Medial Knee Joint Space Research Articles

Medial Knee Joint Space in Relation to Joint Function and Early Knee Pain in 20-45-Year Adults: A Cross Sectional Study.

Anterior knee pain is very common in the young and active age groups but there are no significant studies on the normal population. Therefore, the objective of the study was to understand the relation between medial knee joint space to the development of knee pain and functional disability with special reference to the 20-45-year age group. 250 cases with mean age of 36.36years presenting with knee pain for at least 1month were included in this prospective study (July 2021 and June 2022) and were asked to self-complete questionnaires on knee pain which included KNEST, AKPQ, VAS and IPAQ. Patients underwent X-rays of bilateral knees in AP view with weight bearing and then medial and lateral knee joint spaces were calculated. There was a higher incidence of knee pain in women compared to men. The average medial and lateral joint space widths (MJSW and LJSW) of the right knee were 4.22mm and 4.57mm, respectively. For the left knee it was 4.19mm and 4.42mm, respectively. There is a decrease in MJSW with increasing age, level of pain and BMI. Also, with an increase in physical activity, there was a higher incidence of knee pain. Overuse injuries are the main cause of knee pain in this age group. There is a significant association between medial joint space width and age, gender, level of pain, and BMI. Rising BMI patterns at a young age, leads to an increase in physical activity, which in turn leads to early knee pain and also predisposes to osteoarthritis.

A PROSPECTIVE STUDY OF PROXIMAL FIBULAR OSTEOTOMY IN YOUNG PRIMARY MEDIAL OSTEOARTHRITIS KNEE AND ITS CLINICAL, FUNCTIONAL AND RADIOLOGICAL OUTCOME.

Background: Osteoarthritis (OA) commonly known as wear and tear arthritis. While it can occur even in young people, the chance of developing osteoarthritis rises after age 45. Proximal bular osteotomy (PFO) for young patients of OA knee joint is turning out to be an emerging concept with promising results. The aim of our study was to evaluate clinical, radiological and functional outcomes of PFO in young patients of primary medial compartment osteoarthritis of knee joint. Total 13 patients (20 knees) with moderate to severe pr Method: imary osteoarthritis of knee joint, who underwent PFO, were enrolled. Clinical data, Visual Analogue Scale score (VAS), Knee Society Score (KSS), Medial Knee Joint Space (MJS) and Femorotibial Angle measurements (FTA) were recorded. Patients were followed up at one, three, six months and yearly, postoperatively. 20 knee joints PFO. The mean VAS scores signicantly decreased from Results: 8.25 preoperatively to 2.21 at 12 months postoperatively. In most of patients, signicant medial pain relief was observed after PFO. Mean KSS at preoperative stage was 44.15, which was improved to 77 at 12 months postoperatively, which further suggests improvement in knee joint functions. There was noteworthy increase in Mean joint space postoperatively (1.17) as compared to preoperative stage (0.34). Mean FTA reduced from 182.64 degrees preoperatively to 178.61 at nal follow up. Our study shows Conclusion: that PFO remarkably causes pain relief and improves knee functions with increase in MJS and slight correction of varus deformity in young patients with primary osteoarthritis of knee joint.

Intra-articular Pure Platelet-Rich Plasma Combined With Open-Wedge High Tibial Osteotomy Improves Clinical Outcomes and Minimal Joint Space Width Compared With High Tibial Osteotomy Alone in Knee Osteoarthritis: A Prospective Study

