Median Urinary Iodine Excretion Research Articles

A Clinico-epidemiological Study to Evaluate the Status of Iodine Deficiency Disorder in North 24 Pargana District of West Bengal

Background: Iodine deficiency disorders (IDD) being major public health problems in India, including WestBengal needs to be continuously monitored through recommended methods and indicators.Present study is aiming to assess the total goiter rate, urinary iodine excretion, iodine content of salts at households’ level among primary school children and to find association with the socio-demographic characteristics of the study population.Method: A school-based, cross-sectional study was conducted during March 2019 to August 2019 among 540schoolchildren of class three and four. Goiter was assessed by standard palpation technique, urinary iodineexcretion (UIE) was analyzed by wet digestion method and salt samples were tested by spot iodine testing kits.The total goiter rate (TGR) was 10.56 %. About 97.22 % of the salt samples tested were adequately iodized. Though consumption of iodized salt was adequate irrespective of socio demographic characteristics; goiter prevalence was significantly different with respect to mother’s education level. Median urinary iodine excretion was found to be with in normal range. Lastly, a comparison is made between indicators of IDD over years which showed significant fall of TGR % of North 24 Pgs and a significant increase of adequately iodized salt consumption from 2004 to 2019.Conclucion: 2019 resurvey of North 24 parganas indicates that the district achieved close to the goal of NIDDCP i.e. prevalence of IDD should be below 10%. It also proved that universal salt iodinization program has increased the household’s iodine consumption above national goal of 91.2%. Goiter prevalence is found to be less in children whose mother attend the education up to 12th standard and beyond.

Первичная заболеваемость тиреоидной системы и йодное обеспечение организма взрослого населения Заводского района г. Минска

Currently, iodine deficiency diseases are one of the most common diseases of non-infectious origin. In the Republic of Belarus, preventive measures are being taken to eliminate the problem of iodine deficiency, in particular, a state strategy has been developed and implemented, the main measure of which is the mandatory use of only iodized salt in the food industry and public catering. Despite the measures taken, the problem of iodine deficiency remains relevant, especially for children and pregnant women. According to the results of the assessment of iodine sufficiency in the world, published by the RIAC on Surveillance for Iodine Deficiency Diseases (ICCIDD) - a global non-commercial, spheral need created for the use of iodine deficiency and the consequences of its negative examination on health, adequate iodine intake is provided in the Republic of Belarus. In 2016, the Global Iodine Network published maps characterizing iodine sufficiency for two main assessment categories - school-age children and pregnant women, confirming the status of the Republic of Belarus as a country with adequate iodine sufficiency. However, despite the results achieved, from the standpoint of medical monitoring, the quality of studies conducted to monitor the iodine supply of the population, the risks of excessive salt intake remain relevant. In this paper, a comparative analysis of the dynamics of the primary incidence of thyroid pathology in the population of the Zavodskoy district of the city of Minsk for the period 2016-2020 was carried out. According to the results of the analysis, a positive trend in the primary incidence of simple goiter, nodular non-toxic goiter and thyroiditis was revealed, while the dynamics of the primary incidence of hypothyroidism did not change. According to the data presented, the presence of iodine deficiency with a median urinary iodine excretion of 196.15 gg/l was revealed in pregnant women of the Zavodskoy district of Minsk in 2021. An analysis of the questionnaire survey of the nature of the nutrition of pregnant women showed that most of the surveyed do not know about the benefits of using iodized salt for the development of the fetus, and therefore the reason for the formation of iodine deficiency in the body of pregnant women is the insufficient intake of iodine in the body and refusal to take iodine preparations. In the surveyed region, 22 % of women do not comply with the prescription of endocrinologists about the need to take iodine-containing drugs.

Assessment of the Iodine Status Among Iranian School-aged Children 20 Years After the First National Survey in Iran

: In 1994, the mandatory iodized salt consumption became a law in Iran, and since then, almost all people have routinely and effectively received iodine. This study aimed to compare the iodine sufficiency among Iranian students in 1996 and 2017. We used Iran’s health ministry national data on urinary iodine among 8- to 10-year-old students. A total 13,389 and 2,917 urine samples were examined for monitoring in 2017 and 1996, respectively. The median urinary iodine (MUI) excretion of samples was 18.26 µg/dL in 2017 and 20.5 µg/dL in 1996. Based on the urinary iodine index (< 10 μg/dL), 14.53% and 19.61% of students had iodine deficiency (ID) in 1996 and 2017, respectively, which mild, moderate, and severe insufficiency was 8.83%, 2.3%, and 3.43% in 1996 and 14.86%, 3.72% and 1.01% in 2017. So, the main achievement of this national program was the reduction in severe ID rate during these years (3.43% vs. 1.01%).

