Perspective Of Medicine Research Articles

應該不只有一種公共健康倫理

LANGUAGE NOTE | Document text in Chinese; abstract also in English. Professor Cong Yali’s paper precisely describes the central contradiction in contemporary public health ethics, which is related to the difference between individual liberalism and communitarianism. However, it fails to critique the root cause of this contradiction—the modernity that is the basis of public health’s construction. From the perspective of traditional Chinese medicine and philosophy, it is possible to develop a cognitive approach to human public health that is entirely distinct from modernity, thereby providing a more robust justification for the ‘publicness’ of public health ethics.

Exploring the Medicinal Benefits of Filfil Darāz (Piper longum L.): Insights from Unani Medicine and Modern Perspectives

Backround: Filfil Darāz (Piper longum L.) is an important medicinal plant belonging to the Piperaceae family, is therapeutically used in many traditional systems of medicine, such as Unani, Ayurveda, Siddha, etc. Purpose of Review: This review's primary goal is to investigate data on Piper longum botanical description, Pharmacognostic characteristics, phytochemicals, and therapeutic uses. This information will ultimately help Unani and other scientists plan various studies for additional research on this significant medicinal plant. Materials and Methods: This systemic review was done through an extensive literature survey of Unani classical and other ethnobotanical literature and published research work available on various search engines viz., Science Direct, PubMed, Google Scholar, etc. Result: Piper longum L. is the accepted botanical name of Filfil Darāz, long pepper, Pīplamūl as referred in Unani and other traditional medicines. It is grown in Nepal, India, Indonesia, Malaysia, Sri Lanka, Bhutan, Philippines. In India, the plant is found in the lower hills of West Bengal, the Khasi hills, the evergreen forests of the Western Ghats from Konkan to Kerala, and the Nicobar Islands, it is also found in Assam, Tamil Nadu, Andhra Pradesh, Madhya Pradesh, Maharashtra, Kerala, and Karnataka. Usually, the fruit of this important medicinal plant is therapeutically used for various ailments, including indigestion, constipation, dysentery, neurogenic gastralgia, skin diseases, nervine weakness, weakness of stomach, flatulence, amenorrhea, dribbling of urine, etc. It contains many important secondary metabolites, including alkaloids, flavonoids, esters, piperine, steroids, and essential oils, etc., which have been reported to possess antimicrobial, antiparasitic, anthelminthic, mosquito-larvicidal, anti-inflammatory, analgesic, antioxidant, anti-asthmatic, cardioprotective, anti-snake-venom neuro-pharmacological, immunomodulation, antiarthritic and antiulcer and lipidemic agents. Conclusion: Numerous bioactive chemicals that have been isolated and extracted from piper longum have been found to have potential therapeutic benefits for various bodily systems.

Temporal, spatial and demographic distributions characteristics of COVID-19 symptom clusters from chinese medicine perspective: a systematic cross-sectional study in China from 2019 to 2023

