Mechanism Of Rupture Research Articles

Rupture Mechanics of Blood Clot Fibrin Fibers: A Coarse-Grained Model Study

Thrombosis, when occurring undesirably, disrupts normal blood flow and poses significant medical challenges. As the skeleton of blood clots, fibrin fibers play a vital role in the formation and fragmentation of blood clots. Thus, studying the deformation and fracture characteristics of fibrin fiber networks is the key factor to solve a series of health problems caused by thrombosis. This study employs a coarse-grained model of fibrin fibers to investigate the rupture dynamics of fibrin fiber networks. We propose a new method for generating biomimetic fibrin fiber networks to simulate their spatial geometry in blood clots. We examine the mechanical characteristics and rupture behaviors of fibrin fiber networks under various conditions, including fiber junction density, fiber tortuosity, fiber strength, and the strain limit of single fiber rupture in both tension and simple shear cases. Our findings indicate that the stress-strain relationship of the fibrin fiber network follows a similar pattern to that of individual fibers, characterized by a shortened entropy stretching phase and an extended transition phase. Fiber junction density, fiber strength, and single fiber rupture limit predominantly influence the stress of the network, while fiber tortuosity governs the strain behavior. The availability of more fibers in shear cases to bear the load results in delayed rupture compared to tension cases. With consideration of different factors of fibrin fibers in networks, this work provides a more realistic description of the mechanical deformation process in fibrin fiber networks, offering new insights into their rupture and failure mechanisms. These findings could inspire novel approaches and methodologies for understanding the fracture of fibrin networks during a surgical thrombectomy.

Traumatic rupture of duodenal diverticulum-clinical case in catastrophe setting

Duodenal diverticula are anatomical outpouchings of the gastrointestinal tract, with a prevalence of up to 27% in individuals over 50 years old. While often asymptomatic, complications such as diverticulitis, obstruction, and perforation can occur. Traumatic rupture of a duodenal diverticulum is extremely rare, with only a few cases documented in the literature. We report the case of a 64-year-old female involved in a major traffic accident with multiple injuries. Initially stable, she later developed abdominal tenderness and hypotension, prompting a CT scan that revealed pneumoperitoneum without significant hemoperitoneum. Surgical exploration revealed a ruptured duodenal diverticulum, which was treated with diverticulectomy and omentoplasty. Blunt abdominal trauma typically affects the liver, spleen, and retroperitoneal organs, while isolated duodenal injuries remain rare. Mechanisms for duodenal rupture, particularly in the context of seatbelt use, include sudden intra-abdominal pressure increases during deceleration. Imaging, particularly CT, plays a crucial role in the early detection of such injuries, although resource limitations during mass casualty events may delay its use. Surgical management remains the definitive treatment, and early intervention is essential in unstable patients. Traumatic rupture of a duodenal diverticulum is an uncommon yet life-threatening event. Early suspicion, timely imaging, and surgical intervention are key to successful outcomes. Continuous reassessment is crucial, as trauma-related injuries may present later in the clinical course.

Versatile Mechanochemical Reactions via Tailored Force Transmission in Mechanophores

In polymer mechanochemistry, regulating the intrinsic mechanical reactivity of a mechanophore offers extensive opportunities in material science, enabling the development of hierarchical and multifunctional polymer‐based materials. Recent advances have focused on innovating various types of mechanophores with inherent reactivity (e.g. regioselectivity and stereoselectivity). However, little attention has been given to modulating their reactivity by tailoring force transmission within mechanophores. Here, we introduce a novel approach through the implementation of a cyclic pulling geometry into an anthracene‐maleimide (AM) mechanophore. This approach manipulates force transmission within the mechanophore and effectively regulates its reactivity from 0.0160 min‐1 to 0.00133 min‐1, achieving up to a 12‐fold change. Mechanochemical coupling analysis suggests that the split force transmission within the ring may suppress the sequential bond rupture mechanism in AM mechanophores under applied forces. By leveraging the distinct force transmission pathways within cyclic and linear AM mechanophores, we covalently integrate them with a spiropyran mechanophore to design tandem mechanophore systems for hierarchical mechanochemical activation. These findings highlight the efficacy and versatility of the cyclic pulling strategy in modulating mechanophore reactivity, providing valuable insights for the design of tunable multifunctional polymer‐based materials.