PurposeTo compare the clinical efficacy of the patients with medial compartment knee osteoarthritis who underwent either opening-wedge high tibial osteotomy alone (HTO) or simultaneous HTO and pure platelet-rich plasma therapy (HTO+P-PRP). MethodsEighty patients were divided into 2 groups randomly, the HTO-alone group (n = 41) and the HTO+P-PRP group (n = 39). Patients were matched for preoperative age, sex, and body mass index. The outcomes studied included visual analogue scale (VAS) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lysholm score. The minimum width of medial knee joint (MJSW), medial proximal tibial angle (MPTA), femoral tibial angle (FTA), and weightbearing line (WBL) were measured preoperatively, immediately postoperatively, and 1, 6, 12, and 24 months postoperatively. Paired t test and chi-squared test were used for statistical analysis. ResultsAll patients were followed up at 1, 6, 12, and 24 months postoperatively. At 1, 6, and 12 months, pain and function scores in the HTO+P-PRP group were better than those in the HTO-alone group, especially at 6 months in Lysholm score (HTO alone, 72.5 ± 10.6; HTO+P-PRP, 83.1 ± 14.7; P = .003, 95% CI –14.13 to –10.42) and WOMAC (HTO alone, 90.3 ± 11.9; HTO+P-PRP, 75.6 ± 15.4; P < .001, 95% CI 13.36 to 20.11). For both groups, no difference was found preoperatively (HTO alone, varus 3.5 ± 3.9; HTO+P-PRP, varus 4.1 ± 4.0; P = .898) or postoperatively (HTO alone, valgus 6.7 ± 4.5; HTO+P-PRP, valgus 7.7 ± 2.3; P = .768) in FTA or WBL. The increase of the MJSW in the HTO+P-PRP group was significantly greater than that in the HTO-alone group during the first year, especially at 6 months (HTO alone, 3.8 ± 1.2 mm; HTO+P-PRP, 4.6 ± 1.1 mm; P = .001, 95% CI –1.27 to –0.35). ConclusionsCompared with HTO alone, HTO combined with intra-articular P-PRP improved the minimum medial knee joint space width during the first year postoperatively. Clinically, a higher proportion of patients in the HTO+P-PRP group exceeded the minimal clinically important difference (MCID) in the first year, especially at 6 months in Lysholm score (HTO alone, 65.9%; HTO+P-PRP, 97.4%) and WOMAC (HTO alone, 82.9%; HTO+P-PRP, 100.0%). Level of Evidence2, prospective comparative study.

Does vitamin D3 supplementation improve medial joint space narrowing in patients with osteoarthritis knee

&lt;p class="abstract"&gt;&lt;strong&gt;Background:&lt;/strong&gt; Although vitamin D3 levels are known to improve pain and knee function in patients with knee OA, no clear evidence is available regarding relation between improvement in medial joint space with improvement in vitamin D3 levels. The aim of this study was to evaluate effectiveness of vitamin D3 supplements in improving joint space in the patients with OA knee.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods: &lt;/strong&gt;100 patients with OA Knee who fulfilled inclusion criteria and consented to participate were enrolled for study. Patients of OA Knee were blinded and randomized to receive either tablet vitamin D3 or identical placebo tablet. Vitamin D3 Tab was administered in a dose of 60000U/week for 3 months in 12 doses while placebo tablets with identical dosing schedule were used for control group. The patients who received vitamin D3 tablets were allocated to case group while those receiving identical placebo tablets were grouped as controls. The vitamin D3 levels and medial joint space were assessed at baseline, 3 mo, 6mo and 1 year in both the groups.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; In two groups of patients of OA knee of 50 patients each vitamin D3 supplementation increased levels of vitamin D3 in case group. While no significant improvement in joint space narrowing was noted with vitamin D3 supplementation in case group. Also no significant correlation was observed between vitamin D3 levels and medial joint space narrowing.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;There was no improvement in medial knee joint space with vitamin D3 supplementation.&lt;/p&gt;

Measurement of the near medial knee joint space width (JSW2)

Measurement of the near medial knee joint space width (JSW2)

Measurement of the medial knee joint space width (JSW1)

Measurement of the medial knee joint space width (JSW1)

A machine learning-based predictive model for progression of knee osteoarthritis from clinical data

