Measures Of Auditory Memory Research Articles

No Evidence That Cognitive and Physical Activities Are Related to Changes in EEG Markers of Cognition in Older Adults at Risk of Dementia.

An active lifestyle as well as cognitive and physical training (PT) may benefit cognition by increasing cognitive reserve, but the underlying neurobiological mechanisms of this reserve capacity are not well understood. To investigate these mechanisms of cognitive reserve, we focused on electrophysiological correlates of cognitive performance, namely on an event-related measure of auditory memory and on a measure of global coherence. Both measures have shown to be sensitive markers for cognition and might therefore be suitable to investigate potential training- and lifestyle-related changes. Here, we report on the results of an electrophysiological sub-study that correspond to previously published behavioral findings. Altogether, 65 older adults with subjective or objective cognitive impairment and aged 60–88 years were assigned to a 10-week cognitive (n = 19) or a 10-week PT (n = 21) or to a passive control group (n = 25). In addition, self-reported lifestyle was assessed at baseline. We did not find an effect of both training groups on electroencephalography (EEG) measures of auditory memory decay or global coherence (ps ≥ 0.29) and a more active lifestyle was not associated with improved global coherence (p = 0.38). Results suggest that a 10-week unimodal cognitive or PT and an active lifestyle in older adults at risk for dementia are not strongly related to improvements in electrophysiological correlates of cognition.

P300 as a measure of auditory memory in cochlear implant recipients: A preliminary report

Objectives: This study aimed to check the feasibility of recording autiory P300 in children with cochlear implants using commercially available auditory evoked potential system. The present study also investigated if there is an association between auditory memory and auditory P300. Methods: The participants of the study included 10 children with monaural cochlear implant attending auditory verbal therapy. The age of the children ranged from 2 years to 7 years 8 months years. Audiotry P300 was recorded using Biologic Navigator Pro Auditory Evoked Potential System. Auditory memory was measured using 4-digit sequences. Results: Cortical auditory evoked potential could be recorded from 9 out of 10 children. The latency and amplitude of P300 showed a significant correlation with memory for 4-digit sequences. Discussion: The results of the present study highlights that auditory P300 can be recorded for the passive task from children using cochlear implants. It has been reported in the literature that cognitive and memory abilities are crucial for the development of auditory discrimination and hence can be a factor affecting the outcome of cochlear implants. The results suggest that P300 can probably be used to assess memory and cognitive abilities of children using cochlear implants. Conclusions: The results suggest that P300 can be recorded in clinical setup and probably will help in the objective assessment of memory abilities in children with cochlear implants.

Improved Measurement of Brain Phenylalanine and Tyrosine Related to Neuropsychological Functioning in Phenylketonuria.

Researchers hypothesized that in phenylketonuria (PKU) high brain phenylalanine (Phe) levels and low brain tyrosine (Tyr) levels affect neuropsychological functioning. However, traditional magnetic resonance spectroscopy (MRS) yielded uncertain results of brain Phe and could not adequately measure brain Tyr. This pilot study examined the potential of correlated spectroscopy (COSY) to quantify these biomarkers and explain variability in neuropsychological functioning. Nine adults with early treated classic PKU received magnetic resonance imaging (MRI) with COSY and a battery of neuropsychological tests. Brain Phe and Tyr in parietal white matter (PWM) were compared to results in gray matter of the posterior cingulate gyrus (PCG). Brain Phe ranged from 101 to 182 (mean = 136.76 ± 23.77) μmol/L in PCG and 76 to 185 (mean = 130.11 ± 37.88) μmol/L in PWM. Brain Tyr ranged from 4.0 to 7.4 (mean = 5.44 ± 1.01) μmol/L in PCG and 4.1 to 8.4 (mean = 5.90 ± 1.48) μmol/L in PWM. Correlation coefficients were largest for brain Phe PWM and measures of auditory memory (rho = -0.79), anxiety (rho = 0.79), and executive functioning (rho = 0.69). Associations were in the expected direction, with higher brain Phe and lower brain Tyr related to poorer functioning. The two participants with severe structural MRI abnormalities had low brain Tyr levels in PCG and 3/5 of the participants with moderate to severe MRI abnormalities had higher than average brain Phe levels. COSY has the potential to quantify brain Phe and Tyr at low concentrations and in specific brain regions. In this pilot study, these biomarkers were associated with indices of neuropsychological functioning. Additional studies are needed to validate the COSY results.

BDNF and COMT polymorphisms have a limited association with episodic memory performance or engagement in complex cognitive activity in healthy older adults

Cognitive decline is a major factor in lowering the quality of life in older populations, and contributes substantially to social, economic, and health costs. As humans age, cognitive function decreases differentially, and individual differences in cognitive ageing are likely attributed to a range of causes, including environmental and genetic influences. The current study included 360 participants (240 females and 120 males) aged between 50 and 79years from the Tasmanian Healthy Brain Project. The brain-derived neurotrophic factor (BDNF) Val66Met and Catechol-O-Methyltransferase (COMT) Val158Met polymorphisms were examined for their association with visual and auditory episodic memory performance. The polymorphisms were also investigated for their association with reported life-long engagement in complex cognitive activity using a retrospective questionnaire. Relative to the demographic variables, the gene variations were found to have no association with episodic memory performance, with the exception of the COMT polymorphism on a single measure of auditory memory (RAVLT). Several other studies also demonstrated that these polymorphisms have no, small, or inconsistent effects on memory function. The BDNF Val66Met and COMT Val158Met polymorphisms were also found to be of little significance to active engagement in complex cognitive activity throughout most of the lifespan. An association was detected between BDNF Val66Met and engagement in cognitive activity in early life (p=.04, d=.23), however this did not reach significance when adjusted for multiple comparisons. The biological mechanisms that underlie engagement in cognitive activity are elusive, thus the potential relationship between BDNF Val66Met genotype and early life cognitive engagement warrants further investigation.

Auditory Memory and Perception in Younger and Older Adult Second Language Learners

This study compared younger and older adult monolingual English speakers and bilingual (English/Spanish) speakers on aspects of language learning aptitude, specifically, measures of auditory perception and memory span, in English and Spanish. Multivariate analyses of variance revealed no age difference in auditory memory span in English; however, both older and younger bilinguals performed better than monolinguals on these tasks. Younger subjects performed better than older subjects on measures of auditory perception in English. Older and younger monolinguals performed similarly on a measure of auditory memory span in Spanish, whereas younger monolinguals demonstrated more accuracy on Spanish perception tasks. The Spanish proficiency of the younger bilinguals far exceeded that of the older bilinguals, and their performance was better on measures of auditory memory and perception in Spanish even when differences in proficiency were statistically controlled. However, a comparison of subgroups of older and younger bilinguals showing a similar level of Spanish proficiency revealed that the performance of the older bilinguals approached fairly closely the performance of the younger subjects on the Spanish auditory memory and perception tasks.

Phonological Disability and Reading: What Is the Link?

This article looks at possible reasons for the relationship between phonological disability and reading disability. It reviews the auditory processing factors which have traditionally been considered as implicated in these abilities; special emphasis is placed on phonemic synthesis (sound blending). A study comparing 26 subjects with phonological disability and 26 matched subjects with normal speech is described. Subjects were assessed on measures of auditory memory. auditory discrimination. auditory synthesis and reading ability. There were significant differences between the groups on, the tests of auditory synthesis and reading ability. No significant difference was found between the two groups on auditory discrimination or memory.