Measures Of General Intelligence Research Articles

Neurocognitive Profiles in Adolescents With Postural Tachycardia Syndrome and Perceived Brain Fog: A Preliminary Report

BackgroundPostural tachycardia syndrome (POTS) is associated with complaints of cognitive and emotional difficulties that may contribute to severe functional disability. For high-achieving adolescents, these symptoms can result in decreased participation in school and extracurricular activities. There are very limited data comparing subjective symptom reports to neurocognitive profiles in adolescents presenting with POTS, “brain fog,” and cognitive difficulties. MethodsA review of medical records and neuropsychological data was conducted for six adolescents diagnosed with POTS at a pediatric neurology clinic. All patients had frequent symptoms of orthostatic intolerance for more than three months. There was heart rate increase of ≥40 beats per minute (bpm) within 10 minutes of active standing or head-up tilt test in five patients and 36 bpm in one patient, who was diagnosed with probable POTS. All were referred for neuropsychological evaluations due to reported debilitating cognitive problems and an inability to function in a regular academic setting. Patients underwent a six-hour neuropsychological evaluation utilizing standardized measures of cognitive and emotional functioning. Clinically reported symptoms included fatigue, poor concentration, and memory impairment as well as “brain fog.” ResultsSubjective complaints differed from patients’ performance on standardized neuropsychological measures. Patients performed in the average to superior range across measures of general intelligence, verbal and working memory, processing speed, and sustained attention. ConclusionsFurther research is needed to elucidate the basis for perceived “brain fog” and cognitive impairment in POTS, such as better understanding of patient and parental perceptions of initial medical symptoms and diagnosis as well as symptom amplification due to biopsychosocial processes.

Waiting for a better possibility: delay of gratification in corvids and its relationship to other cognitive capacities.

Self-control, the ability to resist temptation and wait for better but delayed possibilities, is an important cognitive skill that underpins decision-making and planning. The capacity to exert self-control has been linked to intelligence in humans, chimpanzees and most recently cuttlefish. Here, we presented 10 Eurasian jays, Garrulus glandarius, with a delayed maintenance task, which measured the ability to choose a preferred outcome as well as the ability to sustain the delay prior to that outcome. Jays were able to wait for better possibilities, but maximum wait times varied across the subjects. We also presented them with five cognitive tasks that assessed spatial memory, spatial relationships and learning capacity. These tasks are commonly used as measures of general intelligence within an ecological context. Individual performance was correlated across the cognitive tasks, which suggests that there was a general intelligence factor underlying their performance. Performance in these tasks was correlated significantly with the jays' capacity to wait for better possibilities. This study demonstrates that self-control and intelligence are correlated in jays. The fact that this correlation exists in diverse species suggests that self-control is a fundamental feature of cognition. Our results are discussed in the context of convergent evolution. This article is part of the theme issue 'Thinking about possibilities: mechanisms, ontogeny, functions and phylogeny'.

Neurocognitive Profiles of Children With High Intellectual Ability: A Pilot Study

A common question among teachers of students with high intellectual ability is how to best teach this group of children. To answer this question, it is first necessary to better understand their cognitive profiles. Thus, the primary goal of this study was to examine the neurocognitive profiles of children with high intellectual ability. To do this, we used the Discrepancy Consistency Model (Naglieri, 1999), which allows researchers to detect patterns of cognitive strengths and weaknesses. One hundred forty-two children with high intellectual ability (70 females, 72 males; Mage = 127.41 months, SD = 10.76) from Grades 4, 5, and 6 were assessed on measures of general intelligence and academic achievement, as well as on measures of Planning, Attention, Simultaneous, and Successive (PASS) processes. Results showed that 54% of the sample had a PASS score that was significantly lower than that of each student’s average PASS score. Only 8% of the students had a PASS disorder (a score that was low in relation to the student’s average and below 90). Further, 4% of our sample had both a PASS disorder and an academic-skills disorder. The findings suggest that students with high intellectual ability can show variability in PASS scores that may have relevance for instructional programming and for identifying twice-exceptional children.

Beyond IQ: The Importance of Metacognition for the Promotion of Global Wellbeing.

