BackgroundThe transformational potential of electronic medical records (EMRs) in global healthcare is evident, but their adoption in low- and middle-income countries, including Nigeria, remains low.ObjectiveThis study aimed to understand the perceptions of southwestern Nigerian medical students toward EMRs given the limited literature on this topic.MethodsA descriptive, cross-sectional online survey was conducted among 412 medical students from four institutions in southwestern Nigeria. Data on the students' demographics, exposure to, and perspectives on EMR was collected. Data was analyzed using R Version 3.6.1.ResultsMajority (79%) of respondents were in their clinical years. We found that 68.4% of the respondents had good perception (scores ≥ 16) about EMRs while 31.6% were deemed as having fair level of perception (scores < 16). Interestingly, 54.9% had never used an electronic medical record (EMR). Although 46.4% felt very comfortable with EMRs' postgraduation use, 16% felt very uncomfortable. Notably, 94.5% believed that health technology solutions could enhance Nigerian health outcomes. Furthermore, 81.8% felt that their medical education would benefit from greater EMR exposure, while 80.9% believed that EMRs are essential for adequate patient care. Males exhibited significantly more EMR experience and more positive attitudes toward EMRs. However, there was no significant association between the level of study, location of medical school, and respondents' experience or perceptions of EMRs.ConclusionMore than half of students surveyed reported that they have never used EMRs. Despite this, many students felt comfortable with the idea of using EMRs in their future practice. Observed gender differences in EMR use and attitudes highlight the need for targeted strategies to prepare all students, regardless of gender, for the digital transition in healthcare.