BIOCHEMICAL AND CLINICAL CHARACTERIZATION OF IODINE DEFICIENCY DISORDERS IN CENTRAL INDIA

Background: Iodine (I) is a trace element that is required by both humans and animals. It can be found in a variety of chemical forms, including iodine, iodide (I), and iodate (IO3). It is widely distributed across the earth's ecology, with a concentration in the oceans. Iodine entered the natural cycle from the ocean, the atmosphere, and rainfall, as well as from rainfall into streams and rivers. Iodine is absorbed as iodide in human nutrition. Iodine is a necessary micronutrient and a component of thyroid hormones. Fish and seafood have a high iodine level. The amount of iodine in soil and drinking water varies depending on where it comes from. Iodine shortage produces a variety of negative health consequences, which are referred to as iodine deficiency illnesses (IDD). These conditions are caused by a lack of iodine, which causes insufficient thyroid hormone production.
 Aim: The aim of this study is to characterize the iodine deficiency disorder by biochemical and clinical assessment and to correlate the iodine status with thyroid disorder(s) in adults.
 Material and Method: The samples for this investigation were taken from patients at the Department of Endocrine Surgery. This study comprised a total of 100 hundred goiter patients, who had their urinary iodine excretion and thyroid hormone levels examined. For all goiter patients, the grading of goitre was established using the WHO/UNICEF/ICCIDD approved criteria. TSH, Free T4, Free T3 by using ELISA Method using commercial kits. Anti-microsomal antibody (AMA) or Thyroperoxidase antibody (TPO-Ab) by using ELISA Method using commercial kits. Anti-thyroglobulin antibody (ATG) estimated by using ELISA Method using commercial kits.
 Results: The data for each group were presented as Median and inter quarter range (IQR) The median and IQR of Urinary iodine excretion of the hypothyroid, hyperthyroid and Euthyroid goiter subjects were respectively and there was significant difference in the median urinary iodine excretion. The median and IQR of Urinary iodine excretion of the thyroiditis, thyrotoxicosis, cancer of thyroid and benign goiter respectively and there was significant difference in the median urinary iodine excretion.
 Conclusion: For ages, endemic goitre and cretinism have been recognised as public health issues, and iodine deficiency is thought to be the leading cause of preventable mental retardation. Most countries now include iodine deficiency control as part of their national nutrition policies. To eliminate iodine deficiency, several therapies with high efficacy have been employed, including iodized oil capsules (IOC) and universal salt iodisation (USI). Although some progress has been made, efforts to eliminate this devastating health problem must be hastened. Not only should iodine deficiency be monitored, but so should excessive iodine intake, as this is a problem in various areas, including the camps.
 Keywords: IDD, Goitre, TSH, IOC, USI, ATG, AMA, T4, T3.

Iodine nutrition status and thyroid autoimmunity during pregnancy: a cross-sectional study of 4635 pregnant women

BackgroundPregnant women in Shanghai have long been at risk for mild iodine deficiency. Because thyroid autoimmunity in pregnant women can lead to premature birth and miscarriage as well as neurodevelopmental deficits in the fetus, the aim of this study was to explore the association of iodine nutrition status with thyroid antibodies during pregnancy.MethodsA pregnancy-birth cohort was conducted including 4635 pregnant women in Shanghai, China. The eligible participants underwent a face-to-face interview and completed questionnaire surveys to collect baseline information and diet intake. Spot urine samples were collected to test urine iodine. Thyroid antibodies including thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb) and thyrotrophic antibodies (TRAb) were tested. Single-factor analysis and logistic regression were used to evaluate the association between iodine status and thyroid autoimmunity during pregnancy.ResultsThe median urinary iodine excretion level in the sample was 138.14 μg/L (interquartile range [IQR] 80.90–219.00 μg/L). Among all the subjects, 25.9% consumed non-iodized salt, 54.5% had iodine deficiency, and 31.0% had thyroid autoimmunity. The proportion of patients with iodine deficiency was significantly higher among those who consumed non-iodized salt (36.9% vs. 33.1%; p = 0.04). After adjusting for age, educational status, former smoker status, former drinker status, first pregnancy, and previous thyroid disease, non-iodized salt (odds ratio [OR] = 1.394 [confidence interval, CI, 1.165–1.562]; p = 0.003), iodine-rich food (OR = 0.681 [CI 0.585–0.793]; p = 0.003), iodized nutritional supplements (OR = 0.427 [CI 0.347–0.526]; p = 0.003), were found to be individually associated with thyroid autoimmunity in all participants. The results of the multivariable restricted cubic spline regression analysis showed a non-linear relationship between the continuous change in iodine intake and thyroid autoimmunity (p = 0.019). Participants with iodine deficiency (urinary iodine concentration, UIC,< 100 μg/L) had an increased risk of testing positive for thyroid antibodies (TPOAb/TgAb/TRAb[+]; OR = 1.324 [CI 1.125–1.559]; p < 0.001). Moreover, this associated existed even after removing participants with previous thyroid disease.ConclusionInadequate iodine nutrition in pregnant women is an independent risk factor for thyroid autoimmunity in Shanghai. It’s important to maintain the adequate iodine status in pregnant women.