BackgroundThe subtypes diagnosis of disease symptom clusters, grounded in the theory of “Treatment in Accordance with Three Categories of Etiologic Factors” and International Classification of Diseases 11th Revision (ICD-11), is a vital strategy for Chinese Medicine (CM) in treating unknown respiratory infectious diseases. However, the classification of disease symptom clusters continues to depend on empirical observations and lacks robust scientific evidence. Consequently, this study seeks to explore the temporal, spatial and demographic distributions characteristics of Corona Virus Disease 2019 (COVID-19) symptom clusters in China.MethodsPubMed, Web of Science, Science direct, WHO, Litcovid, CNKI databases were searched from inception until December 31, 2023. Optical character recognition technology and image recognition technology were employed to identify tables within the papers. Four researchers independently screened and extracted data, resolving conflicts through discussion. Heat mapping and hierarchical clustering techniques were utilized to analyze COVID-19 symptom clusters. Data analysis and visualization were conducted using R software (4.2.0), while the association analysis of symptom clusters was performed using Cytoscape (3.10.2).ResultsA total of 366 COVID-19 clinical trials with 86,972 cases including 66 clinical symptoms of 7 disease systems and other clinical manifestations in China were included. In temporal distribution, 63 symptoms centered around fatigue and 44 symptoms focused on chest tightness are characteristic of symptom clusters in spring and winter, respectively. With the addition of spatial distribution, the symptom clusters in middle and low latitudes during spring are characterized by 53 symptoms centered around fatigue and cough, and 51 symptoms focused on fatigue, respectively. During winter, the symptom clusters in middle and low latitudes are characterized by 38 symptoms centered around chest tightness and 37 symptoms focused on fever, respectively. When considering demographic distribution, the symptom clusters for < 50 years are characterized by fatigue as the core symptom in middle (44 symptoms)/low (28 symptoms) latitudes during spring and middle latitude (25 symptoms) during winter. For ≥ 50 years, the symptom clusters in middle latitude (49 symptoms) during spring and low latitudes (35 symptoms) during winter are centered around cough, while in low latitude (27 symptoms) focuses on diarrhea during spring, and middle latitude (35 symptoms) emphasizes both diarrhea and chest tightness during winter.ConclusionIn summary, variations in symptom clusters and core symptoms of COVID-19 in temporal, spatial and demographic distributions in China offer a scientific rationale for the “Treatment in Accordance with Three Categories of Etiologic Factors” theory. These interesting findings prompt further investigation into CM patterns in the ICD-11, and suggest potential strategies for personalized precision treatment of COVID-19. High-quality clinical studies focusing on individual symptoms are warranted to enhance understanding of respiratory infectious diseases.

Obesity Treatment from the Unique Perspective of Traditional Chinese Medicine

This paper aims to develop the value and significance of traditional Chinese medicine in the treatment of obesity in the context of the globalization of contemporary obesity, and to explore the causes and treatment methods of obesity. By examining the historical origins of traditional Chinese medicine principles, in conjunction with the teachings of the Emperor's Neijing, as well as the concepts of yin and yang, and qi and blood theory, this paper conducts an analysis on the traditional Chinese medicine perspective on obesity. Specifically, it explores the perception of imbalance in energy and organ function. This paper emphasizes the holistic nature of the human body and argues that treating obesity should not only focus on weight loss, but also on regulating internal organ function and balancing qi, blood, Yin, and Yang to improve overall health. At the same time, the effect of TCM dietary advice on weight loss was studied, and the role of herbal medicine and acupuncture in the treatment of obesity was explained, so as to provide new ideas and methods for the comprehensive treatment of obesity.

Weight control issues: perspectives in aesthetic medicine

Over the past 30 years, the number of people with obesity has almost doubled in the world – a chronic disease accompanied by progressive metabolic disorders and an increased risk of developing diseases such as diabetes, hypertension, coronary heart disease, etc. The rapidly growing number of overweight adults and adolescents, the severity and low efficiency of existing traditional methods of treating obesity, prompt the search for the most effective and safe methods of therapy. Semaglutide is a glucan-like peptide 1 agonist that has demonstrated promising efficacy not only in glycemic control, but also in weight loss by delaying gastric emptying, enhancing and prolonging the feeling of satiety, reducing appetite and energy consumption. The article discusses the main mechanisms of action of semaglutide, and also presents data from STEP studies on the efficacy and safety of semaglutide at a dose of 2.4 mg per week in patients with obesity or overweight without diabetes mellitus.