Global policy makers increasingly adopt subjective wellbeing as a framework within which to measure and address human development challenges, including policies to mitigate consequential societal problems. In this review, we take a systems-level perspective to assemble evidence from studies of wellbeing, of collective intelligence, and of metacognition and argue for a virtuous cycle for health promotion in which the increased collective intelligence of groups: (1) enhances the ability of such groups to address consequential societal problems; (2) promotes the wellbeing of societies and the individual wellbeing of people within groups; and, finally, (3) enables prosocial actions that further promote collective problem-solving and global wellbeing. Notably, evidence demonstrates that effective collaboration and teamwork largely depend on social skills for metacognitive awareness—the capacity to evaluate and control our own mental processes in the service of social problem-solving. Yet, despite their importance, metacognitive skills may not be well-captured by measures of general intelligence. These skills have instead been the focus of decades of research in the psychology of human judgment and decision-making. This literature provides well-validated tests of metacognitive awareness and demonstrates that the capacity to use analysis and deliberation to evaluate intuitive responses is an important source of individual differences in decision-making. Research in network neuroscience further elucidates the topology and dynamics of brain networks that enable metacognitive awareness, providing key targets for intervention. As such, we further discuss emerging scientific interventions to enhance metacognitive skills (e.g., based on mindfulness meditation, and physical activity and aerobic fitness), and how such interventions may catalyze the virtuous cycle to improve collective intelligence, societal problem-solving, and global wellbeing.

Effect of genetic liability to migraine on cognition and brain volume: A Mendelian randomization study.

To investigate potential causality between genetic liability to migraine and Alzheimer's disease, intelligence, and brain volume using two-sample Mendelian randomization. The exposure consisted of independent genetic variants associated with migraine in the largest (59,674 cases/316,078 controls) published genome-wide association study. Outcomes included Alzheimer's disease (71,880 cases/383,378 controls), a measure of general intelligence (n = 269,867), intracranial volume (n = 11,373), and seven subcortical brain volumes (n ∼ 13,000), all with available genome-wide association study summary statistics. Mendelian randomization effects were estimated using inverse-variance weighted analysis. Genetic liability to migraine did not associate with Alzheimer's disease (odds ratio [95% confidence interval] 1.01 [1.00-1.02], p = 0.07), intelligence (standardized beta [95% confidence interval] 0.01 [0.00-0.02], p = 0.13), or any brain volume measures (all p > 0.05). No individual migraine variant associated with any of the outcomes at genome-wide significance. These data do not support a causal effect of migraine liability on Alzheimer's disease, intelligence, or brain volume.

Quality of Life in Type 2 Diabetes Mellitus Patients with Neuropsychological Deficits.

We investigated: (i) the cognitive performance of type 2 diabetes mellitus (T2DM) patients compared to healthy control participants and (ii) the Health-related Quality of life (HRQOL) of type 2 diabetics with neuropsychological deficits. We conducted a prospective study in (N=44) T2DM patients and (N=28) demographically matched healthy controls. All participants were assessed with a flexible comprehensive neuropsychological battery of tests that have been standardized in Greece and found to be sensitive in detecting cognitive deficits in type 2 diabetics. They were additionally assessed on measures of general intelligence, general mental state, and depression. They were also administered the WHO QOL-BREF self-report questionnaire to evaluate perceived health-related quality of life. Groups were well matched on baseline demographic characteristics and estimated premorbid intelligence. The groups did not differ on general mental state but varied in the encoding of verbal material, total verbal learning, delayed recall of verbal information, mental information processing speed, phonological and semantic verbal fluency and executive functions, set-shifting. Glycosylated hemoglobin levels and an interaction of age, education, and premorbid intelligence were the most important predictors of domain-specific neuropsychological performance. T2DM patients with deficits in verbal learning, executive functions, set-shifting, and semantic verbal fluency, had significantly lower QOL in the domains of psychological and environmental health, social relationships, and general health, respectively. T2DM patients have cognitive deficits on several domains compared to healthy participants. Domain specific neuropsychological deficits in middle aged T2DM patients have a significant impact on HRQOL.

