Presence Of Medium Research Articles

Influence of Radiation on the Squeezed flow of Copper-Water Nanofluid between Parallel Plates in Presence of Porous Medium and Magnetic Field

This article highlights the outcome of the investigation on the squeezed flow of copper-water nanofluid between two moving parallel plates filled with a porous medium in presence of a magnetic field using a semi analytical method called Differential Transform Method (DTM). In this study, the influence of radiation parameter and the use of porous medium are considered along with other usual parameters. Impact of physical parameters like. squeezing number, Hartmann number, Darcy number, and Biot number on velocity and energy distributions are presented and examined with the help of graphs and tables. From this study it is apparent that by increasing Biot number, radiation number, and Darcy number, the energy distribution attains a greater level.

Coupled wave instability in pure-quartic dispersive and noninstantaneous Kerr media in presence of walk-off

The letter explores modulational instability (MI) in birefringent optical media with pure-quartic dispersion, relaxed Kerr nonlinearity, and walk-off effects. The linear stage of MI is studied using coupled biharmonic nonlinear Schrödinger equations, and the stability of their continuous wave solutions is used to calculate the growth rate of MI. The latter is then used to characterize MI under the combined effects of nonlinear responses, group-velocity mismatch, and quartic dispersion, with a focus on the pure-quartic soliton regime. The nonlinear stage of MI is also studied through direct numerical simulations, which support the analytical predictions and emphasize the impact of quartic dispersion, relaxed Kerr nonlinearity, and the walk-off effect on the emergence of various nonlinear patterns. These findings provide valuable insights into signal generation and processing in pure-quartic optical materials and have potential applications in nonlinear optics and lasers.

Highly Efficient Detection of Pd2+ in Aqueous Medium by an Elusive Mn(II) Coordination Polymer.

Herein, we report the synthesis of a Mn(II)-based coordination polymer (CP); and its structure, phase consistency and thermal stability have been established by single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD) and thermalgravimetric analysis (TGA) respectively. This is the first example of paramgnetic Mn(II)-based CP that acts as pH-dependent emitting material [λem=525 nm (pH=2.0-4.0) and 450 nm (pH=5.0-12.0)]. Its emission is quenched by Pd2+ in aqueous medium in presence of other thirteen cations with reasonably low pH-dependent limits of detection (LODs) [21.178 ppb (pH=3), 15.005 ppb (pH=7.0) and 59.940 ppb (pH=10.0)] as described by well-established mechanism. Therefore, urgency of such stable sensor remains high in regard to the environmental pollution.

A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response

Background & AimsHepatocellular carcinoma (HCC) is the third leading and fastest rising cause of cancer-related death worldwide. The discovery and preclinical development of compounds targeting HCC is hampered by the absence of authentic tractable systems recapitulating the heterogeneity of patient HCC tumors and the tumor microenvironment (TME). MethodsWe established a novel and simple patient-derived multicellular tumorspheroid model based on clinical HCC tumor tissues, processed using enzymatic and mechanical dissociation. After quality controls, 22 HCC tissues and 17 HCC serum were selected for tumorspheroid generation and perturbation studies. Cells were grown in 3D in optimized medium in presence of patient serum. Characterization of the tumorspheroid cell populations was performed by flow cytometry, immunohistochemistry and functional assays. As a proof of concept, we treated patient-derived spheroids with FDA approved anti-HCC compounds. ResultsThe model was successfully established independently from cancer etiology and grade from 22 HCC tissues. We show that the use of HCC patient serum was essential for tumorspheroid generation, the TME function and to maintain cell viability. The tumorspheroids comprised the main cell compartments including epithelial cancer cells as well as all major cell populations of the TME (cancer-associated fibroblasts, macrophages and T cells, endothelial cells). Tumorspheroids reflect HCC heterogeneity, including variability in cell type proportions and TME, and mimic the original tumor features. Moreover, we observed differential responses to FDA HCC approved drugs between donors as observed in patients. ConclusionThis patient HCC serum-tumorspheroid model provides novel opportunities for drug discovery and development as well as mechanism of action studies including compounds targeting the TME. This model will likely contribute to improve the dismal outcome of patients with HCC. Impact and implicationsHepatocellular carcinoma (HCC) is a leading and fast rising cause of cancer-related death worldwide. Despite approval of novel therapies, the outcome of advanced HCC remains unsatisfactory. By developing a novel patient-derived tumorspheroid model recapitulating tumor heterogeneity and microenvironment, we provide new opportunities for HCC drug development and analysis of mechanism of action in authentic patient tissues. The application of the patient-derived tumorspheroids combined with other HCC models will likely contribute to drug development and to improve the dismal outcome of patients with HCC.