Wrangle with hypertension: lowered salt intake may not compromise iodine status among tribes of Central India.

The most important risk factor of cardiovascular disease is hypertension and high salt intake contributes to high blood pressure. However, to prevent iodine deficiency disorders, the iodisation of salt is a proven strategy. So, on one hand, we suggest people reduced salt consumption but on the other hand, we also fear an increase in the prevalence of iodine deficiency disorders. In the present study, we investigated the possibility of salt intake at WHO recommended levels resulting in higher or lower iodine status in India by assessing the urinary iodine status and its relation with blood pressure. It was a cross-sectional study. It was a community-based study. We collected 24-hour urine samples for estimation of iodine concentrations in urine from 411 adult hypertensives in the Mandla district of central India. Urinary iodine was estimated using Thermo ORION make ion-selective electrodes. The median urinary iodine excretion was 162·6 mcg/l. Interestingly 371 (90·26 %) subjects were observed with > 200 mcg/l urinary iodine concentration level indicating iodine sufficiency. Individuals with high urine Na significantly had high blood pressure as compared with individuals with low urinary Na excretion (P < 0·01). There is a higher probability of high urine iodine levels among individuals with higher urine Na levels. The study revealed that 90 % of the population were excreting excessive iodine in urine, which is more than adequate iodine uptake. This excess uptake enables a scope for reduction in salt intake to control hypertension.

Performance Evaluation of Iodine Deficiency Disorder Control Program in Chikmagalur District: A Cross-Sectional Community-Based Survey.

Routine evaluation of Iodine Deficiency Disorders (IDDs) is done through a national program called National Iodine Deficiency Disorder Control Program (NIDDCP). The aim of this study is to determine the goiter prevalence, to estimate salt Iodine and urinary Iodine levels. An institution-based cross-sectional study was conducted among 2700 school children across seven taluks of Chikmagalur. A total of 2700 children aged 6 to 12 years were selected from 30 clusters by multistage sampling method. The iodometric titration method and Sandell-Kolthoff method were used for the estimation of salt and urinary Iodine, respectively. Descriptive and Inferential statistics were used. The prevalence of goiter was 13.0%. About 153 (28.3%) salt samples had inadequate iodine content (<15 ppm). Median Urinary Iodine Excretion was 126 μg/L. Chikmagalur district is still at risk of a significant public health problem which needs timely interventions and appropriate measures to prevent further consequences due to IDDs.

Burden of iodine deficiency disorders and its association with various sociodemographic variables in a district of North East India.

Iodine is one such micronutrient, the deficiency of which can impair the mental growth and development of young children and is the leading cause of preventable mental impairment. The present study has been conducted to study the prevalence of iodine deficiency disorders (IDDs) and its association with various sociodemographic variables among children (6-12 years) residing in the East Khasi Hills district of Meghalaya. The sample size was 2700 with a multistage 30 cluster sampling method. A questionnaire was used to collect data on the various sociodemographic variables. The weight and height of each child were recorded as per the standard procedure. In order to assess goitre, children were examined as per standard procedures prescribed by the National Iodine Deficiency Disorder Control Programme (NIDDCP). A total of 2700 children were interviewed in total. Out of these, 1365 (50.5%) were males. The total goitre rate was found to be 195 (7.22%), indicating that IDDs are a mild public health problem in the study area. The median (interquartile range) urinary iodine excretion levels were 150 (108.05-189.37) mg/L. With respect to weight-for-age, it was observed that 93 (3.9%) children were severely underweight and 389 (16.8%) had severe stunting. A significant association was observed between goitre with the age group of children (p <.00001), maternal education (p <.00001), prevalence of stunting (p <.00001), and underweight (p <.05).