COGNITIVE FUNCTION IN COUPLES AND COLLABORATIVE INVOLVEMENT IN TYPE 1 DIABETES MANAGEMENT

Managing type 1 diabetes involves coordinating complex daily behaviors that benefit from higher cognitive function. One’s spouse’s cognitive function may also be beneficial as spouses may collaborate in daily adherence behaviors and may be especially beneficial for older adults who may be experiencing poorer cognitive function. We examined: 1) whether one’s own and one’s spouse’s cognitive function predicted lower (better) HbA1c, 2) whether collaborating with a more cognitively capable spouse was especially beneficial, and 3) whether the benefit of partners’ cognitive ability occurred through better adherence. 199 couples were recruited where one member was diagnosed with type 1 diabetes for at least one year (52% females, average age 46.8 years, range 25.9-74.9, average duration of diabetes 27 years). Both patients and spouses completed the information subtest from the Wechsler Adult Intelligence Scale-Fourth Addition as a measure of general intelligence. Patients rated the collaborative involvement of their spouse in their diabetes and their adherence to their medical regimen. Multiple regressions revealed that spouse’ higher intelligence uniquely and solely predicted better HbA1c over patient’s intelligence. Collaborating with a spouse of lower intelligence was associated with higher HbA1c for older adults; collaborating with a spouse of higher intelligence was associated with somewhat lower HbA1c. Mediational analyses indicated that spouse’s intelligence was associated with higher HbA1c through better adherence behaviors. The results suggest that individuals with type 1 diabetes who have a spouse of lower cognitive function may benefit from support from others in their network to manage their diabetes.

Predicting piano skill acquisition in beginners: The role of general intelligence, music aptitude, and mindset

This study was designed to investigate sources of individual differences in musical skill acquisition. We had 171 undergraduates with little or no piano-playing experience attempt to learn a piece of piano music with the aid of a video-guide, and then, following practice with the guide, attempt to perform the piece from memory. A panel of musicians evaluated the performances based on their melodic and rhythmic accuracy. Participants also completed tests of working memory capacity, fluid intelligence, crystallized intelligence, processing speed, and two tests of music aptitude (the Swedish Music Discrimination Test and the Advanced Measures of Music Audiation). Measures of general intelligence and music aptitude correlated significantly with skill acquisition, but mindset did not. Structural equation modeling revealed that general intelligence, music aptitude, and mindset together accounted for 22.4% of the variance in skill acquisition. However, only general intelligence contributed significantly to the model (β = 0.44, p < .001). The contributions of music aptitude (β = 0.08, p = .39) and mindset (β = −0.06, p = .50) were non-significant after accounting for general intelligence. We also found that openness to experience did not significantly predict skill acquisition or music aptitude. Overall, the results suggest that after accounting for individual differences in general intelligence, music aptitude and mindset do not predict piano skill acquisition in beginners.

Interindividual variation in learning ability in honeybees

Performance on different cognitive tasks could either be positively correlated in an individual as a measure of general intelligence or costs related to specific aspects of cognition could give rise to specialized cognitive phenotypes. Social living offers the potential for individual specialization in learning and a cooperative group can benefit from a diversity of learning phenotypes. However, there is little empirical data regarding the nature of such interindividual variation in learning abilities in honeybees, a classic model of animal cognition. We tested for the presence of variation in learning abilities in the honeybee, Apis mellifera, and whether any component of learning has an influence on wing damage, a proxy for performance and survival. Our results show considerable interindividual variation in different types of learning abilities. At the individual level, while landmark and olfactory learning abilities are negatively correlated, olfactory learning shows a positive association with maneuverability performance, a measure which in turn shows a positive influence on wing damage, a proxy for survival. We discuss our results in the context of cognitive diversity and specialization in a social group.

Cognitive functioning following traumatic brain injury: The first 5 years.

This study reports the results from a 5-year longitudinal investigation of the prevalence and severity of cognitive deficits following significant (i.e., ventilation required for > 24 hours) traumatic brain injury. The changes in performance, either improvement or decline, across five domains of cognitive functioning are described. A group of 56 adults was assessed at approximately 6 months, 1 year, and 5 years following injury. Impairment was evident on all measures but prevalence and rate of improvement varied. Overall, by 5 years post-injury over 85% of patients were not impaired on measures of general intelligence, simple attention, and visual perception. However, 28% of patients continued to show some degree of impairment on complex attention and verbal fluency, and performance on verbal memory remained impaired for 60% of patients. There was also evidence for deterioration in complex attention and verbal memory between 1 year and 5 years. ANOVAs showed that improvement occurred on most measures between 6 months and 1 year, but there was both improvement and decline on some measures between 1 year and 5 years. The findings show that there is considerable heterogeneity in cognitive outcome following TBI, with some deterioration evident over the long term.