Speciation of vanadium and the interacted solid surface of δ-alumina adsorbent in aqueous media in presence of humic acid

Speciation of vanadium elements in the presence of δ-alumina in aqueous media was studied to simulate the environmental impact of soil/sediment–water interacted system. Factors affecting this process are pH, presence of humic acid, and δ-alumina concentrations as an abundant sediment/soil components. Different species of both vanadium and surface of δ-alumina were deduced theoretically using MintaqA2 programme. Due to the effect of pH, the anionic species of vanadium at pH 1–3 is prevailed and changed to cationic species at pH range 6–10 at different levels of alumina. Additionally, based on the effect of alumina concertation, high percent uptake, almost 100% was found at 10.0 g/1 concentration of alumina while at level of 0.2 g/1 alumina, the maximum adsorption of vanadium was become 91%. The effect of humic acid on the speciation behavior of vanadium (V) was also studied and compared with that of vanadium (IV) based on XANES (X-ray absorption near edge structure). Adsorption behaviors were studied at concentration 4.71E-4M for vanadium at 0.1M ionic strength. The mechanism of vanadium adsorption in the presence of alumina under the same working conditions was studied and explained based on TLM (Triple layer model) where the results proved good validation and verification of the practically produced data.

Transition metal complexation assisted stabilization of the deprotonated organic moiety: A strategy for colorimetric and electrochemical recognition of fluoride ion in water medium with organic probe molecules

Excess consumption of fluoride through drinking water causes detrimental effects to human health which has been a serious global concern. This situation demands routine monitoring of fluoride in drinking water in fluoride affected regions around the world. A plethora of organic molecules has been demonstrated as chemosensors based on the fluoride induced deprotonation reaction of the probe molecules. However, most of the probe molecules fail to react with fluoride in aqueous medium which limits their application. Herein, we have demonstrated a metal ion, Ni(II) mediated strategy to retain the reactivity and the sensitivity of the probe molecule towards fluoride ion in aqueous medium with the help of two benzothiazole based probe molecules (R and P). Both the probe molecules showed retention of the affinity towards fluoride ion in aqueous medium in presence of Cu2+ ion but the colorimetric response is not upto the mark. On the other hand, the probe molecule P showed excellent affinity and colorimetric response towards aqueous fluoride ion in presence of Ni2+ ion. The methodology is validated with UV–Vis spectroscopy and Differential pulse voltammetry (DPV) technique. Probe molecule P in presence of Ni2+ ion showed limit of detection values 0.60 ppm and 0.57 ppm w.r.t. UV–Visible spectroscopy and DPV technique respectively. Furthermore, the efficiency of the methodology w.r.t. P was tested with real samples collected from the fluoride affected areas of Assam, India and found that the data corroborates well with the results of ion selective electrode. This methodology can provide a new dimension in the development of a low cost method for routine sensing of fluoride ion with organic probe molecules in drinking water for low resource world.