:Retinal Disorders: Genetic Approaches to Diagnosis and Treatment. Second Edition. Cold Spring Harbor Perspectives in Medicine

:<i>Retinal Disorders: Genetic Approaches to Diagnosis and Treatment. Second Edition. Cold Spring Harbor Perspectives in Medicine</i>

Forest bathing and tourism: A bibliometric analysis

The shinrin-yoku activity, or forest bathing, is inspired by a Japanese therapeutic tradition that involves spending time in the forest to improve health. This activity offers various applications for scientific research in different fields such as health, therapy, psychology, or tourism. This work aims to analyze both the current state and the evolution of scientific research on forest bathing activity. Specifically, to discuss the potential of this activity in the dimension of sustainable tourism. For this purpose, using the VOSviewer software, papers published in the Web of Science and Scopus databases between 2008 and 2023 were analyzed. The main results of this research support that forest bathing activity is experiencing progressive growth in the scientific literature, especially from the perspective of health and medicine. However, it is an activity that is little explored from the tourism perspective. The above would be especially interesting in those natural spaces located in rural areas where good tourism management of this activity could be another business opportunity that combats depopulation, socioeconomic underdevelopment, and natural disasters such as fires.

The Narrativist Turn in Healthcare and its Implications on the Experience of Perinatal Grief

The non-recognition of perinatal bereavement in society leads parents to an isolated condition that may hinder their psychological adjustment after the loss (Layne; Markin and Zilcha-Mano). Improving bereaved parents’ experiences of communication in healthcare practice thus seems to be crucial to lessening the risk of dysfunctional grief. This paper presents a research project on the topic of perinatal death, “Words Fail Me”: Naming the Unnamable (PERINAT), funded by the French National Agency for Research (2023-2027). By focusing on the metaphorical constructions used by bereaved parents in their narratives of perinatal death, PERINAT seeks to improve the communication experience of the bereaved by furthering health care practitioners’ understanding of this grief. The study is conducted by means of a dataset collected in 2022-23 from interviews with a hundred bereaved parents in France. The preliminary findings of this ongoing project are meant to be used to inform and improve the support offered by health care providers who are likely to come across a bereaved parent in their professional capacity. More specifically, from a perspective of narrative medicine, this contribution seeks to explore what the study of metaphor can potentially offer to the development of narrative competence in the training of health professionals. By developing higher awareness of bereaved parents’ narrative, more specifically of their use of figurative language, practitioners can make sense of parents’ needs and emotional responses to their experience of loss in order to ease it. As Norwood (122) has it, metaphor, like poetry, “can make unknown known and the unspeakable speakable”. This is also in line with the most recent promotion of a relationship-centered and patient-centred notion of care (Bensing; Pluut).

A narrative review of acupuncture for sexual dysfunction: perspective of traditional Chinese medicine.

Despite the growing popularity of acupuncture for sexual dysfunction (SD) in the Western world, many clinicians struggle to understand the exact therapeutic mechanism of acupuncture which is based on traditional Chinese medicine (TCM). This study aims to describe the fundamentals of acupuncture theory from TCM perspectives and its relevance to SD; evaluate the current state of acupuncture research within literature evidence; and critically analyze its therapeutic effects in premature ejaculation (PE), erectile dysfunction (ED), and female SD. All published English-language SD clinical studies treated by acupuncture were searched in PubMed from database inception to 1 April 2024. Articles in non-English languages, case reports, letters, comments and review articles were excluded. Data accrued from the related studies were extracted by sample, disease, study type, age, acupoints, interventions and clinical outcomes. Out of the 64 articles identified in the database, 15 studies were included in this final review. Acupuncture is effective in improving SD. Of the 114 acupoints identified, the ren meridian had the highest number of occurrences, followed by the liver meridian of foot-jueyin, the kidney meridian of foot-shaoyin, the stomach meridian of foot-yangming and the spleen meridian of foot-taiyin. While acupuncture therapy has its characteristics in treating PE, ED, and female SD, the specific mechanisms should be further explored and validated in larger multicenter clinical trials.

