Department Of Medical Sciences Research Articles

Drug utilization and prescribing pattern in the treatment of urolithiasis: a perspective on World Health Organization recommendations

Background: Drug utilization research (DUR) is essential in promoting rational use of medicine, aimed at understanding the patterns of prescription, administration, and utilization of medications. It provides valuable insights into the actual drug usage patterns for specific disease conditions. To evaluate the current utilization pattern of drugs in patients of urolithiasis in the Department of General Medicine and Surgery at Integral Institute of Medical Science and Research Hospital, Lucknow. Methods: Following the approval of the institutional ethics committee, a prospective observational study was conducted at Integral Institute of Medical Science and Research Department of general medicine and surgery over a six-month period. Urolithiasis patients’ prescriptions were analyzed to study the prescribing patterns. Information about patient demographics, co-morbidities, and the number and types of medications prescribed were collected and analyzed. Results: Out of 102 patients studied, a female preponderance over male patients was observed. The co-morbidities that are encountered most commonly were hydronephrosis, cystitis, and renal cyst. There is averaged 7 medicines per prescription, 15.25% of medicines written by the generic name, 83.33% of patients receiving antibiotics, 54.70% of patients receiving injections, and 83% of drugs prescribed are mentioned in the essential medicine list. Analgesics, antibiotics, nutritional supplements, antiemetic, alkalizing agents, and antispasmodics were among the class of medicines given. Conclusions: This study highlights the current use of medicines and drug utilization in urolithiasis management. The findings show important insights for healthcare professionals to enhance medication therapy, encourage cost-effective healthcare delivery and improve quality of patient in urolithiasis management.

Assessment of gingival recession in patients with fixed orthodontic appliances.

Objective: To assess the gingival recession in patients with fixed orthodontic appliances. Study Design: Descriptive Cross Sectional study. Setting: Department of Orthodontic, Liaquat University of Medical and Health Science Jamshoro and Department of Orthodontic, Civil Hospital Hyderabad. Period: 05-01-2021 to 04-06-2021. Material & Methods: A total of 183 patients aged 18–35 have been included in this descriptive cross-sectional research study. After the history was taken, the study participants went through a clinical examination, but for those patients with ongoing fixed orthodontic treatment, at least three to six months of orthodontic treatment have been completed. Gingival recession was assessed using Millers’ classification and oral hygiene index. Results: The average age of 183 individuals was 22.75+2.29 years. Women outnumbered men 65.5% to 35.5%. According to the oral hygiene index, 28.4% of patients scored exceptional (0-0), 39.3% acceptable (0-0.6), 25.7% fair (0.7-1.8), and 6.6% bad (1.9-3.0). Marginal gingival tissue recession categorization showed that 66.6% of patients had no recession, 21.8% had class I, 10.9% had class II, 0.5% had class III, and 0% had class IV. According to oral hygienic index, marginal tissue recession categorization was significant (p=0.001). At 0.035 significance level, marginal tissue recession and oral hygiene score were positively linked (r=183). Conclusion: Most of the cases with fixed orthodontic appliances had no gingival tissue recession, only few cases seen class I and class II. However, this mild gingival tissue recession was significantly associated to oral hygienic index.

Can robotic gastric bypass be considered a valid alternative to laparoscopy? Our early experience and literature review.