Exploration of the Rate of Forgetting as a Domain-Specific Individual Differences Measure

Learners differ in their learning aptitude. Modern computerized fact-learning systems take these individual differences into account by adapting repetition schedules to the learner’s characteristics. Adaptation is based on monitoring responses during learning and using these responses to inform the model’s decisions about when to introduce and repeat material by updating the model’s internal parameters. Typically, adaptive systems start a learning session with a set of default parameters, with these parameters being updated and adapted to the learner’s characteristics when responses are collected. Here we explore whether domain-general individual differences such as working-memory capacity or measures of general intelligence, which can be assessed prior to learning sessions, can inform the choice of initial model parameters. Such an approach is viable if the domain-general individual differences are related to the model parameters estimated during learning. In the current study, we asked participants to learn factual information, and assessed whether their learning performance, operationalized as (1) a model-parameter that captures the rate of forgetting, and (2) the results on an immediate and delayed post-test, was related to two common measures of individual differences: working memory capacity and general cognitive ability. We failed to find evidence in favor for such relations, suggesting that, at least in this relatively small and homogeneous sample, executive functioning and attentional control did not play important roles in predicting delayed recall. The model parameters estimated during learning, on the other hand, are highly correlated with delayed recall of the studied material.

Nutrient biomarker patterns, cognitive function, and fMRI measures of network efficiency in the aging brain

A central aim of research in the psychological and brain sciences is to establish therapeutic interventions to promote healthy brain aging. Accumulating evidence indicates that diet and the many bioactive substances present in food are reasonable interventions to examine for dementia prevention. However, interdisciplinary research that applies methods from nutritional epidemiology and network neuroscience to investigate the role of nutrition in shaping functional brain network efficiency remains to be conducted. The present study therefore sought to combine methods across disciplines, applying nutrient biomarker pattern (NBP) analysis to capture the effects of plasma nutrients in combination and to examine their collective influence on measures of functional brain network efficiency (small-world propensity). We examined the contribution of NBPs to multiple indices of cognition and brain health in non-demented elders (n = 116), investigating performance on measures of general intelligence, executive function, and memory, and resting-state fMRI measures of brain network efficiency within seven intrinsic connectivity networks. Statistical moderation investigated whether NBPs influenced network efficiency and cognitive outcomes. The results revealed five NBPs that were associated with enhanced cognitive performance, including biomarker patterns high in plasma: (1) ω-3 and ω-6 polyunsaturated fatty acids (PUFAs), (2) lycopene, (3) ω-3 PUFAs, (4) carotenoids, and (5) vitamins B (riboflavin, folate, B12) and D. Furthermore, three NBPs were associated with enhanced functional brain network efficiency, including biomarker patterns high in plasma: (1) ω-6 PUFAs, (2) ω-3 PUFAs, and (3) carotene. Finally, ω-3 PUFAs moderated the fronto-parietal network and general intelligence, while ω-6 PUFAs and lycopene moderated the dorsal attention network and executive function. In sum, NBPs account for a significant proportion of variance in measures of cognitive performance and functional brain network efficiency. The results motivate a multidisciplinary approach that applies methods from nutritional epidemiology (NBP analysis) and cognitive neuroscience (functional brain network efficiency) to characterize the impact of nutrition on human health, aging, and disease.

The PASS to superior reading performance

ABSTRACTAlthough the role of cognitive processes, such as planning, attention, simultaneous, and successive (PASS) processing in reading ability has been examined in samples of typically developing children and children with reading difficulties, it remains unclear if these processes also contribute to superior reading performance. Thus, in this study we examined (a) which PASS processes differentiate superior readers from average readers and (b) what is the individual profile of the superior readers. Thirty-six children with superior reading performance (standard score in Broad Reading equal to or higher than 130) and 43 average readers (standard score in Broad Reading between 85 and 115) were assessed on measures of general intelligence, planning, attention, simultaneous, and successive processing. The results of multivariate analyses indicated that the superior readers performed significantly better than the average readers only in simultaneous and successive processing. However, the superior readers exhibited diverse individual profiles of cognitive assets. The psychoeducational implications of these findings are discussed.

Neurobehavioral Outcomes 11 Years After Neonatal Caffeine Therapy for Apnea of Prematurity.

