Mechanical Load Resistance Research Articles

Optimizing Processing Parameters for NR/EBC Thermoplastic Vulcanizates: A Comprehensive Full Factorial Design of Experiments (DOE) Strategy.

This research explores the development of thermoplastic vulcanizate (TPV) blends derived from natural rubber (NR) and ethylene-butene copolymer (EBC) using a specific blend ratio and melt mixing technique. A comprehensive full factorial design of experiments (DOE) methodology is employed to optimize the processing parameters. TPVs are produced through dynamic vulcanization, combining rubber crosslinking and melt blending within a thermoplastic matrix under high temperatures and shear. The physico-mechanical properties of these TPVs are then analyzed. The objective is to enhance their mechanical performance by assessing the influence of blend ratio, mixing temperature, rotor speed, and mixing time on crucial properties, including tensile strength, elongation at break, compression set, tear strength, and hardness. Analysis of variance (ANOVA) identifies the optimal processing conditions that significantly improve material performance. Validation is achieved through atomic force microscopy (AFM), confirming the phase-separated structure and, thus, the success of dynamic vulcanization. Rubber process analyzer (RPA) and dynamic mechanical analyzer (DMA) assessments provide insights into the viscoelastic behavior and dynamic mechanical responses. Deconvolution analysis of temperature-dependent tan δ peaks reveals intricate microstructural interactions influencing the glass transition temperature (Tg). The optimized TPVs exhibit enhanced stiffness and effective energy dissipation capabilities across a wide temperature range, making them suitable for applications demanding thermal and mechanical load resistance. This study underscores the pivotal role of precise processing control in tailoring the properties of NR/EBC TPVs for specialized industrial uses. It highlights the indispensable contribution of the DOE methodology to TPV optimization, advancing material science and engineering, particularly for industries requiring robust and flexible materials.

A survey on the usage of decellularized tissues in orthopaedic clinical trials

Orthopaedic surgery requires grafts with sufficient mechanical strength. For this purpose, decellularized tissue is an available option that lacks the complications of autologous tissue. However, it is not widely used in orthopaedic surgeries. This study investigated clinical trials of the use of decellularized tissue grafts in orthopaedic surgery. Using the ClinicalTrials.gov (CTG) and the International Clinical Trials Registry Platform (ICTRP) databases, we comprehensively surveyed clinical trials of decellularized tissue use in orthopaedic surgeries registered before 1 September 2022. We evaluated the clinical results, tissue processing methods, and commercial availability of the identified products using academic literature databases and manufacturers' websites. We initially identified 4,402 clinical trials, 27 of which were eligible for inclusion and analysis, including nine shoulder surgery trials, eight knee surgery trials, two ankle surgery trials, two hand surgery trials, and six peripheral nerve graft trials. Nine of the trials were completed. We identified only one product that will be commercially available for use in knee surgery with significant mechanical load resistance. Peracetic acid and gamma irradiation were frequently used for sterilization. Despite the demand for decellularized tissue, few decellularized tissue products are currently commercially available, particularly for the knee joint. To be viable in orthopaedic surgery, decellularized tissue must exhibit biocompatibility and mechanical strength, and these requirements are challenging for the clinical application of decellularized tissue. However, the variety of available decellularized products has recently increased. Therefore, decellularized grafts may become a promising option in orthopaedic surgery.

Tubular laminated composite structural battery

This paper introduces a polymer-matrix composite-based structural lithium-ion battery system with tubular morphology. Its shape and closed cross-section, fabricated during the autoclave process, allow for high electrochemical performance by controlling the electrode distance and battery environment. To prevent the degradation of the organic liquid electrolyte within this continuous resin polymer system, extra components such as thermoplastic hot melt film, a double glass load-bearing separator, aluminum film, and polydimethylsiloxane were implanted. The electrochemical properties of this manufactured multi-functional structural battery design, named the tubular laminated composite battery (TLCB), were tested with a galvanic cell testing machine. The initial specific capacity of TLCB was found to be approximately 120–130 mAh/g with good cycling performance and steady coulombic efficiency. Furthermore, mechanical load resistance and correlation with electrochemical performance were also assessed under the four-point bending load condition. These results show that the TLCB has the potential to operate as a subsidiary energy storage for future electric vehicle systems with a certain level of structural specific capacity and load-bearing properties.

Glycosaminoglycan remodeling during chondrogenic differentiation of human bone marrow-/synovial-derived mesenchymal stem/stromal cells under normoxia and hypoxia.