Seasonal effects on urinary iodine concentrations in women of reproductive age: An observational study in Tanzania and South Africa

Iodine intake in populations is usually assessed by measuring urinary iodine concentrations (UICs) in spot samples. Hot climate conditions may reduce urine volume, thus leading to overestimations of UIC and thereby masking inadequate iodine intake. We investigated the effects of season on UICs in 2 populations exposed to high-temperature climates. In this observational study, we examined women (18-49 years) in Tanzania (ncold=206; nhot=179) and South Africa (ncold=157; nhot=126) during cold and hot seasons. From each woman in both seasons, we obtained two 24-hour urine collections and 2 spot urine samples, as well as salt, water, and cow's milk samples. We measured the urine volume, UIC, and urinary creatinine concentration (UCC). The 24-hour urinary iodine excretion (UIE) was calculated and used to estimate the iodine intake. We used linear mixed-effects models to test for differences between seasons. In Tanzanian women, we observed no seasonal effect on the urine volume, 24-hour UIE, 24-hour UIC, spot UIC, spot UIC:UCC ratio, or salt iodine concentration. In South African women, the median 24-hour urine volume was 1.40 L (IQR, 0.96-2.05 L) in the winter and 15% lower in the summer (P<0.001). The median 24-hour UIE was 184 µg/day (IQR, 109-267µg/day) in the winter and 34% lower in the summer (P<0.001), indicating a lower iodine intake. As a result, UICs did not significantly differ between seasons in 24-hour collections and spot samples, whereas the spot UIC:UCC ratio differed by 21% (P<0.001) and reflected the lower iodine intake. In both study populations, the within- and between-person variabilities in urine volume, 24-hour UICs, and spot UICs were higher than the variability between seasons. Spot UIC may slightly overestimate the iodine intake in hot temperatures due to concentrated urine, and methods to correct for urine volume may be considered. Local seasonal differences in iodine intakes may also occur in some populations. This trial was registered at http://www.clinicaltrials.gov as NCT03215680.

IODINE STATUS IN SCHOOL CHILDREN AND DISTRIBUTION OF IODINE, MERCURY, LEAD IN SOIL AND WATER IN THE ENDEMIC GOITER HILL AREA, PONOROGO

Background. Iodine deficiency disorders (IDD) remained a public health problem. Ponorogo was an IDD endemic area with prominent cases of mental retardation. Despite the lack of iodine intake, exposure to environmental heavy metals can exacerbate the effects of iodine deficiency. Objective. To describe iodine status of school children and distribution of environmental iodine and heavy metals including mercury (Hg), lead (Pb), and cadmium (Cd) in the endemic IDD hill area of Ponorogo. Method. This research is a cross-sectional study conducted in two villages in IDD endemic areas in Ponorogo, namely Dayakan and Watubonang villages, in 2011. A total of 127 urine samples of primary-school-age children were taken and analyzed for urinary iodine excretion (UIE). A total of 29 soil samples and 87 water samples were taken from the study site to measure the concentration of iodine and heavy metals Hg, Pb, and Cd. Types of water source, altitude, and land use, both soil and water source were recorded. Results. The median (min-max) UIE was 130 (14 –1187 µg/L) within the range of adequate population iodine intake according to WHO (100-199 µg/L), while the percentage of UIE &lt;100 µg/L was still around 33.07 percent. The concentration of iodine in the soil was 33.777 mg/kg (6.640 –108.809), and the concentration of iodine in the water was 8.0 µg/L (0-49). The concentration of Hg in the soil was 68.64 ppb (7.43–562.05), and the concentration of Hg in the water was 0.00 ppb (0.00-23.24). The concentration of Pb in the soil was 3.273 ppm (0.000–25.227), while Pb was not identified in the water. The Cadmium was not detectable both in the soil and water. Conclusion. Iodine deficiency is still a public health problem in Dayakan and Watubonang villages. The environment of the endemic IDD area in Ponorogo was not completely poor in iodine, but iodine was not evenly spread and mobilized. There was a risk of environmental heavy metal exposure from Hg in the soil or water and Pb in the soil. Mercury in the environment can cause health problems due to the inhibition of the use of iodine in the thyroid gland.