Multiscale monitoring and analysis of complex rupture and source mechanisms of mining-related seismicity on fault networks

Mining-related seismicity poses significant challenges in underground coal mining due to its complex rupture mechanisms and associated hazards. To bridge gaps in understanding these intricate processes, this study employed a multi-local seismic monitoring network, integrating both in-mine and local instruments at overlapping length scales. We specifically focused on a damaging local magnitude (ML) 2.6 event and its aftershocks that occurred on 10 September 2022 in the vicinity of the 3308 working face of the Yangcheng coal mine in Shandong Province, China. Moment tensor (MT) inversion revealed a complex cascading rupture mechanism: an initial moment magnitude (Mw) 2.2 normal fault slip along the DF60 fault in an ESE–WNW direction, transitioning to a Mw 3.0 event as the FD24 and DF60 faults unclamped. The scale-independent self-similarity and stress heterogeneity of mining-related seismicity were investigated through source parameter calculations, providing valuable insights into the driving mechanism of these seismic sequences. The in-mine network, constrained by its low dynamic changes, captured only the nucleation phase of the DF60 fault. Furthermore, standard decomposition of the MT solution from the seismic network proved inadequate for accurately identifying the complex nature of the rupture. To enhance safety and risk management in mining environments, we examined the implications of source reactivation within the cluster area post-stress-adjustment. This comprehensive multiscale analysis offers crucial insights into the complex rupture mechanisms and hazards associated with mining-related seismicity. The results underscore the importance of continuous multi-local network monitoring and advanced analytical techniques for improved disaster assessment and risk mitigation in mining operations.

Mitigation Strategies against Antibody Aggregation Induced by Oleic Acid in Liquid Formulations.

Polysorbates 20 and 80 (PS20 and PS80) are commonly used in the formulations of biologics to protect against interfacial stresses. However, these surfactants can degrade over time, releasing free fatty acids, which assemble into solid particles or liquid droplets. Here, we apply a droplet microfluidic platform to analyze the interactions between antibodies and oleic acid, the primary free fatty acid resulting from the hydrolysis of PS80. We show that antibodies adsorb within seconds to the polar oleic acid-water interface, forming a viscoelastic protein layer that leads to particle formation upon mechanical rupture. By testing two different monoclonal antibodies of pharmaceutical origin, we show that the propensity to form a rigid viscoelastic layer is protein-specific. We further demonstrate that intact PS80 is effective in preventing antibody adsorption at the oleic acid-water interface only at low antibody concentrations and low pH, where oleic acid is fully protonated. Importantly, introduction of the amino acid l-arginine prevents the formation of the interfacial layer and protein particles even at high antibody concentrations (180 mg mL-1). Overall, our findings indicate that oleic acid droplets in antibody formulations can lead to the formation of protein particles via an interface-mediated mechanism. Depending on the conditions, intact PS80 alone might not be sufficient to protect against antibody aggregation. Additional mitigation strategies include the optimization of protein physicochemical properties, pH, and the addition of arginine.

Management of a Rare Case of Superior Mesenteric Artery Aneurysm Associated with a Pancreatic Cyst Complicated by Acute Rupture: A Case Report and Review of Literature.

Superior mesenteric artery aneurysms are a rare pathology, and rupture due to a pancreatic cyst in the context of alcohol-induced pancreatitis is an even rarer condition. The first line of treatment is usually an endovascular approach. We present the case of a 51-year-old male with alcohol-induced pancreatitis, diagnosed with a superior mesenteric artery aneurysm with active bleeding in close contact with a large pancreatic cyst. A covered stent was used to treat this condition. The patient developed hemorrhagic shock 12 h after the procedure and an urgent laparotomy was performed. A second rupture of the arterial wall at the distal end of the stent was observed and in order to obtain distal perfusion, first, an infrarenal aorta to superior mesenteric artery bypass distal to the rupture was performed in order to exclude the aneurysm. Secondly, a bypass originating from the distal end of the first bypass to the distal end of the superior mesenteric artery was performed. The patient had an uneventful recovery and was discharged after 10 days. We reviewed the literature regarding the incidence and the therapeutic management of superior mesenteric artery aneurysm complicated by pancreatic cyst. An advanced search on PubMed from 2004 to 2024 returned 194 results and after applying the inclusion-exclusion criteria, 11 publications were selected. Although the endovascular approach is usually the first line of treatment with obvious advantages for the patient, a patient-tailored approach should be made in such cases and surgery could be the first option, when considering that the mechanism of aneurysm rupture is due to erosion of the arterial wall by the pancreatic enzymes. Surgery has the advantage of cyst drainage and aneurysm exclusion and in our case proved lifesaving.

