Measurement Of Oxygen Levels Research Articles

In vivo measurements of change in tissue oxygen level during irradiation reveal novel dose rate dependence

Background and purposeThis study aimed to investigate the radiochemical oxygen depletion (ROD) in vivo by directly measuring oxygen levels in various mouse tissues during ultra-high dose rate (UHDR) irradiation at clinically relevant doses and dose rates. Materials and methodsMice bearing subcutaneous human glioblastoma (U-87 MG) tumors were used for tumor and normal tissue (skin, muscle, brain) measurements. An oxygen-sensitive phosphorescent probe (Oxyphor PtG4) was injected into the tissues, and oxygen levels were monitored using a fiberoptic phosphorometer during UHDR irradiation with a 6 MeV electron linear accelerator (LINAC). Dose escalation experiments (10–40 Gy) were performed at a dose rate of 1300 Gy/s, and dose rate escalation experiments were conducted at a fixed dose of 40 Gy with dose rates ranging from 2 to 101 Gy/s. ResultsRadiation-induced change in tissue oxygenation (ΔpO2) increased linearly with dose and correlated with baseline tissue oxygenation levels in the range of 0 – 30 mmHg. At higher baseline tissue oxygenation levels, such as those observed in muscle and brain, there was no corresponding increase in ΔpO2. When we modulated dose rate, ΔpO2 increased steeply up to ∼ 20 Gy/s and plateaued thereafter. The relationship between ΔpO2 and dose rate showcases the interplay between ROD and reoxygenation. ConclusionWhile UHDR irradiation induces measurable oxygen depletion in tissues, the observed changes in oxygenation levels do not support the hypothesis that ROD-induced radioresistance is responsible for the FLASH tissue-sparing effect at clinically relevant doses and dose rates. These findings highlight the need for further investigation into alternative mechanisms underlying the FLASH effect.

Influence of print-chamber oxygen content on the microstructure and properties of 3D-printed 316L

Abstract Samples of 316L stainless steel have been prepared using laser-powder bed fusion from the same batch of powder using different print-chamber oxygen levels, ranging from 50 ppm to 1500 ppm. The oxide particle density is found to increase with oxygen content, while the cell structure is invariant with oxygen level and the grain size shows a relatively sharp transition for measured oxygen levels of above 450 ppm. Based on the microstructural observations it is suggested that the increasing oxygen levels leads to a transition in the solidification pattern. Samples printed at the higher oxygen level show higher strength and lower mechanical anisotropy than samples with a coarser grains structure printed at lower oxygen levels. The main influence of the higher oxide particle content on thermal stability is on the kinetics of recrystallization during isothermal annealing at 1000 °C.

Conducted Electrical Weapon Fire Risk in the Presence of Supplemental Oxygen.

Conducted electrical weapons (CEWs) are nonlethal weapons used in tactical environments. Tactical EMS (TEMS) operators provide patient care in environments where CEWs are present. CEWs may produce a spark that can be a source of ignition. When supplemental oxygen is in use by a TEMS operator, the flammability risk from the CEW is unknown. We measured oxygen levels over 20 minutes in an enclosed space with a supplemental oxygen source maximally flowing. Measurements were taken at various distances from the oxygen source to establish baseline concentrations. These concentrations were replicated within a plexiglass box where a CEW was activated to create a sparking arc between probes embedded in a fresh swine shoulder (with skin intact). Various flammable materials, typically found in a patient care setting were used as potential fuel sources. The highest oxygen levels were achieved directly at the source. At 15cm from the source, the maximum oxygen concentration was 31.5%. Within the box, ignition was only achieved at oxygen concentrations greater than 45% and only when human hair was present as fuel. No ignition was achieved at oxygen levels below this regardless of the tested fuel present. Ignition from a CEW is possible at supplemental oxygen levels greater than 45% when human hair is present. In an enclosed space, oxygen concentration levels of 45% are only present within 15cm of a flush rate oxygen source. The likelihood of CEW-caused ignition in such settings with supplemental oxygen in use is extremely low.