Рівень забезпечення йодом дітей шкільного віку з хронічними соматичними захворюваннями

One of the most common conditions resulting from micronutrient deficiency is iodine deficiency. Purpose — to evaluate the current state of iodine supply in schoolchildren living in the North-Eastern region of Ukraine, including children with digestive diseases and inflammatory joint diseases. Materials and methods. Target group: 86 people (11.8±2.71 years), which included patients with digestive diseases (DD) (26.7%) and juvenile idiopathic arthritis (JIA) (60.5%). Methods: dietary iodine intake evaluation by urinary iodine concentration (Sandell–Kolthoff reaction), followed by calculation of the median. Results. Median urinary iodine excretion was at the lower normal range and amounted to 104.98 μg/l [QR: 59.8; 180.1] in the examined children. Only 51.2% of children had adequate iodine provision; mild iodine deficiency (ID) was diagnosed in 29.1% (Ме=81,91μg/l [QR: 64.26; 90.58]); moderate — 17.4% (Ме=36,19 μg/l [QR: 33.54; 42.24]); severe — in 2.3% of the surveyed (Ме 14,02 μg/l [QR: 12.34; 15.70]). The median urinary iodine excretion in children with somatic diseases was significantly lower than in children of the control group and amounted to 97.26 μg/l [QR 53.7; 148.3] versus 183.71 μg/l [QR 104.4; 287.4], (p=0.003). Conclusions. School-age children have a high incidence of iodine deficiency (51.2%). Often encountered in childhood diseases (DD and JIA) are accompanied by insufficiency of iodine supply. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: iodine deficiency, school-age children, the level of iodine excretion.

Iodine Nutrition Status and Thyroid Autoimmunity During Pregnancy: A Cross-Sectional Study of 4635 Pregnant Women

BackgroundPregnant women in Shanghai have long been at risk for mild iodine deficiency. Because thyroid autoimmunity in pregnant women can lead to premature birth and miscarriage as well as neurodevelopmental deficits in the fetus, the aim of this study was to explore the association of iodine nutrition status with thyroid antibodies during pregnancy.MethodsA pregnancy-birth cohort was conducted including 4635 pregnant women in Shanghai, China. The eligible participants underwent a face-to-face interview and completed questionnaire surveys to collected baseline information and diet intake. Spot urine samples were collected to test urine iodine. Thyroid antibodies including thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb) and thyrotrophic antibodies (TRAb) were tested. Single-factor analysis and logistic regression were used to evaluate the association between iodine status and thyroid autoimmunity during pregnancy.FindingsThe median urinary iodine excretion level in the sample was 138·14 µg/L (interquartile range [IQR] 80·90-219·00 µg/L). The proportion of patients with iodine deficiency was significantly higher among those who consumed non-iodized salt (36·9% vs. 33·1%; p = 0·04). After adjusting for age, educational status, former smoker status, former drinker status, first pregnancy, and previous thyroid disease, non-iodized salt (odds ratio [OR] = 1·394 [confidence interval, CI, 1·165-1·562]; p = 0·003), iodine-rich food (OR = 0·681 [CI 0·585-0·793]; p = 0·003), iodized nutritional supplements (OR = 0·427 [CI 0·347-0·526]; p = 0·003), were found to be individually associated with thyroid autoimmunity in all participants. The results of the multivariable restricted cubic spline regression analysis showed a non-linear relationship between the continuous change in iodine intake and thyroid autoimmunity (p = 0·019). Participants with iodine deficiency (urinary iodine concentration, <100 µg/L) had an increased risk of testing positive for thyroid antibodies (TPOAb/TgAb/TRAb[+]; OR = 1·324 [CI 1·125-1·559]; p < 0·001). Moreover, this associated existed even after removing participants with previous thyroid disease.InterpretationInadequate iodine nutrition in pregnant women is an independent risk factor for thyroid autoimmunity in Shanghai, where the overall nutrition status is good. Funding: This study was supported by the young fund of Shanghai municipal health commission (20194Y0443), food nutrition research and education fund of Danone nutrition center (DIC2019-03), excellent young talents of health system in Shanghai (No. 2017YQ043) and top young talents in Shanghai (No. 2020-8). Declaration of Interest: None to declare. Ethical Approval: The study was approved by the Ethics Committee of Shanghai Center for Disease Control and Prevention (SCDC) and was performed in accordance with the Declaration of Helsinki. Before data collection, written informed consent was obtained from all participants.