Can TDABC (Time-Driven Activity-Based Costing) help the NOVO hospital's medical biology laboratory to value the appropriate prescription? - Role of the biologist in reducing healthcare costs

The relevant and correct prescribing of medical biology is a major public health issue. Correct prescribing is a legal obligation under article L6211-8 of the French Public Health Code and is an integral part of the biologist's daily work, already specified in the 2012 (section 4.7) and 2022 (section 5.3.3) versions of the NF EN ISO 15189 standard. COFRAC document SH REF 02 v08 specifies the requirements for consultancy services. The adaptation of the prescriptions is a revision of the contract with the prescriber, which makes it possible to optimize patient care and ensure the satisfaction of the laboratory users. Although essential, accurate prescribing is time consuming. "Chronophage" is the term that has been used for almost a decade. At present, the work of biologists in this area is not valued. In fact, there is no evaluation system to highlight this regulation control activity. To date, no work has been published to estimate this time, this chronophagy, and to evaluate its impact. Cost measurement using Time-Driven Activity-Based Costing (TDABC), a variant of Activity-Based Costing (ABC), is based on a process approach. The main contribution of TDABC is that it uses a single cost driver: time. Serum immunofixation is a test used to confirm and monitor plasma cell dyscrasias, the archetype of which is multiple myeloma. The learned societies and the IMWG provide explicit diagnostic criteria, but the guidelines do not address the frequency of follow-up. In particular, the frequency of repeat and follow-up serum immunofixation remains unaddressed from an evidence-based medicine perspective. This work has made it possible to highlight the savings made between 1st January and 31th August 2023 thanks to the involvement of the biologist and to highlight his essential role in the process of controlling the overall expenditure (reagents, human resources, time and money) in the specialized biochemistry sector (bench: proteins) and to strengthen the role of the biologist within the institution. The various players in the healthcare sector - prescribing physicians, biologists, hospital administrators and, last but not least, patients - all have an essential role to play in maximizing value for patients and in the healthcare economy.

Opportunities and Challenges of Arginase Inhibitors in Cancer: A Medicinal Chemistry Perspective.

The overexpression of two arginase (ARG) isoforms, ARG1 and ARG2, contributes to the onset of numerous disorders, including cardiovascular and immune-mediated diseases, as well as tumors. To elucidate the specific roles of ARG1 and ARG2 without interfering with their physiological functions, it is crucial to develop effective ARG inhibitors that target only one isoform, while maintaining low toxicity and an adequate pharmacokinetic profile. In this context, we present a comprehensive overview of the different generations of ARG inhibitors. Given the general lack of selectivity in most existing inhibitors, we analyzed the structural features and plasticity of the ARG1 and ARG2 binding sites to explore the potential for designing inhibitors with novel binding patterns. We also review ongoing preclinical and clinical studies on selected inhibitors, highlighting both progress and challenges in developing potent, selective ARG inhibitors. Furthermore, we discuss medicinal chemistry strategies that may accelerate the discovery of selective ARG inhibitors.

Depression, stress, and tryptophan metabolism through the kynurenine pathway: treatment strategies from the perspective of Chinese herbal medicine.

The pathogenesis of depression is complex, involving abnormalities in tryptophan (TRP) metabolism through the kynurenine pathway (KP). Moreover, depression is closely related to the hypothalamic-pituitary-adrenal (HPA) axis, the gut-brain axis, neuroinflammation, and stress. These factors collectively influence the multidimensional pathological mechanisms of depression. TRP, a fundamental amino acid, serves as a precursor for neuroactive metabolites vital to physiological functions. Central to TRP metabolism is the KP, and the imbalance between neurotoxic and neuroprotective metabolites is closely related to the onset and progression of depression. Therefore, maintaining the balance of KP metabolites is important. In this review, we have investigated the role of the KP in depression and explored the complexity of KP dysregulation and its therapeutic importance. Here, we highlight how a deeper understanding of the KP and its regulation can pave the way for new treatment strategies. Specifically, we have summarized the latest advances in elucidating the key mechanisms of rate-limiting enzyme inhibitors, providing insights into their potential therapeutic efficacy. In addition, we have explored the emerging field of Chinese herbal medicine, discussing its potential to regulate KP metabolites and alleviate depressive symptoms, thereby expanding the treatment options for depression. Our findings emphasize the multifaceted nature of depression and the necessity of interdisciplinary research to fully utilize KP regulation and Chinese herbal medicine as strategies to advance the treatment of depression.