Design of Health Monitoring System Based on Internet of Things (IoT): ESP8266 and BLYNK

Health monitoring is important for living creatures. There are many things that are important factors in the health of living creatures, especially humans, including heart rate, body temperature and oxygen saturation. IoT technology is very helpful in the development of health technology so that it becomes possible to monitor patient health in real time and patient emergency information can be accessed easily. This research also aims to design an Android-based heart rate monitoring system using ESP8266 as a microcontroller. The sensor used is Max30102. The research method used is applied research, with experimental research methods. The research stages carried out were literature study, software design, hardware design, system testing, and analysis. The results of the research are the design of a patient health monitoring tool with three measured indicators, namely the patient's heart rate, body temperature and oxygen levels. The system can monitor in real time based on Internet of Things and can be accessed by Android and iOS. From the study results, it was found that the Android-based health monitoring system has an accuracy rate of 97.63% and it can be said that the system can be used for patient measurements. With details, 96.71% is the accuracy level for measuring heart rate, 96.45% accuracy level for measuring oxygen levels in the patient's body, and 99.75% accuracy level for measuring patient temperature.

Machine learning chained neural network analysis of oxygen transport amplifies the physiological relevance of vascularized microphysiological systems.

Since every biological system requires capillaries to support its oxygenation, design of engineered preclinical models of such systems, for example, vascularized microphysiological systems (vMPS) have gained attention enhancing the physiological relevance of human biology and therapies. But the physiology and function of formed vessels in the vMPS is currently assessed by non-standardized, user-dependent, and simple morphological metrics that poorly relate to the fundamental function of oxygenation of organs. Here, a chained neural network is engineered and trained using morphological metrics derived from a diverse set of vMPS representing random combinations of factors that influence the vascular network architecture of a tissue. This machine-learned algorithm outputs a singular measure, termed as vascular network quality index (VNQI). Cross-correlation of morphological metrics and VNQI against measured oxygen levels within vMPS revealed that VNQI correlated the most with oxygen measurements. VNQI is sensitive to the determinants of vascular networks and it consistently correlates better to the measured oxygen than morphological metrics alone. Finally, the VNQI is positively associated with the functional outcomes of cell transplantation therapies, shown in the vascularized islet-chip challenged with hypoxia. Therefore, adoption of this tool will amplify the predictions and enable standardization of organ-chips, transplant models, and other cell biosystems.

Hemoglobin Microbubbles and the Prediction of Different Oxygen Levels Using RF Data and Deep Learning.

Ultrasound contrast agents (UCA) are gas-encapsulated microspheres that oscillate volumetrically when exposed to an ultrasound field producing backscattered signals efficiently, which can be used for improved ultrasound imaging and drug delivery applications. We developed a novel oxygen-sensitive hemoglobin-shell microbubble designed to acoustically detect blood oxygen levels. We hypothesize that structural change in hemoglobin caused due to varying oxygen levels in the body can lead to mechanical changes in the shell of the UCA. This can produce detectable changes in the acoustic response that can be used for measuring oxygen levels in the body. In this study, we have shown that oxygenated hemoglobin microbubbles can be differentiated from deoxygenated hemoglobin microbubbles using a 1D convolutional neural network using radiofrequency (RF) data. We were able to classify RF data from oxygenated and deoxygenated hemoglobin microbubbles into the two classes with a testing accuracy of 90.15%. The results suggest that oxygen content in hemoglobin affects the acoustical response and may be used for determining oxygen levels and thus could open many applications, including evaluating hypoxic regions in tumors and the brain, among other blood-oxygen-level-dependent imaging applications.

Influence of VAC Therapy on Perfusion and Edema of Gracilis Flaps: Prospective Case-control Study

In total, 26 patients with soft tissue defects of lower extremity underwent gracilis muscle flap reconstruction. The study group (VAC, n = 13) was supplied with postoperative negative pressure therapy as a dressing; the control group (NVAC, n = 13) was supplied with conventional fat gauze dressing. Postoperative measurements of micro- and macroperfusion were performed intraoperatively, on postoperative day (POD) 3 and POD 5. Flap edema measurement was performed intraoperatively, on POD 5 and 2 weeks after operation. The VAC group showed significantly better macroflow during intraoperative VAC treatment, as well on POD 3 and POD 5. Venous outflow was also better with lower hemoglobin levels. Microflow was better in the NVAC group with higher measured oxygen levels. All gracilis muscle flaps of the VAC group showed significantly less flap edema compared with the control group. VAC application on free gracilis muscle flaps leads to significantly less postoperative flap edema, improved arterial macroflow, and improved venous outflow. VAC therapy can be used without any danger for patient's safety, as flap survival is not endangered, and presents an easy to handle and pleasant dressing regimen for nursing staff and patients.