Purpose: Knee Osteoarthritis (KOA) is a multi-factorial disease. It poses challenges to precisely predict the progression of KOA, which is required for personalized medicine to prevent the deterioration of joint destruction. There are three KOA progression definitions: WOMAC progression refers to a persistent increase of at least nine points under a normalised scale from 0-100 of McMaster Universities Osteoarthritis Index (WOMAC); KL progression is any increase in KL grade (KLG), except for the increase from KLG 0 to KLG 1; Joint Space Width progression (JSW) progression, which is the loss in the medial knee joint space width of at least 0.7mm. In this study, the rate of KOA progression is further classified as rapid and chronic progression (aggravation of KOA conditions within 48 months and between 48 and 96 months respectively). This study aims to develop a patient-specific predictive model for the progression of KOA via a machine learning approach using the database of FNIH OA biomarker consortium. Methods: In feature selection, as shown in Figure 1, 36 features were selected from the dataset, which could enhance the prediction result of the supervised machine learning model. In order to maintain an adequate sample size for training the model, the Multivariate Imputation by Chained Equation (MICE) was employed to gave the approximation to the missing entries to complete the dataset. It was found that for all the progression types, the Non-progressor Class outnumbered its counterpart in all the instances, resulting in class imbalance. (see Table 1) We developed the ‘Random Feature Generator’, which generated combinations from the feature pool. The outputs were fed into a Logistic Regression model using the 48 and 96-month datasets, cross-validated with 5-fold, finally calculated the average accuracy. Downsampling was used to lower the computational cost. To investigate the performance trend over time, the data points from the 72-month dataset were recruited and compared with 48 and 96-month datasets using paired T-test for all three KOA progression types. In order to examine feature specificity, we extracted the top 50 best performing feature combinations from 48 and 96-month datasets for further analysis. A chart of occurrence frequency of each feature from the 50 selected combinations was plotted. It was hypothesised that the more frequent the feature appears, the more the importance it holds towards KOA progression. Results: From Table 2a and 2b, it was found that the top-performing combinations were from KL progression in both datasets. Moreover, it was observed that both models with feature selection outperformed those without in terms of accuracy using Logistic Regression. Table 3 showed the performance of the original Logistic Regression model could be boost by Multi-layer Perceptron in all metrics. In Figure 2, all the progression types demonstrated a significant increasing accuracy as time proceeds, with KL progression outperforms other progression types in all instances. It could be inferred that the more frequently a feature appears in the top-performing combinations, the more important it is to the prediction of KOA progression. As from Figure 3, it could be observed that the feature frequency distributions for 48 and 96-month datasets were different. However, the most frequently appeared features all fell into the categories of either generic or radiographic information of the subject. It could also be observed features of metabolic syndrome exerted a greater degree of impact to KOA progression in the short term (48 months) than long term (96 months). In short, the above frequency plot could reflect the extent of influence towards KOA progression from different features. Conclusions: In this study, we achieved a top model prediction accuracy for rapid and chronic KOA progression of 0.7059 and 0.7272 respectively. It was also found that the prediction accuracy increases as time progresses for all progression types. This may because due to the characteristic of KOA is a degenerative disease, such that signs and symptoms manifest over time. Furthermore, the model predictive capability was discovered to be specific to each time point, meaning features poses varying influence in model predictive prowess chronologically. As the top five most important and highly correlated features for rapid KOA progression predication were: joint space width, OARSI joint space narrowing grade in the medial compartment, sex, race, and medial meniscus extrusion. As for the chronic KOA progression prediction, sex, KL-grade, weight, habit of smoking, and OARSI joint space narrowing grade in lateral compartment were of most importance. Notably, the above features were all from either generic or radiographic information of the subject. In conclusion, the findings in this study may give insights to the treatment protocol for short, mid and long term disease management.

