Based on ethnographic research in northern Ghana, this article explores the complex logistics of blood and the ways in which the availability of blood has been transformed through the introduction of drones. We explore how drone services affect this ecosystem of supply and contribute to reshaping the practices of physicians, nurses, facility pharmacists and stock managers, as well as the expectations and experiences of patients and their families. Situated at the interface of medical anthropology, critical studies of infrastructure and anthropological studies of digital innovations in healthcare, our paper attends to the emerging anthropological research on medical logistics as a means of connecting people with medical resources. It demonstrates the fundamentally ambivalent nature of technological innovation: on the one hand, drones have fueled health workers' hopes and transformed access to blood. On the other hand, their introduction has also led to connectivity without stock. In line with STS scholarship, we highlight the important role of the physical properties of objects such as blood in shaping their circulation.