Robotic bariatric surgery serves as an alternative to laparoscopy. The technology provides the surgeon with an accurate three-dimensional view, allowing complex maneuvers while maintaining full control of the operating room. We report our experience with this innovative surgery compared with laparoscopy during Roux-en-Y gastric bypass to demonstrate its safety and feasibility. The aim of this study is to evaluate potential differences between the robotic and laparoscopic techniques. Our study retrospectively identified 153 consecutive obese patients who underwent either laparoscopic or robotic gastric bypass (RGB) procedures over a 2-year period at the Department of Medical and Surgical Sciences, University of Foggia. Data on demographics, operative time, conversion rate, length of hospital stay, and mortality were collected and compared between two groups of patients: 82 patients who underwent laparoscopic procedures and 71 who underwent robotic procedures. We analyzed 153 patients who underwent gastric bypass with a mean age of 42.58 years, of whom 74 were female; 71 were treated with a robotic approach and 82 with a laparoscopic approach. The mean operative time was 224.75 ± 10.4 min for RGB (including docking time) and 101.22 min for laparoscopic gastric bypass (LGB) (p < 0.05), which is statistically significant. The median length of stay was 4.1 days for the RGB group and 3.9 days for the LGB group (p = 0.89). There is only one conversion to laparoscopy in the RGB group. We observed only one case of postoperative complications, specifically one episode of endoluminal bleeding in the laparoscopic group, which was successfully managed with medical treatment. No mortality was observed in either group. The statistical analysis shows to support the robotic approach that had a lower incidence of complications but a longer operative duration. Based on our experience, the laparoscopic approach remains a technique with more haptic feedback than the robotic approach, making surgeons feel more confident.This study has been registered on ClinicalTrial.gov Protocol Registration and Results System with this ID: NCT05746936 for the Organization UFoggia (https://clinicaltrials.gov/ct2/show/NCT05746936).

Hydrogen therapy for liver surgery: Current insights and future prospects in ischemia-reperfusion injury

Hydrogen therapy for liver surgery: Current insights and future prospects in ischemia-reperfusion injury Prof. Giovanni Brandi and Dr. Simona Tavolari of the 1 Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy, discuss ischemia-reperfusion injury in hepatic surgery, and the potential to prevent it through hydrogen-therapy. Hepatic surgery is a life-saving procedure for patients with end-stage liver disease, acute liver failure, or some liver malignancies. In most hepatic surgical treatments, such as liver resection and transplantation, ischemia-reperfusion injury (IRI) is a major cause of the development of complications in treated patients, being associated with a high morbidity and mortality rate after surgery.

Radiation dose in radiologist from cerebral angiography using optically stimulated luminescence dosimeter

Background: The number of cerebral angiography procedures is increasing, resulting in higher X-ray radiation doses received by radiologists. Consequently, understanding the radiation doses received by radiologists and the accumulation of radiation in control rooms is crucial for guiding prevention strategies against radiation hazards. Objectives: This study aimed to measure and evaluate radiation doses to the hands, lenses of the eyes, and thyroids of radiologists performing cerebral angiography procedures, as well as to measure the accumulated radiation dose in the control room. Materials and methods: OSL dosimeters were placed on the eyeglass frames, thyroids, hands, and legs of radiologists performing 20 cerebral angiography procedures, as well as on the wall and window of the control room. Results: Radiologists’ average radiation doses were measured at specific body parts as follows: left eye (49 µSv), right eye (15 µSv), left hands (34 µSv), right hands (16 µSv), left legs (27 µSv), right legs (7 µSv), and thyroid glands (14 µSv). Notably, the received doses remained well within the maximum radiation dose limit established by the International Commission on Radiological Protection (ICRP). When calculating the maximum number of procedures that can be performed annually, we based it on the limit of the radiation dose that the eyes’ lenses should not exceed. Our findings revealed that the permissible number of procedures determined by the lens radiation dose limit, should not surpass 405 cases annually (equivalent to 34 cases per month). The radiation dose from therapeutic angiography procedures was discovered to be up to 5 times higher than that from diagnostic angiography procedures. The maximum accumulated radiation dose in the control room was 1.18 µSv/hr, which remained below the limit of the Department of Medical Sciences (&lt; 3 µSv/hr). Conclusion: Radiologists receive less radiation from cerebral diagnostic angiography than therapeutic angiography. Organs on the left side were exposed to greater radiation levels than those on the right side. Wearing radiation protection devices during each procedure can reduce radiation exposure and mitigate long-term effects on radiologists. It is recommended to monitor and calculate the accumulated radiation dose of workers to ensure their exposure remains within safety limits.