IoT-Based Pulse Oximetry Design as Early Detection of Covid-19 Symptoms

Covid-19 patients experience several symptoms such as shortness of breath, abnormal heart rate, lung function abnormalities that are similar to pneumonia symptoms. These symptom conditions indicate that the saturation of oxygen (O2) levels dissolved in the blood is not normal. To measure oxygen levels in the blood using a medical device, one of which is a Pulse Oximeter. Covid-19 patients in the Sapta Taruna Health Center were 665 patients, of which this patient was counted from January 2022 to April 2022. Based on information obtained from the Sapta Taruna Health Center, the only patients that were counted were those who did the PCR/Swab test, while the people who were suspected infected with Covid-19 there are still many who do not do PCR/Swab tests, this refusal is due to fear because Hoax information is spread in the community such as: PCR/Swab tests are painful, if the PCR/Swab test results are positive, fear of being ostracized, feel healthy and other reasons. other. Patients who have been tested positive for Covid-19 will be given drugs such as fever medicine, antibiotics, anti-virus, Vitamin C, and others according to the level of symptoms they feel, if the symptoms are felt at a moderate, mild or even asymptomatic stage, they will be advised to isolate independently (Isoma) at home, but there is no further monitoring from the Sapta Taruna Health Center, even though patients who are self-isolating at home may experience a decrease in blood oxygen levels drastically, so these patients need medical devices such as pulse oximetry so that patients who are isoma can perform independent checking, henceforth the current pulse oximetry cannot provide remote information related to the condition of oxygen saturation in the patient's blood. Judging from the problems above, the research team made a product, namely Pulse Oximetry based on IoT, this tool is to measure oxygen saturation in the patient's blood and the data from the measurements made by the patient will be automatically sent to the server and can be viewed on the Sapta Taruna Health Center website, so that the Sapta Taruna Health Center can monitoring the condition of the patient in real time without having to meet directly with the patient.

Blood Profile of Rattus Nurvegicus Exposed to HgCl2 and Received Combination of IR Bagendit Rice Leaves-Infused Water and Young Coconut Water

Mercury chloride (HgCl2) is widely used in industries; in fact, this chemical substance is deadly for health and causes various health problems, such as liver damage, kidney damage, and hematopoietic disorders, especially in erythropoiesis. This study aims to determine the blood profile in Rattus nurvegicus exposed to HgCl2 by combining IR Bagendit rice leaves-infused water and young coconut water. This study employed an experimental method to examine the positive control group exposed to HgCl2 and the negative control group receiving a placebo. Meanwhile, the treatment groups received a combination of IR Bagendit rice leaves-infused water in stratified compositions and young coconut water. The hematologic profile was examined using a hematologic analyzer, while the reticulocyte count was examined using wet and dry methods. The mean value of each group was tested using ANOVA. This study has successively obtained average levels of Hb (C+ 12,0;C- 14,2;T1 12,5;T2 12,9;T3 12,8), the erythrocyte count (C+ 6,52;C- 7,80;T1 1,44;T2 1,07;T3 7,32), levels of Ht (C+ 35,5;C- 42,9;T1 37,8;T2 37,9;T3 38,2), MCV (C+ 73,7;C- 79,9;T1 80,4;T2 78,7;T3 79,6), MCH (C+ 27,3;C- 29,9;T1 29,5;T2 28,5;T3 29,1), and MCHC (C+ 31,1;C- 34,2;T1 31,9;T2 33,3;T3 32,1), and the reticulocyte count (C+ 2,0;C- 1,2;T1 1,3;T2 1,1;T3 1,3). The significant differences in the groups are found in levels of Hb, Ht, MCV, and MCHC (p-value 0,00; 0,00; 0,03; 0,01). This study concludes that combining IR Bagendit rice leaves-infused water and coconut water could prevent blood profile exposure to HgCl2. Suggestions for further research to increase the intervention time and measure oxygen levels.

Design and demonstration of a laboratory-scale oxygen controlled liquid sodium facility

The control and detection of dissolved oxygen in liquid sodium is important for the mitigation of impurity driven corrosion in containment components used in sodium-cooled fast reactor (SFR) environments. Oxygen purification systems are also necessary in smaller institutions to facilitate benchtop-scale testing of future SFR instrumentation. With interest in increasing laboratory-scale SFR research, this paper focuses on the design and demonstration of a safe and cost-effective purification loop using a cold trap (CT) and a plugging meter (PM) to control and measure oxygen levels. The demonstration of the purification system’s effectiveness to manipulate oxygen concentration was made through a series of validation experiments at several CT set-points in the range of 8–28[wppm]. Agreement below 14[wppm] with a relative error less than 1.8% was observed. These results indicate that an accessible oxygen controlled sodium system can be safely designed and operated at relatively low capital investment.