Therapeutic Potential of Chinese Herbal Medicine and Underlying Mechanism for the Treatment of Myocardial Infarction.

Myocardial infarction (MI) is a prevalent disease with high mortality rates worldwide. The course of MI is intricate and variable, necessitating personalized treatment strategies based on different mechanisms. However, variety of postoperative complications and rejections, such as heart failure, arrhythmias, cardiac rupture, and left ventricular thrombus, contribute to a poor prognosis. Despite the inclusion of antiplatelet agents and statins in the conventional treatment regimen, their clinical applicability is constrained by potential adverse effects and limited efficacy. Additionally, the mechanisms leading to MI are complex and diverse. Therefore, the development of novel compounds for MI treatment. The use of traditional Chinese medicine (TCM) in the prevention and treatment of cardiovascular diseases, including MI, is grounded in its profound historical background, comprehensive theoretical system, and accumulated knowledge. An increasing number of contemporary evidence-based medical studies have demonstrated that TCM plays a significant role in alleviating symptoms and improving the quality of life for MI patients. Chinese herbal formulations and active ingredients can intervene in the pathological process of MI through key factors such as inflammation, oxidative stress, apoptosis, ferroptosis, pyroptosis, myocardial fibrosis, angiogenesis, and autophagy. This article critically reviews existing herbal formulations from an evidence-based medicine perspective, evaluating their research status and potential clinical applications. Additionally, it explores recent advancements in the use of herbal medicines and their components for the prevention and treatment of MI, offering detailed insights into their mechanisms of action.

The Role of Insulin Within the Socio-Psycho-Biological Framework in Type 2 Diabetes-A Perspective from Psychoneuroimmunology.

The interplay between socio-psychological factors and biological systems is pivotal in defining human health and disease, particularly in chronic non-communicable diseases. Recent advancements in psychoneuroimmunology and mitochondrial psychobiology have emphasized the significance of psychological factors as critical determinants of disease onset, progression, recurrence, and severity. These insights align with evolutionary biology, psychology, and psychiatry, highlighting the inherent social nature of humans. This study proposes a theory that expands insulin's role beyond traditional metabolic functions, incorporating it into the Mitochondrial Information Processing System (MIPS) and exploring it from an evolutionary medicine perspective to explore its function in processing psychological and social factors into biological responses. This narrative review comprises data from preclinical animal studies, longitudinal cohort studies, cross-sectional studies, machine learning analyses, and randomized controlled trials, and investigates the role of insulin in health and disease. The result is a proposal for a theoretical framework of insulin as a social substance within the socio-psycho-biological framework, emphasizing its extensive roles in health and disease. Type 2 Diabetes Mellitus (T2DM) with musculoskeletal disorders and neurodegeneration exemplifies this narrative. We suggest further research towards a comprehensive treatment protocol meeting evolutionary expectations, where incorporating psychosocial interventions plays an essential role. By supporting the concept of 'insulin resilience' and suggesting the use of heart rate variability to assess insulin resilience, we aim to provide an integrative approach to managing insulin levels and monitoring the effectiveness of interventions. This integrative strategy addresses broader socio-psychological factors, ultimately improving health outcomes for individuals with T2DM and musculoskeletal complications and neurodegeneration while providing new insights into the interplay between socio-psychological factors and biological systems in chronic diseases.

Clinical Humanistic Needs of Chinese Medicine Treatment for Patients with Chronic Urticaria from the Perspective of Narrative Medicine

Abstract: The curative effect of traditional Chinese medicine (TCM) in the treatment of chronic urticaria has gradually been recognized by the clinic, but the physical symptoms and psychological symptoms of this disease in the clinic are equal, how to play the effect of traditional Chinese medicine more effectively is worth exploring. Narrative medicine is a medical model that attaches great importance to humanistic care. There is a certain correlation between the concept of “holism of body and spirit (形神一体观)” embodied in TCM treatment of chronic urticaria and the key concepts of "narrative lock", "narrative adjustment" and "narrative intervention" in Chinese narrative medicine system. Based on the Chinese narrative medicine system, this paper connects the concept of narrative medicine with the TCM treatment of chronic urticaria, and discusses the clinical humanistic needs of TCM diagnosis and treatment of chronic urticaria patients from the perspective of narrative medicine.