NINJ1 regulates plasma membrane fragility under mechanical tension.

Plasma membrane integrity is vital not only for cell survival but also nearly all aspects of cell functioning1. Mechanical stress can cause plasma membrane damage2, but it is not known whether there are large molecules (proteins) that control plasma membrane integrity. Here we constructed a 384-well cellular stretch system that delivers precise, reproducible mechanical strain to adherent cells. Using the system, we screened 10,843 siRNAs targeting 2,726 multi-pass transmembrane proteins for stretch-induced membrane permeability changes. The screen identified NINJ1, a protein recently proposed to regulate pyroptosis and other lytic cell death3,4, as the top hit. We demonstrate that NINJ1 is a critical regulator for mechanical force-induced plasma membrane rupture (PMR), without the need of stimulating any cell death programs. Low NINJ1 expression renders the membrane more resistant to stretching, while high expression of NINJ1 lowers the threshold of PMR under mechanical strain. NINJ1 level on the plasma membrane is inversely correlated to tension required to rupture the membrane. In the pyroptosis context, NINJ1 on its own is not sufficient to fully rupture the membrane, and additional mechanical stress is required for full PMR. Our work establishes that NINJ1 functions as a bona fide determinant of membrane biomechanical properties. Our study also suggests that PMR across tissues of distinct mechanical environments is subjected to fine tuning by differences in NINJ1 expression and external mechanical forces.

Study on the influence of indentation depths on the fracture characterization and acoustic emission characteristics of minerals in granite using nanoindentation

To investigate the intrinsic mechanisms of rock rupture at the mesoscale, this study employed nanoindentation tests on three primary minerals in granite at various indentation depths. Concurrently, rupture signals generated throughout the indentation process were recorded using the PCI-2 acoustic emission (AE) system. The results revealed that crack lengths in quartz and feldspar increased with indentation depth, whereas mica exhibited negligible radial cracking, showing only short, irregular cracks around the edges of the indentation marks. As indentation depth increased, the intensity of plastic deformation at the indentation point also increased, leading to a gradual reduction in fracture toughness and a corresponding rise in AE amplitude and energy. All three minerals generally showed a higher proportion of high-frequency signals compared to low-frequency signals, with the distribution characteristics of these signals being significantly influenced by the mineral properties. Quartz and feldspar exhibited relatively balanced frequency distributions, while mica had a higher proportion of high-frequency signals. At different indentation depths, most signals displayed characteristics of higher RA values and lower AF values, indicating that, at the mesoscale, the rupture modes of the three major minerals in granite are predominantly shear failures.

Rupture mechanics of blood clots: Influence of fibrin network structure on the rupture resistance

Embolization is a leading cause of mortality, yet we know little about clot rupture mechanics. Fibrin provides the main structural and mechanical stability to blood clots. Previous studies have shown that altering the concentration of coagulation activators (thrombin or tissue factor (TF)) has a significant impact on fibrin structure and viscoelastic properties, but their effects on rupture properties are mostly unknown. Toughness, which corresponds to the ability to resist rupture, is independent of viscoelastic properties. We used varying TF concentrations to alter the structure and toughness of human plasma clots. We performed single-edge notch rupture tests to examine fibrin toughness under a constant strain rate and we assessed viscoelastic mechanics using rheology. We utilized fluorescent confocal and scanning electron microscopy (SEM) to quantify the fibrin network structure under varying TF concentrations. Our results revealed that increased TF concentration resulted in increased number of fibrin fibers with a reduction in network pore size, thinner and shorter fibrin fibers. Increasing TF concentration yielded a maximum toughness at mid-TF concentration, such that fibrin diameter and number of fibers underlie a complex role in influencing the rupture resistance of blood clots, resulting in a nonmonotonic relationship between TF and toughness. A simple mechanical model, built on our findings from our Fluctuating Spring (FS) computational model, adopted to estimate the fracture toughness (critical energy release rate) as a function of TF predicts trends that are in good agreement with experiments. The differences in mechanical responses point to the importance of studying the structure-function relationships of fibrin networks, which may be predictive of the tendency for embolization. Statement of significanceFibrin, a naturally occurring biomaterial, is the main mechanical and structural scaffold of blood clots that provides the necessary strength and stability to the clot, ensuring effective stemming of bleeding. The rupture of blood clots can result in the blockage of downstream vessels thereby blocking blood flow and oxygen supply. The fibrin network structure has been shown to influence the viscoelastic mechanical properties of clots, but has not been explored for fracture mechanics. Here, we modulate the fibrin network structure by varying the concentration of Tissue Factor (TF). Interestingly, the association between TF concentration and maximum toughness of the clots is non-monotonic. The variations in mechanical responses highlight the importance of studying the structure-function relationships of fibrin networks, as these may predict the tendency for embolization.

Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis models.

Animal models of post-traumatic osteoarthritis (PTOA) recapitulate the pathological changes observed in human PTOA. Here, skeletally mature C57Bl6 mice were subjected to either rapid-onset non-surgical mechanical rupture of the anterior cruciate ligament (ACL) or to surgical destabilisation of the medial meniscus (DMM). Transcriptome profiling of micro-dissected cartilage at day7 or day42 following ACL or DMM procedure, respectively, showed that the two models were comparable and highly correlative. Gene ontology (GO) enrichment analysis identified similarly enriched pathways that were overrepresented by anabolic terms. To address the transcriptome changes more completely in the ACL model, we also performed small RNA sequencing, describing the first microRNA profile of this model. miR-199-5p was amongst the most abundant, yet differentially expressed, microRNAs, and its inhibition in primary human chondrocytes led to a transcriptome response that was comparable to that observed in both human 'OA damaged vs intact cartilage' and murine DMM cartilage datasets. We also experimentally verified CELSR1, GIT1, ECE1 and SOS2 as novel miR-199-5p targets. Together, these data support the use of the ACL rupture model as a non-invasive companion to the DMM model.

A Rhodamine-Spiropyran Conjugate Empowering Tunable Mechanochromism in Polymers under Multiple Stimuli.

Mechanochromic functionality realized via the force-responsive mechanophores in polymers has great potential for damage sensing and information storage. Mechanophores with the ability to recognize multiple stimuli for tunable chromic characteristics are highly sought after for versatile sensing ability and color programmability. Nevertheless, the majority of mechanophores are based on single-component chromophores with limited sensitivity, or require additional fabrication technology for multi-modal chromism. Here, we report a novel multifunctional mechanophore capable of vividly detectable and tunable mechanochromism in polymers. This synergistic optical coupling relies on strategically fusing rhodamine and spiropyran (Rh-SP), and tethering polymer chains on both subunits. The mechanochromic behaviors of the Rh-SP-linked polymers under sonication and compression are thoroughly evaluated in response to changes in force and the light-controlled relaxation process. Non-sequential ring-opening of the two subunits under force is identified, endowing high-contrast mechanochromism. Light-induced differential ring-closing reactions of the two subunits, together with the acidichromism of the SP moiety, are employed to engineer elastomers with programmable and wide-spectrum colors. Our work presents an effective strategy for highly appreciable and regulable mechanochromic functionality, and also provides new insights into the rupture mechanisms of π-fused mechanophores, as well as how the stimuli history controls stress accumulation in polymers.

A Rhodamine‐Spiropyran Conjugate Empowering Tunable Mechanochromism in Polymers under Multiple Stimuli