Difluoroboron \u03b2-diketonate polylactic acid oxygen nanosensors for intracellular neuronal imaging

Critical for metabolism, oxygen plays an essential role in maintaining the structure and function of neurons. Oxygen sensing is important in common neurological disorders such as strokes, seizures, or neonatal hypoxic–ischemic injuries, which result from an imbalance between metabolic demand and oxygen supply. Phosphorescence quenching by oxygen provides a non-invasive optical method to measure oxygen levels within cells and tissues. Difluoroboron β-diketonates are a family of luminophores with high quantum yields and tunable fluorescence and phosphorescence when embedded in certain rigid matrices such as poly (lactic acid) (PLA). Boron nanoparticles (BNPs) can be fabricated from dye-PLA materials for oxygen mapping in a variety of biological milieu. These dual-emissive nanoparticles have oxygen-insensitive fluorescence, oxygen-sensitive phosphorescence, and rigid matrix all in one, enabling real-time ratiometric oxygen sensing at micron-level spatial and millisecond-level temporal resolution. In this study, BNPs are applied in mouse brain slices to investigate oxygen distributions and neuronal activity. The optical properties and physical stability of BNPs in a biologically relevant buffer were stable. Primary neuronal cultures were labeled by BNPs and the mitochondria membrane probe MitoTracker Red FM. BNPs were taken up by neuronal cell bodies, at dendrites, and at synapses, and the localization of BNPs was consistent with that of MitoTracker Red FM. The brain slices were stained with the BNPs, and the BNPs did not significantly affect the electrophysiological properties of neurons. Oxygen maps were generated in living brain slices where oxygen is found to be mostly consumed by mitochondria near synapses. Finally, the BNPs exhibited excellent response when the conditions varied from normoxic to hypoxic and when the neuronal activity was increased by increasing K+ concentration. This work demonstrates the capability of BNPs as a non-invasive tool in oxygen sensing and could provide fundamental insight into neuronal mechanisms and excitability research.

Measuring the Bio-Electrical Parameters of a Person Using Bio-Telemetry System for Health Care Monitoring

Biotelemetry is a method of measuring a persons’s Bio-electrical parameters and a Physio-logical parameters from a distance. It’s like a updation of existing methods of measuring physiological parameters and bioelectrical parameters to a method of transmission of resulting data. This will help the consulting doctor for making a better diagnosis without movement or ensuring mobility of both the doctor and patient. Here the parameters of the wireless remote medical system for health monitoring include body temperature, blood oxygen saturation, pulse, electrocardiogram and Electrooculography. In order to measure, monitor and updating the data we require five sensors for each respective parameter so the respective five sensors are AD8232 sensor for measuring Electrocardiogram, pulse sensor for measuring pulse, EOG sensor for measuring Electrooculography, Max30100 sensor for measuring oxygen levels in blood and finally LM35 sensor used for measuring the hotness or coldness of a body. These are connected as one system using Arduino. Transferring of data to the cloud or update the data in cloud, whatever the data came from the sensors will be sent to a WiFi module called Node MCU ESP8266, through which the data will be uploaded on cloud platforms like Ubidots and Things speak. Finally from this Paper it gives the concept of Bio-Telemetry System, in other words a Medical Telemetry System. This system allows continuous monitoring of a patient’s health condition, as well as updating that respective data into their medical history like cloud platform, thus improving the efficiency of nursing care through more effective time management.

Does the application of Opsite\u22c4 Flexigrid\u22c4 occlude the oxygen saturation readings in healthy individuals using the moorVMS-OXY machine?