Iodine status and thyroid parameters of pregnant women living in an iodine sufficient area

During the last few decades painstaking efforts have been made to eliminate iodine deficiency throughout the world. Todays in regions where dietary iodine intake is adequate or borderline, the main focus is increasing dietary iodine supply in the target population during pregnancy and the first years of life. Objective: The aim of this study was to obtain longitudinal data on urinary iodine excretion and the changes of maternal thyroid parameters in two groups of healthy women with mild-to-moderate iodine deficiency and iodine sufficiency residing in an iodine replete area of Tehran capital city of IR Iran, for more than one decade. Research designs and methods: The present study is part of a cohort study, investigating the relative influences of iodine intake on thyroid size and function of mothers and their infants during and after pregnancy. A total of 500 pregnant women enrolled from two mother-child health care centers and was divided into group I, with median urinary iodine excretion (MUIE) &lt; 150 µg/L, and group II with MUIE ≥ 150 µg/L. Sonographic thyroid volume measurement, urinary iodine excretion and thyroid function tests were measured sequentially in all pregnant women during the three trimesters (T) of pregnancy. Results: The mean ± SD age of the participants was 25.1 ± 5.1 years. The MUIE in group I and II in the first, second and third trimester were 123 and 250 µg/L, 127 and 166 µg/L, 120 and 150 µg/L, respectively. The MUIE in the third trimester of pregnancy in group I did not differ significantly from the values in the first and second trimesters (p = 0.67), but it did decline significantly in group II (p &lt; 0.001). The median thyroid volume of subjects, in the first, second and third trimesters were 7.8, 8.2 and 8.1 ml in group I and 7.5, 8.0 and 8.4 ml in group II, respectively. No difference in thyroid volume was found between two groups in each of the three trimesters of pregnancy (p &gt; 0.05). The mean (± SD) TSH concentration of subjects in first, second and third trimester was 2.3(± 2.6), 2.1(± 1.8), 2.3(± 1.7) mIU/L in group I and 2.1(± 3.1), 2.1(± 1.8) and 2.0(± 1.3) mIU/L in group II, respectively. The trend of TSH rising in group I was 26.7% and in group II it was 13.3%. The mean TSH value in three trimesters did not differ significantly in either groups (p &gt; 0.05). The mean (± SD) total T4 concentrations of subjects in first, second and third trimesters were 13.2(± 3.4), 13.8(± 3.3), 13.0(± 2.9) µg/dl in group I and 13.1(± 3.2), 13.7(± 2.9), 13.4(± 3.2) µg/dl in group II, respectively. The mean total T4 value in three trimesters did not differ significantly in either groups (p &gt; 0.05). There was no correlation between the thyroid volume and three observed parameters (UIE, total T4 and TSH) during the pregnancy in either groups. Conclusion: Even in areas with well-established universal salt iodization program, pregnancy could be a risk of having iodine deficiency and systematic dietary fortification needs to be implemented in this vulnerable group.

An Assessment of Iodine Deficiency in School Age Children in ChikkaballapuraDistrict of Karnataka State – A Cross Sectional Study

Background Iodine deficiency has been one among the nutrition problems in India. The deficiency of this micro-nutrient leads to a wide spectrum of disorders from the intrauterine life extending through childhood and adult life with serious health and social implications. Lack of iodine in the diet leads to visible and invisible spectrum of health consequences collectively called Iodine Deficiency Disorders IDDs. Globally India has the been the country with a very large number of children born vulnerable to iodine-deficiency. In India IDD has been identified as a public health problem with 200 million people at risk. Iodine Deficiency Disorders are among the easiest and least expensive of all nutrient disorders to prevent. The addition of a small constant amount of iodine to the salt that people consume daily is all that is needed. Objectives The study aimed to assess the prevalence of Goiter in children aged 6-12 years to determine the median Urinary Iodine Excretion UIE among these children and the salt iodine levels at consumer level in District of Chikkaballapura.Methodology The school officials were informed to request all the children aged 6-12 years to bring salt samples from their residence 3-4 teaspoon of salt in a plastic cover on the day of survey. On the day of survey 90 children 45 boys and 45 girls aged 6-12 years were selected by disproportionate stratified random sampling class studying as the stratum for clinical examination of goiter by doctors.Results A total of 2774 children from 30 schools were screened for thyroid enlargement. A total 368 urine samples were collected of which only 350 samples were analysed for urinary iodine concentration. A total of 18 samples were discarded due to low quantity sediments or turbidity. Salts from 650 households were titrated for iodine content. The overall prevalence of goiter was 8.1. Among the study participants 315 90.9 had normal UIE gt100 microgL. Iodine deficiency was observed in 2.3 study participants.Conclusion The population in Chikkaballapura at present have iodine levels at par to the recommended but continuous efforts from government and non-government organizations are needed to sustain the availability of iodized salt to keep iodine levels at optimum level.

