Introduction: The mediopatellar plica are folds in the synovium that represent the embryological remnant in the development of the synovial cavity of the knee. Our study aim to investigate the damage to the mediopatellar plica using the Sakakibara classification and cartilage lesions using the Outerbridge classification based on the arthroscopy findings of the knee. Methods: A multi-center retrospective cross-sectional analytical study was conducted on patients at Wahidin Sudirohusodo Hospital and network teaching hospitals in Makassar, South Sulawesi Indonesia, the study was conducted in January – March 2021. The results of assessment the damage to mediopatellar plica using the Sakakibara classification and Cartilage lesions use the outer bridge classification. After that, data was processed to analyze the correlation between damage to the mediopatellar plica and cartilage lesions as well as related variables. Results: In the early study, 119 patients were included, where the final follow-up was obtained for 91 patients (76.5%). The existence of a positive correlation between damage to the mediopatellar plica based on the Sakakibara Classification and cartilage lesions based on the Outerbridge Classification, where the greater the damage to the mediopatellar plica based on the Sakakibara Classification, the higher the cartilage lesions based on the Outerbridge Classification. Conclusions: There is a relationship between the characteristics of the sample and plica damage based on the Sakakibara classification, meanwhile, the plica damage based on the Sakakibara classification shows the opposite result. There is a corelation between plica damage based on the Sakakibara classification and Cartilage lesions based on the Outerbridge classification.