Glycosaminoglycans (GAGs) are major components of cartilage extracellular matrix (ECM), which play an important role in tissue homeostasis not only by providing mechanical load resistance, but also as signaling mediators of key cellular processes such as adhesion, migration, proliferation and differentiation. Specific GAG types as well as their disaccharide sulfation patterns can be predictive of the tissue maturation level but also of disease states such as osteoarthritis. In this work, we used a highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to perform a comparative study in terms of temporal changes in GAG and disaccharide composition between tissues generated from human bone marrow- and synovial-derived mesenchymal stem/stromal cells (hBMSC/hSMSC) after chondrogenic differentiation under normoxic (21% O2) and hypoxic (5% O2) micromass cultures. The chondrogenic differentiation of hBMSC/hSMSC cultured under different oxygen tensions was assessed through aggregate size measurement, chondrogenic gene expression analysis and histological/immunofluorescence staining in comparison to human chondrocytes. For all the studied conditions, the compositional analysis demonstrated a notable increase in the average relative percentage of chondroitin sulfate (CS), the main GAG in cartilage composition, throughout MSC chondrogenic differentiation. Additionally, hypoxic culture conditions resulted in significantly different average GAG and CS disaccharide percentage compositions compared to the normoxic ones. However, such effect was considerably more evident for hBMSC-derived chondrogenic aggregates. In summary, the GAG profiles described here may provide new insights for the prediction of cartilage tissue differentiation/disease states and to characterize the quality of MSC-generated chondrocytes obtained under different oxygen tension culture conditions.

Osseous Remodeling Around Dental Implants.

Adequate bone remodeling may be a primary parameter for long-term successful complication-free dental implant treatment. A 1.8-mm osseous thickness around dental implants is thought to be the minimum thickness for adequate vasculature for osteocyte nutrition and function. A dental implant does not provide progenitor cells or angiogenic or osteogenic factors. Thus, the surrounding bone may need to have a 1.8-mm thickness to accommodate the vasculature necessary for nutrients for appropriate remodeling. Additionally, the 1.8-mm dimension may provide for mechanical load resistance. There is no evidence to illustrate the physiologic need for the 1.8-mm dimension. This dimension requirement is based on clinical outcome observations. Basic science research for bone survival around dental implants is needed.

Low-Load Resistance Training With Blood Flow Restriction Improves Clinical Outcomes in Musculoskeletal Rehabilitation: A Single-Blind Randomized Controlled Trial.

Background: There is growing evidence to support the use of low-load blood flow restriction (LL-BFR) exercise in musculoskeletal rehabilitation.Purpose: The purpose of this study was to evaluate the efficacy and feasibility of low-load blood flow restricted (LL-BFR) training versus conventional high mechanical load resistance training (RT) on the clinical outcomes of patient’s undergoing inpatient multidisciplinary team (MDT) rehabilitation.Study design: A single-blind randomized controlled study.Methods: Twenty-eight lower-limb injured adults completed a 3-week intensive MDT rehabilitation program. Participants were randomly allocated into a conventional RT (3-days/week) or twice-daily LL-BFR training group. Outcome measurements were taken at baseline and 3-weeks and included quadriceps and total thigh muscle cross-sectional area (CSA) and volume, muscle strength [five repetition maximum (RM) leg press and knee extension test, isometric hip extension], pain and physical function measures (Y-balance test, multistage locomotion test—MSLT).Results: A two-way repeated measures analysis of variance revealed no significant differences between groups for any outcome measure post-intervention (p > 0.05). Both groups showed significant improvements in mean scores for muscle CSA/volume, 5-RM leg press, and 5-RM knee extension (p < 0.01) after treatment. LL-BFR group participants also demonstrated significant improvements in MSLT and Y-balance scores (p < 0.01). The Pain scores during training reduced significantly over time in the LL-BFR group (p = 0.024), with no adverse events reported during the study.Conclusion: Comparable improvements in muscle strength and hypertrophy were shown in LL-BFR and conventional training groups following in-patient rehabilitation. The LL-BFR group also achieved significant improvements in functional capacity. LL-BFR training is a rehabilitation tool that has the potential to induce positive adaptations in the absence of high mechanical loads and therefore could be considered a treatment option for patients suffering significant functional deficits for whom conventional loaded RT is contraindicated.Trial Registration: ISRCTN Reference: ISRCTN63585315, dated 25 April 2017.

Structural characterization of Ti90Al6V4 alloy and sulphur segregation

Ti90Al6V4 alloy is used in orthopaedic medical implant applications because of its biocompatibility, corrosion resistance and mechanical load resistance. We characterized the time evolution of the surface composition of TiAlV, the surface roughness and the microstructure, which influence the formation of a suitable tissue-implant interface. For this we used Auger electron spectroscopy, X-ray photoelectron spectroscopy, atomic force microscopy and X-ray diffraction. The impurity diffusion was accelerated by annealing in ultra high vacuum. We found sulphur segregation from the bulk to the surface. The value of the activation energy of 150 kJ/mol allows us to conclude that diffusion at room temperature is too slow to influence the composition during the implant lifetime. The microstructure of the alloy is equiaxed at room temperature and is modified by annealing above 950°C with the appearance of a lamellar phase. In the diffractograms after the treatments performed in our study we always observed only the α-phase peaks. During annealing in air the surface oxide thickens and increases its vanadium content compared to the bulk alloy. This finding is relevant for high temperature applications, but also for the machining treatments on devices applied at room temperature since the possible surface heating during wear processes could modify the surface composition.

Load Test of Bolt-Clamped Langevin Type Vibrator

The temperature rise of several kinds of bolt-clamped Langevin type vibrators which are used in the design of high power ultrasonic vibration equipment is measured as a function of operating time. Employing the wattmeter method and the variable mechanical load resistance proposed by the authors, the measurements are carried out for various values of the parameters of mechanical output power, mechanical load resistance and vibration velocity. The electroacoustic efficiencies of the vibrators are also measured using the same method.