Treatment of degenerative medial meniscus injury of knee joint by arthroscopy combined with small needle knife to release superficial medial collateral ligament of knee joint

To explore the clinical effect of arthroscopic combined with small needle knife in the treatment of degenerative medial meniscus (MM) injury of knee joint by releasing the superficial layer of medial collateral ligament (SMCL). From February 2016 to November 2018, 56 patients (56 knees) with limited pain, strangulation and flexion in medial knee joint space were selected. X-ray Kellgren-Lawrence grading was I-II. MRI showed medial meniscus injury(III degree) of knee joint. There were 30 males(30 knees) and 26 females(26 knees). Arthroscopic MM plasty and small needle knife were used to release SMCL. The Lysholm knee score was used to evaluate the effect of operation. All 56 patients were followed up, and the duration ranged from 3 to 24 months, with an average of 10 months. According to the Lysholm knee score standard, the final follow-up was compared with that of before operation. The results showed that the preoperative knee score was 37.24±1.32, the latest follow-up knee score was 85.72±5.28, the knee score was higher than that before the operation(P<0.05). Arthroscopy combined with small needle knife release of superficial medial collateral ligament in the treatment of degenerative medial knee meniscus injury can effectively improve the mechanical balance of the knee joint, improve Lysholm knee score in patients with knee meniscus injury, and promote the recovery of knee joint function, which has clinical value.

Anatomical Study of Saphenous Nerve and Great Saphenous Vein Using a Peripheral Vein Illumination Device and Ultrasonography

Category:Ankle, Basic Sciences/BiologicsIntroduction/Purpose:Usefulness of ultrasonographic guided saphenous nerve block is well known for perioperative pain management of foot and ankle surgery. However, in some cases it may be impossible to identify the saphenous nerve, especially women or obese patients, so successful rate of ultrasonographic guided saphenous nerve block was reported 70 to 80%. Previous reports demonstrated that the saphenous nerve is running adjacent to the greater saphenous vein, which suggests that the greater saphenous vein can be an indicator to identify the saphenous nerve. The purpose of this study was to examine anatomical relationship between the saphenous nerve and the greater saphenous vein which is depicted using the near-infrared (NIR) vascular imaging system, the Vein Viewer Flex®.Methods:Thirty legs as 15 healthy subjects (13 males, 2 females) were included in this study. Average age was 34.2 ± 3.2 years old. In a supine position, the knee joint was flexed 60 degrees with mild flexion, abduction, and external rotation of the hip joint, and the greater saphenous vein was depicted using the Vein Viewer Flex® on the skin of the lower extremity. The vein visualized as a green light was then marked using the skin marker. (Figure 1). After marking the greater saphenous vein, the greater saphenous vein and saphenous nerve were identified under ultrasonography at 5 cm distal from the medial knee joint space (Figure 2). The distance between the greater saphenous vein which was marked using the Vein Viewer Flex® and the saphenous nerve was measured in the ultrasonography images. The circumference of the leg (COL) was also measured.Results:The course of the greater saphenous vein could be depicted by the Vein Viewer Flex® in all cases, and it was confirmed by ultrasonography. It was confirmed that the saphenous nerve was located under the sartorius fascia and it was running posteromedially in parallel of the greater saphenous vein. The mean distance from the saphenous nerve and the greater saphenous vein was 7.9 ± 2.7 mm. There was no significant difference between left and right legs (right: 7.9±2.8 mm, left: 8.0±3.0 mm, P=0.95). The mean COL was 34.2 ± 1.9 mm, and there was a moderate positive correlation (r = 0.45).Conclusion:This study revealed that the saphenous nerve is running in parallel of the greater saphenous vein which can be depicted by the Vein Viewer Flex®. Ultrasonography after depicting greater saphenous vein enabled to confirm the saphenous nerve with certainly and noninvasive. These findings suggested that the combination of the Vein Viewer Flex® and ultrasonography enables the saphenous nerve block to be more reliable procedure even the saphenous nerve is hardly identified by the ultrasonography.

