Hajj Research Articles

Analyzing 1937 AD Diplomacy and Cultural Exchange through the Hispano-Arab-Islamic Mecca Pilgrimage

This research employs Interpretative Phenomenological Analysis (IPA) to delve into the historical interactions between Spain and the Arab-Islamic world during Franco's regime, with a focus on the 1937 pilgrimage to Mecca. This initiative exemplifies the use of cultural and religious diplomacy to enhance bilateral relations, revealing efforts to portray Spain as respectful of Islamic practices. By examining unpublished documents, including Francisco Limiñana's detailed planning of the pilgrimage, the study highlights the complexity of colonial and post-colonial relationships, blending cooperation and power dynamics. The analysis underscores the intertwining of Spain's internal policies with its external posture, aiming to bolster national identity and Franco's legitimacy. The findings challenge oversimplified narratives, offering a nuanced view of Western-Arab-Islamic interactions, essential for understanding contemporary challenges and fostering intercultural dialogue. Significantly, Limiñana's role transitioned from organizing the pilgrimage to becoming Spain's first ambassador to Saudi Arabia in 1956, illustrating the evolution of Spanish-Arab relations.

Qard Al Hasan: Instrumen Moneter Syariah Dalam Peningkatan Kesejahteraan Masyarakat Indonesia

Conventional interest-based monetary policy has yet to be effective in overcoming monetary problems. So, this article is to discuss how to apply qard al hasan as one of the sharia monetary instruments in Indonesia. The method used is literature study. The results of the analysis and discussion show that Qard al Hasan's Monetary Policy can be implemented in Indonesia. This is because Qard al Hasan is very in accordance with the Qur'an and Hadith and the implementation of Qard al Hasan-based monetary policy can not only stabilize prices and inflation, but also can increase national production or GDP and reduce the number of poor people. Bank Indonesia as the executor of Monetary Policy can apply the Qard al Hasan system, because Bank Indonesia has started to create a database of community groups that have Micro, Small and Medium Enterprises, so that the implementation of Qard al Hasan in Indonesia can be implemented.

Baitul Maal wa Tamwil (BMT) Phenomenon on Mosque-Based Syari'ah Economy

This research aims to analyse how to develop the sharia economy of mosques through Baitul Mal wa Tamwil (BMT) in Solok City. BMT Solok City is a non-governmental organisation in the economic sector that has become an icon of Solok City to realise its mission, namely to become the "City of Medina Rice Terraces". The research method used in this research is qualitative research with a case study approach, data analysis used with case studies with data collection techniques through interviews, observation and distributing questionnaires via Google Form. This research shows that BMT management is carried out using the concept of qardh al hasan; institutionally, this institution does not have a legal entity, and its members are active congregants of the local mosque. Regarding BMT activities in Solok City, they are limited to lending and collecting funds and do not have financing service products like other microfinance institutions.

Qard Al-Hasan Revitalization as a Financing Alternative for Micro, Small, and Medium Enterprises: An Analytic Network Process Approach

Purpose: The purpose of this research is to explore aspects of the application of qard al hasan that support the successful implementation of qard al hasan as an Islamic crowdfunding instrument to finance Micro, Small, and Medium Enterprises (MSMEs). Theoretical framework: The proper financing model is required to minimize the risk of Non Performing Loan of qard alhasan financing, so it can serve as an alternative access to financing for MSMEs that are classified as feasible but unbankable businesses. Design/Methodology/Approach: This research utilized the Analytic Network Process (ANP) which is the result of a literature study, and the opinions of practitioners and experts. Findings: To successfully implement qard al hasan as a financing instrument, it must be supported by internal and external aspects of the institution providing qard al hasan financing. Internal aspects consist of system and institutional management sub-aspects. The system sub-aspect consists of the qard al hasan distribution system, fund collection system, revenue system, and internal control system. Institutional management sub-aspect consists of human resources, organizational structure, governance, and business segment of the institution. External aspects consist of customer and authority sub-aspects. The customer sub-aspect consists of customer business management, customer segments, and collateral provision. While the authority sub-aspect includes regulations imposed by the authority to regulate the implementation of qard al-hasan. Research, practical & social implications: The results will provide input to all qard alhasan stakeholders, so the quality of financing is sound and sustainable. As a result, there will be more MSMEs that can be financed. Originality/Values: The originality of the research is in the scope of the discussion of qard al-hasan which is focused on revitalizing the financing aspects of qard alhasan by using the principles of sound financing practices produced by the ANP method as an analytical tool with the aim of producing sound and sustainable financing quality. The results of this research are expected to contribute to the concept of a qard alhasan implementation model that can be used by all stake holders to improve qard al-hasan performance.