AbstractMechanochromic functionality realized via the force‐responsive mechanophores in polymers has great potential for damage sensing and information storage. Mechanophores with the ability to recognize multiple stimuli for tunable chromic characteristics are highly sought after for versatile sensing ability and color programmability. Nevertheless, the majority of mechanophores are based on single‐component chromophores with limited sensitivity, or require additional fabrication technology for multi‐modal chromism. Here, we report a novel multifunctional mechanophore capable of vividly detectable and tunable mechanochromism in polymers. This synergistic optical coupling relies on strategically fusing rhodamine and spiropyran (Rh−SP), and tethering polymer chains on both subunits. The mechanochromic behaviors of the Rh−SP‐linked polymers under sonication and compression are thoroughly evaluated in response to changes in force and the light‐controlled relaxation process. Non‐sequential ring‐opening of the two subunits under force is identified, endowing high‐contrast mechanochromism. Light‐induced differential ring‐closing reactions of the two subunits, together with the acidichromism of the SP moiety, are employed to engineer elastomers with programmable and wide‐spectrum colors. Our work presents an effective strategy for highly appreciable and regulable mechanochromic functionality, and also provides new insights into the rupture mechanisms of π‐fused mechanophores, as well as how the stimuli history controls stress accumulation in polymers.

Research on acoustic emission characteristics of metagabbros with different felsic development under splitting load

The acoustic emission (AE) characteristic signal can reveal the mechanical properties of rock materials and the development characteristics of internal microcracks. Rocks with different mineral development characteristics produce different AE signals during fracture. This study selected variable metagabbros with varying feldspathic development for AE tests under splitting load. The results demonstrated that the characteristics of AE ringing counts during the Brazilian fracture of metagabbro were closely correlated with the content of felsic minerals. The cumulative AE ringing count of metagabbros with feldspar nondevelopment exceeded 250 000, while those of metagabbros with feldspar development did not reach 200 000. As the feldspathic mineral content increases, the AE ringing counts of metagabbro exhibit an increasing trend in the high-energy (1e6–+∞ aJ) and high-amplitude (90–100 dB) intervals. With the development of feldspar minerals, the fracture mode of metagabbro gradually changed from shear failure to tensile failure. The higher the development of felsic minerals, the higher the stress level corresponding to the maximum fractal dimension, the greater the energy released by rock failure, and the more severe the damage. This study is of great significance for revealing the mechanism of rock rupture.

How Induced Earthquakes Respond to Pre‐Existing Fractures and Hydraulic Fracturing Operations? A Case Study in South China

AbstractHydraulic fracturing in shale gas production can induce felt earthquakes, making it crucial to understand and mitigate induced earthquakes. The Cen'gong shale gas block in South China offers extensive data—3D seismic, geological structure, microseismic data, and detailed stimulation operations—allowing a comprehensive investigation into induced earthquakes by hydraulic fracturing. Using a dense temporary seismic array and deep‐learning workflows, we build a high precision earthquake catalog and determine their focal mechanisms. Pre‐existing fractures are identified through the Ant Tracking attribute derived from the 3D seismic data. We analyze the distribution, frequency, magnitude, and focal mechanisms of induced earthquakes, compare them spatially with the distribution of the pre‐existing fractures, and track their temporal changes during and after hydraulic fracturing. Most induced earthquakes occurred along pre‐existing fractures, exhibiting relatively larger magnitudes and persistent trailing seismicity. The number of trailing seismicity is proportional to the response time of stimulation earthquakes. The focal mechanism solutions suggest that the rupture mechanism of the trailing seismicity remained unchanged. By analyzing four clusters of earthquakes, we found that in two of these clusters, the induced earthquakes initiated from the far side of the fractures, then linearly migrated along the pre‐existing fractures. This directional migration pattern is explained by stress rotation along the fractures. Our analysis suggests that both pre‐existing fractures and stimulation operations significantly influence induced earthquake occurrences. Therefore, this work may enhance our understanding of pre‐existing fractures, and optimizing stimulation operations can mitigate earthquake hazards in shale gas production.

Optimization and application of smooth blasting parameters based on radial uncoupling coefficient

For a rational selection of smooth blasting parameters, this study proposes a calculation method for the radial uncoupling coefficient (Kd), based on the rock rupture mechanism under explosive load. The hole spacing (h) and the thickness of the smooth blasting layer (w) were also determined. A numerical analysis model was established to verify the accuracy of the calculated results, which were subsequently applied with success to the Tongchuan Tunnel project. The findings reveal that at the specific tunnel location of DK96+152, the optimal values for Kd, h, and w were calculated to be 1.7, 0.5m, and 0.6m, respectively. The numerical simulation outcomes were found to align with the theoretical calculations. By applying the optimized smooth blasting parameters at the Tongchuan Tunnel construction site, the measured maximum overbreak distance was reduced by 0.27m(64%)compared to the pre-optimization period, and the overbreak area was decreased by 2.82m2(57%). This optimized approach resulted in the achievement of an ideal smooth blasting effect, demonstrating its potential to serve as a valuable reference for the rational selection of smooth blasting parameters in actual engineering projects.