Exploring Methotrexate Route of Administration Decisions for Adults with Rheumatoid Arthritis

Methotrexate is a common first-line treatment for rheumatoid arthritis, yet its widespread and habitual usage often leads physicians to overlook the choice of administration route when planning management strategies. A recent survey involving 30 consultant rheumatologists from France, Germany, Italy, Poland, Spain, and the UK, identified variation in the utilisation and perceptions regarding oral versus subcutaneous delivery for methotrexate. In November 2023, EMJ interviewed Roberto Caporali, Professor of Rheumatology at the University of Milan, and Head of the Department of Rheumatology and Medical Sciences at Gaetano Pini Hospital, Milan, Italy. Caporali’s expertise is in clinical practice, teaching, and research in rheumatology, mainly rheumatoid arthritis and other immune-mediated inflammatory diseases, with a focus on prognostic factors, biomarkers, and treatment for patients with moderate-to-severe active rheumatoid arthritis. During this interview, Caporali discussed the decision-making process for treating rheumatoid arthritis, with a particular focus on the use of methotrexate. The purpose was to gain insights from a rheumatology expert regarding the prevalence and management goals of the disease, and available treatment options. The interview considered key decision-making drivers and barriers to healthcare professionals when selecting the route of administration. Caporali suggested that the efficacy and safety profile of methotrexate when delivered subcutaneously may be the optimal choice for patients, often resulting in higher adherence compared to oral dosing. Caporali recommended education and re-evaluation of local guidelines to improve patient outcomes by better understanding the optimal use and efficacy of methotrexate.

History of the creation, development and achievements of the Department of medical sciences (To the 90th anniversary of the foundation of the National Academy of Sciences of Belarus)

History of the creation, development and achievements of the Department of medical sciences (To the 90th anniversary of the foundation of the National Academy of Sciences of Belarus)

Актуальные проблемы и перспективы развития методологии анализа риска в усло-виях современных вызовов безопасности для здоровья населения Российской Федерации

Medical Sciences Department, Russian Academy of Sciences, 14 Leninskii Av., Moscow, 119071, Russian Federation

Investigating Chronotype and Sleep Quality in Psoriatic Patients: Results from an Observational, Web-Based Survey.

Psoriasis is an inflammatory disease for which the implications and repercussions go far beyond the skin. Psoriasis patients suffer not only due to its skin manifestations and related symptoms but also because of comorbidities and a huge emotional impact. The objective of this study was to investigate chronotype and sleep quality in a group of Italian psoriatic patients. An observational, cross-sectional, web-based study was set up by the Dermatology and Clinical Medicine Sections of the Department of Medical Sciences, University of Ferrara, Italy. The web questionnaire was sent to an email list of an Italian association of psoriatic patients with the aim of recording their main demographic, social, historical, and clinical data. The survey included two questionnaires: the Morningness-Eveningness Questionnaire (MEQ) and the Pittsburg Sleep Quality Index (PSQI). Two hundred and forty-three psoriatic patients (mean age 52.9 ± 12.8 yrs., 32.5% males and 67.5% females) filled out the questionnaire. A good 63.8% of them were affected with psoriasis for more than 10 years, 25.9% reported having a diffuse psoriasis, and 66.7% were on treatment at the time they completed the questionnaire. With reference to chronotype, the mean MEQ score was 55.2 ± 10.7; furthermore, 44% of the patients were "morning-oriented types", M-types, or "larks", 44.5% were "intermediate-types" or I-types, and 11.5% were "evening-oriented types", E-types, or "owls". No correlations were found between chronotype and psoriasis extension. Based on the PSQI results, 72.8% of the study population was judged to have a low sleep quality. Sleep disturbance was significantly related to female sex, living alone, and the presence of comorbidities. Sleep disturbance is very common in psoriatic patients, especially in those with comorbidities, in females, and in patients who live alone. The chronotype in psoriatic patients does not appear different when compared to the general population, nor does it seem to have any link with psoriasis severity.

