Measurement Of Mechanical Axis Research Articles

Assessment of lower limb alignment: supine weight-bearing CT scanograms compared with a standing full-length radiograph.

We identified limb misalignment by applying personalized axial force while the limb was in a supine position to mimic a standing posture. This study aimed to confirm the accuracy of evaluating lower limb alignment using supine weight-bearing CT scanograms. We prospectively compared measurements of the weight-bearing line ratio (WBL), hip-knee-ankle (HKA) angle, and joint convergence angle (JLCA) in 46 sets of supine weight-bearing CT scanograms with those obtained from full-length standing anteroposterior lower extremity radiographs. We achieved the weight-bearing CT scanograms by applying six different levels of axial force: zero, 1/5 of body weight, 2/5 of body weight, 3/5 of body weight, 4/5 of body weight, and full body weight. We assessed the impact of age, body mass index, HKA, and JLCA on the observed mechanical axis deviation differences between the two methods. The average absolute difference between standing radiographs and supine CT scanograms was 4.32% for the WBL ratio (p < 0.05), 1.25° for HKA (p < 0.05), and 0.46 for JLCA (p < 0.05). The mean absolute difference was minimal when applying full body weight axial pressure during CT scanograms (p > 0.05). Age, body mass index, HKA, and JLCA had no effect on the deviation in the mechanical axis measurements obtained through supine weight-bearing CT scanograms with full body weight. No significant differences were found in assessing lower limb alignment between standing radiographs and supine weight-bearing CT scanograms with full body weight. Weight-bearing CT scanograms prove to be a valuable method for assessing lower limb alignment while in a supine position.

A simple formula to control posterior tibial slope during proximal tibial osteotomies

BackgroundHigh tibial osteotomy surgery is a widely successful joint-preserving procedure which alters the hip-knee-ankle axis which can delay the progression of osteoarthritis; however, conventional osteotomy surgical procedures do not adequately control the posterior tibial slope.This study aimed to determine the key variables influencing posterior tibial slope during high tibial osteotomy and provide a simple means of implementing the findings during pre-operative planning. MethodsA virtual cohort of twenty-eight proximal tibia geometries of knee osteoarthritis patients was used in the study. Firstly, absolute posterior tibial slope values were contrasted using anatomical and posterior mechanical axis measurement approaches. Secondly, the influence of variables affecting posterior tibial slope change during osteotomy surgery was investigated using 3D preoperative planning surgical simulation and analytical modelling. FindingsThere was a poor correlation (R2 = 0.38) between the different clinical measurements of posterior tibial slope; with an average of 7.0 ± 1.3° and 14.8 ± 2.2° respectively.An analytical solution for the change in posterior tibial slope was derived based on the hinge axis angle and the osteotomy opening angle. For three different opening angles (6°, 9° and 12°) and seven different hinge axis orientations (−30° to +30°), the results obtained were identical for the analytical model and the 3D preoperative planning. InterpretationThis study determined that the key variables affecting posterior tibial slope during high tibial osteotomy are the osteotomy opening angle and the hinge axis orientation. The derived formula provides a simple means of determining the change in posterior tibial slope resulting from a particular surgical approach.

Unsatisfactory accuracy of recent robotic assisting system ROSA for total knee arthroplasty

PurposeThe purpose of this study was to quantify accuracy of a recently FDA-approved robotic-assisted device.MethodsThirty-seven patients underwent TKA with the Robotic Surgical Assistant (ROSA) by the same operating surgeon and team over the course of 3 months. Intra-operative mechanical axis measurements, composed of alpha (α), beta (β), gamma (γ), and delta (δ) angles, and the hip-knee-ankle angle (HKA) were calculated by the ROSA. Post-operative mechanical implant angles were taken from 36″ stitched post-op films and measured in the PACS imaging system. Accuracy was assessed by comparing the percentage of postoperative long length films within 2° and 3° of the ROSA intra-operative plan.ResultsThe ROSA system accurately calculated the HKA, α, and β angles (95% CI), but was inaccurate in calculating both γ and δ angles. Using a window of ± 3° accuracy, the HKA, α and β angles were accurate at levels of 89, 100 and 92% respectively. In contrast, the sagittal relationships were considerably less accurate at 77 and 74% for the γ and δ angles respectively. Subsequently, the proportion of cases within 2 and 3 degrees of the intra-operative plan for resection angles was considered accurate for HKA (73% within 2°, 89% within 3°), α (92% within 2°, 100% within 3°), and β (76% within 2°, 92% within 3°) angles, but considered inaccurate for γ (51% within 2°, 77% within 3°) and δ angles (57% within 2°, 74% within 3°).ConclusionsThis study demonstrated that while the ROSA system seems to accurately predict coronal plane resections in TKA, it falls short in the sagittal plane. Further research in these deficiencies can provide insight into the overall efficacy of robotic assisted surgery in TKA.Level of EvidenceLevel III Therapeutic Study.