Proximal fibular osteotomy for pain relief and functional improvement in patients of osteoarthritis of knee

Background: The aim of this study was to evaluate the effect of proximal fibular osteotomy in relieving pain and functional improvement in patients of osteoarthritis knee.Methods: We selected 38 patients with KOA, out of which 30 patients gave written informed consent and underwent proximal fibular osteotomy. The median time of follow-up was 13.3 months. Preoperative and postoperative weight-bearing and whole lower extremity radiographs were obtained to analyse the alignment of the lower extremity (tibio-femoral angle) and ratio of the knee joint space (medial/lateral compartment). Assessment of knee pain was done using a visual analogue scale, and knee functional activities were evaluated using the American Knee Society score (KSS 1 and 2) preoperatively and postoperatively.Results: Pain relief was observed in almost all patients after proximal fibular osteotomy. Weight-bearing lower extremity radiographs showed significant change in tibio-femoral angle an average increase in the postoperative medial knee joint space. Additionally, obvious change in alignment was observed in the whole lower extremity radiographs in 24 out of 30 patients. In three patients tibio-femoral angle showed progressive more varus alignment after proximal fibulectomy.Conclusions: In short-term study, proximal fibular osteotomy provides pain relief and functional wellbeing to the patients of KOA.

Acupoint puncture combined with Ilizarov technique for the treatment of elderly paitents with knee osteoarthritis

To explore the clinical effect of acupoint puncture combined with Ilizarov technique in the treatment of knee osteoarthritis in the elderly. From March 2015 to February 2016, 76 patients with primary knee osteoarthritis were treated with tibial osteotomy acupoint puncture grouop and Ilizarov technique anatomical puncture group, including 24 males and 52 females, aged 56 to 75 years old with an average of 61.4 years old, and a course of 3 to 17 years with an average of 5.2 years. Among them, 38 cases were treated with external fixation of acupoint puncture needle and 38 cases were treated with external fixation of anatomical puncture needle. Preoperative full-length X-ray of both lower limbs showed tibial varus deformity, narrowing of medial knee joint space and enlargement of lateral knee joint space. The force line of the affected knee and lower limb was moved inward by body surface measurement, and the KSS knee function score was decreased. Symptoms included medial knee pain, flexion and extension, and conservative treatment for more than 2 years. The lower limb force lines of both groups were corrected and the osteotomy ends healed well. No nonunion of osteotomy, inadequate correction of lower limbs or recurrence of deformity were found. Seventy-five patients were followed up for 3, 6, 12 and 24 months after operation. There was no significant difference in knee joint mobility between the two groups before operation and on 6, 12, 24 months after operation(F=1.346, P>0.05). There were significant difference in KSS pain and total score between the two groups at 3 months after operation, acupoint puncture group was better than anatomical puncture group(P<0.05); there was no significant difference in KSS score at 12 months after operation(P>0.05). The acupoint puncture group formed a potential acupuncture effect in the acupoint area by continuously tightening the steel needle on Ilizarov ring external fixator during the post-operative adjustment. Within three months after wearing external fixator, the knee pain symptoms of knee osteoarthritis were relieved rapidly, continuously and effectively, which was significantly better than that of the anatomical puncture group.

Immunoregulatory properties of I.A. mesenchymal stem cells are maintained in a xenogenic animal model