Carbamazepine adsorption with a series of organoclays: removal and toxicity analyses

Organoclays have been used as efficient adsorbents for pharmaceutical pollutants present in waters. Carbamazepine (CBZ) is one of the drugs most frequently found in water bodies. In this study, four organoclays were prepared by modifying bentonite with the cationic surfactants hexadecyltrimethylammonium bromide (HDTMA) and octadecyltrimethylammonium bromide. The synthesized materials were characterized by XRD, CHN, FTIR, TG, BET and SEM analyses, confirming organophilization. The surfactants were interspersed in different arrangements in the interlayer space. CBZ sorption was investigated through batch equilibrium experiments, under variation of the pH, contact time, dosage of adsorbent, and initial drug concentration. Changes in pH showed no adsorption influence. CBZ sorption by the organoclays followed a pseudo-second-order kinetics. The best sorption performance was obtained for the BCN1-HDTMA100 clay, with a capacity of 34.34 ± 1.41 mg g−1, about ten times greater than the unmodified bentonite under the same conditions. This may be attributed to the higher surfactant content. The adsorption isotherm at 25 ºC showed linear behavior. Toxicity tests of the organoclays and corresponding medium in presence of CBZ were carried out. This is a novelty report. Most of the organoclays had no toxicity against Artemia salina. The toxicity of the medium after adsorptive treatment was eliminated. Organoclay-CBZ hybrids were also characterized after adsorption. FTIR and TG analyzes confirmed the incorporation of the drug. Hydrophobic interaction was the dominant contribution evaluated to the adsorption of CBZ. The results demonstrated that organoclays can be a promising alternative adsorbent for the removal of pharmaceutical pollutants in water remediation.

Entropy generation on MHD motion of hybrid nanofluid with porous medium in presence of thermo-radiation and ohmic viscous dissipation

Hybrid nanotechnology has significantly contributed to enhancing energy efficiency and reducing heat loss. This study addresses entropy analysis in the motion of hybrid nanofluids incorporating magnetohydrodynamic effects, thermal radiation, and ohmic viscous dissipation phenomena. The implementation of magnetohydrodynamic, thermal radiation, and dissipation effects allows for a second law of thermodynamics analysis. The hybrid nanoparticles considered are Graphene Oxide (GO) and Molybdenum Disulphide (MoS2), with water serving as the base liquid. Entropy generation analysis, a thermodynamic approach, quantifies irreversibility and inefficiencies within the system, aiding in understanding losses and identifying areas for improvement. Additionally, a comparative study is conducted. The BVP4C algorithm, implemented using MATLAB, is employed to address this study and obtain solutions. The key findings indicate that heat transfer rates are higher for blade-shaped nanoparticles, and entropy is minimized by controlling parameters such as the radiation parameter, Brinkman parameter, and temperature difference.

Effects of Tripleurospermum caucasicum, Salvia rosmarinus and Tanacetum fruticulosum essential oils on aflatoxin B1 production and aflR gene expression in Aspergillus flavus

Aflatoxin B1 (AFB1) is one of the most hazardous mycotoxins for humans and livestock that mainly produced by members of the genus Aspergillus in a variety of food commodities. In this study, the effect of S. rosmarinus, T. fruticulosum, and T. caucasicum essential oils (EOs) was studied on fungal growth, AFB1 production and aflR gene expression in toxigenic A. flavus IPI 247. The AFB1 producer A. flavus strain was cultured in YES medium in presence of various two-fold concentrations of the plant EOs (62.5–500 μg/mL) for 4 days at 28 °C. EO composition of plants was analyzed by Gas Chromatography/Mass Spectrometry (GC/MS). The amount of fungal growth, ergosterol content of fungal mycelia and AFB1 content of EO-treated and non-treated controls were measured. The expression of aflR gene was evaluated using Real-time PCR in the fungus exposed to minimum inhibitory concentration (MIC50) of EOs. The main constituents of the oils analyzed by GC/MS analysis were elemicin (33.80 %) and 2,3-dihydro farnesol (33.19 %) in T. caucasicum, 1,8-cineole (17.87 %), trans-caryophyllene (11.14 %), α and ẞ-pinene (10.92 and 8.83 %) in S. rosmarinus, and camphor (17.65 %), bornyl acetate (15.08 %), borneol (12.48 %) and camphene (11.72 %) in T. fruticulosum. The results showed that plant EOs at the concentration of 500 μg/mL suppressed significantly the fungal growth by 35.24–71.70 %, while mycelial ergosterol content and AFB1 production were inhibited meaningfully by 36.20–65.51 % and 20.61–89.16 %. T. caucasicum was the most effective plant, while T. fruticulosum showed the lowest effectiveness on fungal growth and AFB1 production. The expression of aflR in T. caucasicum and S. rosmarinus -treated fungus was significantly down-regulated by 2.85 and 2.12 folds, respectively, while it did not change in T. fruticulosum-treated A. flavus compared to non-treated controls. Our findings on the inhibitory activity of T. caucasicum and S. rosmarinus EOs toward A. flavus growth and AFB1 production could promise these plants as good candidates to control fungal contamination of agricultural crops and food commodities and subsequent contamination by AFB1. Down-regulation of aflR as the key regulatory gene in AF biosynthesis pathway warrants the use of these plants in AF control programs. Further studies to evaluate the inhibitory activity of studied plants EOs in food model systems are recommended.