Enigmatic Bones: A Few Archaeological, Bioanthropological, and Historical Considerations Regarding an Atypical Deposit of Skeletonized Human Remains Unearthed in Khirbat al-Dusaq (Southern Jordan)

Abstract This article presents the results of the archaeological, bioanthropological, and historical analysis of an atypical human bone deposit found at the medieval Islamic desert site of Khirbat al-Dusaq in southern present-day Jordan. This site has yielded several human remains deposits, most of which appear to be either ordinary or reorganised burials with a clearly identifiable sepulchral function. However, one particular deposit (labelled “Structure no 1 (Pièce 5)”) displays several atypical features which complicate its interpretation. As such, radiocarbon dating of this particular deposit indicates a chronological range extending from the second half of the seventeenth century CE to the end of the eighteenth century CE. In addition, the human bones contained within this deposit tend to show unusual osteological characteristics, such as possible cut marks resembling peri-mortem lesions inflicted upon the deceased by third parties armed with sharp objects. The precise historical contextualisation of this deposit enables us to discuss different scenarios that could explain the circumstances of its inception. In this sense, the spectrum of possible explanatory interpretations ranges from the conjecture that the remains under study represent one or several victims of an inter-tribal conflict, a brigandage or retaliation attack, a crushed popular uprising, or even individuals who died during one of the violent raids perpetrated by local Bedouin tribes against the Mecca pilgrimage caravans during the Ottoman period.

Contextualization Of Educational Scriptures In Science Education As A Form Of Strengthening The Faith And Islamic Student

The reality of learning Science in schools is still urban. In the context of achieving the goals of education in the law, one of which is that students have religious spiritual strength and good morals, it is very important that science learning is contextualized with educational verses. Because with this contextualization model in each sub-theme of learning can strengthen understanding of the material theoretically and in general can increase the faith and Islam of students. One example, students are more grateful for the majesty of Allah and increasingly believe that science learning is still related to the Qur'an. This contextualization has been carried out by a science teacher at a Muhammadiyah 3 junior high school in Jember Regency by providing verses related to sub-themes. The purpose of contextualization is to strengthen the position of the material and explain the content of the verse related to the greatness of God in the creation of humans, nature, and the surrounding environment. Please note that science material is listed in the Qur'an such as the human reproductive system which has been clearly explained in the letter Al Mursalat verse 20, At Tariq verse 6, Al Insan verse 2, Al Mukminun verse 13-14, Al Haj verse 5, Noah verses 13-14. Teachers need to develop this learning model, starting with the preparation of a lesson plan (RPP) and material containing Islamic values and then implementing it in classroom learning.

Population genetics of Anopheles arabiensis, the primary malaria vector in the Republic of Sudan

BackgroundAnopheles arabiensis is a member of Anopheles gambiae complex and the main malaria vector in Sudan. There is insufficient population genetics data available on An. arabiensis for an understanding of vector population structure and genetics, which are important for the malaria vector control programmes in this country. The objective of this investigation is to study the population structure, gene flow and isolation by distance among An. arabiensis populations for developing control strategies.MethodsMosquitoes were collected from six sites located in three different states in Sudan, Khartoum, Kassala and Sennar, using pyrethrum spray catch of indoor resting mosquitoes. Anopheline mosquitoes were identified morphologically and based on species specific nucleotide sequences in the ribosomal DNA intergenic spacers (IGS). Seven published An. gambiae microsatellite loci primers were used to amplify the DNA of An. arabiensis samples.ResultsPCR confirmed that An. arabiensis was the main malaria vector found in the six localities. Of the seven microsatellite loci utilized, six were found to be highly polymorphic across populations, with high allelic richness and heterozygosity with the remaining one being monomorphic. Deviation from Hardy–Weinberg expectations were found in 21 out of 42 tests in the six populations due to heterozygote deficiency. Bayesian clustering analysis revealed two gene pools, grouping samples into two population clusters; one includes four and the other includes two populations. The clusters were not grouped according to the three states but were instead an admixture. The genetic distances between pairs of populations ranged from 0.06 to 0.24. Significant FST was observed between all pairwise analyses of An. arabiensis populations. The Kassala state population indicated high genetic differentiation (FST ranged from 0.17 to 0.24) from other populations, including one which is also located in the same state. High gene flow (Nm = 1.6–8.2) was detected among populations within respective clusters but limited between clusters particularly with respect to Kassala state. There was evidence of a bottleneck event in one of the populations (Al Haj Yousif site). No isolation by distance pattern was detected among populations.ConclusionsThis study revealed low levels of population differentiation with high gene flow among the An. arabiensis populations investigated in Sudan, with the exception of Kassala state.

