IntroductionThis cross-sectional study investigates the prevalence of knowledge and awareness of Helicobacter pylori (H. pylori) infection among the urban population of the Kingdom of Saudi Arabia (KSA). The study is motivated by the need to understand the specific demographic segments within the urban setting and their awareness levels of this prevalent bacterial infection affecting the digestive system. MethodologyThe cross-sectional study, employing a purposive sampling method and involving 840 participants from major cities in the KSA, utilized a structured survey questionnaire to gather data on demographic factors, awareness levels, attitudes, and experiences related to H. pylori infection, with subsequent statistical analysis and adherence to ethical guidelines for participant confidentiality and privacy protection. ResultThe study involved 840 participants from major cities, revealing that 59.16% were aware of H. pylori. Demographic variations included higher participation from Jeddah and Riyadh, with the majority being females aged 18-25, Saudi nationals, and individuals with undergraduate education. About 57.02% reported experiencing suspected H. pylori symptoms, and 49.16% had prior infections, with varying severity. Hesitancy toward screening (42.61%), but 72.97% believed in preventability. Limited awareness of treatments (15.35%) and identification of factors like water and food were noted. Participants perceived the seriousness of H. pylori in the mid-range (5 to 7). ConclusionThe findings shed light on variations in awareness, knowledge gaps, and attitudes, emphasizing the need for targeted public health interventions, educational campaigns, and policy measures to address the challenges associated with H. pylori infections in urban areas.