Increased dietary intake of ultraprocessed foods and mitochondrial metabolism alterations in pediatric obesity

The increased intake of ultraprocessed foods (UPFs) in the pediatric age paralleled with the risen prevalence of childhood obesity. The Ultraprocessed Foods in Obesity (UFO) Project aimed at investigating the potential mechanisms for the effects of UPFs in facilitating pediatric obesity, focusing on the direct role of advanced glycation end-products (AGEs) on mitochondrial function, the key regulator of obesity pathophysiology. We comparatively investigated the daily dietary intake of UPFs, energy, nutrients, dietary AGEs [Nε -(carboxymethyl)lysine (CML), Nε -(1-carboxyethyl)lysine (CEL), and Nδ -(5-hydro-5- methyl-4-imidazolon-2-yl)-ornithine (MG-H1)] in 53 obese patients and in 100 healthy controls visiting the Tertiary Center for Pediatric Nutrition of the Department of Translational Medical Science at the University of Naples “Federico II”. AGEs skin accumulation and mitochondrial function in peripheral blood mononuclear cells (PBMCs) were also assessed. A higher intake of UPFs and AGEs, energy, protein, fat, and saturated fatty acids was observed in obese patients. Obese children presented significantly higher skin AGEs accumulation and alterations in mitochondrial metabolism. PBMCs from healthy controls exposed to AGEs showed the same mitochondrial alterations observed in patients. These findings support the UPFs role in pediatric obesity, and the need for dietary strategies limiting UPFs exposure for obesity prevention and treatment.

Kenya Medical Training College laboratory student perception on adequacy of teaching and learning resources in the advent of COVID-19

The emergence of COVID-19 presented a big challenge in medical education, especially with regard to the adequacy of teaching and learning resources. In addition, an increase in student intake and demand for Kenya Medical Training College courses could compromise these resources. This study investigated the perceptions of students towards the adequacy of teaching and learning resources at Kenya Medical Training College in the advent of COVID-19. The general objective was to determine the perceived adequacy of teaching and learning resources in the advent of COVID-19 by students in the department of Medical Laboratory Sciences at Kenya Medical Training College. A descriptive cross-sectional study design using mixed methods (triangulation) was used. Simple random sampling of the eight regions in the country was used to select one region (the Eastern Region). Census sampling was used to select all the four campuses in the region namely Machakos, Meru, Embu, and Kitui, which offer medical laboratory sciences. The study population was students in the department of medical laboratory sciences on these campuses, with 220 students participating. The data collection instrument was a self- administered closed- and open-ended questionnaires. Quantitative data collected was analysed using SPSS software, while qualitative data was analysed using themes. The response rate was 100% (220 students). The gender distribution among students showed a higher percentage in male (58%). Majority of the students were 21-23 years (35%). One-way ANOVA presented a statistically significance between and within groups (P&lt;0.05). Majority of students (51.8%) were not satisfied with adequacy of human resources. Majority of students perceived the state of physical facilities to be in poor state with a mean of 1.76, while the satisfaction level of majority of students’ on teaching aids was below 3.40 representing very inadequate to neutral. Ordinal regression tests on satisfaction level on teaching aids in relation to gender, year of study and campus was significant (chi-square test p&lt;0.000) while the goodness of fit model was (p=1.000) indicating it was a good model. R^2 value (Nagelkerke=99%) indicated that the study factors had great variations. The spearman’s rank test showed that laboratory equipment and computer assisted aids, internet, learning systems have negative correlation but with very strong coefficient correlation of 1.0000. Satisfaction levels with teaching aids in relation to gender, year of study, and campus were significant with a chi-square test of P &lt; 0.000. The study concluded that there were inadequate teaching and learning resources on the four KMTC campuses before COVID-19.

Researchers' Knowledge About the Ethical Norms of National Natural Science Foundation of China Funded Medical Research:Current Status and Suggestions

Objective To understand the current status of Chinese medical researchers' knowledge regarding the ethical norms of the research involving humans or laboratory animals,and provide reference for further improving the ethics review norms. Methods The questionnaire method was employed to survey the applicants for the 2019 projects supported by the Department of Medical Sciences,National Natural Science Foundation of China (NSFC) about their knowledge of ethical requirements.Furthermore,the ethical supervision of the NSFC and affiliations at the project application and implementation stages was analyzed. Results The survey showed that 29.9% medical researchers were familiar with NSFC's ethical requirements for research involving human or laboratory animals.During the project application stage,59.0% affiliations adopted the simplified review method.Regarding the ethical supervison,95.5% medical researchers believed that the affiliations should fulfill the ethical supervision obligations and take relevant measures during the project implementation period.In addition,55.0% medical researchers fully agreed to discuss with the review experts about the ethical issues involved in the project. Conclusions The NSFC should establish rules and regulations to improve institutional management responsibilities and institutionalize the training about research ethics to comprehensively strengthening the training.Taking the management of research project ethics as a starting point,the NSFC should form a multi-party linkage between project funding and management and establish an accountability mechanism for ethics management.Furthermore,the NSFC should double the endeavors at the review of ethical issues during expert review and process management and attach importance to the research,judgment,and prevention of ethical risks.