Large Scale Simulation of 3D Fault Rupture Subjected to Far‐Field Loading With PDS‐FEM: Application to the 2018 Palu Earthquake

AbstractSimulating dynamic rupture of fault systems can be computationally demanding, as it requires reproducing complex fault geometry and accurately capturing waves propagating away from the rupture front. It is in particular challenging to predict an initial stress state consistent with fault geometries, heterogeneous distribution of surrounding materials, and far‐field tectonic loading. While standard techniques such as contact analysis and Lagrangian multipliers can be used to model the fault, it can lead to significant computational overhead in FEM. We extended Particle Discretization Scheme‐FEM, which provides numerically efficient crack treatment, without requiring contact analysis, to simulate dynamic fault rupture as a frictional crack propagating along a pre‐existing shear crack surface. Initial stress, which is consistent with initial frictional forces, material distribution and fault geometry, is derived using Coulomb friction and far‐field boundary conditions. The study first demonstrates the ability of the numerical method to reproduce a 2D ideal supershear scenario, and the underlying Burridge‐Andrew rupture mechanism. The methodology is then applied to the large scale simulation of the 2018 Palu earthquake on the Palu‐Koro fault. The simulation successfully reproduces the early and sustained supershear rupture which was observed for the Palu earthquake. Also, it indicates that the presence of an off‐fault damage zone can contribute to the low rupture velocity measured during the earthquake. Unlike sub‐Rayleigh earthquakes, the shockwave propagation was observed to lead to significant amplitudes of the ground motion even far from the fault.

Real-Time Observation of Protein Aggregation at Liquid-Liquid Interfaces in a Microfluidic Device.

A droplet microfluidic device to capture in real-time protein aggregation at liquid-liquid interfaces is described. In contrast to conventional methods, typically characterized by a lag time between the application of interfacial stress and the measurement of protein aggregation, here protein adsorption, the formation of a viscoelastic protein layer, aggregation, and shedding of protein particles into solution is simultaneously monitored. The device is applied to analyze the stability of antibodyformulations over a wide range of concentrations (1-180mgmL-1) at the silicone oil (SO)-water interface under controlled mechanical deformation. The adsorption onto oil droplets induces the formation of a viscoelastic protein layer on a subsecond timescale, which progressively restricts the relaxation of the droplets within the chip. Upon mechanical rupture, the protein layer releases particles in solution. The rate of particle formation increases strongly with concentration, similar to the bulk viscosity. Concentrations above 120mgmL-1 lead to aggregation in seconds and drastically decrease the mechanical perturbations required to shed protein particles in solution. These results are important for the development of formulations at high-protein concentrations (>100mgmL-1) and indicate that particular attention should be given to interface-induced particle formation in this concentration range. In this context, low-volume microfluidic platforms allow the assessment of protein physical instabilities early in development and represent attractive tools to optimize antibody stability and formulation design consuming limited amounts ofmaterial.

TO EVALUATE THE FUNCTIONAL OUTCOME IN PATIENTS WITH FLOATING KNEE WHO UNDERWENT MAGNETIC RESONANCE IMAGING

Objective: The incidence of floating knee injuries has traditionally been underestimated. However, with the increased use of magnetic resonance imaging (MRI) and arthroscopy, their frequency has risen. There is a crucial need to classify this complex injury pattern by also considering associated soft-tissue injuries. Soft-tissue injuries might be missed during clinical examination due to tenderness and swelling but can be detected through immediate MRI scans. This study aimed to evaluate the functional outcomes of patients with floating knee injuries who underwent MRI for soft tissue injuries. Methods: This study was conducted at a tertiary care center from February 2021 to January 2024. The study involved 100 patients with floating knee injuries who underwent MRI assessments for soft-tissue injuries. Follow-ups were scheduled at 1 month, 3 months, 6 months, and 1 year, with a maximum follow-up duration of 2½ years. The outcomes of floating knee injuries were assessed using the Karlstrom Olerud criteria. Results: Among 100 patients with floating knee injuries who underwent MRI, 72 had meniscus or ligament injuries, and nine had patellar fractures with extensor mechanism rupture. According to the Karlstrom Olerud criteria, seven patients had excellent outcomes, 46 had good outcomes, 33 had fair outcomes, and six had poor outcomes. Eight patients were lost to follow-up. Conclusion: Our aim is to ensure timely and accurate treatment by thoroughly addressing all associated injuries, including often-overlooked ligament damage around the knee. To improve clinical outcomes, we recommend a multidisciplinary approach involving various specialists in the care of these patients.