Purpose: Osteoarthritis is a chronic joint disease afflicting a significant portion of the world’s population with no currently available cure. Clinical trials using mesenchymal stem cell-based therapies have a positive effect on pain and quality of life in osteoarthritis but the mechanism of action remains unclear. This study aimed to identify the lymphocyte response to a xenogeneic human umbilical cord-derived MSC-based cell therapy in the face of osteoarthritis progression. Methods: A unilateral medial meniscal release model was employed in 14 sheep to create OA where n=7 sheep received I.A. cell therapy (OACT) in the operated knee and n=7 received saline as controls (OA). Another unoperated group (n=7) received cell therapy (CT Control). Three months later IA cell therapy consisting of 1.0× 107 Human SHC-MSCs* (Small Mesenchymal Stem Cells primed with Hypoxia and Calcium ions) was administered into the medial knee joint space. Synovial fluid was aspirated periodically for 13 weeks for flow cytometry analysis. At termination of the study, the stifle joints underwent macroscopic and histologic assessments using the OARSI histology scoring system for subchondral bone, cartilage and synovial membrane. Flow cytometry data was analyzed with a linear mixed effects model while pathology scores were analyzed by the Mann-Whitney U test and Wilcoxon signed rank test, with the Bonferroni correction for multiple comparisons. Results: There were no adverse reactions to the I.A. therapy. Cell therapy administration induced an influx of CD4+ leukocytes (Fig 1). Of these there was a significant increase in the proportion of CD4+CD25+ and CD4+CD25hi leukocytes; the CD4+CD25hi being subset that may be composed of regulatory T cells. There was no significant effect of the cell therapy treatment on the proportion of synovial fluid CD8+ cells or B cells (BAQ44A+), and B cells occurred in small numbers. Conclusions: Xenogeneic cell therapy did not trigger a classical host versus graft reaction leading to tissue injury. Cell therapy induced chemotaxis of CD4+ cells to the joint space but this was not associated with pathological change in tissues. Despite expression of activation markers (CD25+) these cells may regulate the immune response since CD4+cells can be sources of anti-inflammatory cytokines such as IL-4 and IL-10, as well as inhibiting the release of pro-inflammatory cytokines such as IL-1β or TNF-α. These findings support the notion that phenomena unrelated to long-term survival and engraftment of injected cells may have clear immunoregulatory effects.

Reliability of measuring the medial knee joint space using ultrasound imaging

Background: The use of ultrasound to perform quantitative musculoskeletal (MSK) measurements requires reliability among different providers with varied levels of experience and training. Recent studies have shown that physical therapists (PT) can reliably measure the glenohumeral joint space using ultrasound imaging (USI) and operator experience or well defined training protocols influences the reliability. Few studies have reported the reliability of medial knee gap measurements with USI. Objective: Evaluate inter- and intra-rater reliability of a novel approach to measuring knee gapping using experienced and trained novice clinicians. Design: Inter-rater and intra-rater reliability study Setting: Physical therapy program Participants: Novice researchers were three upper-year Doctor of Physical Therapy students. Experienced researchers were two PT certified in MSK USI with eight years of experience. Methods: A total of 166 images of two subject’s medial knee joint gaps were captured in resting by a single experience researcher. Three novice researchers, who underwent a three-hour training protocol and two experienced researchers measured the images individually. Measurements were taken using standardized bony landmarks and internal calipers. All researchers were blinded to the subjects and results. Main outcome measures: Data was analyzed using two-way ICC mixed-model single measurement, SEM run for all researchers compared with experienced researcher one. Results: An excellent degree of reliability was found for both intra-rater and inter-rater measurements for Novice One and a good degree of reliability was found between Experienced One and Novice Two and Three. Conclusion: Both experienced and novice researchers attained a clinically significant ICC when compared to Experienced One. An accurate and reliable measurement of the medial knee joint gap maybe useful for further studies and help with diagnosis of joint pathologies. Level of study: IIB

Higher Bone Turnover Detected by Serum Levels of Tartrate-Resistant Acid Phosphatase 5b (TRACP-5b) Is a Risk for the Radiographic Medial Knee Joint Space Narrowing in Men in Early Forties Without Knee Pain - A Three Years Prospective Observational Study “Sportology Core Study 1”

Higher Bone Turnover Detected by Serum Levels of Tartrate-Resistant Acid Phosphatase 5b (TRACP-5b) Is a Risk for the Radiographic Medial Knee Joint Space Narrowing in Men in Early Forties Without Knee Pain - A Three Years Prospective Observational Study “Sportology Core Study 1”

Meniscal extrusion seen on ultrasonography affects the development of radiographic knee osteoarthritis: a 3-year prospective cohort study.