First Round of External Quality Assessment Scheme for SARS-CoV-2 Laboratories During the COVID-19 Pandemic in Thailand.

The emergence of SARS-CoV-2 necessitated the rapid deployment of tests to diagnose COVID-19. To monitor the accuracy of testing across the COVID-19 laboratory network in Thailand, the Department of Medical Sciences under the Ministry of Public Health launched a national external quality assessment (EQA) scheme using samples containing inactivated SARS-CoV-2 culture supernatant from a predominant strain in the early phase of the Thailand outbreak. All 197 laboratories in the network participated; 93% (n=183) of which reported correct results for all 6 EQA samples. Ten laboratories reported false-negative results, mostly for samples with low viral concentrations, and 5 laboratories reported false-positive results (1 laboratory reported false positives and false negatives). An intralaboratory investigation of 14 laboratories reporting incorrect results revealed 2 main causes of error: (1) RNA contamination of the rRT-PCR reaction and (2) poor-quality RNA extraction. Specific reagent combinations were significantly associated with false-negative reports. Thailand's approach to national EQA for SARS-CoV-2 can serve as a roadmap for other countries interested in implementing a national EQA program to ensure laboratories provide accurate testing results, which is crucial in diagnosis, prevention, and control strategies. A national EQA program can be less costly and thus more sustainable than commercial EQA programs. National EQA is recommended to detect and correct testing errors and provide postmarket surveillance for diagnostic test performance.

Exploring Variations in Abstract Writing Formats and Structures Among Ph.D. Students

Background: &#x0D; The introduction, a crucial component of any research paper, must be well-written so that readers can evaluate its quality. A typical five-paragraph abstract includes an introduction, objective or purpose, methodology, findings/results, and conclusion. However, not all Ph.D. candidates follow this structure and format when writing their abstracts.&#x0D; Methodology: &#x0D; The purpose of this study was to identify and describe variations in abstract writing formats and structures among Surabaya state university Ph.D. candidates. Using a qualitative descriptive methodology, the researchers analyzed 15 dissertation abstracts: eight from the Faculty of Civil Engineering and Planning at FTSP-ITS and seven from the Medical Science department at Airlangga University Surabaya. They examined the number of paragraphs and the structure of the abstract in each.&#x0D; Findings: &#x0D; The study indicated various abstract structures and writing formats: 40% of the abstracts had three paragraphs, 26.66% had five paragraphs, 20% had four paragraphs, and 13.33% had one paragraph. In terms of abstract structure, 60% lacked a conclusion, 33.33% lacked an objective, 26.66% lacked all five abstract structures, 26.66% lacked both the objective and the conclusion, and 6.66% lacked an introduction.&#x0D; Conclusion: &#x0D; In conclusion, the study found several variations in dissertation abstract writing formats regarding both paragraph count and abstract structure.&#x0D; Originality: &#x0D; The novelty of this study rests in its focus on analyzing variations in abstract writing formats and structures among Surabaya state university Ph.D. candidates. By examining 15 dissertation abstracts from various faculties, this study sheds light on the inconsistencies and deviations from the standard format and structure of abstracts, which may impact readers' ability to comprehend and evaluate research papers. This study contributes to a better understanding of how Ph.D. students' abstract writing practices vary and identifies potential enhancement areas.