406.2: Utility of Donor-derived Cell-free DNA in Assessing Simultaneous Pancreas-Kidney Transplantation Rejection

Introduction: Among solid organ transplants, pancreas transplantation has one of the highest rates of acute rejection within the first 12 months. Graft biopsy, the gold standard, is risky and often not available. Hence, a non-invasive biomarker with good predictive value, such as donor-derived cell free DNA (dd-cfDNA), may be useful in predicting risk of rejection. In this study we sought to analyze the performance of a dd-cfDNA test in patients with simultaneous pancreas kidney (SPK) transplant. Methods: A retrospective study was conducted from 2017 to 2020 on patients admitted for pancreas graft biopsy at the Hospital Clínic Barcelona. Plasma samples were collected on the day of biopsy. dd-cfDNA fraction was assessed using the ProsperaTM test, a SNP-based mmPCR methodology to predict risk of rejection (including T-cell mediated rejection [TCMR] and antibody mediated rejection [ABMR]). Results: Plasma samples (n=50) were obtained from 37 SPK recipients. Pancreas biopsies were collected from 30 patients. Of the 50 plasma samples, 36 were plasma-biopsy paired and per Banff criteria were categorized as no rejection (n=21) and acute rejection (aTCMR and aABMR; n=15). Median dd-cfDNA levels were significantly elevated in samples with graft rejection diagnosis: 1.11 [0.83–1.66] vs. no rejection 0.65 [0.28–1.00]; p=0.004),especially after 45 days post transplantation (AR: 0.83[0.67–1.59], NR:0.45[0.13–0.55], p=0.004) (Figure 1). The overall performance of the test after 45 days of transplant is as follows: sensitivity 71.4%, specificity 91.6%, PPV: 83.8%, NPV:84.6%. Conclusion: dd-cfDNA assay can accurately differentiate active rejection from non rejection through a non-invasive, simple blood test in SPK patients as early as 45 days post SPK transplant.Medical writing support was provided by Nour Al Haj Baddar, Ph.D. from Natera, Inc. at San Carlos, CA.

Macroscopic View: Crowd Evacuation Dynamics at T-Shaped Street Junctions Using a Modified Aw-Rascle Traffic Flow Model

This study investigates a dynamic flow model for crowd evacuation at T-shaped street junctions (TSJs) from a macroscopic view. The Aw-Rascle traffic flow model is modified by constructing an impact matrix in the street intersection area to practically describe the crowd convergence mechanism at a TSJ. For coherence, this modified model is proved to be anisotropic, similar to the original Aw-Rascle traffic flow model. To describe real scenarios with higher crowd density and lower speeds during organized pilgrimages, the initial Gaussian distribution of the crowd is improved to a higher-order smoothing function. To validate the modified Aw-Rascle traffic flow model, we reconstruct the drastic stampede that occurred at the TSJ of streets 204 and 223 during the 2015 Mecca pilgrimage. Further, the main environmental parameters that potentially lead to a stampede are discussed with numerical simulations. A valuable suggestion is that the street width ratio should be extended from 1.1 to 1.4 to prevent stampedes, matching the expansion engineering of street 204 reported by BBC News. An interesting phenomenon is that the closer the bus unloading location on street 223 is to the TSJ center, the lower the maximum crowd density and the safer the pedestrians will be. With this modified Aw-Rascle flow model at TSJs, this paper provides strategic and technical suggestions for future crowd flow control to reduce the risk of crowd stampedes.