Angular deformities after percutaneous epiphysiodesis for leg length discrepancy.

Purpose:The purpose of this study was to systematically analyze the presence of secondary angular deformities after percutaneous epiphysiodesis based on long-standing radiographs, and to see if the occurrence and magnitude of angular deformities after percutaneous epiphysiodesis correlated with the amount of remaining growth at the time of surgery.Methods:From a local Health Register consisting of patients investigated using the Moseley Straight-Line Graph, we identified 269 patients who had undergone percutaneous epiphysiodesis from 2002 until 2020. Radiographic analysis included the measurement of mechanical axis and joint orientation angles on long-standing anterior–posterior radiographs. Remaining growth was analyzed based on the Menelaus method.Results:One hundred and forty epiphysiodeses (71 femurs and 69 tibiae) in 88 patients (39 girls and 49 boys) could be included in the study. Mean age at surgery was 13.2 (10–16.8) years, and mean skeletal age at surgery was 13.0 (9.8–15.7) years. A change of the MA (Mechanical axis) ≥10 mm was found in eight patients (9%). Secondary frontal plane deformities after percutaneous epiphysiodesis correlated significantly with the remaining growth at the time of surgery (p = 0.003).Conclusion:We found a high rate of secondary angular deformities after percutaneous epiphysiodesis, and the magnitude of the deformities correlated with the amount of remaining growth at the time of surgery. A modification of the original surgical method for percutaneous epiphysiodesis to also include ablation of central parts of the growth plate might be considered. Patients should be enrolled in a systematic follow-up scheme which allows for the early detection of possible angular deformities.Level of evidence:level III study.

Spacer-based gap balancing is useful in total knee arthroplasty: a 3-year follow-up of a retrospective study

BackgroundWhich technique, gap balancing or measured resection, can obtain better femoral component alignment and soft tissue balance in total knee arthroplasty (TKA) is still controversial. This study aimed to determine whether the gap balancing technique using a modified spacer block in TKA can result in better postoperative clinical outcomes than the measured resection technique.MethodsA total of 124 patients who underwent consecutive primary TKA between May 2016 and August 2018 were retrospectively reviewed. The gap balancing technique assisted by a modified spacer block was used in 61 patients, and the measured resection technique was used in 63 patients. The surgical, imaging and knee function outcomes of the two groups were compared.ResultsThe thickness of the posterior medial condyle bone resection using the modified spacer block tool in gap balancing was significantly larger than that of the MR technique (P = 0.001). Compared with the measured resection group, the gap balancing group had a greater external rotation resection angle of the femur (4.06 ± 1.10° vs. 3.19 ± 0.59°, P < 0.001°). Despite these differences, the mean ROM, KSS scores, and WOMAC scores at the 6-week, 1-year, and 2-year follow-ups were not significantly different. Postoperatively, there was no significant difference between the two groups in mechanical axis measurements (P = 0.275), the number of HKA outliers (P = 0.795) or the joint line displacement (P = 0.270).ConclusionThe functional outcomes of the gap balancing technique based on the modified spacer are similar to those of measured resection at 3 years. Compared with the MR technique, the GB technique resulted in a greater external rotation resection angle and thicker posterior medial condylar cuts in TKA with knee varus.