BackgroundA proportion of people who have been diagnosed with peripheral arterial disease and diabetes mellitus will be susceptible to chronic wounds. Oxygen is vital for wound healing, so oxygen measurements should to be taken as predictive values for wound healing in patients. When measuring oxygen at the wound bed, there is potentially a risk of cross-infection if no protective barrier is used; and skin stripping if an adhesive barrier is used on the wound bed. This cross sectional within subject repeated measures pilot study, aims to determine if the application of opsite film, as an infection control measure, in one or two layers, impacts on tissue oxygenation readings obtained when using the MoorVMS-OXY.MethodsMean oxygen saturation percentages were measured from 29 limbs of 18 healthy participants. Oxygen saturation was measured for 20 s and analysed at the first metatarsophalangeal joint using no film, one and two layers using the MoorVMS-OXY. A one-way repeated ANOVA with a Bonferroni post hoc test was performed to test for statistically significant differences between the values of the three parameters and multiple pairwise comparisons was completed.ResultsAmongst the three layers, there was a statistically significant difference in oxygen saturation between the two layers of Opsite Flexigrid and none; and also between the two layers of Flexigrid and single layer (p < 0.05). It was also established that there was no statistically significant difference between the single layer of Opsite Flexigrid and no Flexigrid layer (p > 0.05).ConclusionsThe results imply that one layer of Opsite Flexigrid is a suitable protective barrier to use when establishing capillary bed oxygen perfusion with the MoorVMS-OXY. However, the application of two Opsite Flexigrid layers, to prevent skin stripping, decreases the recorded values of oxygen saturation percentages significantly, therefore providing inaccurate results. Indicating that a double layer cannot be used over ulceration sites if measuring oxygen levels at the wound bed.

Cerebral oxygenation during locomotion is modulated by respiration

In the brain, increased neural activity is correlated with increases of cerebral blood flow and tissue oxygenation. However, how cerebral oxygen dynamics are controlled in the behaving animal remains unclear. We investigated to what extent cerebral oxygenation varies during locomotion. We measured oxygen levels in the cortex of awake, head-fixed mice during locomotion using polarography, spectroscopy, and two-photon phosphorescence lifetime measurements of oxygen sensors. We find that locomotion significantly and globally increases cerebral oxygenation, specifically in areas involved in locomotion, as well as in the frontal cortex and the olfactory bulb. The oxygenation increase persists when neural activity and functional hyperemia are blocked, occurred both in the tissue and in arteries feeding the brain, and is tightly correlated with respiration rate and the phase of respiration cycle. Thus, breathing rate is a key modulator of cerebral oxygenation and should be monitored during hemodynamic imaging, such as in BOLD fMRI.

Diurnal and Seasonal Variability of Near‐Surface Oxygen in the Strait of Georgia

AbstractDissolved oxygen (O2) concentrations in waters of the ocean surface mixed layer are generally close to thermodynamic equilibrium with atmospheric concentrations. However, near‐surface O2 levels are also affected by other processes, including primary productivity, and thus measurements of near‐surface O2 can in theory be used to estimate productivity. Here we discuss variations in near‐surface O2 concentrations in the Strait of Georgia by examining a variety of data sets, focusing primarily on ferry‐based measurements over a 3‐year period (2015–2017). Both diurnal, seasonal, and interannual variations are quantified, and various fluxes into and out of the surface waters are estimated so that the degree to the measured oxygen variations representing biological activity can be assessed. On average, advective and vertical transport makes only a small negative contribution, while other budget terms show a strong seasonal cycle, lowest in winter, peaking in spring and slowly dropping to winter level during summer and autumn. For most of the year, the air‐sea flux is the largest term, but the storage term is important during the spring blooms. Diurnal variations of 5–10% saturation in measured oxygen levels must therefore largely reflect diurnal cycles in productivity and respiration. We estimate respiration effects from the rate of decay of O2 at night, which yields an average respiration rate of 459 mmol·m−2·day−1. This value is almost an order of magnitude larger than the other budget terms we have discussed, suggesting that a future focus on diurnal variations might provide most insight into biological processes in the Strait.

Oximeter Breakthrough

New wearable device capable of measuring oxygen levels anywhere in the human body

A Wearable Pulse Oximeter With Wireless Communication and Motion Artifact Tailoring for Continuous Use.

Advances in several engineering fields have led to a trend toward miniaturization and portability of wearable biosensing devices, which used to be confined to large tools and clinical settings. Various systems to continuously measure electrophysiological activity through electrical and optical methods are one category of such devices. Being wearable and intended for prolonged use, the amount of noise introduced on sensors by movement remains a challenge and requires further optimization. User movement causes motion artifacts that alter the overall quality of the signals obtained, hence corrupting the resulting measurements. This paper introduces a fully wearable optical biosensing system to continuously measure pulse oximetry and heart rate, utilizing a reflectance-based probe. Furthermore, a novel data-dependent motion artifact tailoring algorithm is implemented to eliminate noisy data due to the motion artifact and measure oxygenation level with high accuracy in real time. By taking advantages of current wireless transmission and signal processing technologies, the developed wearable photoplethysmography device successfully captures the measured signals and sends them wirelessly to a mobile device for signal processing in real time. After applying motion artifact tailoring, evaluating accuracy with a continuous clinical device, the blood oxygenation measurements obtained from our system yielded an accuracy of at least 98%, when compared to a range of 93.6%-96.7% observed before from the same initial data. Additionally, heart rate accuracy above 97% was achieved. Motion artifact tailoring and removal in real time, continuous systems will allow wearable devices to be truly wearable and a reliable electrophysiological monitoring and diagnostics tool for everyday use.