The Use of Herbs According to the Perspective of Traditional Malay Medicine in Selangor, Malaysia

The Use of Herbs According to the Perspective of Traditional Malay Medicine in Selangor, Malaysia

Parkinson's Disease: Unravelling the Medicinal Perspectives and Recent Developments of Heterocyclic Monoamine Oxidase-B Inhibitors.

Parkinson's disease is a neurodegenerative condition characterized by slow movement (bradykinesia), tremors, and muscle stiffness. These symptoms occur due to the degeneration of dopamine- producing neurons in the substantia nigra region of the brain, leading to reduced dopamine levels. The development of Parkinson's Disease (PD) involves a combination of genetic and environmental factors. PD is associated with abnormal regulation of the monoamine oxidase (MAO) enzyme. Monoamine oxidase inhibitors (MAOIs) are an important class of drugs used to treat PD and other neurological disorders. In the early stages of PD, monotherapy with MAO-B inhibitors has been shown to be both safe and effective. These inhibitors are also commonly used as adjuncts in long-term disease management, as they can improve both motor and non-motor symptoms, reduce "OFF" periods, and potentially slow disease progression. However, current MAO-B inhibitors come with side effects like dizziness, nausea, vomiting, light-headedness, and fainting. Therefore, accelerating the development of new MAO-B inhibitors with fewer side effects is crucial. This review explores natural compounds that may inhibit monoamine oxidase B (MAO-B), focusing on key findings from the past seven years. It highlights the most effective heterocyclic compounds against MAO-B, including thiazolyl hydrazone, pyridoxine-resveratrol, pyridazine, isoxazole, oxadiazole, benzothiazole, benzoxazole, coumarin, caffeine, pyrazoline, piperazine, piperidine, pyrrolidine, and morpholine derivatives. The review covers in vitro, in silico, and in vivo data, along with the structure- activity relationship of these compounds. These findings offer valuable insights for the development of more effective MAO-B inhibitors and advancements in Parkinson's disease research.

Treatment of trigeminal neuralgia by acupuncture combined with Chinese medicine from the perspective of modern medicine: A review.

Trigeminal neuralgia (TN) is characterized by recurrent episodes of transient severe pain in its distribution area, with abrupt onset and termination. With the progression of the disease, patients are prone to concurrent psychiatric disorders, such as anxiety and depression, which seriously affect patients' quality of life. Currently, anticonvulsant drugs are commonly used in clinical practice as the primary treatment, but long-term use of drugs is prone to drug resistance, limiting clinical application. Acupuncture and traditional Chinese medicine (TCM), as alternative and complementary therapies, can make up for the deficiencies in modern medicine and are accepted by patients with the advantages of safety and effectiveness. TCM therapy works by promoting the release of endogenous opioid peptides, adjusting the level of inflammatory factors, and improving negative emotions to exert analgesic effects. This paper discusses the clinical efficacy and safety of acupuncture combined with Chinese medicine in the treatment of TN from the perspective of modern medicine and provides a theoretical basis for seeking better therapeutic targets.

Research Trend and Future Perspectives of Traditional Chinese Medicine for Atopic Dermatitis from 2004 to 2023: A Bibliometric Analysis.