Paraneoplastic leukocytosis induces NETosis and thrombosis in bladder cancer PDX model.

Paraneoplastic leukocytosis (PNL) in genitourinary cancer, though rare, can indicate aggressive behavior and poor outcomes. It has been potentially linked to cancer expressing G-CSF and GM-CSF, along with their respective receptors, exerting an autocrine/paracrine effect. In our study, we successfully established four patient-derived xenograft (PDX) lines and related cell lines from urothelial cancer (UC), conducting next-generation sequencing (NGS) for genetic studies. UC-PDX-LN1, originating from bladder cancer, exhibited two druggable targets - HRAS and ERCC2 - responding well to chemotherapy and targeted therapy, though not to tipifarnib, an HRAS inhibitor. Transcriptome analysis post-treatment illuminated potential mechanisms, with index protein analysis confirming their anticancer pathways. Mice implanted with UC-PDX-LN1 mirrored PNL observed in the patient's original tumor. Cytokine array and RT-PCR analyses revealed high levels of G-CSF and GM-CSF in our PDX and cell lines, along with their presence in culture media and tumor cysts.Leukocytosis within small vessels in and around the tumor, associated with NETosis and thrombus formation, suggested a mechanism wherein secreted growth factors were retained, further fueling tumor growth via autocrine/paracrine signaling. Disrupting this cancer cell-NETosis-thrombosis cycle, we demonstrated that anti-neutrophil or anticoagulant interventions enhanced chemotherapy's antitumor effects or prolonged survival in mice, even though these drugs lacked direct antitumor efficacy when used independently. Clinical observations in bladder cancer patients revealed PNL in 1.61% of cases (35/2162) with associated poor prognosis. These findings propose a novel approach, advocating for the combination of anticancer/NETosis/thrombosis strategies for managing UC patients presenting with PNL in clinical settings.

Oxidation of D-Glucose and D-Fructose by N-Bromosaccharin in Aqueous Acetic Acid Medium in Presence of NaLS: A Comparative Study

The oxidation of D-Glucose and D-Fructose was monitored iodometrically by N-Bromosaccharin in the aqueous acetic acid medium in presence of NaLS (Sodium Lauryl Sulphate). Reaction demonstrated that oxidative species HOBr and H2O⊕Br were involved in the acidic oxidation of Carbohydrates. It was established that respective acids of carbohydrates gluconic acid and arabinoic acid were the oxidation products. Respective acids of carbohydrates were the results of reactive HOBr in acidic conditions. The reaction follows first-order kinetics with respect to HOBr, Glucose, Fructose, and [H+] uniformly and is homogeneous. The Effect of varying salt electrolyte concentration was insignificant showing that the molecular species was involved in the rate-determining step. The Reaction was monitored at 600C (±10C) temperature and thermodynamic activation parameters were determined. Binding parameters have been calculated by analyzing the data using the model suggested by Menger Portnoy and Piszkiwicz's model. Kinetic studies, stoichiometry of the reaction and product analysis have been proposed for the oxidation of sugars in the presence of NaLS.

