Abstract BACKGROUND: The South Carolina Cancer Disparities Research Center (SC CADRE) U54 conducted the Culturally-Sensitive, State-of-the-Art Treatment to Eliminate Cancer Disparities Conference in February of 2021. This virtual live webinar was a cancer-disparities-focused Continuing Medical Education (CME) Conference, held for health professionals and community stakeholders to improve the quality of cancer care in South Carolina and to bridge the gap in health care. PURPOSE: The course objective included identifying and/or implementing new cancer treatments to decrease cancer disparities rates in South Carolina, pertaining to rural cancer screening, advanced glycation end products (AGES), breast cancer, and prostate cancer. This conference was designated as a virtual live webinar; therefore, the format included lectures and question-and-answer segments. This conference also served as an enduring activity; therefore, this program was recorded and made available on the South Carolina Area Health Education Center (AHEC) Learning Platform for additional health professionals to attain CME credits. The Medical University of South Carolina designated this live and enduring activity for a maximum of 3.00 AMA PRA Category 1 Credit(s)TM. METHOD: The CME co-course director moderated the virtual conference in WebEx. The first presentation addressed the rural cancer disparities in the United States and in South Carolina. The second presentation addressed AGES, lifestyle, and disease. The third presentation addressed breast cancer incidence in the United States and in South Carolina. The fourth presentation addressed prostate cancer screening and treatment considerations. Conference participants placed their questions in the chat box for presenters to address. Conference participants were sent a program evaluation electronically, and it resulted in a 72% response rate. RESULTS: Fifty-three health care professionals participated in the conference. Seventy-seven percent of the conference attendees were women. The course/conference participants consisted of the following: medical physicians (7.5%), health administrators (13%), registered nurses (16%), nurse practitioners (5%), social workers (16%), retiree (1%), other health care providers (13%), public health providers (11%), Ph.D. Researcher (3%), clinical lab scientists (1%), student (1%), pediatrician (1%), health education specialists (1%), and physician assistants (1%). CONCLUSIONS: At completion of this course, health care professionals and community stakeholders are able to increase the awareness of the social determinants of health in relation to rural cancer disparities, define AGES, learn how AGES can damage the body, what to do to combat AGES, and interventions. In addition, course/conference participants would learn about existing disparities in breast cancer screening, and treatment and how minorities are affected by breast cancer. In conclusion, conference participants would learn about prostate cancer screening, diagnosis and treatment. Citation Format: Latecia M. Abraham-Hilaire, Gayenell Magwood, David P Turner, Andrea Abbott, Stephen J. Savage, Judith Salley, Marvella E. Ford. South Carolina Cancer Disparities Research Center's (SC CADRE) culturally-sensitive, state-of-the-art treatment to eliminate cancer disparities conference [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-053.