Critically Ill Pediatric Oncology Patients: What the Intensivist Needs to Know? Pediatric Critical Care Medicine

Cancer is an evolving cause of morbidity and mortality in children worldwide. In recent decades, there has been a significant increase in the survival of children with cancer, after applying new methods and treatment protocols in practice. However, the complexity of the disease itself, as well as the intensity and toxicity of treatment is such that many children require admission to the pediatric intensive care unit (PICU) which should be well equipped and led by personnel who have adequate training and expertise to provide optimum care to these complex patients. Most oncology patients who require PICU admission categorized into oncological emergencies, and/or decompensation from treatment and its side effects. In this study, we provide a summary of the essential and most recent evidence-based recommendations from published reviews and articles to aid PICU physicians and to ensure the best treatment and outcome possible for the children with such disease.How to cite this article: Al Haj Moussa A, Maaz AUR, Faqih N, Sundaram M. Critically Ill Pediatric Oncology Patients: What the Intensivist Needs to Know? Pediatric Critical Care Medicine. Indian J Crit Care Med 2020;24(12):1256–1263.

The Life of Ṣaḥābī ʿUrwa b. Masʿūd el-Thaqafī

Hz. Peygamber’in sahâbîlerinden bir tanesi Tâifli Sakîf kabilesinden Urve b. Mes‘ûd’dur. O, kabilesinin en önde gelenlerinden birisidir. O, Sakîf kabilesinin Ahlâf koluna mensuptur ve bu kolun yöneticisidir. Urve Mes‘ûd’un nesebi, Kasî’ye (Sakîf) kadar ihtilafsız bilinmektedir. Onun künyesi Ebû Ya‘fûr bir rivayate göre de Ebû Mes‘ûd’dur. Urve’nin babası da önemli bir şahsiyet-tir. O da kabilesinin reislerindendir ve Ficar savaşlarında Sakîf kabilesinin Ahlâf koluna komu-tanlık yapmıştır. Urve’nin annesi ise Mekkeli Ümeyyeoğullarından Sübey‘a bint Abdüşems’dir. Böylece Urve’nin hem Ümeyyeoğulları ile hem Hz. Peygamber ile akrabalık bağı olmaktadır. Dolayısıyla nesebi, babası ve annesi itibariyle Urve, çok önemli bir konuma sahiptir. Onun Mekke ve Kureyş ile ilgisi de bu konumunu güçlendirmektedir. Kaynaklarımızda Urve b. Mes‘ûd’un doğum tarihi veya vefat yaşı ile ilgili bir bilgi bulunamamıştır. Kabilesinin reisi olu-şuna, vefat ettikten sonra oğlunun Müslüman oluşuna bakıldığında Müslüman olduğunda orta yaşın üzerinde olması muhtemeldir. Urve b. Mes‘ûd’un evlilikleri ile ilgili bilgi de azdır. Onun Müslüman olmadan önce on eşi olduğu rivayet edilmektedir. Müslüman olduktan sonra Hz. Peygamber dört eşini seçmesini istemiştir. Onun dört eşinden bir tanesi Ebû Süfyan’ın kızıdır. Ancak onun eşlerinin isimleri ile ilgili net bilgiler yoktur. Onun erkek çocuklarının isimleri Âsım, Ebû Mürre, Muaviye, Ebû Müleyh, Davud, Hemmâm ve Hişâm; kız çocuklarının isimleri Hz. Ali ile evli olan Ümmü Saîd ve Halime’dir. Hudeybiye Antlaşması öncesinde onun elçilik görevi yaptığını görmekteyiz. Onun elçilik görevi, konumunun üstünlüğünü ortaya koymakta-dır. Ayrıca bu elçilik, barış görüşmelerinde çok etkili olmuştur. Burada Mekkeliler ile olan akrabalık bağını gündeme getirmiştir. Hz. Peygamber ile kendisinin konuşmasının faydalı olacağını söylemiştir. Mekkeliler de ona olan güvenlerini açıklamışlardır. Bu elçilik esnasında iki tarafın da