Steady Jeffery Fluid through Porous Media in Presence of a Baffle in a Vertical Channel

In this paper we have studied the Jeffrey fluid flow through a porous medium in a vertical channel with baffle. The channel is divided into two phases by a thin perfectly conductive plate and governing equations are simplified analytically by using boundary and interface condition at different baffle position, result are plotted for various important parameters and exposed graphically. We found that, the expression for increases in porous parameter, chemical reaction parameter which decrease the velocity and temperatures in both the regions. And also an increase in Thermal Grashof number leads to increases in both velocity and temperature profiles.

Optimal system of solution using group invariance technique for shock wave in a non-ideal self-gravitating gas in rotating medium in presence of magnetic field

Abstract This work demonstrates the study of the optimal system of solutions for shock wave propagation in a non-ideal self-gravitating gas in rotating medium with magnetic field (axial or azimuthal) for the adiabatic flow in cylindrical geometry by applying the group invariance technique. Using the group invariance technique, we have obtained the one-dimensional (1-D) optimal system of sub-algebra for the basic governing equations. The infinitesimal group optimal classes are obtained and the similarity solution in four possible cases (two cases for perfect gas and two cases for non-ideal gas) with exponential law shock path are discussed. The numerical solution by using the Runge Kutta 4th order method is obtained and the distribution of physical variables are shown via graph. The impact of the rotational parameter, non-idealness parameter, shock Cowling number, similarity exponent and gravitational parameter on the strength of the shock and flow variables are investigated. With an increase in the shock Cowling number, non-idealness and rotational parameters, the shock strength decreases, i.e., they have decaying impact on shock wave; whereas the shock strength increases with gravitational parameter and similarity exponent. Also, the strength of the shock is reduced by considering the magnetic field to be axial instead of azimuthal.

Dual solutions for magnetic-convective-quadratic radiative MoS2 − SiO2/H2O hybrid nanofluid flow in Darcy-Fochheimer porous medium in presence of second-order slip velocity through a permeable shrinking surface: Entropy and stability analysis

ABSTRACT This investigation aims to scrutinize the flow phenomenon and thermal variations of magnetohydrodynamic hybrid nanofluid flow induced by a shrinking surface. The novelty of the work is to examine the flow and heat transport behavior with entropy production of mixed convective / hybrid nanofluid through a Darcy–Forchheimer porous medium in the presence of nonlinear quadratic thermal radiation with second-order velocity slip over a contracting surface. Nanoparticles molybdenum disulfide and silicon dioxide are coupled with the base fluid water () to construct / hybrid nanofluid. The governing set of nonlinear partial differential equations with corresponding boundary constraints is converted into a set of nonlinear ordinary differential equations using the similarities transformation before being solved numerically with the help of the default solver in the MATLAB bvp4c package. A dual solution is determined based on the emerging parameters, including a certain amount of mass suction parameter, nanoparticle volume fractions, magnetic field, Grashof number, nonlinear quadratic thermal radiation, Darcy–Forchheimer factor, and first- and second-order velocity slip factors, for the velocity, temperature, skin friction, and local Nusselt number, and they are analyzed tabularly and graphically. These results also indicate that the solution for the upper branch was stable, while it was unstable for the lower branch based on the stability analysis. Quadratic thermal radiation has been discovered to considerably impact the fluid’s temperature and the pace of heat transfer. The magnetic field resistance and Forchheimer number slow the flow of the liquid and increase its temperature. Furthermore, by combining silicon oxide with a volume percentage of molybdenum disulfide, the flow is retarded, and heat transfer is enhanced. With an increase in the nanoparticle volume fraction by , the skin friction is boosted up by almost and and local Nusselt number is decelerated by almost , for a particular upper branch over the shrinking surface due to the influences of and nanoparticles, respectively. Furthermore, quadratic thermal radiation and first-second-order velocity slip considerably enhance the entropy formation.

Surfactants reduce aggregation of monoclonal antibodies in cell culture medium with improvement in performance of mammalian cell culture.

