Two-dimensional (2-D) small-signal gain is measured using amplification method in a laser diode-pumped flowing inorganic aprotic liquid laser medium which is prepared by dissolving 0.3 mol/l neodymium ions (Nd3+) in a mixture of phosphorous oxychloride (POCl3) host solvent and Lewis acid tin tetrachloride (SnCl4). An experimental setup is developed for the small-signal gain measurement which helps in investigating the liquid medium response under high power laser diode pumping. The liquid medium is circulated transversely through the laser cavity under laminar flow regime at flow rates of 15–20 l/min to mitigate the thermal induced effects. The spatial (2-D) profile of the small-signal gain is plotted and uniform gain of 0.01 cm−1 is measured along the optic axis at diode pump power of 1497 W. The 2-D distribution of small-signal gain in the liquid medium is also calculated theoretically. The measured and calculated values of small-signal gain are observed to be in close agreement with each other. Hence, the results are promising towards laser power scale up.