The learning model is a logical stage for learning students. The learning process must pay attention to the steps that become the basic framework for creating an effective and meaningful student learning process. This study aims to innovate biology learning in metabolism material. The innovation is done by integrating several technologies namely Wordwall, Virtual Lab, and Ms. PowerPoint on the Constructivist Teaching Sequence model. The research method used is a literature review sourced from books, journal articles, research reports, and other relevant documents. This research flow has several stages consisting of literature identification, literature selection, literature analysis, synthesis of findings, and learning model innovation design. The result of this research is an innovative learning recommendation using the technology-assisted Constructivist Teaching Sequence model that can be an alternative high school biology learning model.