A semi-phenomenological dynamics model for full-life predictions of stress corrosion cracking

A semi-phenomenological model mimicking the full-time process of stress corrosion cracking (SCC) is proposed, and its attractive characteristics can be summarised as follows. Firstly, the role played by the hydrostatic pressure gradient at a crack tip in anodic dissolution is centralised by the proposed partial differential equation system, so as to formulate the interplay of load and corrosion in a mechanistic manner. As a result, the model can naturally reproduce the repeated film rupture mechanism that is believed central to general SCC phenomena. Secondly, the model implementation is extremely efficient, outputting a full-life SCC prediction within a few seconds on a normal laptop computer. Thirdly, a general rule for model calibration is introduced against limited experimental data, enabling its predictability over SCC indices that are not experimentally trackable. The efficacy and the generality of the proposed model are examined with three SCC scenarios, including (a) Inconel 600 alloys in nuclear pipelines, (b) stainless steels in oil pipelines, and (c) magnesium alloys used as structural materials in blood vessels. It is shown that SCC indices such as the SCC incubation period, which may be too long to be experimentally measured, can be quickly predicted with the present model after being calibrated.

Creep rupture properties of dissimilar welded joint of ferritic/martensitic P92 steel and Inconel 617 alloy

The dissimilar welded joint (DWJ) comprising P92 steel and Inconel 617 (IN617) is frequently utilized in advanced ultra-supercritical (AUSC) boilers. In present work the creep rupture behaviour, rupture mechanism and microstructure evolution of DWJ of P92 steel and IN617 with Ni-based ERNiCrCoMo-1 filler, were examined at 650 °C under the stress range of 120–200 MPa. The results of the creep test indicated that the location of creep rupture varied across different testing conditions, encompassing areas such as P92 base metal and the fine-grained heat-affected zone (FGHAZ). The creep tested specimens within the stress range of 180–200 MPa exhibited failure originating from P92 base metal, predominantly influenced by plastic deformation. The failure manifested in a transgranular mode, driven by the formation, growth, and eventually coalescence of microvoids. The creep tested specimens within the stress range of 120–150 MPa displayed the characteristic ofType IV failure, primarily attributed to matrix softening and the absence of adequate precipitates to pin the PAGBs. Microstructural characterization unveiled the presence of microvoids along the PAGBs, facilitating microvoid nucleation primarily owing to the existence of the coarse brittle carbide phase. The growth of these microvoids over a period of time during tertiary stage of creep which lead to their coalescence and the formation of microcracks, ultimately resulting in premature intergranular failure. The specimen creep exposed at 650 °C under the lower stress of 120 MPa exhibited higher creep rupture life for 432 h. The SEM/EDS study of the crept sample of 120 MPa is also confirmed the presence of intermetallic laves phases in regions near the fracture tip and in the heat-affected zones (HAZs). Although the creep tested specimens at 150 MPa and 120 MPa exhibited failure in the FGHAZ and their elemental SEM/EDS analysis confirmed the presence of an oxide layer and notch formation near the interface of P92 base metal and ErNiCrCoMo-1 filler weld. The FESEM study revealed the growth of the oxide layer in the notch region, and it also showed the presence of multiple cracks and microvoids in the oxide layer. The formation and propagation of the oxide notch mainly led to the interfacial failure. The crept specimens subjected to 180 MPa and 200 MPa did not exhibit any cracks or microvoids in HAZs. However, specimens that failed under applied stresses of 120 MPa and 150 MPa revealed the presence of a high density of microvoids in the FGHAZ, inter-critical heat-affected zone (ICHAZ), and in the region of the coarse-grained heat-affected zone (CGHAZ) adjacent to the interface attached with an oxide layer.