An Assessment of Iodine Deficiency in School Age Children in Chitradurga District of Karnataka State – A Cross-Sectional Study

Background Iodine deficiency is one of the important nutrition problems in India. The deficiency of this micro-nutrient leads to a wide spectrum of disorders from the intrauterine life extending through childhood and adult life with serious health and social implications. Lack of Iodine in the diet leads to visible and invisible spectrum of health consequences collectively called Iodine Deficiency Disorders IDDs. Globally India has the largest number of children born vulnerable to iodine-deficiency. In India IDD has been identified as a public health problem with 200 million people at risk. Iodine Deficiency Disorders are among the easiest and least expensive of all nutrient disorders to prevent. The addition of a small constant amount of iodine to the salt that people consume daily is all that is needed.Objectives The study aimed to assess the prevalence of Goitre in children aged 6-12 years to determine the median Urinary Iodine Excretion among these children and the salt iodine level at consumer level.Methodology The school authorities were informed to request all the children aged 6-12 years to bring salt samples from their residence 3-4 teaspoon of salt in a plastic cover on the day of survey. On the day of survey 90 children 45 boys and 45 girls aged 6-12 years were selected by disproportionate stratified random sampling class studying as the stratum for clinical examination of goitre by doctors.Results A total of 2900 children from 30 schools were screened for thyroid enlargement. A total 359 Urine samples were collected of which only 296 were analysed for urinary iodine concentration. A total of 63 samples discarded due to low quantity sediments or turbidity. Salts from 650 households were titrated for iodine content.The overall prevalence of goitre was 10.3. 269 90.9 of the study participants had normal UIE gt100 microgL. 27 9.1 study participants had iodine deficiency.Conclusion The population in Chitradurga at present have iodine nutrition at par to the recommended but continuous efforts from governmental and non-governmental organizations are needed to sustain the availability of iodized salt to keep iodine nutrition at optimum level.

Salt-reduction strategies may compromise salt iodization programs: Learnings from South Africa and Ghana

ObjectivesUniversal salt iodization has been adopted by many countries to address iodine deficiency. More recently, salt-reduction strategies have been widely implemented to meet global salt intake targets of <5 g/d. Compatibility of the two policies has yet to be demonstrated. This study compares urinary iodine excretion (UIE) according to 24-h urinary sodium excretion, between South Africa (SA) and Ghana; both countries have implemented universal salt iodization, but in Ghana no salt-reduction legislation has been implemented. MethodsParticipants from the World Health Organization's Study on Global Ageing and Adult Health Wave 3, with survey and valid 24-h urinary data (Ghana, n = 495; SA, n = 707), comprised the sample. Median 24-h UIE was compared across salt intake categories of <5, 5–9 and >9 g/d. ResultsIn Ghana, median sodium excretion indicated a salt intake of 10.7 g/d (interquartile range [IQR] = 7.6), and median UIE was 182.4 µg/L (IQR = 162.5). In SA, both values were lower: median salt = 5.6 g/d (IQR = 5.0), median UIE = 100.2 µg/L (IQR = 129.6). UIE differed significantly across salt intake categories (P < 0.001) in both countries, with positive correlations observed in both—Ghana: r = 0.1501, P < 0.0011; South Africa: r = 0.4050, P < 0.0001. Participants with salt intakes <9 g/d in SA did not meet the World Health Organization's recommended iodine intake of 150 µg/d, but this was not the case in Ghana. ConclusionsMonitoring and surveillance of iodine status is recommended in countries that have introduced salt-reduction strategies, in order to prevent reemergence of iodine deficiency.

Iodine deficiency disorders in a South Indian district: still a public health problem?