Assessing in vivo articular cartilage mechanosensitivity as outcome of high tibial osteotomy in patients with medial compartment osteoarthritis: Experimental protocol

To propose an experimental protocol for using high tibial osteotomy (HTO) as a model for studying in vivo biological effects of large permanent changes in ambulatory load. This study is a prospective multimodal (clinical, biomechanical, biological) data collection without randomization. The study will examine a cohort of 40 patients with medial compartment knee OA undergoing opening wedge HTO. Before planned HTO, patients will be clinically assessed (including mechanical axis measurement from radiographs) and complete questionnaires on physical function. Patients will complete a walking stress test with blood sampling (30min walking, 5.5h sitting), and undergo gait analysis. Six weeks after HTO (at the time of full weight bearing), the mechanical axis will be measured from radiographs. Patients will complete the questionnaires and a walking stress test with blood sampling, and undergo gait analysis 6 months after HTO. The peak external knee adduction moment, knee external knee adduction moment impulse and peak external knee flexion moment will be used as surrogates of ambulatory load. Load-induced changes in cartilage biomarkers will be used as surrogates of metabolic changes in response to ambulatory load. At the 12-month follow-up, subjects will complete the questionnaires. The results of this study can be considered as proof-of-concept of a potential diagnostic test (walking stress test) for cartilage degeneration and its prognostic value. A direct relationship between ambulatory load and cartilage metabolism assessed as degradation to synthesis ratio would allow developing novel load-modifying interventions and evaluating the efficacy of existing interventions.

What Determines the Success of Closed-Wedge High Tibial Osteotomy: Severity of Malalignment, Obesity, Follow-up Period, or Age?

Objectives:High tibial osteotomy (HTO) is a well-established procedure for the treatment of medial knee osteoarthritis originating from malalignment of the lower extremity. The current study was designed to evaluate the clinical and radiographic results of closed-wedge HTO for the treatment of medial knee osteoarthritis and to reveal factors affecting the outcome.Methods:A retrospective study was conducted with 138 patients who were operated on for medial knee osteoarthritis between 2000 and 2007 using closed-wedge HTO. Preoperative and follow-up physical examination findings, body mass index (BMI) values, and Hospital for Special Surgery (HSS) and Lysholm knee scores were reviewed. Radiographic evaluation included measurement of the mechanical axis preoperatively and the most recent follow-up orthoroentgenograms. The follow-up knee scores were evaluated according to preoperative mechanical axis, obesity, age, follow-up period, and gender of the patient. The mechanical axis measurement was assessed based on obesity, age, and follow-up period.Results:The mean preoperative and latest follow-up mechanical axis was 4.92o±4.24o varus and 3.43o±3.74o valgus, respectively (p=0.0001). Improvement in the Lysholm (p=0.0001) and HSS (p=0.0001) knee scores was significant. The preoperative mechanical axis, obesity, follow-up period, and gender had no negative effect on the follow-up knee scores, whereas a preoperative age over 50 years had a negative effect on the follow-up knee score. Obesity and the length of the postoperative follow-up period did not have a negative effect on the postoperative mechanical axis, whereas a preoperative age over 50 had a negative effect on the postoperative mechanical axis.Conclusion:The results of this study suggest that medial knee osteoarthritis may be treated successfully with closed-wedge HTO. The analysis indicated that factors such as obesity, the degree of preoperative deformity, and gender do not adversely affect the success of treatment. However, a preoperative age over 50 adversely affected the outcome.

Abnormal tibiofemoral contact kinematics are related to superficial cartilage damage

Abnormal tibiofemoral contact kinematics are related to superficial cartilage damage

Early experiences with robot-assisted total knee arthroplasty using the DigiMatch™ ROBODOC® surgical system.

The use of robotics in total knee arthroplasty (TKA) has been shown to minimise human error, as well as improve the accuracy and precision of component implantation and mechanical axis alignment. The present study aimed to demonstrate that robot-assisted TKA using ROBODOC® is safe and capable of producing a consistent and accurate postoperative mechanical axis. We prospectively recruited 27 consecutive patients who underwent robot-assisted TKA between May and December 2012. Two patients were excluded from the study due to intraoperative technical problems with the robot. Long-leg radiography and computed tomography were performed prior to surgery, and used for mechanical axis measurements and component sizing. DigiMatch™ ROBODOC® Surgical System software version 4.3.6 (Curexo Technology Corp, Fremont, CA, USA) was used in all cases to perform bone cuts in accordance with the preoperative plan. The postoperative coronal mechanical alignment was within 3 degrees, with a mean alignment of -0.4 ± 1.7 degrees, confirming the accuracy of the preoperative surgical plan and bone cuts. The mean operating time was 96 ± 15 min, and preoperative planning yielded 100% implant sizing accuracy. Robotics has the potential to enable surgeons to consistently attain ideal postoperative alignment. The use of bone movement monitors and an integrated navigation system enhances the safety profile of ROBODOC® by minimising errors. However, the role of the surgeon in TKA is still vital, as the surgeon is ultimately in charge of planning the surgery, its execution and ensuring soft tissue balance during TKA.