savaştan uzak durması gerektiğini ifade etmiştir. Bu bağlamda Mekkelilere, Hz. Peygamber’in etrafındakilerin ona çok bağlı olduklarını; Hz. Peygamber’e ise etrafındaki insan-ların hemen dağılacağını söylemiştir. Elçiliği, onun herkes tarafından sözü dinlenilen, itibar edilen, zeki ve ikna kabiliyeti yüksek bir kişi olduğunu göstermektedir. Urve, sahâbenin Hz. Peygamber’e olan bağlılığını gözlemlemiştir. Bu bağlılığın hiçbir hükümdar ve çevresindeki-lerde olmayacağını itiraf etmiştir. Bu gözleminin, onun Müslümanlığında etkili olması muhte-meldir. Mekke’nin fethi ve ardından yaşananlar, Tâiflileri endişeye sevk etmiştir. Bu sebeple Tâifliler, Huneyn Savaşı’nda Hevâzinlilerle birlikte Müslümanlara karşı savaşmışlardır. Bu esnada Urve b. Mes‘ûd ile Gaylân b. Seleme’yi bazı savaş araç ve tekniklerini öğrenmeleri için Yemen’in Cüreş şehrine göndermişlerdi. Bu sebeple ikisi de Huneyn ve Tâif gazvelerine katıla-mamışlardı. Hz. Peygamber Tâif kuşatmasına son verip Medine’ye döndü. Bu esnada Urve ve arkadaşı da Yemen’den döndü. Rivayetlere göre Hz. Peygamber Medine’ye dönüş yolunda veya Medine’ye varınca Urve onun yanına gitti ve Müslüman oldu. Bazıları onun İslam’a giriş tarihi ile ilgili Hz. Ebû Bekir’in hac emirliği görevinin öncesi veya sonrasını söylerler. Ancak rivayet-ler incelendiğinde onun Hz. Peygamber’in Tâif muhasarasından 4-5 ay sonra, Tebük seferinden 3-4 ay önce 9/630 yılı Rebîulevvel veya Rebîulâhir (Temmuz veya Ağustos) ayında Müslüman olduğu söylenebilir. Urve’nin Müslüman olmasıyla ilgili temel kaynaklarımız “Allah, Urve’nin kalbine İslâm’ı ilham etti ve üzerinde bulunduğu hali değiştirdi. Bu hali ile Rasûlullah’ın yanına gitti ve Müslüman oldu.” der ve belirli bir sebep belirtmezler. Ancak sonraki dönemde onun Müslüman oluşuyla ilgili Necran’a ticaret için yaptığı yolculukta yaşadıkları sebep gösterilir. Bu yolculukta gizemli iki genç kız ve Necran’daki rahip son peygamberin çıktığını Urve’ye söyler. Onlar, Urve’nin ona tabi olması gerektiğini de belirtirler. Urve de dönüşte Müslüman olur. Bu rivayet hem senet hem metin itibariyle problemlidir. Urve, Müslüman olduktan sonra kavmini İslam’a davet için Hz. Peygamber’den izin istemiştir. İlk etapta Hz. Peygamber, Tâiflilerin İs-lam’a karşı kibirli karşı duruşundan dolayı bunu kabul etmek istememiş ve Urve’ye Sakîflilerin kendisini öldürebileceğini söylemiştir. Nitekim Urve, Hz. Peygamber’in izniyle şehrine gitmiş ve onları İslam’a davet etmiştir. Onlar kabul etmemişler ve kötü sözler söylemişlerdir. Ertesi sabah Urve sabah ezanı okumuş, halkı onu öldürmüştür. Hz. Peygamber tarafından Hz. İsa’ya benzetilen Urve b. Mes‘ûd es-Sekafî’nin Zuhruf suresinde ifade edilen “iki şehrin büyüğünden birisi” olduğu genel olarak kabul edilmiştir. Birkaç gün Müslüman olarak yaşayabilen ve kavmi tarafından şehit edilen Urve’den sadece iki tane zayıf rivayet nakledilmiştir.

Hajj health <em> istithaah </em> amid the COVID-19 pandemic

[No abstract available]

Assessments of physico-chemical parameters of Garaet Hadj Tahar wetland and their effect on waterbirds settlement

Assessments of physico-chemical parameters of Garaet Hadj Tahar wetland and their effect on waterbirds settlement

Knowledge, Attitudes, and Practices (KAPs) of Healthcare Workers towards MERS-CoV Infection at PHCs in Madinah, KSA during Hajj 1440, 2019