Caffeine is effective in the treatment of apnea of prematurity. Although caffeine therapy has a benefit on gross motor skills in school-aged children, effects on neurobehavioral outcomes are not fully understood. We aimed to investigate effects of neonatal caffeine therapy in very low birth weight (500-1250 g) infants on neurobehavioral outcomes in 11-year-old participants of the Caffeine for Apnea of Prematurity trial. Thirteen academic hospitals in Canada, Australia, Great Britain, and Sweden participated in this part of the 11-year follow-up of the double-blind, randomized, placebo-controlled trial. Measures of general intelligence, attention, executive function, visuomotor integration and perception, and behavior were obtained in up to 870 children. The effects of caffeine therapy were assessed by using regression models. Neurobehavioral outcomes were generally similar for both the caffeine and placebo group. The caffeine group performed better than the placebo group in fine motor coordination (mean difference [MD] = 2.9; 95% confidence interval [CI]: 0.7 to 5.1; P = .01), visuomotor integration (MD = 1.8; 95% CI: 0.0 to 3.7; P < .05), visual perception (MD = 2.0; 95% CI: 0.3 to 3.8; P = .02), and visuospatial organization (MD = 1.2; 95% CI: 0.4 to 2.0; P = .003). Neonatal caffeine therapy for apnea of prematurity improved visuomotor, visuoperceptual, and visuospatial abilities at age 11 years. General intelligence, attention, and behavior were not adversely affected by caffeine, which highlights the long-term safety of caffeine therapy for apnea of prematurity in very low birth weight neonates.

Effect of Trinucleotide Repeats in the Huntington's Gene on Intelligence

BackgroundHuntington's Disease (HD) is caused by an abnormality in the HTT gene. This gene includes trinucleotide repeats ranging from 10 to 35, and when expanded beyond 39, causes HD. We previously reported that CAG repeats in the normal range had a direct and beneficial effect on brain development with higher repeats being associated with higher cognitive function. The current study now expands this line of inquiry to evaluate the effects of CAG repeat throughout the entire spectrum of repeats from 15 to 58. MethodsWe evaluated brain function in children ages 6–18 years old. DNA samples were processed to quantify the number of CAG repeats within HTT. Linear regression was used to determine if number of CAG repeats predicted measures of brain function. FindingsThe number of repeats in HTT, had a non-linear effect on a measure of general intelligence with an inverted U shape pattern. Increasing repeat length was associated with higher GAI scores up until roughly 40–41 repeats. After this peak, increasing repeat length was associated with declining GAI scores. InterpretationHTT may confer an advantage or a disadvantage depending upon the repeat length, playing a key role in the determination of intelligence, or causing a uniquely human brain disease.

Personality Differences between Dog People and Cat People

Abstract Understanding the relationship between human personality and preferences for pet species is important for bettering human-animal relationships, supporting animal welfare, and supporting pet therapy. The present study examined personality differences between dog people and cat people with the objective of addressing some discrepancies in previous research that could be traced to the use of broadly defined versus narrowly defined traits. Participants were 418 undergraduates who completed the Sixteen Personality Factors Questionnaire (16PF) and a Pet Survey that classified them as dog or cat people. The 16PF contains 15 narrowly defined primary personality traits, a brief measure of general intelligence, and 5 global factors that are comparable in meaning to those of the Five Factor Model. The principal differences were that the 352 dog people scored higher on warmth, liveliness, rule consciousness, and social boldness compared to the 66 cat people. The latter scored higher on general intelligence, abstractedness, and self-reliance. Overall, primary traits corresponded to a pattern known to be associated with creative personalities and produced better discrimination between the two groups than traits corresponded to the Five Factor Model. Some traits were more salient for females than they were for males.

General intelligence in friendship selection: A study of preadolescent best friend dyads

Research on the topics of general intelligence and friendship formation separately has elicited a tremendous amount of attention across decades of psychological scholarship. To date, however, less effort has been aimed at uniting these lines of inquiry. In particular, do friendship bonds emerge, based in part, on shared levels of cognitive ability? Several disparate lines of evidence suggest this might be the case, however, a need remains to replicate this work using large national samples coupled with psychometrically sound measurement. The current study helps to fill this void in the literature using a national sample of American children. Our results reveal that preadolescent friendship dyads are robustly correlated on measures of general intelligence, and the effects withstand correction for potentially confounding variables.