Background: Iodine deficiency disorders (IDD) constitute the single largest cause of preventable brain damage worldwide leading to learning disabilities and psychomotor impairment. Nearly 266 million school children worldwide have insufficient iodine intake. IDD was found to be a public health problem in 47 countries. Since the information on current prevalence of goiter in Kolar was not available, the present study was undertaken.Methods: A cross-sectional study was conducted among school children aged 6-12 years in Kolar taluk. A total of 2700 children were selected for goiter examination by multistage random cluster sampling technique. A total of 270 children were tested for the median urinary concentration and 540 salt samples were tested from the households of the study population.Results: The total goiter rate was 5.66% among primary school children aged 6-12 years with a significant difference between ages. As the age increased the goiter prevalence also increased. The median urinary iodine excretion level was found to be 105 mcg/l and 92.788.7% salt samples had &gt;15 ppm iodine content.Conclusions: Present study shows mild goiter prevalence in primary school children in Kolar district and an adequate iodine content of salt in urine.

Iodine Deficiency Disorders in Children in East Khasi Hills District of Meghalaya, India

To assess the prevalence of iodine deficiency disorders among school-going children in Meghalaya. Multi-stage 30 cluster sampling with probability proportionate to size (PPS) method was used. Children (age 6-12years) were examined clinically for goiter. Urinary iodine excretion (UIE) was performed by spectrophotometric method. Iodine content in the salt was analyzed using iodized salt test kits. A total of 195 (7.22%) out of 2700 children had goiter on examination. Goitre prevalence was significantly associated with wasting (P<0.05) and stunting (P <0.001). The median (IQR) UIE level was 150 (108.05 - 189.37) µg/dL. Nineteen (9.74%) children had severe iodine deficiency (UIE<20µg/L). Iodine content was above the recommended level of 15 ppm in 95.9% salt samples. A positive correlation was observed between household salt consumption and UIE levels (r=0.25; P<0.001). Iodine deficiency disorder is a public health problem in Meghalaya, which needs to be addressed.

A Cross-sectional study assessing the Prevalence ofIodine Deficiency Disorders among school children aged6 to 12 years in Tumakuru district of Karnataka

Background Iodine deficiency disorders IDD constitute a major public health problem in India. Deficiency of iodine can cause physical and mental retardation cretinism abortions stillbirth deaf mutism squint amp various types of goitre. Methodology A community ndash based cross section survey was undertaken during the February-March 2019 in Tumakuru district of Karnataka to find out prevalence of goitre estimate urinary iodine excretion in 6-12 years old school children and household salt iodine concentrations. 2875 school children aged 6-12 years were examined for goitre. Urine samples of 270 childrenwere collected for estimation of urinary iodine using Sandell-Kolthoff method. Household salt samples of the 540 selected children from schools were analyzed for its iodine content by standard iodometric titration method. Results The overall prevalence of Goitre was found to be 9.5 among children examined. The median urinary iodine excretion UIE was 104 mugL. All the household salt samples were adequately iodized having Iodine content of gt15ppm. Conclusion Considering prevalence of goitre in 6-12 years children Tumakuru district is lsquoendemicrsquo for IDD. But as inferred from median UIE obtained IDD is not a public health problem of significance. Household level salt is adequately iodized as per NIDDCP recommendations

Universal Salt Iodinization is not that Universal - A study among school age children in Mandla District, Madhya Pradesh.

Background: Iodine deficiency is a preventable cause of brain damage. Aims &amp;Objectives: The present study was conducted to determine the prevalence of goiter in school going children clinically, to assess the iodine status (urinary iodine excretion) of school children, and to assess the iodine content of the salt consumed by the population. Materials and Methods: It is school based cross-sectional study, conducted in Mandla district of Madhya Pradesh state in central India in 2016. The study participants were school children in 6-12 years of age. Probability-proportional-to-size cluster sampling was used. Palpation method was used to identify the presence of goiter. Urine samples were collected and median urinary iodine excretion was found. The salt samples were also collected from the households and local market to determine the iodinization status. Results: A total of 2700 school children were studied. The total goitre rate was 0.74%. Among those clinically palpable goiter 15(75%) were girls. The prevalence of goitre higher among girls was statically significant with p=0.025. All the cases of clinically palpable goiter belonged to caste other than general with p&lt;0.001. The median urinary iodine excretion of 270 urine samples of school children was 184 µg/l. The prevalence of iodine deficiency disorders using urinary iodine excretion as indicator in the present study was 22.9% Seven percent of the samples had median urinary iodine The normal iodine content i.e more than the 15 ppm iodine was present in 84% of samples collected from households. Conclusion: The children of Mandla district of Madhya Pradesh had low prevalence of goiter. However, there is significant burden of goiter among backward classes.