Cumulative oxygen consumption during development of two postharvest insect pests: Callosobruchus maculatus Fabricius and Plodia interpunctella Hübner

Insect pests such as Callosobruchus maculatus Fabricius and Plodia interpunctella Hübner cause substantial losses to grain during postharvest storage. In the last few years, hermetic storage technologies have been successfully used by smallholder farmers in Africa and Asia to protect their harvested grain against insect pests. Hermetic technologies owe much of their effectiveness to restricting oxygen availability to insects confined in the containers. There is a need to better understand the biology of specific storage insect pests and their responses to hypoxia. We employed a novel and non-invasive analytical technology, the OxySense 5250i, to measure oxygen levels in closed containers, and evaluated its effectiveness in measuring the total oxygen consumption of two insect pests during their development: C. maculatus and P. interpunctella. The total amount of oxygen consumed by C. maculatus during its larval development period determined with the OxySense apparatus was not different from that previously recorded using another instrument, the Mocon Pac Check 325 gas analyzer. Using the OxySense 5250i, we found that P. interpunctella consumes nearly three times as much oxygen per insect over its larval-to-adult developmental period compared to C. maculatus. Information on the lifetime oxygen consumption of insects provides relevant information to the effectiveness and ability of hermetic technologies to protect stored products against insect pests.

Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles.

Oxygen homeostasis is important in the regulation of biological function. Disease progression can be monitored by measuring oxygen levels, thus producing information for the design of therapeutic treatments. Noninvasive measurements of tissue oxygenation require the development of tools with minimal adverse effects and facile detection of features of interest. Fluorine magnetic resonance imaging (19F MRI) exploits the intrinsic properties of perfluorocarbon (PFC) liquids for anatomical imaging, cell tracking, and oxygen sensing. However, the highly hydrophobic and lipophobic properties of perfluorocarbons require the formation of emulsions for biological studies, though stabilizing these emulsions has been challenging. To enhance the stability and biological loading of perfluorocarbons, one option is to incorporate perfluorocarbon liquids into the internal space of biocompatible mesoporous silica nanoparticles. Here, we developed perfluorocarbon-loaded ultraporous mesostructured silica nanoparticles (PERFUMNs) as 19F MRI detectable oxygen-sensing probes. Ultraporous mesostructured silica nanoparticles (UMNs) have large internal cavities (average = 1.8 cm3 g-1), facilitating an average 17% loading efficiency of PFCs, meeting the threshold fluorine concentrations needed for imaging studies. Perfluoro-15-crown-5-ether PERFUMNs have the highest equivalent nuclei per PFC molecule and a spin-lattice (T1) relaxation-based oxygen sensitivity of 0.0032 mmHg-1 s-1 at 16.4 T. The option of loading PFCs after synthesizing UMNs, rather than traditional in situ core-shell syntheses, allows for use of a broad range of PFC liquids from a single material. The biocompatible and tunable chemistry of UMNs combined with the intrinsic properties of PFCs makes PERFUMNs a MRI sensor with potential for anatomical imaging, cell tracking, and metabolic spectroscopy with improved stability.

Oxygen Detection in Biological Aqueous Solutions using Positive Muon for Cancer Research

&lt;p&gt;Spin relaxation of muonium (Mu) observed in molecular oxygen (O&lt;sub&gt;2&lt;/sub&gt;) dissolved in water shows characteristic behaviour which enables us to detect O&lt;sub&gt;2&lt;/sub&gt; in aqueous solution of albumin, serum and haemoglobin (Hb). These results suggest development of a new method using positive muon to measure oxygen level in biological systems which can be applied for diagnosis and treatment of cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Journal of Nepal Physical Society&lt;/strong&gt;&lt;br /&gt;Volume 4, Issue 1, February 2017, Page: 7-10&lt;/p&gt;