The application of bibliometric analysis gives insights into research trend and future perspectives. This paper aims to understand the current status of studies on traditional Chinese medicine (TCM) in the treatment of atopic dermatitis (AD), and to investigate the cooperation network, hotspots and trends in the field. The original data were retrieved from the Web of Science Core Collection by searching for the topic "atopic dermatitis" and "traditional Chinese medicine" with the time span of 2004-2023. Microsoft Excel was used to create statistical tables and charts, whereas CiteSpace and VOSViewer were applied for knowledge mapping. In total, 252 publications were identified and downloaded. Current research on TCM treating AD is in the steady growth period. China has the largest number of publications, whereas the USA has the greatest international influence. Notably, the Arab Emirates, Malaysia, India and Bangladesh all have a high research impact but with a low amount of publications. Universities in Hong Kong China have the largest number of publications, but their interaction with other institutions is very poor. The top three most productive authors are all from Hong Kong, having a strong collaboration network with each other. The popular research topics in this field are "children" "cell" "activation" "nf kappa b" "inflammation" "asthma" "extract" "management" and "cytokine". According to the analysis of leading co-cited journals and authors, "J ETHNOPHARMACOL" has the largest amount of citations whilst "AM J CHINESE MED" the strongest academic influence. The largest number of co-cited authors comes from "Hon Karn-Lun Ellis", a well-known scholar from Hong Kong. TCM has been widely used in AD treatment, honored for its individualized therapeutic concepts of evidence-based treatment. The academic community must form a continuous and deep-going pattern to achieve higher international influence and a stronger research degree in this field.

Integrative Lipid Pseudotargeted Metabolomics and Amino Acids Targeted Metabolomics Unravel the Therapeutic Mechanism of Rhizoma Paridis Saponins on Experimental Colitis of Damp-Heat Type.

Inflammatory bowel disease (IBD) is a serious disease that affects the metabolism and inflammatory responses of human beings. From the perspective of traditional Chinese medicine, damp-heat syndrome is one of the main syndromes of IBD. Rhizoma Paridis, also known as the root of Paris polyphylla, a well-known herbal medicine used in China, is used to treat IBD with damp-heat syndrome (IBD-DH). However, uncertainty still exists regarding the underlying mechanisms and the impact of Rhizoma Paridis on IBD-DH. The rats in the model (DAT) and medication administration (Rhizoma Paridis total saponins (RPTS) and Pennogenin (PN)) groups were given a high temperature and high humidity environment, high fat and high sugar diet combined with 2,4,6-trinitrobenzene sulfonic acid (TNBS) to establish the model of experimental colitis of damp-heat type, and the normal control group (RNC) rats were given a normal diet at normal temperature and humidity. Damp-heat control group (DNC) was set with the same condition as DAT without TNBS. Hematoxylin-Eosin (HE) staining was used to observe the histopathological morphology of the rat colorectum. The expression of the metabolism-related genes (Phospholipase A2 (sPLA2, cPLA2), and phosphatidylethanolamine N-methyltransferase (PEMT)) was assessed by using real-time quantitative PCR analysis (RT-qPCR). And the levels of the metabolism-related proteins (sPLA2, cPLA2), S100A8/9, Arg-1, and cytokines were detected by enzyme-linked immunosorbent assay (ELISA) kit. To investigate lipids and amino acids which closely associated with the IBD and IBD-DH, lipid pseudotargeted metabolomics with UHPLC-TQ/MS analysis method, as well as targeted quantitative amino acid analysis were performed. Our data showed that RPTS (50 mg/kg) and PN (20 mg/kg) significantly ameliorated the severity of TNBS-induced colitis and downregulated the levels of circulating proinflammatory cytokines. Compared with RNC group, lipid pseudotargeted metabolomics demonstrated that glycerophospholipids, sphingolipids, carnitine, and glycerolipids were the four most perturbed lipid classes, and amino acids targeted metabolomics demonstrated that serine, N-acetylneuraminic acid, histidine, proline, taurine, and kynurenine changed significantly in DAT group . Correlation analyses showed tight associations between most of differential metabolites and proinflammatory cytokines. RPTS and PN both regulated glycerophospholipid metabolism and sphingolipid metabolism. However, both of them did not have a significant effect on amino acid modulation. RPTS and PN potentially regulated sPLA2, cPLA2, and PEMT. These results showed that RPTS (50 mg/kg) and PN (20 mg/kg) effectively alleviated rats' colitis of damp-heat type, affected cytokines, and altered lipid metabolism without significant modulation on amino acid metabolism.