Effect of intraoperative weight-bearing simulation on the mechanical axis in total knee arthroplasty

Successful outcome after total knee arthroplasty (TKA) requires precise realignment of the mechanical axis. The intraoperative assessment of the mechanical axis is difficult. Intraoperatively, the effect of weight bearing on the lower limb mechanical axis is ignored. We developed a custom-made mechanical loading device to simulate weight-bearing conditions intraoperatively and analysed its effect on the mechanical axis during TKA. Measurements of the mechanical axis were obtained during 30 consecutive primary TKAs in osteoarthritic patients using image-free knee navigation system. Half body weight was applied intraoperatively using our device to quantify the effect of intraoperative load application on the mechanical axis, thus receiving indirect information about soft tissue balancing. Furthermore, the intraobserver and interobserver reliability of navigated mechanical axis measurement with and without load was determined. Before TKA, mean mechanical axis was 4.0°±4.9° without load. Under loading conditions, the mean change of the mechanical axis was 2.1°±2.8°. Repetitive measurements of the senior surgeon and junior surgeon revealed a high intraobserver (ICC 0.997) and interobserver reliability (ICC 0.998). The registration of the mechanical axis without and with application of intraoperative loading demonstrated no significant differences during insertion of the trial components (SD 0.29±0.29) and after the definitive component cementation (SD 0.63±0.44). Intraoperative quantification and analysis of the mechanical lower limb axis applying defined axial loading by our custom-made loading apparatus is reliable. Ligament stability was unbalanced before TKA and balanced after TKA. For TKA, intraoperative simulation of weight bearing may be helpful to quantify, control and correct knee stability and its influence of mechanical axis.

Retraction: Comparison of Accuracy of Navigation between Infrared Optical and Electromagnetic Systems

Purpose: This study compared the accuracy of mechanical axis measurement between infrared optical and electromagnetic navigation. Materials and Methods: We compared the preoperative mechanical axes of 20 TKAs using both navigation systems. Experimentally, the mechanical axes of the synthetic bone model were compared and the true mechanical axis was determined using the ORTHODOC. Additionally, a surgeon intentionally registered incorrect landmarks and then measured the amount of mechanical axis change in the two navigation methods. Results: Clinically, AxiEM provided greater varus () than Orthopilot (). The mean mechanical axis difference was and a difference greater than in the same patient occurred in 15% of patients. For the synthetic bone, the true mechanical axis was varus , OrthoPilot displayed varus and AxiEM varus . The mechanical axis differences were not significantly different, but OrthoPilot had more reproducibility. When anatomical landmarks were erroneously identified, AxiEM showed a greater change in the mechanical axis. Conclusion: Both navigation systems provided high mechanical axis accuracy and reproducibility under experimental conditions. Infrared optical navigation was more reproducible than electromagnetic navigation. In the clinical setting, there was a disparity of mechanical axis difference greater than in 15% between the two navigation methods in the same patient.

Are Mechanics Different between Male and Female Runners with Patellofemoral Pain?

Patellofemoral pain (PFP) has often been attributed to abnormal hip and knee mechanics in females. To date, there have been few investigations of the hip and knee mechanics of males with PFP. The purpose of this study was to compare the lower extremity mechanics and alignment of male runners with PFP with healthy male runners and female runners with PFP. We hypothesized that males with PFP would move with greater varus knee mechanics compared with male controls and compared with females with PFP. Furthermore, it was hypothesized that males with PFP would demonstrate greater varus alignment. A gait and single-leg squat analysis was conducted on each group (18 runners per group). Measurement of each runner's tibial mechanical axis was also recorded. Motion data were processed using Visual 3D (C-Motion, Bethesda, MD). ANOVAs were used to analyze the data. Males with PFP ran and squatted in greater peak knee adduction and demonstrated greater peak knee external adduction moment compared with healthy male controls. In addition, males with PFP ran and squatted with less peak hip adduction and greater peak knee adduction compared with females with PFP. The static measure of mechanical axis of the tibial was not different between groups. However, a post hoc analysis revealed that males with PFP ran with greater peak tibial segmental adduction. Males with PFP demonstrated different mechanics during running and during a single-leg squat compared with females with PFP and with healthy males. Based upon the results of this study, therapies for PFP may need to be sex specific.