Therapeutic monoclonal antibodies (mAbs) are biologics produced using mammalian cells and represent an important class of biotherapeutics. Aggregation in mAbs is a major challenge that can be mitigated by rigorous and reproducible upstream and downstream approaches. The impact of frequently used surfactants, like polysorbate 20, polysorbate 80, poloxamer 188, and 2-hydroxypropyl-beta-cyclodextrin, on aggregation of mAbs during cell culture was investigated in this study. Their impact on cell proliferation, viability, and mAb titer was also investigated. Polysorbate 20 and polysorbate 80 at the concentration of 0.01 g/L and poloxamer 188 at the concentration of 5 g/L were found to be effective in reducing aggregate formation in cell culture medium, without affecting the cell growth or viability. Furthermore, their presence in culture media resulted in increased cell proliferation as compared to the control group. Addition of these surfactants at the specified concentrations increased monomer production while decreasing high molecular weight species in the medium. After mAbs were separated, using protein "A" chromatography, flasks with surfactant exhibited improved antibody stability, when analyzed by DLS. Thus, while producing aggregation-prone mAbs via mammalian cell culture, these excipients may be employed as cell culture medium supplements to enhance the quality and yield of functional mAbs.

First 24-Membered Macrocyclic 1,10-Phenanthroline-2,9-Diamides-An Efficient Switch from Acidic to Alkaline Extraction of f-Elements.

A reaction of acyl chlorides derived from 1,10-phenanthroline-2,9-dicarboxylic acids with piperazine allows the preparation of the corresponding 24-membered macrocycles in good yield. The structural and spectral properties of these new macrocyclic ligands were thoroughly investigated, revealing promising coordination properties towards f-elements (Am, Eu). It was shown that the prepared ligands can be used for selective extraction of Am(III) from alkaline-carbonate media in presence of Eu(III) with an SFAm/Eu up to 40. Their extraction efficiency is higher than calixarene-type extraction of the Am(III) and Eu(III) pair. Composition of macrocycle-metal complex with Eu(III) was investigated by luminescence and UV-vis spectroscopy. The possibility of such ligands to form complexes of L:Eu = 1:2 stoichiometry is revealed.

Electrochemical and surface study of an antibiotic drug as sustainable corrosion inhibitor on mild steel in 0.5 M H2SO4

Corrosive degradation of mild steel using the antibiotic ethambutol hydrochloride drug as a sustainableinhibitor in 0.5 M sulphuric acid was studied and found as an efficient inhibitor. The inhibitive action showed an increase with an upsurge in the drug concentration, but with escalating temperature, inhibition efficiency declined. The drug showed a best of 92.78% inhibition efficiency at 1000 ppm and 313 K. The thermodynamic, kinetic and adsorption parameters were evaluated and established the physisorption of the drug over the metal surface following Langmuir adsorption isotherm. The EIS analysis confirmed the adsorption of inhibitor on the metal surface by showing the lowering in the value of double layer capacitance, Cdl; improvement in charge transfer resistance, Rct as the surface modulus raised. The mixed type of inhibition mechanism was confirmed by a Potentiodynamic polarization experiment. Surface morphology through Atomic Force Microscopy (AFM) validated the less deteriorated metal surface exposed to corrosive medium in presence of the drug.

Eggshell powder as an efficient recyclable catalyst generates H2O2 prompted radicals for selective oxidative mineralization of crystal violet dye at room temperature