This research study aims at investigating knowledge, attitudes, and practices (KAPs) of healthcare workers towards the Middle East respiratory syndrome (MERS), also known as camel flu, caused by the MERS-CoV coronavirus. The present study focuses on the Hajj season in 2019 in the city of Al-Madinah Al-Munawwarah in Saudi Arabia as it is one of the most beloved cities for Muslim pilgrims who keep visiting its famous and lovely prophetic Mosque (Al-Masjid Al-Nabawi). For that, almost 500.000 visitors come to Al-Madinah everyday. Most of the year, the prophetic Masjid is crowded from inside and the crowdedness expands to include the mosque’s piazzas and even the streets outside the masjid. Unfortunately, overcrowdedness is a risk factor for transmitting many serious respiratory diseases as MERS-CoV. Also, this study is an effort to obtain significant insights and to evaluate the health practices among healthcare workers particularly in the primary healthcare domain. Data collection involves a survey questionnaire distributed to all healthcare workers participating in care delivery during the Hajj season 1440 hijri calendar (2019 Gregorian calendar). Participants were medical students, physicians and nurses at Taibah University, King Fahd hospital and primary healthcare centers (PHCs) taking into account the work experience duration and the study level. MERS-CoV viruses are enveloped RNA viruses that fall into six strains. MERS-CoV viruses cause zoonotic diseases belonging to the gamma genus of corona viruses. MERS CoV infection may be caused by droplet, close patients contact and exposure to camels. March–May period is the season of greatest disease transmission. Incubation period is 3-4 days with respiratory and renal symptoms and subclinical infection. The questionnaire investigated all this basic medical knowledge about MERS-CoV. Responses collected from the questionnaire were analyzed using SPSS where percent reliability was calculated. Results revealed that the current knowledge of health care personnel needs to be augmented and updated for improving the common goal of declining the transmission rates of MERS-CoV.

Pengaruh Intensitas Penggunaan Gadget Terhadap Konsep Diri

This research was conducted to find out the extent of the influence of the intensity of the use of gadgets on the self-concept of class XI SMA Plus AL HASAN Panti. The research method used is quantitative method and simple correlation. The participants were taken randomly using simple random sampling. This research was conducted by distributing questionnaire to a predetermined sample. Based on the statistical test using the Pearson product moment test, the r-value was 0.317 compared to the r table, the results obtained was 0.213. Further, the t-value was 3,064 compared to the t table, the results was 1,989, which means Ha was accepted and HO was rejected. Therefore, gadget has positive correlation with the students’ self-concept. Keywords: gadgets, self concept

Abstract 4711: PRMT5 selective inhibitor enhances therapeutic efficacy of cisplatin in lung adenocarcinoma cells

Abstract Background: Lung cancer is the most common cancer globally, with an estimate of more than 2 million new cases every year. Protein arginine methyltransferase 5 (PRMT5) is an enzyme that is identified to be involved in multiple cellular events, including gene expression regulation transcriptional regulation and cell division. It has been shown that PRMT5 is highly expressed in cancers including lung adenocarcinoma, hepatocellular carcinoma, and melanoma, raising evidence that PRMT5 might be involved in tumorigenesis. The aim of this study is to examine the potential selective anti-neoplastic activity of AMI-1 and cisplatin on lung adenocarcinoma. Experimental methods: The effect of AMI-1 and subsequent PRMT5 activity inhibition on lung adenocarcinoma (A549 cell line) behavior with the standard chemotherapeutic agent, cisplatin was assessed, by measuring cell viability using MTT assay, PMRT5/β-catenin protein levels via Western Blotting, the extent of cell migration through wound healing assay, and survival of cancer cells by performing cell cycle progression and Annexin-V staining assays along with both drugs combination potential toxicity that was evaluated in human bronchial epithelial cells (HBEC). Results and Discussions: Combination treatment with 10 µM AMI-1 and IC50 of Cisplatin (23.4 µM) significantly reduced viable cell percentages at 24 and 48 hours. Treatment with both drugs at 48 hours led to a decreased cells migration rate. G2/M arrest in A549 cells was evident at 24 hours of AMI-1 addition, which was reinforced after drugs combined treatment. Furthermore, 48 hours of both drug administration hindered the ability of A549 cells to recycle again as they G1 occupying cells percentage was increased after 48 hours of combination treatment. There was a minor cell death induction after 48 hours of treatment with both drugs. Western blot analysis showed that there was no evidence change in total PRMT5 and β-catenin protein levels. Nevertheless, there was a reduction in demethylation Histone 4, a PRMT5- downstream target, after 48 hours treatment with AMI-1 alone or in combination with Cisplatin. Interestingly, as combination approach increased anti-survival effect on lung cancer cells, it exhibited cyto-protective abilities on normal epithelial cells. Conclusion: This study shows a novel selective antitumor activity of AMI-1 and cisplatin in adenocarcinoma cells. Citation Format: Khuloud Bajbouj, Rakhee Ramakrishnan, Ahmed M.H.Ihmaid, Suhaib Al Haj Ali, Abdulla Alalool, Reem Abdullah, Maha Saber-Ayad, Qutayba Hamid. PRMT5 selective inhibitor enhances therapeutic efficacy of cisplatin in lung adenocarcinoma cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4711.