Differences in Measurement of Lower Limb Alignment Among Different Registration Methods of Navigation and Radiographs in TKA Using the OrthoPilot System

The purposes of this study were (1) to compare lower limb alignment measurements between radiographs and computer-assisted surgery and (2) to evaluate the discrepancy in lower limb alignment between computer-assisted surgery with a high tibial osteotomy protocol and computer-assisted surgery with a total knee arthroplasty (TKA) protocol in the same knee. Seventy-one TKAs were performed on patients with primary osteoarthritis using computer-assisted surgery. Preoperative lower limb alignment was measured using the mechanical axis during bipedal, weight-bearing, whole-leg anteroposterior radiography (measure 1). The intraoperative mechanical axis was measured with computer-assisted surgery according to the high tibial osteotomy protocol before joint exposure (measure 2). After changing the software and joint exposure, the intraoperative mechanical axis was measured with computer-assisted surgery according to TKA protocol (measure 3). After final TKA implantation, the lower limb mechanical axis was measured with computer-assisted surgery following the TKA protocol (measure 4). Postoperative lower limb alignment was measured using the mechanical axis on whole-leg standing anteroposterior radiographs (measure 5). The mechanical axis and median value from each group were compared. Factors affecting the mechanical axis measurement were also analyzed. The difference in the mechanical axis between measures 1 and 2, measures 1 and 3, and measures 2 and 3 was significant (P<.0001, <.0001, and =.0007, respectively). The difference between measures 4 and 5 was also significant (P<.0001). Factors affecting the mechanical axis measurement, such as age, height, weight, and range of motion, showed no correlation (R(2)=.07244 and adjusted R(2)=.01622). The pre- and postoperative radiological measurements of limb alignment using the mechanical axis were different from the intraoperative measurements with navigation.

The value of the intra-operative clinical mechanical axis measurement in open-wedge valgus high tibial osteotomies

IntroductionIn high tibial osteotomies (HTO) the correction needs to be precise and intra-operative assessment is essential. The purpose of this study was to evaluate the use of the intra-operative clinical mechanical axis measurement and compare it to the post-operative weight bearing situation on standing whole leg radiographs (WLR). Secondly, we evaluated the preoperative planned wedge size and compared it to the final results in 27 HTOs. MethodsThe mechanical axis deviation (MAD), expressed as a percentage of the tibial width (0% is medial edge, 100% is lateral edge) and the hip–knee–ankle angle (HKA) were calculated and analyzed. Preoperative planning was done by projecting the desired mechanical axis on the lateral tibial spine on the WLR and subsequently calculating the necessary correction angle. A 3° valgus correction was desired. ResultsThe results showed a preoperative standing MAD of 26.6%, or about halfway the medial tibial plateau. The MAD was corrected to 57.0% intra-operative, meaning a slight valgus. On the postoperative standing WLR, the MAD had shifted significantly to 62.0% (95% CI=−9.2 to −2.7; p<0.01) compared to the intra-operative 57.0% axis. The HKA angle changed 8.2° from 5.1° varus preoperative to 3.1° valgus postoperative. ConclusionWhen aiming the mechanical axis at the lateral tibial spine, a slight undercorrection was introduced, but due to a valgus shift while weight bearing, a satisfying final outcome of 3° valgus average was achieved. Preoperative calculation of the wedge size remains important for surgical planning, but it does not always correspond to the actual used wedge size.

Upright MRI measurement of mechanical axis and frontal plane alignment as a new technique: a comparative study with weight bearing full length radiographs

The purpose of this prospective study was to investigate the practicality, accuracy, and reliability of upright MR imaging as a new radiation-free technique for the measurement of mechanical axis. We used upright MRI in 15 consecutive patients (30 limbs, 44.7 ± 20.6 years old) to measure mechanical axis deviation (MAD), hip-knee-ankle (HKA) angle, leg length, and all remaining angles of the frontal plane alignment according to Paley (mLPFA, mLDTA, mMPTA, mLDTA, JLCA). The measurements were compared to weight bearing full length radiographs, which are considered to be the standard of reference for planning corrective surgery. FDA-approved medical planning software (MediCAD) was used for the above measurements. Intra- and inter-observer reproducibility using mean absolute differences was also calculated for both methods. The correlation coefficient between angles determined with upright MRI and weight bearing full length radiographs was high for mLPFA, mLDTA, mMPTA, mLDTA, and the HKA angle (r > 0.70). Mean interobserver and intraobserver agreements for upright MRI were also very high (r > 0.89). The leg length and the MAD were significantly underestimated by MRI (-3.2 ± 2.2 cm, p < 0.001 and -6.2 ± 4.4 mm, p = 0.006, respectively). With the exception of underestimation of leg length and MAD, upright MR imaging measurements of the frontal plane angles are precise and produce reliable, reproducible results.