Eggshell powder (ESP) was explored as a selective heterogeneous catalyst for oxidative degradation of crystal violet (CV) dye in aqueous media in presence of H2O2 at room temperature. Natural but throw-away material ESP as a carbonate (CO32−) source facilitated the formation of carbonate anion radicals in presence of H2O2. Carbonate anion radicals (CO3•−), though a weaker oxidant than ∙OH radical, efficiently served as a selective oxidant. Selective degradation of CV dye in aqueous solution was confirmed from the quenching experiments. Synergistic effects of both the radicals (CO3•− and ∙OH) in the dye degradation process was experimentally verified. At a dose of 10 g/L of ESP, 91% removal of CV (initial concentration: 10 mg/L) was achieved in 60 min. The reaction kinetics followed first order rate model. Intermediate products formed during CV degradation and the extent of mineralization were confirmed from MALDI-TOF-MS and TOC analysis, respectively. The turnover number (TON) and turnover frequency (TOF) were obtained as 2.45 × 10−6 mol per g and 6.81 × 10−10 mol per g per second. A promising reusability was achieved up to seven cycles. The ESP catalyst used in this study was characterized by SEM, FTIR, XRD, XPS, BET surface area analysis, UV–visible DRS, XRF, and pHZPC analyses. The present work offers a novel facile but selective route for CV degradation and opens up newer possibilities for eggshell waste utilization as catalyst.

Computational analysis of MHD Cross nanofluid containing gyrotactic microorganisms over a permeable horizontal cylinder through a porous medium in presence of thermal radiation and chemical reaction

In the current work, mathematical analysis of bioconvective heat and mass transfer in generalized fluid containing nanoparticles and motile gyrostatic microorganisms over a permeable horizontal cylinder embedded in a porous medium is investigated in the existence of chemical reaction, thermophoresis, and Brownian motion. Moreover, the influence of thermal radiation and magnetic field is considered. The temperature, concentration of nanoparticles, and density of microorganisms at the cylinder surface are considered nonlinear variations. The governing equations are transformed into nondimensional forms containing a set of bio-convection parameters. The transformed equations are solved numerically by a computational method composed of the finite difference technique and Newton’s linearization scheme. The computational results are validated by comparisons of some special cases of the present work with previously reported results in the literature, and an excellent agreement is obtained. The impact of included parameters is discussed and performed in graphs and tabular forms. The present study revealed that the increment in the Brownian motion leads to accelerating the velocity but reducing the temperature and the concentrations of nanoparticles and microorganisms. On the contrary, the thermophoresis force and magnetic field have the opposite effect of Brownian motion. Moreover, the rise in thermal radiation increases in velocity and temperature distributions but the opposite result occurs for nanoparticles and microorganisms concentrations. It is noticed that many important phenomena can be determined by the parameters included in the current study; therefore it has significant applications in various fields such as polymerization, petroleum industries, biotechnology, and biomedicine as in medical imaging and medicinal therapy.

Double-diffusive peristaltic MHD Sisko nanofluid flow through a porous medium in presence of non-linear thermal radiation, heat generation/absorption, and Joule heating

This article studied a numerical estimation of the double-diffusive peristaltic flow of a non-Newtonian Sisko nanofluid through a porous medium inside a horizontal symmetric flexible channel under the impact of Joule heating, nonlinear thermal radiation, viscous dissipation, and heat generation/absorption in presence of heat and mass convection, considering effects of the Brownian motion and the thermophoresis coefficients. On the other hand, the long wave approximation was used to transform the nonlinear system of partial differential equations into a nonlinear system of ordinary differential equations which were later solved numerically using the fourth-order Runge–Kutta method with shooting technique using MATLAB package program code. The effects of all physical parameters resulting from this study on the distributions of velocity, temperature, solutal concentration, and nanoparticles volume fraction inside the fluid were studied in addition to a study of the pressure gradients using the 2D and 3D graphs that were made for studying the impact of some parameters on the behavior of the streamlines graphically within the channel with a mention of their physical meaning. Finally, some of the results of this study showed that the effect of Darcy number Da and the magnetic field parameter M is opposite to the effect of the rotation parameter Omega on the velocity distribution whereas, the two parameters nonlinear thermal radiation R and the ratio temperature {theta }_{w} works on a decrease in the temperature distribution and an increase in both the solutal concentration distribution, and the nanoparticle's volume fraction. Finally, the impact of the rotation parameter Omega on the distribution of pressure gradients was positive, but the effect of both Darcy number Da and the magnetic field parameter M on the same distribution was negative. The results obtained have been compared with the previous results obtained that agreement if the new parameters were neglected and indicate the phenomenon's importance in diverse fields.