Aiming at the three-dimensional deformation measurement requirement of the high-stability structure of spacecraft in space multi-physical fields, a comprehensive instrument protection device in a vacuum high-low temperature environment is developed using ultra-low temperature anti-condensation and vacuum heat insulation technology. This ensures that the digital image correlation (DIC) measurement camera always remains in a constant temperature and pressure environment and can stably exert its original efficiency in space multi-physical field environments. Subsequently, a path-dependent DIC method based on a graphics processing unit computing parallel acceleration is proposed by combining a pre-interpolation strategy and integrated image technology, which realizes high-precision matching of digital images before and after deformation in a spatial multi-physical field environment and improves the computing efficiency. To address the problem that a common reference point may deform significantly in a space environment with a large temperature change, which leads to inaccurate system accuracy, combined with a random sampling consistency algorithm and singular value decomposition method, the optimal registration of the coordinate system and the solution of deformation were realized by setting the threshold of the reference point margin screening. Finally, a three-dimensional deformation measurement system in high- and low-temperature vacuum environments was built, and the three-dimensional deformation measurement of the satellite antenna in high- and low-temperature vacuum environments was verified, which proves the effectiveness and accuracy of the above method.