JOSHUA NELSON, MD, PharmD, on “A Prospective Randomized Study of Minimally Invasive Total Knee Arthroplasty Compared with Conventional Surgery” by Nikolaus Wülker, PhD, MD, et al.

This prospective randomized multicenter trial from five European sites compares the clinical and radiographic outcomes of total knee arthroplasty, utilizing two separate techniques. This study is registered on ClinicalTrials.gov (NCT00853398) and is sponsored by Smith and Nephew (Memphis, Tennessee) for evaluation of the Genesis II minimally invasive total knee system. For this study, a minimally invasive approach was defined by an incision of 15 cm. Clinical outcomes for both the minimally invasive and standard cohorts were determined with use of Knee Society scores and visual analog pain scores. Radiographic measurements included coronal and sagittal alignment measurements as well as a mechanical axis measurement. This study was originally designed to …

Editorial: What is Varus or Valgus Knee Alignment?

Editorial: What is Varus or Valgus Knee Alignment?

Comparison of Accuracy of Navigation between Infrared Optical and Electromagnetic Systems

Purpose: This study compared the accuracy of mechanical axis measurement between infrared optical and electromagnetic navigation. Materials and Methods: We compared the preoperative mechanical axes of 20 TKAs using both navigation systems. Experimentally, the mechanical axes of the synthetic bone model were compared and the true mechanical axis was determined using the ORTHODOC. Additionally, a surgeon intentionally registered incorrect landmarks and then measured the amount of mechanical axis change in the two navigation methods. Results: Clinically, AxiEM provided greater varus () than Orthopilot (). The mean mechanical axis difference was and a difference greater than in the same patient occurred in 15% of patients. For the synthetic bone, the true mechanical axis was varus , OrthoPilot displayed varus and AxiEM varus . The mechanical axis differences were not significantly different, but OrthoPilot had more reproducibility. When anatomical landmarks were erroneously identified, AxiEM showed a greater change in the mechanical axis. Conclusion: Both navigation systems provided high mechanical axis accuracy and reproducibility under experimental conditions. Infrared optical navigation was more reproducible than electromagnetic navigation. In the clinical setting, there was a disparity of mechanical axis difference greater than in 15% between the two navigation methods in the same patient.

Reproducibility of intra-operative measurement of the mechanical axes of the lower limb during total knee replacement with a non-image-based navigation system

Objective: The restoration of a normal mechanical axis of the lower limb following total knee prosthesis (TKP) depends on the accuracy of the intra-operative measurement of the femoro-tibial angle. We have studied the reproducibility of intra-operative measurement of the coronal mechanical femoro-tibial axis with the OrthoPilot® (Aesculap, Tuttlingen, Germany) non-image-based navigation system.Material and Methods: A consecutive series of 20 TKP (Aesculap SEARCH Evolution® prosthesis) implanted by the same surgical team of two senior orthopedic surgeons was analyzed. They used a non-image-based navigation system that allows the mechanical axes of the femur and tibia to be defined with a kinematic analysis. The operating surgeon and assistant surgeon performed the kinematic analysis twice and once, respectively, and measured coronal mechanical femoro-tibial angles in maximal extension and at 90° flexion without varus or valgus stress.Results: The mean intra-observer variation in the measurement of the coronal mechanical femoro-tibial angle in maximal extension was 0.1° (SD=0.7°). The mean intra-observer variation in the measurement of the coronal mechanical femoro-tibial angle at 90° of knee flexion was 0.2° (SD=0.6°). The mean inter-observer variation in the measurement of the coronal mechanical femoro-tibial angle in maximal extension was 0.1° (SD=0.7°). The mean inter-observer variation in the measurement of the coronal mechanical femoro-tibial angle in maximal extension was 0.0° (SD=0.6°). There were no significant differences and a high correlation between all paired intra- and inter-observer measurements.Conclusion: This system allows high reproducibility of the intra-operative measurement of the mechanical axes of the lower limb by a non-image-based kinematic registration of the hip, knee and ankle centers.