Comparing implications of cardiovascular risk of abacavir and integrase inhibitors: why scientific community is confused and timid?

aModena HIV Metabolic Clinic bDepartment of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia cDepartment of Infectious Diseases, Azienda Ospedaliero-Universitaria, Policlinico of Modena, Modena, Italy. Correspondence to Giovanni Guaraldi, MD, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Largo del Pozzo 71, 41124 Modena, Italy. Tel: +39 059 422 5318; fax: +39 335 33 34 34; e-mail: [email protected] Received 13 January, 2023 Accepted 8 February, 2023

Reply to: It is necessary to assess olfactory and gustatory functions in post Covid-19 patients due to the omicron variant infection.

International Forum of Allergy & RhinologyEarly View REPLY Reply to: It is necessary to assess olfactory and gustatory functions in post-COVID-19 patients due to the omicron variant infection Paolo Boscolo-Rizzo MD, Corresponding Author Paolo Boscolo-Rizzo MD [email protected] orcid.org/0000-0002-4635-7959 Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy Correspondence Paolo Boscolo-Rizzo, Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada di Fiume 447, 34149 Trieste, Italy. Email: [email protected]Search for more papers by this authorThomas Hummel MD, Thomas Hummel MD Smell & Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, Dresden, GermanySearch for more papers by this authorSara Invitto PhD, Sara Invitto PhD INSPIRE LAB-Laboratory of Cognitive and Psychophysiological Olfactory Processes, DiSTeBA, University of Salento, Lecce, ItalySearch for more papers by this authorGiacomo Spinato MD, Giacomo Spinato MD Department of Neurosciences, Section of Otolaryngology, University of Padova, Treviso, ItalySearch for more papers by this authorLuigi Angelo Vaira MD, Luigi Angelo Vaira MD orcid.org/0000-0002-7789-145X Department of Medicine, Surgery and Pharmacy, Maxillofacial Surgery Operative Unit, University of Sassari, Sassari, ItalySearch for more papers by this authorJerome R. Lechien MD, PhD, Jerome R. Lechien MD, PhD Department of Anatomy and Experimental Oncology, Mons School of Medicine, UMONS. Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, BelgiumSearch for more papers by this authorAnna Menini PhD, Anna Menini PhD Neurobiology Group, SISSA, Scuola Internazionale Superiore di Studi Avanzati, Trieste, ItalySearch for more papers by this authorClaire Hopkins MA(Oxon), DM, Claire Hopkins MA(Oxon), DM orcid.org/0000-0003-3993-1569 Ear, Nose and Throat Department, Guy's and St Thomas’ Hospitals, London, UKSearch for more papers by this authorGiancarlo Tirelli MD, Giancarlo Tirelli MD Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, ItalySearch for more papers by this author Paolo Boscolo-Rizzo MD, Corresponding Author Paolo Boscolo-Rizzo MD [email protected] orcid.org/0000-0002-4635-7959 Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy Correspondence Paolo Boscolo-Rizzo, Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada di Fiume 447, 34149 Trieste, Italy. Email: [email protected]Search for more papers by this authorThomas Hummel MD, Thomas Hummel MD Smell & Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, Dresden, GermanySearch for more papers by this authorSara Invitto PhD, Sara Invitto PhD INSPIRE LAB-Laboratory of Cognitive and Psychophysiological Olfactory Processes, DiSTeBA, University of Salento, Lecce, ItalySearch for more papers by this authorGiacomo Spinato MD, Giacomo Spinato MD Department of Neurosciences, Section of Otolaryngology, University of Padova, Treviso, ItalySearch for more papers by this authorLuigi Angelo Vaira MD, Luigi Angelo Vaira MD orcid.org/0000-0002-7789-145X Department of Medicine, Surgery and Pharmacy, Maxillofacial Surgery Operative Unit, University of Sassari, Sassari, ItalySearch for more papers by this authorJerome R. Lechien MD, PhD, Jerome R. Lechien MD, PhD Department of Anatomy and Experimental Oncology, Mons School of Medicine, UMONS. Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, BelgiumSearch for more papers by this authorAnna Menini PhD, Anna Menini PhD Neurobiology Group, SISSA, Scuola Internazionale Superiore di Studi Avanzati, Trieste, ItalySearch for more papers by this authorClaire Hopkins MA(Oxon), DM, Claire Hopkins MA(Oxon), DM orcid.org/0000-0003-3993-1569 Ear, Nose and Throat Department, Guy's and St Thomas’ Hospitals, London, UKSearch for more papers by this authorGiancarlo Tirelli MD, Giancarlo Tirelli MD Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, ItalySearch for more papers by this author First published: 24 March 2023 https://doi.org/10.1002/alr.23159Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. 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Correction to: Mortality and Cardiovascular Outcomes in Patients Presenting With Non-ST Elevation Myocardial Infarction Despite No Standard Modifiable Risk Factors: Results From the SWEDEHEART Registry.

