Measurement Of Venous Oxygenation Research Articles

Venous oxygen saturation in critical illness.

To review clinically relevant features of systemic oxygen delivery and consumption and the technique and use of venous oxygenation monitoring in human and veterinary medicine. Veterinary and human peer-reviewed medical literature including scientific reviews, clinical and laboratory research articles, and authors' clinical research experience. Measurement of venous hemoglobin oxygen saturation (venous oxygenation) provides insight into the balance between oxygen supply and tissue demand. In people, measurement of venous oxygen saturation can reveal decompensation that is missed by physical examination and other routinely monitored parameters. Therefore, measurement of mixed or central venous oxygenation measurement may help guide therapy and predict outcome of critically ill patients. In dogs, low central venous oxygen saturation has been associated with impaired cardiopulmonary function and poor outcome in several small studies of experimental shock or severe clinical illness, suggesting that monitoring this variable may assist the treatment of severe illness in this species as well. Venous oxygenation reflects systemic oxygenation status and can be used to guide treatment and estimate prognosis in critically ill patients. Measurement of venous oxygenation in veterinary patients is feasible and is a potentially valuable tool in the management of patients with severe disease. This review is intended to increase the understanding and awareness of the potential role of venous oxygen measurement in veterinary patients.

Global intravascular and local hyperoxia contrast phase-based blood oxygenation measurements

The measurement of venous cerebral blood oxygenation (Yv) has potential applications in the study of patient groups where oxygen extraction and/or metabolism are compromised. It is also useful for fMRI studies to assess the stimulus-induced changes in Yv, particularly since basal Yv partially accounts for inter-subject variation in the haemodynamic response to a stimulus. A range of MRI-based methods of measuring Yv have been developed recently. Here, we use a method based on the change in phase in the MR image arising from the field perturbation caused by deoxygenated haemoglobin in veins. We build on the existing phase based approach (Method I), where Yv is measured in a large vein (such as the superior sagittal sinus) based on the field shift inside the vein with assumptions as to the vein's shape and orientation. We demonstrate two novel modifications which address limitations of this method. The first modification (Method II), maps the actual form of the vein, rather than assume a given shape and orientation. The second modification (Method III) uses the intra and perivascular phase change in response to a known change in Yv on hyperoxia to measure normoxic Yv in smaller veins. Method III can be applied to veins whose shape, size and orientation are not accurately known, thus allowing more localised measures of venous oxygenation. Results demonstrate that the use of an overly fine spatial filter caused an overestimation in Yv for Method I, whilst the measurement of Yv using Method II was less sensitive to this bias, giving Yv=0.62±0.03. Method III was applied to mapping of Yv in local veins across the brain, yielding a distribution of values with a mode of Yv=0.661±0.008.

New developments in arterial spin labeling pulse sequences

Since it was introduced over 20 years ago, arterial spin labeling and related methods have steadily evolved over the years, and the field has seen not only improvements in technical specifications, such as signal-to-noise ratio and accuracy, but also the introduction of methods that allow for the collection of new information, such as maps of vascular territories and measurement of venous oxygenation. Some of these recent advances are reviewed here.

Vessel‐specific quantification of blood oxygenation with T2‐relaxation‐under‐phase‐contrast MRI

Measurement of venous oxygenation (Yv) is a critical step toward quantitative assessment of brain oxygen metabolism, a key index in many brain disorders. The present study aims to develop a noninvasive, rapid, and reproducible method to measure Yv in a vessel-specific manner. The method, T2-Relaxation-Under-Phase-Contrast MRI, utilizes complex subtraction of phase-contrast to isolate pure blood signal, applies nonslice-selective T2-preparation to measure T2, and converts T2 to oxygenation using a calibration plot. Following feasibility demonstration, several technical aspects were examined, including validation with an established global Yv technique, test-retest reproducibility, sensitivity to detect oxygenation changes due to hypoxia and caffeine challenges, applicability of echo-planar-imaging (EPI) acquisition to shorten scan duration, and ability to study veins with a caliber of 1-2 mm. T2-Relaxation-Under-Phase-Contrast was able to simultaneously measure Yv in all major veins in the brain, including sagittal sinus, straight sinus, great vein, and internal cerebral vein. T2-Relaxation-Under-Phase-Contrast results showed an excellent agreement with the reference technique, high sensitivity to oxygenation changes, and test-retest variability of 3.5 ± 1.0%. The use of segmented-EPI was able to reduce the scan duration to 1.5 minutes. It was also feasible to study pial veins and deep veins. T2-Relaxation-Under-Phase-Contrast MRI is a promising technique for vessel-specific oxygenation measurement.

CeVOX for continuous central venous oxygenation measurement in patients undergoing off-pump coronary artery bypass grafting

CeVOX for continuous central venous oxygenation measurement in patients undergoing off-pump coronary artery bypass grafting

Validation of CeVOX for continuous central venous oxygenation measurement in patients undergoing off-pump coronary artery bypass grafting

Validation of CeVOX for continuous central venous oxygenation measurement in patients undergoing off-pump coronary artery bypass grafting

Continuous central venous oxygenation measurement by CeVOX in patients undergoing off-pump coronary artery bypass grafting

Less invasive measurement of central venous O2 saturation(ScvO2) has shown to be a valuable alternative to the determination of mixed venous O2 saturation for monitoring of O2 supply/demand [1,2]. The aim of this study was to compare ScvO2 measured continuously by the new CeVOX (Pulsion Medical System, Munich, Germany) device (CScvO2) with ScvO2 determined by blood gas co-oximetry (BScvO2).