Associations of Newborn Brain Magnetic Resonance Imaging with Long-Term Neurodevelopmental Impairments in Very Preterm Children

To determine the relationship between brain abnormalities on newborn magnetic resonance imaging (MRI) and neurodevelopmental impairment at 7 years of age in very preterm children. A total of 223 very preterm infants (<30 weeks of gestation or <1250 g) born at Melbourne's Royal Women's Hospital had a brain MRI scan at term equivalent age. Scans were scored using a standardized system that assessed structural abnormality of cerebral white matter, cortical gray matter, deep gray matter, and cerebellum. Children were assessed at 7 years on measures of general intelligence, motor functioning, academic achievement, and behavior. One hundred eighty-six very preterm children (83%) had both an MRI at term equivalent age and a 7-year follow-up assessment. Higher global brain, cerebral white matter, and deep gray matter abnormality scores were related to poorer intelligence quotient (IQ) (Ps < .01), spelling (Ps < .05), math computation (Ps < .01), and motor function (Ps < .001). Higher cerebellum abnormality scores were related to poorer IQ (P = .001), math computation (P = .018), and motor outcomes (P = .001). Perinatal, neonatal, and social confounders had little effect on the relationships between the MRI abnormality scores and outcomes. Moderate-severe global abnormality on newborn MRI was associated with a reduction in IQ (-6.9 points), math computation (-7.1 points), and motor (-1.9 points) scores independent of the other potential confounders. Structured evaluation of brain MRI at term equivalent is predictive of outcome at 7 years of age, independent of clinical and social factors.

Assessing the Willingness to Elaborate among Young Students: Psychometric Evaluation of a Swedish Need for Cognition Scale

The personality trait Need for Cognition (NFC) has been studied for many years, and found to be important for individuals’ educational achievement. The original NFC-scale was developed in the eighties, and during the following decade the scale was translated and adapted into a number of other languages. A renewed interest for the personality trait of NFC has made these scales interesting to use. It is though vital that instruments used for studies of individual differences in the area of educational research, or in any other area, can portray valid results today. The aim of the present paper was to evaluate validity and reliability of the short version of the Mental Effort Tolerance Questionnaire, a Swedish adaption of the NFC-scale made in 1991, which has not been previously evaluated. This study involved 420 young students, and the evaluation of reliability includes a study of temporal stability (test-retest), as well as internal stability. Further, the evaluation of validity includes construct and criterion validity. Regarding reliability, the results showed a test-retest reliability coefficient of .88 (n = 108), and an internal stability (Cronbach’s alpha) of .88 (n = 420). Evaluation of construct validity found evidence for a five factor dimensional structure (n = 420), discriminant validity to measures of general intelligence (r = .25; n = 122), working memory (r = .22; n =164), and the personality trait Grit (r = .26; n = 169). Finally, criterion validity was found for grades (r =.35; n =125). Overall, the results of the evaluation show that the inferences made from the results of the short version of the Swedish NFC-scale exhibits satisfactory reliability and validity, suggesting that the questionnaire can be used in educational contexts. The questionnaire might, however, benefit from being even more shortened.

Smoking in pregnancy, adolescent mental health and cognitive performance in young adult offspring: results from a matched sample within a Finnish cohort

BackgroundThe association between prenatal exposure to maternal cigarette smoking (PEMCS) and adult cognition is debated, including if there are differences according to sex. We aimed to determine if there are associations between PEMCS and cognition in early adulthood in men and women and examine if observed associations were mediated by adolescent mental health factors that are associated with cognition, namely psychotic-like experiences (PLEs), inattention and hyperactivity, and other externalizing behaviors.MethodsParticipants were 471 individuals drawn from the general population-based Northern Finland 1986 Birth Cohort (NFBC 1986) followed up from pregnancy and birth to early adulthood; individuals with PEMCS were matched with those without PEMCS by socioeconomic and demographic factors. Cognitive performance in adulthood was assessed with a range of tests and their association with PEMCS was measured by sex using hierarchical linear regression, unadjusted and then controlling for potential confounders, mediators and moderators, including adolescent mental health factors.ResultsThere were no associations between PEMCS and cognitive scores in females. In males, there were associations with vocabulary (beta = -0.444, 95% CI: -0.783, -0.104) and matrix reasoning (beta = -0.379, 95% CI: -0.711, -0.047).ConclusionsWhile associations between PEMCS and cognition were limited, observed findings with measures of general intelligence in males contribute to suggestions of differences in response to PEMCS by sex. Furthermore, observed associations may be partly mediated by earlier inattention and hyperactivity. Findings add support to efforts aimed to eliminate smoking in pregnancy.