HomeJournal of the American Heart AssociationVol. 12, No. 7Correction to: Mortality and Cardiovascular Outcomes in Patients Presenting With Non‐ST Elevation Myocardial Infarction Despite No Standard Modifiable Risk Factors: Results From the SWEDEHEART Registry Open AccessCorrectionPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citations ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toOpen AccessCorrectionPDF/EPUBCorrection to: Mortality and Cardiovascular Outcomes in Patients Presenting With Non‐ST Elevation Myocardial Infarction Despite No Standard Modifiable Risk Factors: Results From the SWEDEHEART Registry Originally published28 Mar 2023https://doi.org/10.1161/JAHA.121.027668Journal of the American Heart Association. 2023;12:e027668This article corrects the followingMortality and Cardiovascular Outcomes in Patients Presenting With Non–ST Elevation Myocardial Infarction Despite No Standard Modifiable Risk Factors: Results From the SWEDEHEART RegistryOther version(s) of this articleYou are viewing the most recent version of this article. Previous versions: March 28, 2023: Ahead of Print In the article by Gemma A. Figtree et al, “Mortality and Cardiovascular Outcomes in Patients Presenting With Non‐ST Elevation Myocardial Infarction Despite No Standard Modifiable Risk Factors: Results From the SWEDEHEART Registry,” which published on July 25, 2022, and appeared in the August 2, 2022, issue of the Journal (J Am Heart Assoc. 2022;11:e024818. DOI: 10.1161/JAHA.121.024818), a correction was needed.The affiliation for Dr Hagström was incorrect in the published version of the article. On page 12, under the Affiliations heading, Dr Hagström's affiliation has been updated as follows:Department of Medical Sciences, Uppsala University, Uppsala, Sweden (N.H., J.S., E.H.)The authors regret the error.The online version of the article has been updated and is available here: https://www.ahajournals.org/doi/10.1161/JAHA.121.024818. Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesMortality and Cardiovascular Outcomes in Patients Presenting With Non–ST Elevation Myocardial Infarction Despite No Standard Modifiable Risk Factors: Results From the SWEDEHEART RegistryGemma A. Figtree, et al. Journal of the American Heart Association. 2022;11 April 4, 2023Vol 12, Issue 7Article InformationMetrics Copyright © 2023 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley BlackwellThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.https://doi.org/10.1161/JAHA.121.027668PMID: 36974762 Originally publishedMarch 28, 2023 PDF download

Prevalence of Ponticulus Posticus and Migraine in 220 Orthodontic Patients: A Cross-Sectional Study

Ponticulus posticus (PP) is a medical term that describes an anomaly of the atlas (C1), which has a complete or partial bone bridge over the vertebral artery (VA) groove. The purpose of the study is to estimate the prevalence of PP in patients with a diagnosis of migraine. Cone beam CT (CBCT) scans (n = 220) were reviewed for the detection of PP in the University "G. D'Annunzio" of Chieti in the Department of Medical, Oral and Biotechnological Sciences. The sample included 220 Italian patients between 18 and 87 years. Pearson chi-square analysis (p < 0.05 and 95% CI) was used to establish an association between migraine and PP. The present study found a prevalence of PP of 20.9% and a prevalence of migraine of 12.272%. The association between migraine and PP was confirmed by the chi-square statistic, since the p-value was 0.008065 (significant at p < 0.05). PP was more frequent in the migraine without aura group, without a statistical difference relative to the migraine with aura group. The study concluded that PP is positively associated with migraine.

Like Two Little Cowboys: Lucky Luke Dermatitis.