The objective of this study is to determine whether meniscal extrusion (ME) of the medial meniscus on ultrasonography affects knee osteoarthritis (KOA) progression during 3-year follow-up. Two hundred seventy volunteers (70 men, 200 women; mean age 60.5years) participated. Weight-bearing radiographs were evaluated. All subjects had medial radiographic KOA (Kellgren-Lawrence grade [KLG], ≥2) in at least one knee at baseline (BL). KLG 2 was defined as moderate KOA (MKOA); KLG 3 and 4 were defined as severe KOA (SKOA). Medial and lateral joint space width (MJSW and LJSW) were measured at the minimum width of femoro-tibial compartment. The medial and lateral osteophyte area (MOPA and LOPA) were measured. Rapid joint space narrowing progression (RP) was defined as ≥25% loss of JSW from BL. ME was measured at the medial knee joint space on the medial collateral ligament with ultrasonography. The optimal ME cut-off for RP was determined by ROC curve. The relationship between ME and the longitudinal change of radiographic parameters was elucidated by linear and logistic regression analysis. In the 460 OA knees at BL, both MOPA and LOPA increased, while only MJSW narrowed after 3years. RP occurred in 25 knees among 281 MKOA knees and 42 among 179 SKOA knees. ME was associated with medial joint space narrowing only in the SKOA group, while the ME was associated with MOPA in the MKOA and SKOA groups. The cut-off value to detect RP was 5.5mm only in the SKOA group. Ultrasonographic evaluation of medial ME was useful to detect radiographic KOA progression.

The lower ratio of the cartilage destruction and synthesis biomarkers is a risk for the radiographic medial knee joint space narrowing in men in early forties without knee osteoarthritis – A three years prospective observational study “sportology core study 1”

The lower ratio of the cartilage destruction and synthesis biomarkers is a risk for the radiographic medial knee joint space narrowing in men in early forties without knee osteoarthritis – A three years prospective observational study “sportology core study 1”

Proximal fibular osteotomy: a new surgery for pain relief and improvement of joint function in patients with knee osteoarthritis.

ObjectiveTo explore the effects of proximal fibular osteotomy as a new surgery for pain relief and improvement of medial joint space and function in patients with knee osteoarthritis.MethodsFrom January 2015 to May 2015, 47 patients who underwent proximal fibular osteotomy for medial compartment osteoarthritis were retrospectively followed up. Preoperative and postoperative weight-bearing and whole lower extremity radiographs were obtained to analyse the alignment of the lower extremity and ratio of the knee joint space (medial/lateral compartment). Knee pain was assessed using a visual analogue scale, and knee ambulation activities were evaluated using the American Knee Society score preoperatively and postoperatively.ResultsMedial pain relief was observed in almost all patients after proximal fibular osteotomy. Most patients exhibited improved walking postoperatively. Weight-bearing lower extremity radiographs showed an average increase in the postoperative medial knee joint space. Additionally, obvious correction of alignment was observed in the whole lower extremity radiographs in 8 of 47 patients.ConclusionsThe present study demonstrates that proximal fibular osteotomy effectively relieves pain and improves joint function in patients with medial compartment osteoarthritis at a mean of 13.38 months postoperatively.

Higher bone turnover detected by serum levels of tartrate-resistant acid phosphatase 5b (TRACP-5b) is a risk for the radiographic medial knee joint space narrowing in men in early forties without knee pain the three years prospective observational study

Higher bone turnover detected by serum levels of tartrate-resistant acid phosphatase 5b (TRACP-5b) is a risk for the radiographic medial knee joint space narrowing in men in early forties without knee pain the three years prospective observational study

Clinical predictors of medial knee osteoarthritis progression over 2 years

The overall aim of this study was to identify risk factors for knee osteoarthritis (OA) structural disease progression. More specifically, we aimed to identify what personal factors (age, sex, obesity, co-morbidity, Herberden’s nodes, history of injury, manual occupation and medication use), radiographic findings (Kellgren and Lawrence (K&L) grade, joint space width, alignment) and activity limitations (self-reported physical activity and physical function) independently predict medial knee joint space narrowing (JSN) over 2 years in people with painful medial knee OA.

Cartilage Metabolic Status for the Radiographic Medial Knee Joint Space Narrowing in Men in Early Forties Without Knee Pain

Cartilage Metabolic Status for the Radiographic Medial Knee Joint Space Narrowing in Men in Early Forties Without Knee Pain