. Notably, we generated these MBs around functionalized AgNPs in a biocompatible nanocomposite medium by utilizing low-power light excitation. By readily binding potent cancer drugs to AgNPs through simple physical mixing, these medications can be securely encapsulated within bubbles and precisely guided to targeted locations within the human body. This capability to deliver drugs directly to the tumor site, while minimizing contact with healthy tissues, can lead to improved treatment outcomes and reduced side effects, significantly enhancing the quality of life for cancer patients.

Home-based self-management multimodal cancer interventions & cardiotoxicity: a scoping review

BackgroundDue to advancements in methods of cancer treatment, the population of people living with and beyond cancer is dramatically growing. The number of cancer survivors developing cardiovascular diseases and heart failure is also rising, due in part to the cardiotoxic nature of many cancer treatments. Guidelines are being increasingly released, emphasising the need for interdisciplinary action to address this gap in survivorship care. However, the extent to which interventions exist, incorporating the recommendations of cardio-oncology research, remains undetermined.ObjectiveThe aim of this scoping review is to assess the nature, extent and remit of existing cancer care interventions and their integration of cardio-oncology principles.MethodsThe review was conducted in accordance with the PRISMA Extension for Scoping Reviews Guidelines. Databases were independently searched for articles from 2010 to 2022, by two members of the research team. Data were charted and synthesised using the following criteria: (a) the focus of the intervention (b) the medium of delivery (c) the duration (d) the modalities included in the interventions (e) the research articles associated with each intervention (f) the type of studies conducted (g) key measures used (h) outcomes reported.ResultsInterventions encompassed six key modalities: Psychological Support, Physical Activity, Nutrition, Patient Education, Lifestyle and Caregiver Support. The focus, medium of delivery and duration of interventions varied significantly. While a considerable number of study protocols and pilot studies exist documenting HSMIs, only 25% appear to have progressed beyond this stage of development. Of those that have, the present review did not identify any ‘feasible’ interventions that covered each of the six modalities, while being generalisable to all cancer survivors and incorporating the recommendations from cardio-oncology research.ConclusionDespite the substantial volume of research and evidence from the field of cardio-oncology, the findings of this scoping review suggest that the recommendations from guidelines have yet to be successfully translated from theory to practice. There is an opportunity, if not necessity, for cardiac rehabilitation to expand to meet the needs of those living with and beyond cancer.