ROLE OF MASTER HAJJ ABDURRAHMAN YA’KUB IN THE DEVELOPMENT OF ISLAMIC EDUCATION IN INDRAGIRI HILIR REGENCY RIAU PROVINCE, INDONESIA

This study aims to reveal the role and contribution of Master Hajj Abdurrahman Ya’kub in the development of Islamic education in Riau Province, especially Indragiri Hilir. From many theologians, Master Hajj Abdurrahman Ya’kub because of his figure plays a major role in educating, guiding and educating the people. His creations, such as: Amtsilatul mukhtasar, Qawaidun nahwiyah, Nailul amani, Ahwalul waratsati fi tajsimit tarikah became the community’s reference in the interaction of social and religious life. In exploring Master Hajj Abdurrahman Ya’kub’s figure, the approach is used in this study was a historical approach, namely: heuristics, verification (source criticism), interpretation and historiography (Kuntowijoyo, 2003., [1] and [2] Data was obtained through direct interviews, documentation and observation.

Embryonic Cell Extracts Ameliorate Wound Healing in Diabetic Mice

Wound healing (WH) is a physiological function in which a balanced inflammatory response is required for tissue regeneration and successful wound closure. In diabetic patients WH is impaired and negatively impacts diabetic individuals in terms of morbidity, mortality and social disability, while the lack of an effective wound care highlights the need for novel therapeutic strategies. Extracts obtained from embryonic stem cells (EXTs) exhibited immunomodulatory properties and we hypothesize that EXTs may improve WH in diabetes. Here we explored the in vitro and in vivo effect of EXTs on WH using the diabetic db/db mouse model. Our data show that in vivo EXT topical administration ameliorates wound closure, contraction and re-epithelization by significantly reducing local inflammation and enhancing angiogenesis as compared to acellular protein extracts from 3T3 fibroblast cells (3T3xt) or no treatment. EXTs increased the percentage of regulatory T cells in the wound in vivo and inhibited T cell activation and IFNγ production in vitro. Db/db-derived dendritic cells exposed to EXTs showed decreased maturation, with downregulation of the costimulatory molecules CD80, CD86 and CD40. On the other hand, in vivo 3T3xt administration caused poorer wound closure with enhanced leucocyte infiltration of wounds and CD80, CD86 and CD40 upregulation on activated dendritic cells both in vivo and in vitro. Finally, proteomic analysis revealed 82 molecular entities differentially segregating in the EXT and 3T3xt group. Following unbiased selection, 10 proteins were filtered and assayed for their immune activity. Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) revealed strong immunomodulatory properties at ELISpot analysis by inhibiting IFNγ secretion of human PBMCs. APEX1 may result as the key factor mediating the beneficial effect of EXT on WH. EXTs or acellular extracts with upregulated APEX1 is a tool of remarkable translational potential for a safe, innovative and cost-effective application in the clinic. Disclosure C. Loretelli: None. M. Ben Nasr: None. G. Al Haj: None. F. Rocchio: None. S. Faravelli: None. A. Malvandi: None. F. D'Addio: None. A. Maestroni: None. T. Letizia: None. E. Assi: None. V. Usuelli: None. E. Castillo Leon: None. R. Meroni: None. G. Zuccotti: None. P. Fiorina: None.

Reply to Al-Hasan et al

Reply to Al-Hasan et al

Protection amid Chaos: The Creation of Property Rights in Palestinian Refugee Camps, by Nadya Hajj

Book Review: Protection amid Chaos: The Creation of Property Rights in Palestinian Refugee Camps Nadya Hajj New York: Columbia University Press, 2016, pp. 214