Dermatitis®Ahead of Print Pearls & ZebrasLike Two Little Cowboys: Lucky Luke DermatitisElisa Marzola, Natale Schettini, Alessandro Borghi, and Monica CorazzaElisa MarzolaAddress reprint requests to Elisa Marzola, MD, Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Via Ludovico Ariosto, 35, Ferrara 44121, Italy. E-mail Address: elis.marzola@gmail.comhttps://orcid.org/0000-0002-5905-6186From the Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.E.M. and N.S. contributed to writing the original draft. A.B. was involved in writing—review and editing. M.C. carried out conceptualization and writing—review and editing.Search for more papers by this author, Natale SchettiniFrom the Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.E.M. and N.S. contributed to writing the original draft. A.B. was involved in writing—review and editing. M.C. carried out conceptualization and writing—review and editing.Search for more papers by this author, Alessandro BorghiFrom the Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.E.M. and N.S. contributed to writing the original draft. A.B. was involved in writing—review and editing. M.C. carried out conceptualization and writing—review and editing.Search for more papers by this author, and Monica CorazzaFrom the Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.E.M. and N.S. contributed to writing the original draft. A.B. was involved in writing—review and editing. M.C. carried out conceptualization and writing—review and editing.Search for more papers by this authorPublished Online:6 Feb 2023https://doi.org/10.1089/derm.2022.0079AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View article"Like Two Little Cowboys: Lucky Luke Dermatitis." Dermatitis, , pp. –FiguresReferencesRelatedDetails Volume 0Issue 0 Information© 2023 American Contact Dermatitis Society. All Rights Reserved.To cite this article:Elisa Marzola, Natale Schettini, Alessandro Borghi, and Monica Corazza.Like Two Little Cowboys: Lucky Luke Dermatitis.Dermatitis®.ahead of printhttp://doi.org/10.1089/derm.2022.0079Online Ahead of Print:February 6, 2023PDF download

The Detection Limits of Legionella According to the EU Directive 2020/2184. Could That Be Too Permissive?

The problem of detecting legionella after a case of legionellosis from the source of environmental contamination has been known since a long time ago. Legionella is a bacterium present in various natural and artificial habitats and especially in surface fresh waters. It is found in greater concentration in warm waters, at temperatures between 20°C and 42°C. The greatest risk factor for humans is represented by the presence of Legionella in water distribution systems in hospitals, medical equipment (e.g. respirators, dialyzers, inhalers, humidifiers, water, massage equipment used in balneotherapy) and turbines used in dental practices, especially for hospitalized individuals. In the EU directive 2020/2184, issued by the European parliament on 16/12/2020, the concentration of Legionella was added to the parameters to be determined in assessing the quality of drinking water intended for human consumption. The objectives were to improve the quality standard of drinking water, reduce the consumption of bottled water and consequently reduce plastic waste. The WHO notes that Legionella causes the greatest burden from a health point of view and it is included among the parameters that require careful monitoring with a limit of less than 1000 CFU/L. The aim of this report was to evaluate the new EU directive 2020/2184 on the light of our laboratory experience. A total of 459 samples were processed at our Hygiene of food Laboratory - Department of Medical Sciences and Public Health. All statistical analyses were conducted using the SPSS statistical package (version 23 for Windows. SPSS, Inc. Chicago, Ill). Of the 67 structures examined where the cases occurred, 35 showed samples with at least one over-threshold value considering the reference value of 100 CFU/L, whereas using the new limit of 1000 CFU/L, only 25 structures resulted as having at least one sample above the threshold. In our experience as a regional reference laboratory for Legionella research, the increase from 100 CFU/L to 1,000 CFU/L could lead to a lower alert level. In fact, in the period between October 2017 and October 2021, the median value of CFU/L in presence of a case was 0 (0-100). Despite the large amount of studies on Legionella only a few relate the withdrawals and the consequent CFU/L with the confirmed cases of legionellosis, as in our analysis. The 75° percentile values of the Legionella concentration equal to 100 CFU/L in all samples associated with cases and clusters leads us to hypothesize that the limit equal to 1000 CFU/L that will be introduced for environmental monitoring as per recent European regulations may not be sufficiently protective for minimizing risk in the population, especially in healthcare facilities where fragile patients are assisted.